IMP

Process View

Homo sapiens

25 genes annotated in human

renal system process

A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "renal system process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "renal system process" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.998
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.989
FHL2	four and a half LIM domains 2	0.968
HBA2	hemoglobin, alpha 2	0.889
DRD2	dopamine receptor D2	0.845	Mouse
GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	0.718
CUL3	cullin 3	0.536
AXL	AXL receptor tyrosine kinase	0.482
PTEN	phosphatase and tensin homolog	0.428
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.403
ENG	endoglin	0.386
APAF1	apoptotic peptidase activating factor 1	0.350
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.337
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.312
KLHL3	kelch-like 3 (Drosophila)	0.300
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.300
BCL2L1	BCL2-like 1	0.250
WNK4	WNK lysine deficient protein kinase 4	0.226
CAV1	caveolin 1, caveolae protein, 22kDa	0.215
TBC1D10A	TBC1 domain family, member 10A	0.201
C1QA	complement component 1, q subcomponent, A chain	0.189	Human
KLHL2	kelch-like 2, Mayven (Drosophila)	0.188	Human
DAPK1	death-associated protein kinase 1	0.178
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.177	Human
FN1	fibronectin 1	0.172
C1QB	complement component 1, q subcomponent, B chain	0.171	Human
COL4A2	collagen, type IV, alpha 2	0.148
AQP2	aquaporin 2 (collecting duct)	0.148	Fly
PDZK1	PDZ domain containing 1	0.138	Human
GOPC	golgi-associated PDZ and coiled-coil motif containing	0.127
KLHL12	kelch-like 12 (Drosophila)	0.126	Human
XIAP	X-linked inhibitor of apoptosis	0.121
SLC17A1	solute carrier family 17 (sodium phosphate), member 1	0.119
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.114
TIMP3	TIMP metallopeptidase inhibitor 3	0.112
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.088
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.074
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.067
ADORA2A	adenosine A2a receptor	0.067	Rat
TLN1	talin 1	0.066
PTPRC	protein tyrosine phosphatase, receptor type, C	0.062
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.061
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.059	Human
PRODH2	proline dehydrogenase (oxidase) 2	0.057
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.053
PRMT6	protein arginine methyltransferase 6	0.051
FLNA	filamin A, alpha	0.050
PDGFA	platelet-derived growth factor alpha polypeptide	0.050
MDFI	MyoD family inhibitor	0.049
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.047
ADAMTSL4	ADAMTS-like 4	0.043
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.043
EZR	ezrin	0.042
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.041
AQP7	aquaporin 7	0.040
GLIS2	GLIS family zinc finger 2	0.038
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.038
ITGA6	integrin, alpha 6	0.037	Human
MAPK12	mitogen-activated protein kinase 12	0.036
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.036
DPYSL4	dihydropyrimidinase-like 4	0.035
HNF4A	hepatocyte nuclear factor 4, alpha	0.034
AVPR2	arginine vasopressin receptor 2	0.034	Rat
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.033
HNF1B	HNF1 homeobox B	0.033	Human
SPRR2D	small proline-rich protein 2D	0.032
ARRDC3	arrestin domain containing 3	0.030
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.030
OXSR1	oxidative-stress responsive 1	0.030
PLG	plasminogen	0.029
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.029
KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	0.029	Mouse
CLEC4M	C-type lectin domain family 4, member M	0.028
MSN	moesin	0.028
CD34	CD34 molecule	0.028
PDIA3	protein disulfide isomerase family A, member 3	0.028
CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	0.028	Human
ZNF282	zinc finger protein 282	0.028
APPBP2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	0.027
ITGB4	integrin, beta 4	0.027
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.027
