IMP

Process View

Homo sapiens

2 genes annotated in human

late endosome to vacuole transport

The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "late endosome to vacuole transport"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "late endosome to vacuole transport" (in gray)

Name	Description	Probability	Func Analog Organism
MON1B	MON1 homolog B (yeast)	0.935
CHMP1A	chromatin modifying protein 1A	0.680
PDCD6IP	programmed cell death 6 interacting protein	0.672
CALCOCO2	calcium binding and coiled-coil domain 2	0.539
ARCN1	archain 1	0.499
COPA	coatomer protein complex, subunit alpha	0.492
FBXL15	F-box and leucine-rich repeat protein 15	0.452
COPB1	coatomer protein complex, subunit beta 1	0.428
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.326	Yeast
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.316	Yeast
ANKRD13A	ankyrin repeat domain 13A	0.314
CHMP4B	chromatin modifying protein 4B	0.313
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.279
OCRL	oculocerebrorenal syndrome of Lowe	0.273
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.263
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.235	Yeast
SMAD4	SMAD family member 4	0.224
EEA1	early endosome antigen 1	0.210
ARRB2	arrestin, beta 2	0.195
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.190
EPS15	epidermal growth factor receptor pathway substrate 15	0.179
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.163	Yeast
SACM1L	SAC1 suppressor of actin mutations 1-like (yeast)	0.132
ZFYVE9	zinc finger, FYVE domain containing 9	0.105
DEDD	death effector domain containing	0.097
SMAD1	SMAD family member 1	0.087
COPG	coatomer protein complex, subunit gamma	0.081
LRRK2	leucine-rich repeat kinase 2	0.077
CARD11	caspase recruitment domain family, member 11	0.076
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.072
VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)	0.065
CXXC5	CXXC finger protein 5	0.065
SOX7	SRY (sex determining region Y)-box 7	0.062
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.060
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.060
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.056
PDCD6	programmed cell death 6	0.055
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.052
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.052	Yeast
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.052	Yeast
TDP2	tyrosyl-DNA phosphodiesterase 2	0.051
TRIM37	tripartite motif containing 37	0.050
VPS33A	vacuolar protein sorting 33 homolog A (S. cerevisiae)	0.046
RNF11	ring finger protein 11	0.045
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.044
ING2	inhibitor of growth family, member 2	0.043
SMAD7	SMAD family member 7	0.043
RNF168	ring finger protein 168	0.043
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.040
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.040
STAMBP	STAM binding protein	0.038
C1orf93	chromosome 1 open reading frame 93	0.037
TRAF4	TNF receptor-associated factor 4	0.037
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	0.036
SH3GL2	SH3-domain GRB2-like 2	0.036
WASL	Wiskott-Aldrich syndrome-like	0.036
SH3KBP1	SH3-domain kinase binding protein 1	0.035
WNK1	WNK lysine deficient protein kinase 1	0.034
ZFAND5	zinc finger, AN1-type domain 5	0.032
KLF5	Kruppel-like factor 5 (intestinal)	0.031
LNX1	ligand of numb-protein X 1	0.031
SDCBP2	syndecan binding protein (syntenin) 2	0.030
ERBB2IP	erbb2 interacting protein	0.030
R3HCC1	R3H domain and coiled-coil containing 1	0.029
ADAM15	ADAM metallopeptidase domain 15	0.029
SNX9	sorting nexin 9	0.028
UBQLN2	ubiquilin 2	0.028
PTK2	PTK2 protein tyrosine kinase 2	0.028
CCDC127	coiled-coil domain containing 127	0.027
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.027
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.027
SBF1	SET binding factor 1	0.027
GGA3	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	0.027
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.026
SMAD5	SMAD family member 5	0.026
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.026
KRT15	keratin 15	0.025
GOLGA5	golgin A5	0.023
DNM1	dynamin 1	0.023
PPIL4	peptidylprolyl isomerase (cyclophilin)-like 4	0.022
UVRAG	UV radiation resistance associated gene	0.022
ZFYVE20	zinc finger, FYVE domain containing 20	0.022
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.022
NBR1	neighbor of BRCA1 gene 1	0.022
TM9SF4	transmembrane 9 superfamily protein member 4	0.022
PIK3C3	phosphoinositide-3-kinase, class 3	0.022
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.021
PTEN	phosphatase and tensin homolog	0.021
TSG101	tumor susceptibility gene 101	0.020
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.020
MKL2	MKL/myocardin-like 2	0.020
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.019
