IMP

Process View

Homo sapiens

3 genes annotated in human

epithelial cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "epithelial cell fate commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "epithelial cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
RARA	retinoic acid receptor, alpha	1.000	Mouse
NCOA1	nuclear receptor coactivator 1	1.000
RXRA	retinoid X receptor, alpha	0.999	Human
MED25	mediator complex subunit 25	0.999
JAG1	jagged 1	0.984
TGFB1	transforming growth factor, beta 1	0.981
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.947	Human
FKBP1A	FK506 binding protein 1A, 12kDa	0.935
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.934
NOTCH1	notch 1	0.933	Mouse
NOTCH3	notch 3	0.894
BMP2	bone morphogenetic protein 2	0.889
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.779
GDF5	growth differentiation factor 5	0.746
SMAD7	SMAD family member 7	0.651
PROX1	prospero homeobox 1	0.600
TGFB3	transforming growth factor, beta 3	0.556
TGFBR1	transforming growth factor, beta receptor 1	0.553	Human
HNF4A	hepatocyte nuclear factor 4, alpha	0.550	Human
ACVR1	activin A receptor, type I	0.523
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.494
SPOP	speckle-type POZ protein	0.487
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.483	Human
FSTL1	follistatin-like 1	0.419
PRKG1	protein kinase, cGMP-dependent, type I	0.400
MAML1	mastermind-like 1 (Drosophila)	0.388
GFI1B	growth factor independent 1B transcription repressor	0.379
ENG	endoglin	0.350
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.324	Zebrafish Mouse
PTCH1	patched 1	0.322
MAPK8	mitogen-activated protein kinase 8	0.251
BMPR1A	bone morphogenetic protein receptor, type IA	0.242	Human
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.202
FGF1	fibroblast growth factor 1 (acidic)	0.194
ATXN1L	ataxin 1-like	0.190
NRP1	neuropilin 1	0.160
NCOR2	nuclear receptor corepressor 2	0.155
RXRB	retinoid X receptor, beta	0.144	Human
TBX5	T-box 5	0.142
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.139
KANK2	KN motif and ankyrin repeat domains 2	0.129
TAOK1	TAO kinase 1	0.112
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.093
NOTCH2	notch 2	0.087
DLL1	delta-like 1 (Drosophila)	0.085
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.080
HNF1A	HNF1 homeobox A	0.077
BMP4	bone morphogenetic protein 4	0.076
EGFL7	EGF-like-domain, multiple 7	0.068
PDX1	pancreatic and duodenal homeobox 1	0.064
SREBF2	sterol regulatory element binding transcription factor 2	0.063
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.062
XIAP	X-linked inhibitor of apoptosis	0.058
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.053
ZNF331	zinc finger protein 331	0.050
ACVR1B	activin A receptor, type IB	0.043	Human
AXIN1	axin 1	0.043
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.042
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.041
KRT8	keratin 8	0.040
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.040
IQGAP1	IQ motif containing GTPase activating protein 1	0.038
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.038
ZMYND11	zinc finger, MYND-type containing 11	0.037
HOXA10	homeobox A10	0.036
CTBP2	C-terminal binding protein 2	0.036
RARG	retinoic acid receptor, gamma	0.036
PAX6	paired box 6	0.035
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.034
DHH	desert hedgehog	0.034
RXRG	retinoid X receptor, gamma	0.033	Human
HNF1B	HNF1 homeobox B	0.033
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.032
TGFBR3	transforming growth factor, beta receptor III	0.032
NCOA6	nuclear receptor coactivator 6	0.029
KLF13	Kruppel-like factor 13	0.029
FGFR2	fibroblast growth factor receptor 2	0.027
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.027
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.027
HAND2	heart and neural crest derivatives expressed 2	0.026
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.026
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.026
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.026
HIPK3	homeodomain interacting protein kinase 3	0.024
PDGFC	platelet derived growth factor C	0.024
SMAD6	SMAD family member 6	0.024
SEMA4G	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	0.022
PPL	periplakin	0.022
BBS10	Bardet-Biedl syndrome 10	0.021
ZNF205	zinc finger protein 205	0.021
TADA3	transcriptional adaptor 3	0.021
JUB	jub, ajuba homolog (Xenopus laevis)	0.021
FOXA2	forkhead box A2	0.021
ACVR2B	activin A receptor, type IIB	0.021
INHBB	inhibin, beta B	0.021
CIR1	corepressor interacting with RBPJ, 1	0.020
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.020
HOXA11	homeobox A11	0.020
CDX2	caudal type homeobox 2	0.019
ZNF579	zinc finger protein 579	0.019
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.019
LAMA5	laminin, alpha 5	0.019
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.018
ANTXR2	anthrax toxin receptor 2	0.018
FHL1	four and a half LIM domains 1	0.018
VIL1	villin 1	0.017
SOX13	SRY (sex determining region Y)-box 13	0.017
SART1	squamous cell carcinoma antigen recognized by T cells	0.017
SMAD2	SMAD family member 2	0.017
MSX1	msh homeobox 1	0.017
HAP1	huntingtin-associated protein 1	0.017
TLE2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	0.017
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.016
GATA5	GATA binding protein 5	0.016
FOXC1	forkhead box C1	0.016
