IMP

Process View

Homo sapiens

34 genes annotated in human

cellular biogenic amine metabolic process

The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular biogenic amine metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular biogenic amine metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
APOA1	apolipoprotein A-I	0.993
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	0.873
HP	haptoglobin	0.699
APOE	apolipoprotein E	0.694	Human
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.582
PRKCZ	protein kinase C, zeta	0.520	Human
ZNF71	zinc finger protein 71	0.455
A2M	alpha-2-macroglobulin	0.453
INSR	insulin receptor	0.445
CCR5	chemokine (C-C motif) receptor 5	0.385
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.359
SAT1	spermidine/spermine N1-acetyltransferase 1	0.342	Human
NOXA1	NADPH oxidase activator 1	0.336
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.331
APOC1	apolipoprotein C-I	0.331
PDZD11	PDZ domain containing 11	0.320
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.315
LCAT	lecithin-cholesterol acyltransferase	0.225
ALB	albumin	0.213
NUMB	numb homolog (Drosophila)	0.206
DCTN1	dynactin 1	0.187
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.159
NCF1	neutrophil cytosolic factor 1	0.153
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.145
SIGMAR1	sigma non-opioid intracellular receptor 1	0.140
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.129
APOC3	apolipoprotein C-III	0.129
EIF1AX	eukaryotic translation initiation factor 1A, X-linked	0.115
FGA	fibrinogen alpha chain	0.107
APOC2	apolipoprotein C-II	0.097
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.093
APOA2	apolipoprotein A-II	0.092
MAPT	microtubule-associated protein tau	0.084
SAT2	spermidine/spermine N1-acetyltransferase family member 2	0.084
APOB	apolipoprotein B (including Ag(x) antigen)	0.075
CCDC115	coiled-coil domain containing 115	0.074
INO80C	INO80 complex subunit C	0.073
DDA1	DET1 and DDB1 associated 1	0.069
SH3RF1	SH3 domain containing ring finger 1	0.067
PCSK9	proprotein convertase subtilisin/kexin type 9	0.063
TMEM66	transmembrane protein 66	0.062
DUSP23	dual specificity phosphatase 23	0.060
TMEM33	transmembrane protein 33	0.058
IDI1	isopentenyl-diphosphate delta isomerase 1	0.056
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.054
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.054
TMED7	transmembrane emp24 protein transport domain containing 7	0.053
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.052
F11R	F11 receptor	0.050
FUNDC2	FUN14 domain containing 2	0.050
IRF3	interferon regulatory factor 3	0.050
CDCP1	CUB domain containing protein 1	0.049
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.049
CHUK	conserved helix-loop-helix ubiquitous kinase	0.048
BRF2	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like	0.047
UCK2	uridine-cytidine kinase 2	0.045
GTPBP4	GTP binding protein 4	0.045
CYBA	cytochrome b-245, alpha polypeptide	0.044
CD2	CD2 molecule	0.044
RUNX1	runt-related transcription factor 1	0.043
GBP2	guanylate binding protein 2, interferon-inducible	0.042
PICK1	protein interacting with PRKCA 1	0.042
VHL	von Hippel-Lindau tumor suppressor	0.041
PPIF	peptidylprolyl isomerase F	0.039
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.038
SC4MOL	sterol-C4-methyl oxidase-like	0.037
TM9SF3	transmembrane 9 superfamily member 3	0.036
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.034
PNO1	partner of NOB1 homolog (S. cerevisiae)	0.034
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.033
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.033
UBXN2A	UBX domain protein 2A	0.033
FYN	FYN oncogene related to SRC, FGR, YES	0.033
ENPP4	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)	0.032	Human
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.031
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.031
ETF1	eukaryotic translation termination factor 1	0.030
RARA	retinoic acid receptor, alpha	0.030
ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	0.030	Human
TCF25	transcription factor 25 (basic helix-loop-helix)	0.029
LRRK2	leucine-rich repeat kinase 2	0.029
EIF4E	eukaryotic translation initiation factor 4E	0.029
TUBB2A	tubulin, beta 2A	0.029
ATP2C1	ATPase, Ca++ transporting, type 2C, member 1	0.029
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.029
FGFR2	fibroblast growth factor receptor 2	0.028
TTR	transthyretin	0.027
ACADVL	acyl-CoA dehydrogenase, very long chain	0.027
LNX1	ligand of numb-protein X 1	0.027
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.026
RAN	RAN, member RAS oncogene family	0.026
CCL14	chemokine (C-C motif) ligand 14	0.026
CMPK1	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic	0.026
PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	0.025
CCDC47	coiled-coil domain containing 47	0.025
LIN7C	lin-7 homolog C (C. elegans)	0.024
PRKCB	protein kinase C, beta	0.024
