IMP

Process View

Homo sapiens

23 genes annotated in human

Multi-species View

trna processing

GO:0008033

The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "trna processing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "trna processing" (in gray)

Name	Description	Probability	Func Analog Organism
IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	1.000	Yeast
ELP3	elongation protein 3 homolog (S. cerevisiae)	0.999	Yeast
ELP2	elongation protein 2 homolog (S. cerevisiae)	0.995	Yeast
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.985	Yeast
WDR4	WD repeat domain 4	0.983
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.924	Yeast
METTL1	methyltransferase like 1	0.898
ELP4	elongation protein 4 homolog (S. cerevisiae)	0.886	Yeast
ASCC2	activating signal cointegrator 1 complex subunit 2	0.651
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.621
TP53RK	TP53 regulating kinase	0.488
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.433	Yeast
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.409	Yeast
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.332	Yeast
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.296
FBXL15	F-box and leucine-rich repeat protein 15	0.261
CELF1	CUGBP, Elav-like family member 1	0.257
XRN2	5'-3' exoribonuclease 2	0.256
CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon	0.252
EIF2B2	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	0.239
ZFYVE9	zinc finger, FYVE domain containing 9	0.222
ANKRD28	ankyrin repeat domain 28	0.205
C7orf36	chromosome 7 open reading frame 36	0.199
MMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	0.179
CPSF6	cleavage and polyadenylation specific factor 6, 68kDa	0.169
C14orf126	chromosome 14 open reading frame 126	0.149
UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	0.142
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.128	Yeast
FAM96B	family with sequence similarity 96, member B	0.107
NARS2	asparaginyl-tRNA synthetase 2, mitochondrial (putative)	0.093
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.084	Yeast
FKBP3	FK506 binding protein 3, 25kDa	0.082
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.082
C14orf104	chromosome 14 open reading frame 104	0.081
DDX1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	0.080
NVL	nuclear VCP-like	0.080
ARL6IP4	ADP-ribosylation-like factor 6 interacting protein 4	0.075
BCS1L	BCS1-like (S. cerevisiae)	0.074
ANKRD52	ankyrin repeat domain 52	0.073
CXXC5	CXXC finger protein 5	0.071
METTL18	methyltransferase like 18	0.071
POU5F1	POU class 5 homeobox 1	0.070
OGFOD1	2-oxoglutarate and iron-dependent oxygenase domain containing 1	0.070
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.067
PRMT3	protein arginine methyltransferase 3	0.066
PCBP1	poly(rC) binding protein 1	0.062
LAGE3	L antigen family, member 3	0.061
ARMC6	armadillo repeat containing 6	0.060
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.059
ANKRD13A	ankyrin repeat domain 13A	0.058
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.053
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.052
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.051	Yeast
MATR3	matrin 3	0.051
PDCD2	programmed cell death 2	0.048
OCLN	occludin	0.048
RHOA	ras homolog gene family, member A	0.044
FAM98B	family with sequence similarity 98, member B	0.043
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.042
PUS1	pseudouridylate synthase 1	0.042
KATNB1	katanin p80 (WD repeat containing) subunit B 1	0.041
PPP6R3	protein phosphatase 6, regulatory subunit 3	0.041
FASTKD2	FAST kinase domains 2	0.040
LARS	leucyl-tRNA synthetase	0.040
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.040
