IMP

Process View

Homo sapiens

3 genes annotated in human

phagocytosis recognition

The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "phagocytosis recognition"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "phagocytosis recognition" (in gray)

Name	Description	Probability	Func Analog Organism
SYK	spleen tyrosine kinase	0.997
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.994	Human
KLRC3	killer cell lectin-like receptor subfamily C, member 3	0.917	Human
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.877
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.809
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.789
KLRC2	killer cell lectin-like receptor subfamily C, member 2	0.752	Human
LCK	lymphocyte-specific protein tyrosine kinase	0.733
GZMK	granzyme K (granzyme 3; tryptase II)	0.696
TYROBP	TYRO protein tyrosine kinase binding protein	0.654
ZCCHC17	zinc finger, CCHC domain containing 17	0.640
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.582
BRD4	bromodomain containing 4	0.562
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.561	Human
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.493
ITK	IL2-inducible T-cell kinase	0.490
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.459
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.452
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.445
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.442
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.427
PRF1	perforin 1 (pore forming protein)	0.426
CD33	CD33 molecule	0.412
PILRA	paired immunoglobin-like type 2 receptor alpha	0.399
CLEC4A	C-type lectin domain family 4, member A	0.379
KLRC1	killer cell lectin-like receptor subfamily C, member 1	0.370	Human
CD163	CD163 molecule	0.337
PECAM1	platelet/endothelial cell adhesion molecule	0.281
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.273
KLRG1	killer cell lectin-like receptor subfamily G, member 1	0.266	Human
IFNG	interferon, gamma	0.246
GPR65	G protein-coupled receptor 65	0.243
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.227
GNLY	granulysin	0.227
PRPF38A	PRP38 pre-mRNA processing factor 38 (yeast) domain containing A	0.222
EPOR	erythropoietin receptor	0.216
CCR5	chemokine (C-C motif) receptor 5	0.209
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.206
UBASH3B	ubiquitin associated and SH3 domain containing B	0.167
FASLG	Fas ligand (TNF superfamily, member 6)	0.149
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.144
CCR1	chemokine (C-C motif) receptor 1	0.129
KLRC4	killer cell lectin-like receptor subfamily C, member 4	0.125	Human
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.121
CCR2	chemokine (C-C motif) receptor 2	0.117
CD84	CD84 molecule	0.109
FGL2	fibrinogen-like 2	0.109
GPR171	G protein-coupled receptor 171	0.105
CXCR6	chemokine (C-X-C motif) receptor 6	0.104
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.096
CCL4	chemokine (C-C motif) ligand 4	0.096
F13A1	coagulation factor XIII, A1 polypeptide	0.094
CD160	CD160 molecule	0.094
CD2	CD2 molecule	0.091
IGSF6	immunoglobulin superfamily, member 6	0.088
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.085
LEPROTL1	leptin receptor overlapping transcript-like 1	0.085
CYBB	cytochrome b-245, beta polypeptide	0.083
CXCL9	chemokine (C-X-C motif) ligand 9	0.082
GIMAP4	GTPase, IMAP family member 4	0.071
SH3BP2	SH3-domain binding protein 2	0.070
CD53	CD53 molecule	0.066
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.065
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.063
XCL2	chemokine (C motif) ligand 2	0.063
CD93	CD93 molecule	0.062
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.062
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.062
NKG7	natural killer cell group 7 sequence	0.059
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.058
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.055	Mouse
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.055
P2RY13	purinergic receptor P2Y, G-protein coupled, 13	0.055
FYB	FYN binding protein	0.055
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.054
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.050
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.050
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.046
IL18RAP	interleukin 18 receptor accessory protein	0.046
CLEC5A	C-type lectin domain family 5, member A	0.046
TLR2	toll-like receptor 2	0.046
VSIG4	V-set and immunoglobulin domain containing 4	0.046
ADORA3	adenosine A3 receptor	0.044
CD1C	CD1c molecule	0.042
TFEC	transcription factor EC	0.042
KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	0.042
FPR3	formyl peptide receptor 3	0.042
MSR1	macrophage scavenger receptor 1	0.041
IL4R	interleukin 4 receptor	0.041
CD96	CD96 molecule	0.041