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.016
SOX7	SRY (sex determining region Y)-box 7	0.016
MNX1	motor neuron and pancreas homeobox 1	0.016
SOX11	SRY (sex determining region Y)-box 11	0.016
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.016
ZFPM2	zinc finger protein, multitype 2	0.015
HOXB13	homeobox B13	0.015
ONECUT1	one cut homeobox 1	0.015
GATA4	GATA binding protein 4	0.015	Mouse
AGRN	agrin	0.015
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.015
HIC1	hypermethylated in cancer 1	0.014
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.014
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.014
ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0.014
CCDC17	coiled-coil domain containing 17	0.014
PAX4	paired box 4	0.013
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.013
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.013
PCDH18	protocadherin 18	0.013
ACVR2A	activin A receptor, type IIA	0.013
HOXA3	homeobox A3	0.013
FZD5	frizzled homolog 5 (Drosophila)	0.013
NELL2	NEL-like 2 (chicken)	0.013
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.013
NKX6-1	NK6 homeobox 1	0.013
NOG	noggin	0.013
GJB1	gap junction protein, beta 1, 32kDa	0.013
CHGB	chromogranin B (secretogranin 1)	0.013
MYT1	myelin transcription factor 1	0.013
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.013
PTMS	parathymosin	0.013
DLL3	delta-like 3 (Drosophila)	0.013
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.013
LRP12	low density lipoprotein receptor-related protein 12	0.013
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.013
ARX	aristaless related homeobox	0.013	Mouse
JAG2	jagged 2	0.012	Mouse
LTBP4	latent transforming growth factor beta binding protein 4	0.012
FGF9	fibroblast growth factor 9 (glia-activating factor)	0.012
EPHB3	EPH receptor B3	0.012
HOXC12	homeobox C12	0.012
HIP1	huntingtin interacting protein 1	0.012
COL2A1	collagen, type II, alpha 1	0.012
FOXD3	forkhead box D3	0.012
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.012
LHX2	LIM homeobox 2	0.012
USHBP1	Usher syndrome 1C binding protein 1	0.012
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.012
SOX9	SRY (sex determining region Y)-box 9	0.012
FZD7	frizzled homolog 7 (Drosophila)	0.012
PGR	progesterone receptor	0.012
FOXD2	forkhead box D2	0.012
RARB	retinoic acid receptor, beta	0.012
AMBP	alpha-1-microglobulin/bikunin precursor	0.012
ALX4	ALX homeobox 4	0.012
PITX2	paired-like homeodomain 2	0.011
HOXB7	homeobox B7	0.011
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.011
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.011
PER1	period homolog 1 (Drosophila)	0.011
IRX5	iroquois homeobox 5	0.011
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.011
CLDN11	claudin 11	0.011
HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	0.011
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.011
TACC1	transforming, acidic coiled-coil containing protein 1	0.011
HOXB8	homeobox B8	0.011
FGF18	fibroblast growth factor 18	0.011
INSM1	insulinoma-associated 1	0.011
PRKD2	protein kinase D2	0.011
PAWR	PRKC, apoptosis, WT1, regulator	0.011
CEP164	centrosomal protein 164kDa	0.011
HOXD1	homeobox D1	0.011
IGSF1	immunoglobulin superfamily, member 1	0.011
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.011
LAMB1	laminin, beta 1	0.011
CSNK1E	casein kinase 1, epsilon	0.011
CLU	clusterin	0.011
MBNL2	muscleblind-like 2 (Drosophila)	0.011
ONECUT2	one cut homeobox 2	0.011
HOXA2	homeobox A2	0.011
GAL3ST1	galactose-3-O-sulfotransferase 1	0.011
HOXA1	homeobox A1	0.011
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.011
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.011
FGFR4	fibroblast growth factor receptor 4	0.011
PMEL	premelanosome protein	0.011
PHACTR2	phosphatase and actin regulator 2	0.011
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.011
LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)	0.011
MMP15	matrix metallopeptidase 15 (membrane-inserted)	0.011
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.011
GDNF	glial cell derived neurotrophic factor	0.011
NPM3	nucleophosmin/nucleoplasmin 3	0.011
BMPR1B	bone morphogenetic protein receptor, type IB	0.011	Human
VTN	vitronectin	0.010
C19orf46	chromosome 19 open reading frame 46	0.010
TGFB2	transforming growth factor, beta 2	0.010
MAGEA4	melanoma antigen family A, 4	0.010
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.010
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.010
GCM2	glial cells missing homolog 2 (Drosophila)	0.010
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.010
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.010
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.010
SIM2	single-minded homolog 2 (Drosophila)	0.010
OCEL1	occludin/ELL domain containing 1	0.010
PRAME	preferentially expressed antigen in melanoma	0.010
ERF	Ets2 repressor factor	0.010
RUNDC3A	RUN domain containing 3A	0.010
FAM110C	family with sequence similarity 110, member C	0.010
GCG	glucagon	0.010
HOXD9	homeobox D9	0.010
DUSP9	dual specificity phosphatase 9	0.010
SRI	sorcin	0.010
EPHB4	EPH receptor B4	0.010
TBX1	T-box 1	0.010
OLIG2	oligodendrocyte lineage transcription factor 2	0.010
DLL4	delta-like 4 (Drosophila)	0.010
NRTN	neurturin	0.010
C9orf96	chromosome 9 open reading frame 96	0.010
ESRRA	estrogen-related receptor alpha	0.010