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.039
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.038
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.037
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.036
UTP20	UTP20, small subunit (SSU) processome component, homolog (yeast)	0.034
LENG1	leukocyte receptor cluster (LRC) member 1	0.034
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.034
GTPBP6	GTP binding protein 6 (putative)	0.034
WDR92	WD repeat domain 92	0.033
CENPB	centromere protein B, 80kDa	0.033
USP45	ubiquitin specific peptidase 45	0.033
POLR1B	polymerase (RNA) I polypeptide B, 128kDa	0.032
RBM41	RNA binding motif protein 41	0.032
FAM203A	family with sequence similarity 203, member A	0.032
C2orf56	chromosome 2 open reading frame 56	0.032
TBCE	tubulin folding cofactor E	0.032
FAM110A	family with sequence similarity 110, member A	0.032
UBA1	ubiquitin-like modifier activating enzyme 1	0.031
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.031
CNBP	CCHC-type zinc finger, nucleic acid binding protein	0.030
CDK11B	cyclin-dependent kinase 11B	0.030
CRAMP1L	Crm, cramped-like (Drosophila)	0.029
TSEN54	tRNA splicing endonuclease 54 homolog (S. cerevisiae)	0.029
ELAC2	elaC homolog 2 (E. coli)	0.029
SLC4A1AP	solute carrier family 4 (anion exchanger), member 1, adaptor protein	0.029
C9orf142	chromosome 9 open reading frame 142	0.028
EIF2B1	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	0.028
MCC	mutated in colorectal cancers	0.027
RPS6KB2	ribosomal protein S6 kinase, 70kDa, polypeptide 2	0.027
YBX1	Y box binding protein 1	0.027
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.027
PTCD2	pentatricopeptide repeat domain 2	0.027
PSMG2	proteasome (prosome, macropain) assembly chaperone 2	0.027
NOL8	nucleolar protein 8	0.026
MARS	methionyl-tRNA synthetase	0.026
RNF168	ring finger protein 168	0.025
TSEN2	tRNA splicing endonuclease 2 homolog (S. cerevisiae)	0.025
TBL3	transducin (beta)-like 3	0.025
ZNF775	zinc finger protein 775	0.025
PRMT6	protein arginine methyltransferase 6	0.024
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.022
SRI	sorcin	0.022
PWP1	PWP1 homolog (S. cerevisiae)	0.022
OLA1	Obg-like ATPase 1	0.022
TTC27	tetratricopeptide repeat domain 27	0.022
TRAF4	TNF receptor-associated factor 4	0.022
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.022
WDR3	WD repeat domain 3	0.021
RMND1	required for meiotic nuclear division 1 homolog (S. cerevisiae)	0.021
GFM1	G elongation factor, mitochondrial 1	0.021
THUMPD3	THUMP domain containing 3	0.021
XPO5	exportin 5	0.021
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.021
CALCOCO2	calcium binding and coiled-coil domain 2	0.021
MINA	MYC induced nuclear antigen	0.021
ESF1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	0.021
NTHL1	nth endonuclease III-like 1 (E. coli)	0.020
SLC25A12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	0.020
WDR75	WD repeat domain 75	0.020
LMO3	LIM domain only 3 (rhombotin-like 2)	0.020
OSGEPL1	O-sialoglycoprotein endopeptidase-like 1	0.020
NCL	nucleolin	0.020
SMAD7	SMAD family member 7	0.020
DTX1	deltex homolog 1 (Drosophila)	0.020
SDAD1	SDA1 domain containing 1	0.020
PPP6R2	protein phosphatase 6, regulatory subunit 2	0.019
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.019
FAM110C	family with sequence similarity 110, member C	0.019
NOM1	nucleolar protein with MIF4G domain 1	0.019
SETD6	SET domain containing 6	0.018
CIAPIN1	cytokine induced apoptosis inhibitor 1	0.018
DHX33	DEAH (Asp-Glu-Ala-His) box polypeptide 33	0.018
GFER	growth factor, augmenter of liver regeneration	0.018
FARSB	phenylalanyl-tRNA synthetase, beta subunit	0.018
C22orf28	chromosome 22 open reading frame 28	0.018