CSF1R	colony stimulating factor 1 receptor	0.040
SIGLEC7	sialic acid binding Ig-like lectin 7	0.038
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.038
PYHIN1	pyrin and HIN domain family, member 1	0.038
GRAP2	GRB2-related adaptor protein 2	0.038
CD226	CD226 molecule	0.037
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.036
SRSF4	serine/arginine-rich splicing factor 4	0.035
MNDA	myeloid cell nuclear differentiation antigen	0.035
CD28	CD28 molecule	0.034
CD3D	CD3d molecule, delta (CD3-TCR complex)	0.034
SLAMF1	signaling lymphocytic activation molecule family member 1	0.033
ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	0.032
TRAT1	T cell receptor associated transmembrane adaptor 1	0.032
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.032	Mouse
LYZ	lysozyme	0.032
C3AR1	complement component 3a receptor 1	0.032
CD72	CD72 molecule	0.031
MICA	MHC class I polypeptide-related sequence A	0.031
MPEG1	macrophage expressed 1	0.030
GIMAP5	GTPase, IMAP family member 5	0.030
TXK	TXK tyrosine kinase	0.030
KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	0.029
CCNL1	cyclin L1	0.029
KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	0.029
KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 and killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	0.028
NCR1	natural cytotoxicity triggering receptor 1	0.028
TREM2	triggering receptor expressed on myeloid cells 2	0.027
LAIR2	leukocyte-associated immunoglobulin-like receptor 2	0.027
CTSW	cathepsin W	0.027
CLEC7A	C-type lectin domain family 7, member A	0.027
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.026
CLEC4E	C-type lectin domain family 4, member E	0.026
CD8A	CD8a molecule	0.025
RNASE6	ribonuclease, RNase A family, k6	0.025
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.025
PLCG1	phospholipase C, gamma 1	0.025
TRD@	T cell receptor delta locus	0.024
PLEK	pleckstrin	0.024
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.024
GPNMB	glycoprotein (transmembrane) nmb	0.024
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.024
CLU	clusterin	0.024
THBD	thrombomodulin	0.023
RNASE3	ribonuclease, RNase A family, 3	0.023
MARCH1	membrane-associated ring finger (C3HC4) 1	0.023
CD180	CD180 molecule	0.023
CD80	CD80 molecule	0.023
CTSS	cathepsin S	0.022
CRTAM	cytotoxic and regulatory T cell molecule	0.022
CD101	CD101 molecule	0.022
PTGDR	prostaglandin D2 receptor (DP)	0.022
FCAR	Fc fragment of IgA, receptor for	0.022
GZMM	granzyme M (lymphocyte met-ase 1)	0.021
MRC1	mannose receptor, C type 1	0.021
CLEC10A	C-type lectin domain family 10, member A	0.021
FABP4	fatty acid binding protein 4, adipocyte	0.020
SIGLEC10	sialic acid binding Ig-like lectin 10	0.020
KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	0.020
LY86	lymphocyte antigen 86	0.020
TARP	TCR gamma alternate reading frame protein	0.020
OLFML3	olfactomedin-like 3	0.020
PRKCQ	protein kinase C, theta	0.020
THEMIS	thymocyte selection associated	0.019
TLR7	toll-like receptor 7	0.019
NKAP	NFKB activating protein	0.019
SIRPB1	signal-regulatory protein beta 1	0.019	Mouse
TM6SF1	transmembrane 6 superfamily member 1	0.019
CMKLR1	chemokine-like receptor 1	0.019
SH2D1A	SH2 domain containing 1A	0.019
RGS18	regulator of G-protein signaling 18	0.019
SLFN12	schlafen family member 12	0.019
CLEC12A	C-type lectin domain family 12, member A	0.018	Human
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	0.018
KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	0.018
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.018	Human
SLAMF6	SLAM family member 6	0.018
P2RY10	purinergic receptor P2Y, G-protein coupled, 10	0.018
ICOS	inducible T-cell co-stimulator	0.017
CD22	CD22 molecule	0.017
STAT4	signal transducer and activator of transcription 4	0.017
CLEC4M	C-type lectin domain family 4, member M	0.017	Mouse
CPA3	carboxypeptidase A3 (mast cell)	0.017
DNASE1L3	deoxyribonuclease I-like 3	0.017
GPR34	G protein-coupled receptor 34	0.017
TLR4	toll-like receptor 4	0.017
ADAMDEC1	ADAM-like, decysin 1	0.017
C5AR1	complement component 5a receptor 1	0.017
FGD5	FYVE, RhoGEF and PH domain containing 5	0.017
CD209	CD209 molecule	0.017	Mouse
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.016
IPCEF1	interaction protein for cytohesin exchange factors 1	0.016
CAMK4	calcium/calmodulin-dependent protein kinase IV	0.016
TXNDC3	thioredoxin domain containing 3 (spermatozoa)	0.016
GFI1	growth factor independent 1 transcription repressor	0.016
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.016
CD36	CD36 molecule (thrombospondin receptor)	0.016	Mouse
CLC	Charcot-Leyden crystal protein	0.015
ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	0.015
SKAP1	src kinase associated phosphoprotein 1	0.015
SPP1	secreted phosphoprotein 1	0.015
