IMP

Process View

Homo sapiens

30 genes annotated in human

response to xenobiotic stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
GSTM1	glutathione S-transferase mu 1	1.000
S100B	S100 calcium binding protein B	0.995	Human
S100A8	S100 calcium binding protein A8	0.994	Human
RARA	retinoic acid receptor, alpha	0.994
SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	0.992
SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	0.991
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.991
S100A6	S100 calcium binding protein A6	0.989	Human
GSTM2	glutathione S-transferase mu 2 (muscle)	0.988
S100A9	S100 calcium binding protein A9	0.985	Human
SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	0.967	Human Zebrafish Rat Fly
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.964	Human
S100A16	S100 calcium binding protein A16	0.961	Human
S100A4	S100 calcium binding protein A4	0.954	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.951
ANXA2	annexin A2	0.948
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	0.946
S100A14	S100 calcium binding protein A14	0.941	Human
S100A1	S100 calcium binding protein A1	0.932	Human
GSTM4	glutathione S-transferase mu 4	0.916
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.912
NCOR2	nuclear receptor corepressor 2	0.906
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.887
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.864
MED25	mediator complex subunit 25	0.838
HNF4A	hepatocyte nuclear factor 4, alpha	0.836
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.710
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.605
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.596
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.596
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.591	Zebrafish Fly
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.587	Zebrafish Fly
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	0.555
ESR1	estrogen receptor 1	0.538	Zebrafish
NCOA1	nuclear receptor coactivator 1	0.503
GCLM	glutamate-cysteine ligase, modifier subunit	0.460
ARNT	aryl hydrocarbon receptor nuclear translocator	0.453	Zebrafish Worm
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.445	Zebrafish Fly
AHR	aryl hydrocarbon receptor	0.427
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.418
ALS2CR12	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	0.370
PSMB6	proteasome (prosome, macropain) subunit, beta type, 6	0.351
SPOP	speckle-type POZ protein	0.349
UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	0.321
APAF1	apoptotic peptidase activating factor 1	0.312
AREG	amphiregulin	0.299
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.295
PRDX1	peroxiredoxin 1	0.287
XIAP	X-linked inhibitor of apoptosis	0.286
KNG1	kininogen 1	0.249
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.243	Human
UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	0.222
CREBBP	CREB binding protein	0.219
C6	complement component 6	0.213
CTSB	cathepsin B	0.179
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.177
XDH	xanthine dehydrogenase	0.177
CAPG	capping protein (actin filament), gelsolin-like	0.171
LGALS1	lectin, galactoside-binding, soluble, 1	0.168
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.156	Human Zebrafish Fly
A1CF	APOBEC1 complementation factor	0.153
S100A2	S100 calcium binding protein A2	0.144	Human
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.129
S100P	S100 calcium binding protein P	0.122	Human
HR	hairless homolog (mouse)	0.121
AGER	advanced glycosylation end product-specific receptor	0.121
FMO4	flavin containing monooxygenase 4	0.120	Human
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.120	Rat
OTC	ornithine carbamoyltransferase	0.116
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.115
ALDOB	aldolase B, fructose-bisphosphate	0.112
UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17	0.109	Human
S100A11	S100 calcium binding protein A11	0.108	Human
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.107	Zebrafish Fly
HRG	histidine-rich glycoprotein	0.107
TMSB10	thymosin beta 10	0.105
F9	coagulation factor IX	0.102
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.100
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.094
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.093	Human
TIMP2	TIMP metallopeptidase inhibitor 2	0.089
PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7	0.088
IL1RN	interleukin 1 receptor antagonist	0.087
ADH6	alcohol dehydrogenase 6 (class V)	0.084
EPAS1	endothelial PAS domain protein 1	0.082
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.082	Human Fly
C8A	complement component 8, alpha polypeptide	0.080
CLIC1	chloride intracellular channel 1	0.080
MASP2	mannan-binding lectin serine peptidase 2	0.079
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.079
PPARG	peroxisome proliferator-activated receptor gamma	0.075	Human
AADAC	arylacetamide deacetylase (esterase)	0.075
TIMP1	TIMP metallopeptidase inhibitor 1	0.073
MTTP	microsomal triglyceride transfer protein	0.071
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.070	Human Fly
NCOA3	nuclear receptor coactivator 3	0.070
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.069
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.069
FTL	ferritin, light polypeptide	0.068
FAM46A	family with sequence similarity 46, member A	0.067
ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	0.067
GLYAT	glycine-N-acyltransferase	0.067