SEC16A	SEC16 homolog A (S. cerevisiae)	0.018
GTF3C5	general transcription factor IIIC, polypeptide 5, 63kDa	0.018
CUX1	cut-like homeobox 1	0.018
TYW3	tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)	0.018
CCDC127	coiled-coil domain containing 127	0.018
CUTC	cutC copper transporter homolog (E. coli)	0.017
SNX18	sorting nexin 18	0.017
SETDB1	SET domain, bifurcated 1	0.017
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.017
C8orf59	chromosome 8 open reading frame 59	0.017
RAD50	RAD50 homolog (S. cerevisiae)	0.017
TELO2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.016
STAMBP	STAM binding protein	0.016
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.016
YDJC	YdjC homolog (bacterial)	0.016
GPN1	GPN-loop GTPase 1	0.016
FASTKD1	FAST kinase domains 1	0.016
C12orf66	chromosome 12 open reading frame 66	0.016
METTL8	methyltransferase like 8	0.016	Human
SNX9	sorting nexin 9	0.016
CSNK1D	casein kinase 1, delta	0.016	Yeast
MNAT1	menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)	0.016
RTN4IP1	reticulon 4 interacting protein 1	0.016
FPGS	folylpolyglutamate synthase	0.016
GEMIN5	gem (nuclear organelle) associated protein 5	0.016
MED22	mediator complex subunit 22	0.015
PTBP2	polypyrimidine tract binding protein 2	0.015
ATN1	atrophin 1	0.015
RBM8A	RNA binding motif protein 8A	0.015
DEDD	death effector domain containing	0.015
C11orf51	chromosome 11 open reading frame 51	0.015
C16orf88	chromosome 16 open reading frame 88	0.015
NUBPL	nucleotide binding protein-like	0.015
C19orf60	chromosome 19 open reading frame 60	0.015
NME7	non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)	0.015
RPL26L1	ribosomal protein L26-like 1	0.015
FBXO22	F-box protein 22	0.015
ZNHIT6	zinc finger, HIT-type containing 6	0.015
ARRDC3	arrestin domain containing 3	0.015
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.015
ELMOD1	ELMO/CED-12 domain containing 1	0.015
COASY	CoA synthase	0.015
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.014
ZC3H8	zinc finger CCCH-type containing 8	0.014
NOC3L	nucleolar complex associated 3 homolog (S. cerevisiae)	0.014
ADARB1	adenosine deaminase, RNA-specific, B1	0.014	Human
TRIT1	tRNA isopentenyltransferase 1	0.014
DDX49	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	0.014
SMAD5	SMAD family member 5	0.014
ING2	inhibitor of growth family, member 2	0.014
ZFR	zinc finger RNA binding protein	0.014
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.014
ZNF579	zinc finger protein 579	0.014
ZFAND5	zinc finger, AN1-type domain 5	0.014
FAM173A	family with sequence similarity 173, member A	0.014
QRSL1	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	0.014
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.014
NUBP2	nucleotide binding protein 2 (MinD homolog, E. coli)	0.014	Yeast
WDR70	WD repeat domain 70	0.014
RDH14	retinol dehydrogenase 14 (all-trans/9-cis/11-cis)	0.014
USP5	ubiquitin specific peptidase 5 (isopeptidase T)	0.014
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.014
DPH2	DPH2 homolog (S. cerevisiae)	0.014
SMAD1	SMAD family member 1	0.013
VPS4A	vacuolar protein sorting 4 homolog A (S. cerevisiae)	0.013
MBD1	methyl-CpG binding domain protein 1	0.013
SRFBP1	serum response factor binding protein 1	0.013
MTMR4	myotubularin related protein 4	0.013
FKTN	fukutin	0.013
SMAD4	SMAD family member 4	0.013
KIAA0664	KIAA0664	0.013
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.013
ACBD6	acyl-CoA binding domain containing 6	0.013
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.013
DCAF17	DDB1 and CUL4 associated factor 17	0.013
COX16	COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)	0.013
SNAPIN	SNAP-associated protein	0.013