CD63	CD63 molecule	0.027
PAX8	paired box 8	0.026
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.026	Mouse
AMBRA1	autophagy/beclin-1 regulator 1	0.025
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.025
PLEC	plectin	0.025
CAV2	caveolin 2	0.025
TMEM30A	transmembrane protein 30A	0.024
KCTD17	potassium channel tetramerisation domain containing 17	0.024
PXN	paxillin	0.024
PDX1	pancreatic and duodenal homeobox 1	0.024
VCAM1	vascular cell adhesion molecule 1	0.024
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.023
C1QC	complement component 1, q subcomponent, C chain	0.023	Human
TSC22D4	TSC22 domain family, member 4	0.023
CLCNKB	chloride channel Kb	0.023
DGCR14	DiGeorge syndrome critical region gene 14	0.023
CD44	CD44 molecule (Indian blood group)	0.022
SH3GL3	SH3-domain GRB2-like 3	0.022
NRP1	neuropilin 1	0.022
THBS1	thrombospondin 1	0.022
AQP6	aquaporin 6, kidney specific	0.022	Fly
KLK2	kallikrein-related peptidase 2	0.021
DPPA4	developmental pluripotency associated 4	0.021
HNF1A	HNF1 homeobox A	0.020
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.020
LGALS4	lectin, galactoside-binding, soluble, 4	0.020
KBTBD7	kelch repeat and BTB (POZ) domain containing 7	0.020
PTHLH	parathyroid hormone-like hormone	0.020
GFAP	glial fibrillary acidic protein	0.020
XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.020
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.020
SLC22A2	solute carrier family 22 (organic cation transporter), member 2	0.020	Human
CD9	CD9 molecule	0.020
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.020
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.019
HBD	hemoglobin, delta	0.019
EDN1	endothelin 1	0.019	Mouse
PTH1R	parathyroid hormone 1 receptor	0.019
STC1	stanniocalcin 1	0.018
EDNRA	endothelin receptor type A	0.018	Rat
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.018	Human
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.018
IGK@	immunoglobulin kappa locus	0.018
SLC13A3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	0.018
CHRND	cholinergic receptor, nicotinic, delta	0.018	Human
BID	BH3 interacting domain death agonist	0.018
PROCR	protein C receptor, endothelial	0.018
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.018
SPOP	speckle-type POZ protein	0.018
VEGFA	vascular endothelial growth factor A	0.017
ADAM9	ADAM metallopeptidase domain 9	0.017
CLCN3	chloride channel 3	0.017
DARC	Duffy blood group, chemokine receptor	0.017
SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	0.017
SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	0.017
STAB1	stabilin 1	0.016
TBXA2R	thromboxane A2 receptor	0.016
ADAM11	ADAM metallopeptidase domain 11	0.016
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.016	Human
SHARPIN	SHANK-associated RH domain interactor	0.016
SSTR4	somatostatin receptor 4	0.016
BECN1	beclin 1, autophagy related	0.016
CD46	CD46 molecule, complement regulatory protein	0.016
SLC26A3	solute carrier family 26, member 3	0.016
GLYAT	glycine-N-acyltransferase	0.016
PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	0.015
ZBTB16	zinc finger and BTB domain containing 16	0.015
JAG1	jagged 1	0.015
GJA1	gap junction protein, alpha 1, 43kDa	0.015
MED28	mediator complex subunit 28	0.015
COL5A1	collagen, type V, alpha 1	0.015
DAO	D-amino-acid oxidase	0.015
COL3A1	collagen, type III, alpha 1	0.015
ADRB3	adrenergic, beta-3-, receptor	0.015
GJA5	gap junction protein, alpha 5, 40kDa	0.014	Rat
AGXT	alanine-glyoxylate aminotransferase	0.014
HBG2	hemoglobin, gamma G	0.014
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.014
PTPRN	protein tyrosine phosphatase, receptor type, N	0.014
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.014
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.014
TGFB1	transforming growth factor, beta 1	0.014
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.013	Human
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.013
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.013
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.013