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.066	Human
C8B	complement component 8, beta polypeptide	0.066
ANXA1	annexin A1	0.066
MDH1	malate dehydrogenase 1, NAD (soluble)	0.065
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.065
PI3	peptidase inhibitor 3, skin-derived	0.063
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.062
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.062	Human
UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	0.061
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.060
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.058	Human
NAMPT	nicotinamide phosphoribosyltransferase	0.058
NCOA7	nuclear receptor coactivator 7	0.057
MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	0.056
MCMBP	minichromosome maintenance complex binding protein	0.055
S100A12	S100 calcium binding protein A12	0.053
HIPK2	homeodomain interacting protein kinase 2	0.050
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.050
DAO	D-amino-acid oxidase	0.049
UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	0.049
TTPA	tocopherol (alpha) transfer protein	0.048
ITIH2	inter-alpha (globulin) inhibitor H2	0.047
GSTM3	glutathione S-transferase mu 3 (brain)	0.046
RXRA	retinoid X receptor, alpha	0.045	Human
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.044
CSTA	cystatin A (stefin A)	0.044
CSTB	cystatin B (stefin B)	0.043
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.042
UGT1A10	UDP glucuronosyltransferase 1 family, polypeptide A10	0.042
CDT1	chromatin licensing and DNA replication factor 1	0.040
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.040
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.040
RPL11	ribosomal protein L11	0.039
MEP1B	meprin A, beta	0.039
ESRRG	estrogen-related receptor gamma	0.038
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.037
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.037
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.037	Human
APOBEC1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.037	Human
AR	androgen receptor	0.036
IGSF21	immunoglobin superfamily, member 21	0.036
MCM2	minichromosome maintenance complex component 2	0.035
LGALS3	lectin, galactoside-binding, soluble, 3	0.035
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.035
TXN	thioredoxin	0.033
NPC2	Niemann-Pick disease, type C2	0.033
RB1	retinoblastoma 1	0.032
BHMT	betaine--homocysteine S-methyltransferase	0.032
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.031
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.031
F11	coagulation factor XI	0.030
PCDHA4	protocadherin alpha 4	0.030
PON1	paraoxonase 1	0.029
APCS	amyloid P component, serum	0.029
PRKG2	protein kinase, cGMP-dependent, type II	0.029
GSTM5	glutathione S-transferase mu 5	0.029	Human
PROX1	prospero homeobox 1	0.028
MAT1A	methionine adenosyltransferase I, alpha	0.028
NCF2	neutrophil cytosolic factor 2	0.028
ANXA5	annexin A5	0.027
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.027	Human Zebrafish Rat
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.027
NADSYN1	NAD synthetase 1	0.027
PPARA	peroxisome proliferator-activated receptor alpha	0.026	Human
HSPB1	heat shock 27kDa protein 1	0.026
KLF4	Kruppel-like factor 4 (gut)	0.026
EMP3	epithelial membrane protein 3	0.026
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.026
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.025
LGALS4	lectin, galactoside-binding, soluble, 4	0.025
CFHR4	complement factor H-related 4	0.025
HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.025	Rat
KANK2	KN motif and ankyrin repeat domains 2	0.024
TM4SF4	transmembrane 4 L six family member 4	0.023
ACSM5	acyl-CoA synthetase medium-chain family member 5	0.023
ATOX1	ATX1 antioxidant protein 1 homolog (yeast)	0.023
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.023	Human
FMO5	flavin containing monooxygenase 5	0.022	Human
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.022
GLRX	glutaredoxin (thioltransferase)	0.022
DBI	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)	0.022
PARK7	Parkinson disease (autosomal recessive, early onset) 7	0.022
REG1A	regenerating islet-derived 1 alpha	0.022
SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.022
MCM7	minichromosome maintenance complex component 7	0.022
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.021
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.021
AHNAK	AHNAK nucleoprotein	0.021
CCL16	chemokine (C-C motif) ligand 16	0.020
CD63	CD63 molecule	0.020
GLA	galactosidase, alpha	0.020
AMPD1	adenosine monophosphate deaminase 1	0.020
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.020
AFM	afamin	0.019
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.019
SULT1C2	sulfotransferase family, cytosolic, 1C, member 2	0.019	Human Fly
C20orf24	chromosome 20 open reading frame 24	0.019
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.019
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.018
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.018
TALDO1	transaldolase 1	0.018
SGK2	serum/glucocorticoid regulated kinase 2	0.018
DIO1	deiodinase, iodothyronine, type I	0.018
ANXA13	annexin A13	0.018
GC	group-specific component (vitamin D binding protein)	0.018
CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.018
TAT	tyrosine aminotransferase	0.018
FABP1	fatty acid binding protein 1, liver	0.018
PON3	paraoxonase 3	0.018	Rat
RXRG	retinoid X receptor, gamma	0.018	Human
ADM	adrenomedullin	0.018
