IMP

Process View

Homo sapiens

1 genes annotated in human

regulation of transcription by chromatin organization

Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of transcription by chromatin organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of transcription by chromatin organization" (in gray)

Name	Description	Probability	Func Analog Organism
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.872
NBN	nibrin	0.715
CREBBP	CREB binding protein	0.597
CBX5	chromobox homolog 5	0.543
EP300	E1A binding protein p300	0.494
TRRAP	transformation/transcription domain-associated protein	0.456
MCM7	minichromosome maintenance complex component 7	0.429
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.335
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.299
RB1	retinoblastoma 1	0.240
RAD50	RAD50 homolog (S. cerevisiae)	0.229
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.227
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.209
SSRP1	structure specific recognition protein 1	0.201
TGIF1	TGFB-induced factor homeobox 1	0.196
HIST1H3B	histone cluster 1, H3b	0.168
LBR	lamin B receptor	0.154
WRN	Werner syndrome, RecQ helicase-like	0.135
ADNP	activity-dependent neuroprotector homeobox	0.119
NRIP1	nuclear receptor interacting protein 1	0.103
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.102
RAD21	RAD21 homolog (S. pombe)	0.102
CBX1	chromobox homolog 1	0.101
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.099
ATXN7	ataxin 7	0.093
PRRC2C	proline-rich coiled-coil 2C	0.085
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.084	Yeast
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.083
MCM2	minichromosome maintenance complex component 2	0.081
CDK2	cyclin-dependent kinase 2	0.080
RANBP2	RAN binding protein 2	0.078
INCENP	inner centromere protein antigens 135/155kDa	0.077
BCLAF1	BCL2-associated transcription factor 1	0.075
CREB1	cAMP responsive element binding protein 1	0.070
USP22	ubiquitin specific peptidase 22	0.068
CHRAC1	chromatin accessibility complex 1	0.067
SMC1A	structural maintenance of chromosomes 1A	0.065
RBBP4	retinoblastoma binding protein 4	0.063
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.063
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.058
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.055
HIPK2	homeodomain interacting protein kinase 2	0.053
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.052
MCM3	minichromosome maintenance complex component 3	0.050
RBBP8	retinoblastoma binding protein 8	0.050
KAT2B	K(lysine) acetyltransferase 2B	0.049	Yeast
ORC6	origin recognition complex, subunit 6	0.048
PML	promyelocytic leukemia	0.047
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.047
MBD1	methyl-CpG binding domain protein 1	0.047
DAXX	death-domain associated protein	0.046
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.044
NCOA3	nuclear receptor coactivator 3	0.043
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.040
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.038
MCMBP	minichromosome maintenance complex binding protein	0.038
TOPORS	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	0.037
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.035
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.033
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.033
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.032
APC	adenomatous polyposis coli	0.032
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.031
MDC1	mediator of DNA-damage checkpoint 1	0.031
EED	embryonic ectoderm development	0.030
PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	0.029
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.029
AR	androgen receptor	0.028
NUP50	nucleoporin 50kDa	0.028
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.027
MCM4	minichromosome maintenance complex component 4	0.027
TADA2A	transcriptional adaptor 2A	0.027
FOXO3	forkhead box O3	0.027
CDK6	cyclin-dependent kinase 6	0.027
HDAC1	histone deacetylase 1	0.026
NCOA1	nuclear receptor coactivator 1	0.026
ADNP2	ADNP homeobox 2	0.025
MORC3	MORC family CW-type zinc finger 3	0.025
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.025
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.025
RSF1	remodeling and spacing factor 1	0.025
MIS12	MIS12, MIND kinetochore complex component, homolog (S. pombe)	0.025
H2AFV	H2A histone family, member V	0.025
POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.024
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.024
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.024
TADA3	transcriptional adaptor 3	0.023
H3F3B	H3 histone, family 3B (H3.3B)	0.023
CRY1	cryptochrome 1 (photolyase-like)	0.023