ZBTB4	zinc finger and BTB domain containing 4	0.024
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.024
ZHX1	zinc fingers and homeoboxes 1	0.024
IL32	interleukin 32	0.024
INSIG1	insulin induced gene 1	0.024
PPAT	phosphoribosyl pyrophosphate amidotransferase	0.024
HIPK2	homeodomain interacting protein kinase 2	0.024
PLTP	phospholipid transfer protein	0.023
YIPF6	Yip1 domain family, member 6	0.022
FAM176A	family with sequence similarity 176, member A	0.022
MAT2A	methionine adenosyltransferase II, alpha	0.022
NUS1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	0.022
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.022
MGAT4B	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B	0.022
PTMA	prothymosin, alpha	0.022
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.022
TYK2	tyrosine kinase 2	0.022
NOL3	nucleolar protein 3 (apoptosis repressor with CARD domain)	0.021
BZW1	basic leucine zipper and W2 domains 1	0.021
RFK	riboflavin kinase	0.021
SOX12	SRY (sex determining region Y)-box 12	0.020
KAT2B	K(lysine) acetyltransferase 2B	0.020
STX12	syntaxin 12	0.020
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.020
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.019
PEBP4	phosphatidylethanolamine-binding protein 4	0.019
GSPT1	G1 to S phase transition 1	0.019
CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.019
HN1	hematological and neurological expressed 1	0.019
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.019
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.019
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.019
GABARAPL1	GABA(A) receptor-associated protein like 1	0.018
SDF2L1	stromal cell-derived factor 2-like 1	0.018
C2orf18	chromosome 2 open reading frame 18	0.018
LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	0.018
AP1AR	adaptor-related protein complex 1 associated regulatory protein	0.018
CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	0.018
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.017
TMEM165	transmembrane protein 165	0.017
RBM18	RNA binding motif protein 18	0.017
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.017
POFUT1	protein O-fucosyltransferase 1	0.017
CCL19	chemokine (C-C motif) ligand 19	0.017
MTMR6	myotubularin related protein 6	0.017
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.016
CREM	cAMP responsive element modulator	0.016
SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.016
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.016
EXOSC4	exosome component 4	0.016
SDCBP	syndecan binding protein (syntenin)	0.016
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.016
SERINC1	serine incorporator 1	0.016
FAM18B1	family with sequence similarity 18, member B1	0.016
XPOT	exportin, tRNA (nuclear export receptor for tRNAs)	0.016
SPRR2A	small proline-rich protein 2A	0.016
SESN2	sestrin 2	0.015
NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	0.015
EIF4A1	eukaryotic translation initiation factor 4A1	0.015
CP	ceruloplasmin (ferroxidase)	0.015
CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1	0.015
MED25	mediator complex subunit 25	0.015
COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.015
RAD23B	RAD23 homolog B (S. cerevisiae)	0.015
FADS1	fatty acid desaturase 1	0.015
IL1RAP	interleukin 1 receptor accessory protein	0.015
RAD23A	RAD23 homolog A (S. cerevisiae)	0.015
IPO7	importin 7	0.015
TUBB2C	tubulin, beta 2C	0.015
SLC35B2	solute carrier family 35, member B2	0.015
FAM83C	family with sequence similarity 83, member C	0.015
SLC38A7	solute carrier family 38, member 7	0.015
DGAT1	diacylglycerol O-acyltransferase 1	0.014
DPP4	dipeptidyl-peptidase 4	0.014
RNF6	ring finger protein (C3H2C3 type) 6	0.014
CCL4	chemokine (C-C motif) ligand 4	0.014
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.014
LRP1	low density lipoprotein receptor-related protein 1	0.014
SRGN	serglycin	0.014
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.014
ELANE	elastase, neutrophil expressed	0.014
UFM1	ubiquitin-fold modifier 1	0.014
AUP1	ancient ubiquitous protein 1	0.014
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.014
SH2D1A	SH2 domain containing 1A	0.014
SCARB1	scavenger receptor class B, member 1	0.014	Mouse
PRKCA	protein kinase C, alpha	0.014
NUP153	nucleoporin 153kDa	0.014
GLRX3	glutaredoxin 3	0.014
ATG9A	ATG9 autophagy related 9 homolog A (S. cerevisiae)	0.014
GNLY	granulysin	0.014
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.014
UNC45A	unc-45 homolog A (C. elegans)	0.014
BAG3	BCL2-associated athanogene 3	0.013
ATXN1	ataxin 1	0.013
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.013
CXCL9	chemokine (C-X-C motif) ligand 9	0.013
C2	complement component 2	0.013
ACSL1	acyl-CoA synthetase long-chain family member 1	0.013
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.013
SPRED1	sprouty-related, EVH1 domain containing 1	0.013
SQLE	squalene epoxidase	0.013
FLII	flightless I homolog (Drosophila)	0.013