MCM6	minichromosome maintenance complex component 6	0.018
ARL2	ADP-ribosylation factor-like 2	0.017
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.017
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.017
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.017
F13B	coagulation factor XIII, B polypeptide	0.017
HGD	homogentisate 1,2-dioxygenase	0.017
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.017
REG3A	regenerating islet-derived 3 alpha	0.016
S100A10	S100 calcium binding protein A10	0.016	Human
AICDA	activation-induced cytidine deaminase	0.016	Human
CA1	carbonic anhydrase I	0.016
CA5A	carbonic anhydrase VA, mitochondrial	0.016
FMO3	flavin containing monooxygenase 3	0.016	Human
MEP1A	meprin A, alpha (PABA peptide hydrolase)	0.016
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.016
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.016
G6PC	glucose-6-phosphatase, catalytic subunit	0.016
CENPM	centromere protein M	0.016
MIA2	melanoma inhibitory activity 2	0.016
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.016
GYS2	glycogen synthase 2 (liver)	0.016
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.015
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	0.015
AQP8	aquaporin 8	0.015
DYNLT1	dynein, light chain, Tctex-type 1	0.015
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.015
FMO1	flavin containing monooxygenase 1	0.015	Human
USP2	ubiquitin specific peptidase 2	0.015
LY6G6C	lymphocyte antigen 6 complex, locus G6C	0.015
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.015
BTNL3	butyrophilin-like 3	0.015
FKBP4	FK506 binding protein 4, 59kDa	0.015
HPD	4-hydroxyphenylpyruvate dioxygenase	0.015
TM4SF5	transmembrane 4 L six family member 5	0.015
SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	0.014
CDA	cytidine deaminase	0.014
LHCGR	luteinizing hormone/choriogonadotropin receptor	0.014
RPL10	ribosomal protein L10	0.014
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.014
DHPS	deoxyhypusine synthase	0.014
GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.014
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.014
CNGA1	cyclic nucleotide gated channel alpha 1	0.014
CTSL1	cathepsin L1	0.014
LECT2	leukocyte cell-derived chemotaxin 2	0.014
SNX1	sorting nexin 1	0.014
FGL1	fibrinogen-like 1	0.014
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.013
RPS27L	ribosomal protein S27-like	0.013
EP300	E1A binding protein p300	0.013
ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	0.013
HAL	histidine ammonia-lyase	0.013
UGT1A8	UDP glucuronosyltransferase 1 family, polypeptide A8	0.013
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.013
HP	haptoglobin	0.013
CD163	CD163 molecule	0.013
DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4	0.013
ZG16	zymogen granule protein 16 homolog (rat)	0.013
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.013
EMP1	epithelial membrane protein 1	0.013
APOC4	apolipoprotein C-IV	0.013
FXYD3	FXYD domain containing ion transport regulator 3	0.013
LAMC3	laminin, gamma 3	0.013
SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9	0.013
GPA33	glycoprotein A33 (transmembrane)	0.013
LRRC31	leucine rich repeat containing 31	0.013
GSTA3	glutathione S-transferase alpha 3	0.012	Human Rat
CAT	catalase	0.012
S100A13	S100 calcium binding protein A13	0.012
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.012
NSFL1C	NSFL1 (p97) cofactor (p47)	0.012
EPHX2	epoxide hydrolase 2, cytoplasmic	0.012
MBL2	mannose-binding lectin (protein C) 2, soluble	0.012
CES1	carboxylesterase 1	0.012
GCKR	glucokinase (hexokinase 4) regulator	0.012
SP1	Sp1 transcription factor	0.012
PAH	phenylalanine hydroxylase	0.011
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.011
ABCC3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	0.011
GPNMB	glycoprotein (transmembrane) nmb	0.011
C1orf124	chromosome 1 open reading frame 124	0.011
CIDEB	cell death-inducing DFFA-like effector b	0.011
GSTA2	glutathione S-transferase alpha 2	0.011
SAA4	serum amyloid A4, constitutive	0.011
HYAL1	hyaluronoglucosaminidase 1	0.011
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.011
PZP	pregnancy-zone protein	0.011
ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	0.011
PPHLN1	periphilin 1	0.011
PRC1	protein regulator of cytokinesis 1	0.011
SETD7	SET domain containing (lysine methyltransferase) 7	0.011
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011
APOC3	apolipoprotein C-III	0.011
BIRC2	baculoviral IAP repeat containing 2	0.011
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.011
GYPB	glycophorin B (MNS blood group)	0.011
ME1	malic enzyme 1, NADP(+)-dependent, cytosolic	0.011
THBD	thrombomodulin	0.011
C4BPA	complement component 4 binding protein, alpha	0.011
NONO	non-POU domain containing, octamer-binding	0.011
GIF	gastric intrinsic factor (vitamin B synthesis)	0.010
MOGAT2	monoacylglycerol O-acyltransferase 2	0.010
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.010
MAOA	monoamine oxidase A	0.010
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.010
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.010
ECM1	extracellular matrix protein 1	0.010
SLC7A9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.010
SLC30A10	solute carrier family 30, member 10	0.010
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.010
CYB5A	cytochrome b5 type A (microsomal)	0.010	Zebrafish
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.010	Human Zebrafish
ENOX1	ecto-NOX disulfide-thiol exchanger 1	0.010