IMP

Process View

Homo sapiens

14 genes annotated in human

renal tubule morphogenesis

The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "renal tubule morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "renal tubule morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
FGFR2	fibroblast growth factor receptor 2	0.999
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.778	Fly
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.760
CUL3	cullin 3	0.726
SMAD3	SMAD family member 3	0.620
FGF1	fibroblast growth factor 1 (acidic)	0.558
TP53	tumor protein p53	0.539
FSTL1	follistatin-like 1	0.492
FGF10	fibroblast growth factor 10	0.487	Human
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.375
BMPR1A	bone morphogenetic protein receptor, type IA	0.338
MEIS1	Meis homeobox 1	0.324
NRP1	neuropilin 1	0.320
HDAC4	histone deacetylase 4	0.288
MSN	moesin	0.206
COL4A5	collagen, type IV, alpha 5	0.201	Human Fly
COL4A4	collagen, type IV, alpha 4	0.194	Human Fly
EGR2	early growth response 2	0.192	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.189
ADAM17	ADAM metallopeptidase domain 17	0.181
MEIS2	Meis homeobox 2	0.178
FGFR1	fibroblast growth factor receptor 1	0.169
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.167	Human
NKX2-1	NK2 homeobox 1	0.158
FGF8	fibroblast growth factor 8 (androgen-induced)	0.136
KLHL12	kelch-like 12 (Drosophila)	0.135	Human
EGR3	early growth response 3	0.133	Human
ZFYVE9	zinc finger, FYVE domain containing 9	0.123
DAPK1	death-associated protein kinase 1	0.102
COL4A6	collagen, type IV, alpha 6	0.102	Human Fly
BCL2L1	BCL2-like 1	0.087
FGF4	fibroblast growth factor 4	0.087	Human
KLHL2	kelch-like 2, Mayven (Drosophila)	0.087	Human
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.086	Fly
PJA1	praja ring finger 1	0.083
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.082
MEOX1	mesenchyme homeobox 1	0.080
PAX8	paired box 8	0.073
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.070
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.070
WNT1	wingless-type MMTV integration site family, member 1	0.067	Human Mouse Fly
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.064
EGR1	early growth response 1	0.062	Human
NCOR2	nuclear receptor corepressor 2	0.058
FGF18	fibroblast growth factor 18	0.056
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.056	Fly
FGF3	fibroblast growth factor 3	0.054	Human
SKIL	SKI-like oncogene	0.054
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.054
HOXB5	homeobox B5	0.053
FN1	fibronectin 1	0.052
MAGED2	melanoma antigen family D, 2	0.051
TSC22D4	TSC22 domain family, member 4	0.050
GLIS2	GLIS family zinc finger 2	0.048
BMP7	bone morphogenetic protein 7	0.048
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.045
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.045
ENG	endoglin	0.043
PAX3	paired box 3	0.043
HOXA10	homeobox A10	0.038
THBS1	thrombospondin 1	0.038
TGFBR1	transforming growth factor, beta receptor 1	0.038
LBX1	ladybird homeobox 1	0.037
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.036
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.032
HDAC9	histone deacetylase 9	0.031
HMGA2	high mobility group AT-hook 2	0.031
COL7A1	collagen, type VII, alpha 1	0.030
WNT7A	wingless-type MMTV integration site family, member 7A	0.030	Human
COL2A1	collagen, type II, alpha 1	0.029
PARVA	parvin, alpha	0.028
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.027
PAX2	paired box 2	0.027
EPAS1	endothelial PAS domain protein 1	0.024
GDNF	glial cell derived neurotrophic factor	0.024
TGFB3	transforming growth factor, beta 3	0.024
DGCR14	DiGeorge syndrome critical region gene 14	0.024
