IMP

Process View

Homo sapiens

23 genes annotated in human

natural killer cell mediated cytotoxicity

The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "natural killer cell mediated cytotoxicity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "natural killer cell mediated cytotoxicity" (in gray)

Name	Description	Probability	Func Analog Organism
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.991	Rat
B2M	beta-2-microglobulin	0.989
HLA-A	major histocompatibility complex, class I, A	0.976
HLA-G	major histocompatibility complex, class I, G	0.954	Human
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.936
HLA-B	major histocompatibility complex, class I, B	0.913
HLA-C	major histocompatibility complex, class I, C	0.816	Human
TAPBP	TAP binding protein (tapasin)	0.809
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.755
HLA-E	major histocompatibility complex, class I, E	0.701
HLA-F	major histocompatibility complex, class I, F	0.620	Human
CD84	CD84 molecule	0.604
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.572	Human
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.431	Rat
SH2D1A	SH2 domain containing 1A	0.359	Mouse
SLAMF1	signaling lymphocytic activation molecule family member 1	0.358
DDIT3	DNA-damage-inducible transcript 3	0.332
PILRA	paired immunoglobin-like type 2 receptor alpha	0.234
GBA	glucosidase, beta, acid	0.216
IL2RB	interleukin 2 receptor, beta	0.147
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.131
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.110
SIGLEC7	sialic acid binding Ig-like lectin 7	0.109
SNAP23	synaptosomal-associated protein, 23kDa	0.096
IL23A	interleukin 23, alpha subunit p19	0.096
ITM2B	integral membrane protein 2B	0.082
PVRL4	poliovirus receptor-related 4	0.076
CSK	c-src tyrosine kinase	0.058
GZMK	granzyme K (granzyme 3; tryptase II)	0.053
KLRC3	killer cell lectin-like receptor subfamily C, member 3	0.049	Human
ARRB1	arrestin, beta 1	0.048	Human
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.046
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.042
RAB14	RAB14, member RAS oncogene family	0.041
IFNG	interferon, gamma	0.037
MLPH	melanophilin	0.037
MICA	MHC class I polypeptide-related sequence A	0.036
SH2D1B	SH2 domain containing 1B	0.035	Mouse
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.034
KLRC2	killer cell lectin-like receptor subfamily C, member 2	0.032	Human
LGALS3	lectin, galactoside-binding, soluble, 3	0.031
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.031
INSR	insulin receptor	0.030
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.029
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.028
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.028	Human
PVRL3	poliovirus receptor-related 3	0.028	Human
STAP2	signal transducing adaptor family member 2	0.026
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.026
KLRC1	killer cell lectin-like receptor subfamily C, member 1	0.025	Human
MAP2K4	mitogen-activated protein kinase kinase 4	0.025
JAK2	Janus kinase 2	0.024
NCSTN	nicastrin	0.024
PTAFR	platelet-activating factor receptor	0.023
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.023	Human
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.021
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.021
MAPK10	mitogen-activated protein kinase 10	0.021
HK3	hexokinase 3 (white cell)	0.021
EPOR	erythropoietin receptor	0.021
NLRP3	NLR family, pyrin domain containing 3	0.021
CLINT1	clathrin interactor 1	0.021
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.020
ARRB2	arrestin, beta 2	0.020
KLRC4	killer cell lectin-like receptor subfamily C, member 4	0.019	Human
HCST	hematopoietic cell signal transducer	0.019
BTN3A1	butyrophilin, subfamily 3, member A1	0.019
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.019
CCL5	chemokine (C-C motif) ligand 5	0.018
GNS	glucosamine (N-acetyl)-6-sulfatase	0.018
CARS	cysteinyl-tRNA synthetase	0.018
KLRG1	killer cell lectin-like receptor subfamily G, member 1	0.018	Human
C1orf38	chromosome 1 open reading frame 38	0.018
ATF7IP	activating transcription factor 7 interacting protein	0.017
TNFRSF21	tumor necrosis factor receptor superfamily, member 21	0.017
TXN	thioredoxin	0.017
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.016
IRF1	interferon regulatory factor 1	0.016
SH3BGRL	SH3 domain binding glutamic acid-rich protein like	0.016
CTSA	cathepsin A	0.016
PRF1	perforin 1 (pore forming protein)	0.016
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.016
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.015	Human
BTN3A3	butyrophilin, subfamily 3, member A3	0.015
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.014
MYO5A	myosin VA (heavy chain 12, myoxin)	0.014
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.014
AOAH	acyloxyacyl hydrolase (neutrophil)	0.014
BTN3A2	butyrophilin, subfamily 3, member A2	0.014
CD33	CD33 molecule	0.013
TREM1	triggering receptor expressed on myeloid cells 1	0.013
TPP1	tripeptidyl peptidase I	0.013
TLR8	toll-like receptor 8	0.013
PYHIN1	pyrin and HIN domain family, member 1	0.013
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.013
CCNK	cyclin K	0.013
TJP1	tight junction protein 1 (zona occludens 1)	0.013
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.013
CCR1	chemokine (C-C motif) receptor 1	0.013
TYMP	thymidine phosphorylase	0.013
CCR5	chemokine (C-C motif) receptor 5	0.013
CD48	CD48 molecule	0.012
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.012
CD226	CD226 molecule	0.012
IL18RAP	interleukin 18 receptor accessory protein	0.012
HCP5	HLA complex P5	0.012
HFE	hemochromatosis	0.012	Human
IL10RB	interleukin 10 receptor, beta	0.012
AQP9	aquaporin 9	0.012
CD8A	CD8a molecule	0.012
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.012	Human
CMKLR1	chemokine-like receptor 1	0.012
CD244	CD244 molecule, natural killer cell receptor 2B4	0.011
SIRPB1	signal-regulatory protein beta 1	0.011
KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	0.011
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.011	Human
TAPBPL	TAP binding protein-like	0.011
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.011
CD160	CD160 molecule	0.011
PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	0.011
IL32	interleukin 32	0.011
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.011
YY1	YY1 transcription factor	0.010
GNLY	granulysin	0.010
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.010
WARS	tryptophanyl-tRNA synthetase	0.010
CAV1	caveolin 1, caveolae protein, 22kDa	0.010
BIN2	bridging integrator 2	0.010
PSEN1	presenilin 1	0.010
XCL2	chemokine (C motif) ligand 2	0.010