C17orf75	chromosome 17 open reading frame 75	0.013
GTF2E2	general transcription factor IIE, polypeptide 2, beta 34kDa	0.013
SNW1	SNW domain containing 1	0.012
STK38L	serine/threonine kinase 38 like	0.012
TCTEX1D2	Tctex1 domain containing 2	0.012
RPUSD1	RNA pseudouridylate synthase domain containing 1	0.012
SSNA1	Sjogren syndrome nuclear autoantigen 1	0.012
PPID	peptidylprolyl isomerase D	0.012
ATP5D	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit	0.012
SARS	seryl-tRNA synthetase	0.012
HACL1	2-hydroxyacyl-CoA lyase 1	0.012
OPTN	optineurin	0.012
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.012
FANCF	Fanconi anemia, complementation group F	0.012
R3HCC1	R3H domain and coiled-coil containing 1	0.012
DIS3L	DIS3 mitotic control homolog (S. cerevisiae)-like	0.012
EZR	ezrin	0.012
PNPT1	polyribonucleotide nucleotidyltransferase 1	0.012
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.012
METTL2B	methyltransferase like 2B	0.012
JAM2	junctional adhesion molecule 2	0.012
TIMM9	translocase of inner mitochondrial membrane 9 homolog (yeast)	0.012
NKIRAS2	NFKB inhibitor interacting Ras-like 2	0.012
TRMT12	tRNA methyltransferase 12 homolog (S. cerevisiae)	0.012
SURF6	surfeit 6	0.011
C18orf21	chromosome 18 open reading frame 21	0.011
FAM83H	family with sequence similarity 83, member H	0.011
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.011
KPNA1	karyopherin alpha 1 (importin alpha 5)	0.011
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.011
CPSF3L	cleavage and polyadenylation specific factor 3-like	0.011
TP63	tumor protein p63	0.011
TMEM5	transmembrane protein 5	0.011
CUL1	cullin 1	0.011
RAD17	RAD17 homolog (S. pombe)	0.011
SCAND1	SCAN domain containing 1	0.011
YAP1	Yes-associated protein 1	0.011
FAM35A	family with sequence similarity 35, member A	0.011
C2orf44	chromosome 2 open reading frame 44	0.011
PET117	cytochrome c oxidase assembly factor-like	0.011
PUS7L	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	0.011
PLEKHJ1	pleckstrin homology domain containing, family J member 1	0.011
TYW1	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	0.011	Yeast
DOCK9	dedicator of cytokinesis 9	0.011
MARK2	MAP/microtubule affinity-regulating kinase 2	0.011
FOXD3	forkhead box D3	0.011
COG2	component of oligomeric golgi complex 2	0.011
ACTG1	actin, gamma 1	0.011
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.011
WDR36	WD repeat domain 36	0.011
SAP30BP	SAP30 binding protein	0.011
WARS2	tryptophanyl tRNA synthetase 2, mitochondrial	0.011
C2orf43	chromosome 2 open reading frame 43	0.011
PTCD3	Pentatricopeptide repeat domain 3	0.011
WDR89	WD repeat domain 89	0.011
ERCC8	excision repair cross-complementing rodent repair deficiency, complementation group 8	0.011
C20orf4	chromosome 20 open reading frame 4	0.011
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.010
MAF1	MAF1 homolog (S. cerevisiae)	0.010
FGFR1	fibroblast growth factor receptor 1	0.010
POGLUT1	protein O-glucosyltransferase 1	0.010
HPS6	Hermansky-Pudlak syndrome 6	0.010
NOL10	nucleolar protein 10	0.010
KLF5	Kruppel-like factor 5 (intestinal)	0.010
THOC3	THO complex 3	0.010
METTL5	methyltransferase like 5	0.010
NUDT16L1	nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1	0.010
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.010
NUPL2	nucleoporin like 2	0.010
ZC3H14	zinc finger CCCH-type containing 14	0.010
CLCC1	chloride channel CLIC-like 1	0.010
EXOC2	exocyst complex component 2	0.010
TRMT2A	TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)	0.010
TSC22D4	TSC22 domain family, member 4	0.010
SARS2	seryl-tRNA synthetase 2, mitochondrial	0.010
NME6	non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)	0.010