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.023
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.022
MSH6	mutS homolog 6 (E. coli)	0.022
POGZ	pogo transposable element with ZNF domain	0.021
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.021
TOP1	topoisomerase (DNA) I	0.021
HMGXB4	HMG box domain containing 4	0.021
ZEB1	zinc finger E-box binding homeobox 1	0.020
NCOA6	nuclear receptor coactivator 6	0.020
ANKRD17	ankyrin repeat domain 17	0.020
H2AFX	H2A histone family, member X	0.020
ZNF267	zinc finger protein 267	0.019
POLE	polymerase (DNA directed), epsilon	0.019
SMNDC1	survival motor neuron domain containing 1	0.019
TTC3	tetratricopeptide repeat domain 3	0.018
NUP98	nucleoporin 98kDa	0.018
IRF2	interferon regulatory factor 2	0.018
EIF4E	eukaryotic translation initiation factor 4E	0.018
RPA2	replication protein A2, 32kDa	0.018
NCOR1	nuclear receptor corepressor 1	0.018
C1orf9	chromosome 1 open reading frame 9	0.018
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.018
ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	0.018
IK	IK cytokine, down-regulator of HLA II	0.017
KIAA1033	KIAA1033	0.017
PARP1	poly (ADP-ribose) polymerase 1	0.017
SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	0.017
LIG1	ligase I, DNA, ATP-dependent	0.017
TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa	0.017
RBM25	RNA binding motif protein 25	0.017
TPR	translocated promoter region (to activated MET oncogene)	0.016	Fly
SRP9	signal recognition particle 9kDa	0.016
AHCTF1	AT hook containing transcription factor 1	0.016
FOXO1	forkhead box O1	0.016
POLR1A	polymerase (RNA) I polypeptide A, 194kDa	0.016
SATB1	SATB homeobox 1	0.015
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.015
NIPBL	Nipped-B homolog (Drosophila)	0.015
FN3KRP	fructosamine 3 kinase related protein	0.015
KIAA1377	KIAA1377	0.015
SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	0.015
LCORL	ligand dependent nuclear receptor corepressor-like	0.015
SOX13	SRY (sex determining region Y)-box 13	0.015
CDCA4	cell division cycle associated 4	0.015
RUNX1	runt-related transcription factor 1	0.014
SMAD7	SMAD family member 7	0.014
MYST2	MYST histone acetyltransferase 2	0.014
CEP72	centrosomal protein 72kDa	0.014
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.014
USF1	upstream transcription factor 1	0.014
C20orf20	chromosome 20 open reading frame 20	0.013
CDYL	chromodomain protein, Y-like	0.013
E2F3	E2F transcription factor 3	0.013
CHD3	chromodomain helicase DNA binding protein 3	0.013
KLF4	Kruppel-like factor 4 (gut)	0.013
TP53BP2	tumor protein p53 binding protein, 2	0.013
RPA1	replication protein A1, 70kDa	0.013
AHR	aryl hydrocarbon receptor	0.013
TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	0.013
MBNL1	muscleblind-like (Drosophila)	0.013
GINS4	GINS complex subunit 4 (Sld5 homolog)	0.013
TELO2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.012
ACACA	acetyl-CoA carboxylase alpha	0.012
RRP8	ribosomal RNA processing 8, methyltransferase, homolog (yeast)	0.012
SCAF8	SR-related CTD-associated factor 8	0.012
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.012
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.012
STRN3	striatin, calmodulin binding protein 3	0.012
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.012
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.012	Yeast
GABPB1	GA binding protein transcription factor, beta subunit 1	0.012
CCNH	cyclin H	0.012
TPP2	tripeptidyl peptidase II	0.011
CHD1L	chromodomain helicase DNA binding protein 1-like	0.011
LGALS8	lectin, galactoside-binding, soluble, 8	0.011
VPS72	vacuolar protein sorting 72 homolog (S. cerevisiae)	0.011
MED24	mediator complex subunit 24	0.011
MED1	mediator complex subunit 1	0.011
MEF2C	myocyte enhancer factor 2C	0.011
RBM39	RNA binding motif protein 39	0.011
JMY	junction mediating and regulatory protein, p53 cofactor	0.011
MAGEA2	melanoma antigen family A, 2	0.011
CNN3	calponin 3, acidic	0.011
CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.011	Yeast
DICER1	dicer 1, ribonuclease type III	0.011
CUX1	cut-like homeobox 1	0.011
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.011
E2F1	E2F transcription factor 1	0.011
AMD1	adenosylmethionine decarboxylase 1	0.011
EIF4A2	eukaryotic translation initiation factor 4A2	0.011
EID1	EP300 interacting inhibitor of differentiation 1	0.011
TRIM33	tripartite motif containing 33	0.011
ZNF689	zinc finger protein 689	0.010
ZNF217	zinc finger protein 217	0.010
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.010
THAP11	THAP domain containing 11	0.010
MCM5	minichromosome maintenance complex component 5	0.010
TCF4	transcription factor 4	0.010