TGFB2	transforming growth factor, beta 2	0.023
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.023
AMBRA1	autophagy/beclin-1 regulator 1	0.023
BMP4	bone morphogenetic protein 4	0.022
FGFR3	fibroblast growth factor receptor 3	0.021
SNAI1	snail homolog 1 (Drosophila)	0.021	Fly
GABARAP	GABA(A) receptor-associated protein	0.021
BCL6	B-cell CLL/lymphoma 6	0.020
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.020
CTGF	connective tissue growth factor	0.020
HNF1A	HNF1 homeobox A	0.019
INHBB	inhibin, beta B	0.019
NFIB	nuclear factor I/B	0.019
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.018
IER2	immediate early response 2	0.018
TAOK1	TAO kinase 1	0.018
HOXD13	homeobox D13	0.018
SIM2	single-minded homolog 2 (Drosophila)	0.018
WT1	Wilms tumor 1	0.018
PKN2	protein kinase N2	0.018
ZNF331	zinc finger protein 331	0.017
SFRP1	secreted frizzled-related protein 1	0.017
SOX1	SRY (sex determining region Y)-box 1	0.017
NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	0.017
BBS10	Bardet-Biedl syndrome 10	0.017
HES2	hairy and enhancer of split 2 (Drosophila)	0.017
CLDN7	claudin 7	0.016
NID1	nidogen 1	0.016
FGF2	fibroblast growth factor 2 (basic)	0.016
HOXB6	homeobox B6	0.015
WNT3	wingless-type MMTV integration site family, member 3	0.015	Human
NCOR1	nuclear receptor corepressor 1	0.015
HOXA11	homeobox A11	0.015	Mouse
WNT10A	wingless-type MMTV integration site family, member 10A	0.015	Human
NEUROG2	neurogenin 2	0.015
DAXX	death-domain associated protein	0.015
SIX6	SIX homeobox 6	0.015
FOXA2	forkhead box A2	0.015	Fly
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.014
MYOD1	myogenic differentiation 1	0.014
BMP2	bone morphogenetic protein 2	0.014	Human Mouse Fly
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.014
CALCA	calcitonin-related polypeptide alpha	0.014
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.014
FZD8	frizzled homolog 8 (Drosophila)	0.014
PGR	progesterone receptor	0.014
BHLHE40	basic helix-loop-helix family, member e40	0.013
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.013
PAX7	paired box 7	0.013
PML	promyelocytic leukemia	0.013
ZBTB16	zinc finger and BTB domain containing 16	0.013
WNT9B	wingless-type MMTV integration site family, member 9B	0.013	Human
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.013
CLDN4	claudin 4	0.013
FOXL1	forkhead box L1	0.012
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.012
SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11	0.012
RAX	retina and anterior neural fold homeobox	0.012
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.012
IHH	Indian hedgehog	0.012
FGF7	fibroblast growth factor 7	0.012	Human
HOXB1	homeobox B1	0.012
PARVB	parvin, beta	0.012
HOXC5	homeobox C5	0.012
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.012
HBEGF	heparin-binding EGF-like growth factor	0.012
VEGFA	vascular endothelial growth factor A	0.012	Mouse Fly
IRX4	iroquois homeobox 4	0.012
HOXB9	homeobox B9	0.012
T	T, brachyury homolog (mouse)	0.012	Fly
AXIN1	axin 1	0.012
NGFR	nerve growth factor receptor	0.011
MNX1	motor neuron and pancreas homeobox 1	0.011
FOXF1	forkhead box F1	0.011
PDX1	pancreatic and duodenal homeobox 1	0.011
PRMT6	protein arginine methyltransferase 6	0.011
NOG	noggin	0.011	Mouse
FOXF2	forkhead box F2	0.011
FOXN4	forkhead box N4	0.011
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.011
PXDN	peroxidasin homolog (Drosophila)	0.011
VSX1	visual system homeobox 1	0.011
TBX5	T-box 5	0.010
DLX4	distal-less homeobox 4	0.010
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.010
COL13A1	collagen, type XIII, alpha 1	0.010
EYA2	eyes absent homolog 2 (Drosophila)	0.010
HOXD9	homeobox D9	0.010