IMP

Process View

Homo sapiens

11 genes annotated in human

type i interferon signaling pathway

A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "type i interferon signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "type i interferon signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
GHR	growth hormone receptor	0.985
IFITM3	interferon induced transmembrane protein 3 (1-8U)	0.962	Mouse
JAK1	Janus kinase 1	0.961
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.937	Mouse
HLA-A	major histocompatibility complex, class I, A	0.935
IFITM1	interferon induced transmembrane protein 1 (9-27)	0.903	Mouse
HLA-C	major histocompatibility complex, class I, C	0.843
B2M	beta-2-microglobulin	0.833
HLA-E	major histocompatibility complex, class I, E	0.817
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.688	Human
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.680
IRF9	interferon regulatory factor 9	0.534
STAT2	signal transducer and activator of transcription 2, 113kDa	0.469
MYD88	myeloid differentiation primary response gene (88)	0.455
HLA-B	major histocompatibility complex, class I, B	0.453
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.452
RIPK2	receptor-interacting serine-threonine kinase 2	0.331
TMEM173	transmembrane protein 173	0.242
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.240
HLA-G	major histocompatibility complex, class I, G	0.234
HLA-F	major histocompatibility complex, class I, F	0.207
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.198
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.173
PIAS4	protein inhibitor of activated STAT, 4	0.157
STAT1	signal transducer and activator of transcription 1, 91kDa	0.148	Mouse
FAS	Fas (TNF receptor superfamily, member 6)	0.135
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.128
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.126
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.117
MBD4	methyl-CpG binding domain protein 4	0.112
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.109
IRAK1	interleukin-1 receptor-associated kinase 1	0.105
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.092
IRF3	interferon regulatory factor 3	0.082	Mouse
FZD1	frizzled homolog 1 (Drosophila)	0.082
SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.079
PTPRB	protein tyrosine phosphatase, receptor type, B	0.076
C19orf66	chromosome 19 open reading frame 66	0.074
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.072	Human
IRF7	interferon regulatory factor 7	0.071	Mouse
CYLD	cylindromatosis (turban tumor syndrome)	0.061
CAV2	caveolin 2	0.053
STAT5A	signal transducer and activator of transcription 5A	0.053
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.052
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.051
INSR	insulin receptor	0.046
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.046
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.043
CALCOCO2	calcium binding and coiled-coil domain 2	0.041
FASLG	Fas ligand (TNF superfamily, member 6)	0.040
ABHD16A	abhydrolase domain containing 16A	0.039
F2R	coagulation factor II (thrombin) receptor	0.038
NAMPT	nicotinamide phosphoribosyltransferase	0.037
MAVS	mitochondrial antiviral signaling protein	0.037
IRAK2	interleukin-1 receptor-associated kinase 2	0.035
LRP6	low density lipoprotein receptor-related protein 6	0.035
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.034
LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	0.034
BCAR1	breast cancer anti-estrogen resistance 1	0.032
BST2	bone marrow stromal cell antigen 2	0.032
NSF	N-ethylmaleimide-sensitive factor	0.031
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.030
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.029
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.028
LY6E	lymphocyte antigen 6 complex, locus E	0.026
STAT5B	signal transducer and activator of transcription 5B	0.022
HSPH1	heat shock 105kDa/110kDa protein 1	0.022
PPP5C	protein phosphatase 5, catalytic subunit	0.022
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.022
ELK1	ELK1, member of ETS oncogene family	0.022
GRB10	growth factor receptor-bound protein 10	0.019
PLCG1	phospholipase C, gamma 1	0.019
TRADD	TNFRSF1A-associated via death domain	0.018
IRS1	insulin receptor substrate 1	0.018
IFNA14	interferon, alpha 14	0.017
ITGA1	integrin, alpha 1	0.017
TRAF3	TNF receptor-associated factor 3	0.017
IFNA4	interferon, alpha 4	0.017
JAK2	Janus kinase 2	0.016
FKBP4	FK506 binding protein 4, 59kDa	0.016
ANG	angiogenin, ribonuclease, RNase A family, 5	0.016
IFNA16	interferon, alpha 16	0.015	Human
NCOA1	nuclear receptor coactivator 1	0.015
IFI6	interferon, alpha-inducible protein 6	0.015
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.014
BID	BH3 interacting domain death agonist	0.014
GBP5	guanylate binding protein 5	0.013
FTL	ferritin, light polypeptide	0.013
USP18	ubiquitin specific peptidase 18	0.013
SOCS2	suppressor of cytokine signaling 2	0.012
IFNA17	interferon, alpha 17	0.012
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.012
IFNA21	interferon, alpha 21	0.012	Human
APBA3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.012
FTSJD2	FtsJ methyltransferase domain containing 2	0.012
SH2B1	SH2B adaptor protein 1	0.011
SHISA5	shisa homolog 5 (Xenopus laevis)	0.011
IFNA10	interferon, alpha 10	0.011	Human
IRAK3	interleukin-1 receptor-associated kinase 3	0.011
ZNFX1	zinc finger, NFX1-type containing 1	0.011
PRKD2	protein kinase D2	0.011
NOD1	nucleotide-binding oligomerization domain containing 1	0.010