CCL2	chemokine (C-C motif) ligand 2	0.013
SEPP1	selenoprotein P, plasma, 1	0.013
YRDC	yrdC domain containing (E. coli)	0.013
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.013
JAK3	Janus kinase 3	0.013
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.013
C20orf24	chromosome 20 open reading frame 24	0.012
CCDC148	coiled-coil domain containing 148	0.012
CYB5A	cytochrome b5 type A (microsomal)	0.012
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.012
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.012
IL2RB	interleukin 2 receptor, beta	0.012
IFRD1	interferon-related developmental regulator 1	0.012
CCL8	chemokine (C-C motif) ligand 8	0.012
CCHCR1	coiled-coil alpha-helical rod protein 1	0.012
CREBBP	CREB binding protein	0.012
HOXB9	homeobox B9	0.012
BHMT	betaine--homocysteine S-methyltransferase	0.012
C14orf147	chromosome 14 open reading frame 147	0.012
TRIM9	tripartite motif containing 9	0.012
CA5A	carbonic anhydrase VA, mitochondrial	0.012
ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	0.012
TUBA1B	tubulin, alpha 1b	0.012
HPD	4-hydroxyphenylpyruvate dioxygenase	0.011
ADAP1	ArfGAP with dual PH domains 1	0.011
PKLR	pyruvate kinase, liver and RBC	0.011
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.011
AURKC	aurora kinase C	0.011
RIT1	Ras-like without CAAX 1	0.011
ELOVL1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1	0.011
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.011
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.011
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.011
C1QC	complement component 1, q subcomponent, C chain	0.011
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.011
NUPR1	nuclear protein, transcriptional regulator, 1	0.011
MESDC2	mesoderm development candidate 2	0.011
FHOD3	formin homology 2 domain containing 3	0.011
STAT4	signal transducer and activator of transcription 4	0.011
CTSW	cathepsin W	0.011
KLHL2	kelch-like 2, Mayven (Drosophila)	0.011
WWC1	WW and C2 domain containing 1	0.011
VCAM1	vascular cell adhesion molecule 1	0.011
SLC25A32	solute carrier family 25, member 32	0.011
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.011
LARP4	La ribonucleoprotein domain family, member 4	0.011
PANK3	pantothenate kinase 3	0.011
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.011
CXCR6	chemokine (C-X-C motif) receptor 6	0.011
CTSL1	cathepsin L1	0.011
RAB8A	RAB8A, member RAS oncogene family	0.011
NXF1	nuclear RNA export factor 1	0.011
FABP1	fatty acid binding protein 1, liver	0.011
PTPRS	protein tyrosine phosphatase, receptor type, S	0.011
BCL10	B-cell CLL/lymphoma 10	0.011
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.011
ASGR1	asialoglycoprotein receptor 1	0.011
HOXB6	homeobox B6	0.011
FABP2	fatty acid binding protein 2, intestinal	0.011
HSPA13	heat shock protein 70kDa family, member 13	0.011
RHEB	Ras homolog enriched in brain	0.011
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.011
TUBA1C	tubulin, alpha 1c	0.011
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.011
AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	0.011	Human
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.011
SYT11	synaptotagmin XI	0.011
DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	0.011
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.011
DNTT	deoxynucleotidyltransferase, terminal	0.011
SKAP1	src kinase associated phosphoprotein 1	0.011
OTC	ornithine carbamoyltransferase	0.011
CYCS	cytochrome c, somatic	0.011
CTNS	cystinosis, nephropathic	0.011
LBP	lipopolysaccharide binding protein	0.011
CPA3	carboxypeptidase A3 (mast cell)	0.010
CETP	cholesteryl ester transfer protein, plasma	0.010
RNF123	ring finger protein 123	0.010
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.010
AGXT	alanine-glyoxylate aminotransferase	0.010
ARL8B	ADP-ribosylation factor-like 8B	0.010
TFRC	transferrin receptor (p90, CD71)	0.010
SIN3B	SIN3 homolog B, transcription regulator (yeast)	0.010
SLC25A39	solute carrier family 25, member 39	0.010
FABP5	fatty acid binding protein 5 (psoriasis-associated)	0.010	Mouse
SH2D2A	SH2 domain containing 2A	0.010
TMEM38B	transmembrane protein 38B	0.010
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.010
LDLRAP1	low density lipoprotein receptor adaptor protein 1	0.010
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.010
SORBS1	sorbin and SH3 domain containing 1	0.010
DYNLL1	dynein, light chain, LC8-type 1	0.010
B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	0.010
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.010
LSM12	LSM12 homolog (S. cerevisiae)	0.010
NCL	nucleolin	0.010
NLK	nemo-like kinase	0.010
TBC1D23	TBC1 domain family, member 23	0.010
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.010
C8B	complement component 8, beta polypeptide	0.010
ADAM10	ADAM metallopeptidase domain 10	0.010
CTSG	cathepsin G	0.010
DPYS	dihydropyrimidinase	0.010