CPD	carboxypeptidase D	0.013
PRLH	prolactin releasing hormone	0.013
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.013
SESN2	sestrin 2	0.013
SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.013
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.013
BAX	BCL2-associated X protein	0.013
ADIPOQ	adiponectin, C1Q and collagen domain containing	0.013
BTBD10	BTB (POZ) domain containing 10	0.013
NAT8B	N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)	0.013
PDCD6	programmed cell death 6	0.013
PTGIR	prostaglandin I2 (prostacyclin) receptor (IP)	0.013
CRYBB3	crystallin, beta B3	0.013
CHRNG	cholinergic receptor, nicotinic, gamma	0.013	Human
AIPL1	aryl hydrocarbon receptor interacting protein-like 1	0.013
CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.013
ZBTB41	zinc finger and BTB domain containing 41	0.012
SH3GL1	SH3-domain GRB2-like 1	0.012
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.012
ZMAT3	zinc finger, matrin-type 3	0.012
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.012
DOCK7	dedicator of cytokinesis 7	0.012
ACVRL1	activin A receptor type II-like 1	0.012
CIZ1	CDKN1A interacting zinc finger protein 1	0.012
SYT9	synaptotagmin IX	0.012
PRKCDBP	protein kinase C, delta binding protein	0.012
FOXI1	forkhead box I1	0.012
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.012
PROX1	prospero homeobox 1	0.012
F2R	coagulation factor II (thrombin) receptor	0.012	Mouse Rat
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.012
KNG1	kininogen 1	0.012
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	0.012
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.012
DPYS	dihydropyrimidinase	0.012
OPRK1	opioid receptor, kappa 1	0.012
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.012
SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	0.012	Rat
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.012
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.011
NGFR	nerve growth factor receptor	0.011
SMR3A	submaxillary gland androgen regulated protein 3A	0.011
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.011
UPB1	ureidopropionase, beta	0.011
SFRP1	secreted frizzled-related protein 1	0.011
MCAM	melanoma cell adhesion molecule	0.011
MUC13	mucin 13, cell surface associated	0.011
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.011
CRYAA	crystallin, alpha A	0.011
VEGFC	vascular endothelial growth factor C	0.011
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.011
SDPR	serum deprivation response	0.011
BCR	breakpoint cluster region	0.011
DCN	decorin	0.011
HOXB5	homeobox B5	0.011
SSTR3	somatostatin receptor 3	0.011
KRT17	keratin 17	0.011
NPNT	nephronectin	0.011
IGFBP5	insulin-like growth factor binding protein 5	0.011
FZD4	frizzled homolog 4 (Drosophila)	0.011
RHO	rhodopsin	0.011
ADRA1D	adrenergic, alpha-1D-, receptor	0.011	Rat
GPR6	G protein-coupled receptor 6	0.011
ANGPTL2	angiopoietin-like 2	0.011
ARHGEF15	Rho guanine nucleotide exchange factor (GEF) 15	0.011
PTGER1	prostaglandin E receptor 1 (subtype EP1), 42kDa	0.010
ENPEP	glutamyl aminopeptidase (aminopeptidase A)	0.010
SIM2	single-minded homolog 2 (Drosophila)	0.010
C4B	complement component 4B (Chido blood group)	0.010
SFTPB	surfactant protein B	0.010
CIDEC	cell death-inducing DFFA-like effector c	0.010
MADCAM1	mucosal vascular addressin cell adhesion molecule 1	0.010
COL2A1	collagen, type II, alpha 1	0.010
USP19	ubiquitin specific peptidase 19	0.010
COL4A1	collagen, type IV, alpha 1	0.010
ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	0.010
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.010
LAMA5	laminin, alpha 5	0.010
GLTPD1	glycolipid transfer protein domain containing 1	0.010
LAMC3	laminin, gamma 3	0.010
ESRRB	estrogen-related receptor beta	0.010
CCND3	cyclin D3	0.010
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.010
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.010
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.010
EMCN	endomucin	0.010
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.010