VPS18	vacuolar protein sorting 18 homolog (S. cerevisiae)	0.019	Yeast
BCAR1	breast cancer anti-estrogen resistance 1	0.019
BECN1	beclin 1, autophagy related	0.019
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.019
RABGEF1	RAB guanine nucleotide exchange factor (GEF) 1	0.019
POLH	polymerase (DNA directed), eta	0.019
MTMR4	myotubularin related protein 4	0.018
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.018
YAP1	Yes-associated protein 1	0.018
SUN2	Sad1 and UNC84 domain containing 2	0.017
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.017
SYNJ1	synaptojanin 1	0.017
MYO6	myosin VI	0.017
DNM2	dynamin 2	0.017
SMAD6	SMAD family member 6	0.017
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.017
ARRDC3	arrestin domain containing 3	0.017
SNX6	sorting nexin 6	0.016
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.016
DTX1	deltex homolog 1 (Drosophila)	0.016
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.016
RAB10	RAB10, member RAS oncogene family	0.016
RAP1B	RAP1B, member of RAS oncogene family	0.016
COPG2	coatomer protein complex, subunit gamma 2	0.016
GMEB1	glucocorticoid modulatory element binding protein 1	0.016
OSBPL11	oxysterol binding protein-like 11	0.016	Yeast
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.016
SEC22B	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)	0.015
VPS25	vacuolar protein sorting 25 homolog (S. cerevisiae)	0.015
PHAX	phosphorylated adaptor for RNA export	0.015
RAB1B	RAB1B, member RAS oncogene family	0.015
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.015
WRNIP1	Werner helicase interacting protein 1	0.015
ACBD3	acyl-CoA binding domain containing 3	0.015
POLI	polymerase (DNA directed) iota	0.015
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.015
RIOK3	RIO kinase 3 (yeast)	0.015
OSBPL9	oxysterol binding protein-like 9	0.015	Yeast
NDFIP2	Nedd4 family interacting protein 2	0.015
WBP2	WW domain binding protein 2	0.015
PGAM5	phosphoglycerate mutase family member 5	0.015
UBE4A	ubiquitination factor E4A (UFD2 homolog, yeast)	0.014
RHOA	ras homolog gene family, member A	0.014
ZC3HC1	zinc finger, C3HC-type containing 1	0.014
PRKCZ	protein kinase C, zeta	0.014
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.014
ING1	inhibitor of growth family, member 1	0.014
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.014
TRAPPC8	trafficking protein particle complex 8	0.014
DOCK8	dedicator of cytokinesis 8	0.014
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.014
NCKAP1	NCK-associated protein 1	0.014
POU5F1	POU class 5 homeobox 1	0.013
RHOXF2	Rhox homeobox family, member 2	0.013
ZNF512B	zinc finger protein 512B	0.013
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.013
TGFBR1	transforming growth factor, beta receptor 1	0.013
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.013
BTBD10	BTB (POZ) domain containing 10	0.013
APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.013
DBNL	drebrin-like	0.013
ADARB1	adenosine deaminase, RNA-specific, B1	0.013
SNX33	sorting nexin 33	0.013
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.013
SOX2	SRY (sex determining region Y)-box 2	0.012
KLHL12	kelch-like 12 (Drosophila)	0.012
RAB7A	RAB7A, member RAS oncogene family	0.012
CENPB	centromere protein B, 80kDa	0.012
FAM192A	family with sequence similarity 192, member A	0.012
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.012
UBB	ubiquitin B	0.012
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.012
BCL10	B-cell CLL/lymphoma 10	0.012
DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	0.012
VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	0.012
AES	amino-terminal enhancer of split	0.012
SOX5	SRY (sex determining region Y)-box 5	0.012
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.011
VPS16	vacuolar protein sorting 16 homolog (S. cerevisiae)	0.011	Yeast
ZMYND11	zinc finger, MYND-type containing 11	0.011
USP2	ubiquitin specific peptidase 2	0.011
SRI	sorcin	0.011
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.011
ADRB2	adrenergic, beta-2-, receptor, surface	0.011
ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	0.011
ACD	adrenocortical dysplasia homolog (mouse)	0.011
CNOT1	CCR4-NOT transcription complex, subunit 1	0.011
KIAA0930	KIAA0930	0.011
OXR1	oxidation resistance 1	0.011
DOCK9	dedicator of cytokinesis 9	0.011
CLPTM1	cleft lip and palate associated transmembrane protein 1	0.011
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.011
B4GALT7	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)	0.011
USP8	ubiquitin specific peptidase 8	0.011
AP1S1	adaptor-related protein complex 1, sigma 1 subunit	0.011
GATAD2B	GATA zinc finger domain containing 2B	0.010
GRAP2	GRB2-related adaptor protein 2	0.010
IGSF21	immunoglobin superfamily, member 21	0.010
CHMP7	CHMP family, member 7	0.010