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.015
P2RY14	purinergic receptor P2Y, G-protein coupled, 14	0.015
SLA	Src-like-adaptor	0.015
LPAR1	lysophosphatidic acid receptor 1	0.015
CPVL	carboxypeptidase, vitellogenic-like	0.015
SIGLEC5	sialic acid binding Ig-like lectin 5	0.015
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.015
FAM9A	family with sequence similarity 9, member A	0.014
ADPRH	ADP-ribosylarginine hydrolase	0.014
HIST1H2BJ	histone cluster 1, H2bj	0.014
CXCR2	chemokine (C-X-C motif) receptor 2	0.014
NCR3	natural cytotoxicity triggering receptor 3	0.014
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.014
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.014
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.014
BMP1	bone morphogenetic protein 1	0.014
HDC	histidine decarboxylase	0.014
CLEC2D	C-type lectin domain family 2, member D	0.014
HBB	hemoglobin, beta	0.014
MME	membrane metallo-endopeptidase	0.014
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.014
PLBD1	phospholipase B domain containing 1	0.014
OLFML2B	olfactomedin-like 2B	0.014
CD300LF	CD300 molecule-like family member f	0.014
TREM1	triggering receptor expressed on myeloid cells 1	0.013
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.013
SDCBP2	syndecan binding protein (syntenin) 2	0.013
IL12RB2	interleukin 12 receptor, beta 2	0.013
PDK4	pyruvate dehydrogenase kinase, isozyme 4	0.013
KIR2DL4	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	0.013
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.013
CALCRL	calcitonin receptor-like	0.013
SLAMF7	SLAM family member 7	0.013
ARSB	arylsulfatase B	0.013
TLR5	toll-like receptor 5	0.013
FAM198B	family with sequence similarity 198, member B	0.012
TM7SF4	transmembrane 7 superfamily member 4	0.012
ART4	ADP-ribosyltransferase 4 (Dombrock blood group)	0.012
LPL	lipoprotein lipase	0.012
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.012
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	0.012
EOMES	eomesodermin	0.012
APOA2	apolipoprotein A-II	0.012
OLFML1	olfactomedin-like 1	0.012
FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	0.012
RANBP10	RAN binding protein 10	0.012
TLR8	toll-like receptor 8	0.012
XCL1	chemokine (C motif) ligand 1	0.012
CLEC1A	C-type lectin domain family 1, member A	0.012	Human
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.012
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.012
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.011
TMSB4Y	thymosin beta 4, Y-linked	0.011
NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	0.011
NLRP3	NLR family, pyrin domain containing 3	0.011
CHERP	calcium homeostasis endoplasmic reticulum protein	0.011
RSPO2	R-spondin 2 homolog (Xenopus laevis)	0.011
IL2RB	interleukin 2 receptor, beta	0.011
CCR3	chemokine (C-C motif) receptor 3	0.011
S100A12	S100 calcium binding protein A12	0.011
FAM105A	family with sequence similarity 105, member A	0.011
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.011
GPR124	G protein-coupled receptor 124	0.011
IL7R	interleukin 7 receptor	0.011
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.011
TLR6	toll-like receptor 6	0.011
CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	0.011
CD86	CD86 molecule	0.011
AQP9	aquaporin 9	0.011
CFHR2	complement factor H-related 2	0.011
CD5L	CD5 molecule-like	0.011
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.011
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.011
CCL13	chemokine (C-C motif) ligand 13	0.011
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.011
ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	0.011
C6orf25	chromosome 6 open reading frame 25	0.011
MYCT1	myc target 1	0.011
C17orf97	chromosome 17 open reading frame 97	0.011
MS4A2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.011
SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	0.011
CTSK	cathepsin K	0.011
GPR183	G protein-coupled receptor 183	0.011
HPGDS	hematopoietic prostaglandin D synthase	0.011
FLT3	fms-related tyrosine kinase 3	0.010
NINL	ninein-like	0.010
MRC2	mannose receptor, C type 2	0.010
IL1RL1	interleukin 1 receptor-like 1	0.010
EMR3	egf-like module containing, mucin-like, hormone receptor-like 3	0.010
SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	0.010
STAC3	SH3 and cysteine rich domain 3	0.010
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.010
HSPA12A	heat shock 70kDa protein 12A	0.010
CNTNAP1	contactin associated protein 1	0.010
CD244	CD244 molecule, natural killer cell receptor 2B4	0.010
BTLA	B and T lymphocyte associated	0.010
MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	0.010
APCS	amyloid P component, serum	0.010
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.010
FAM124B	family with sequence similarity 124B	0.010