IMP

Process View

Homo sapiens

24 genes annotated in human

lytic vacuole organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lytic vacuole organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lytic vacuole organization" (in gray)

Name	Description	Probability	Func Analog Organism
AKTIP	AKT interacting protein	0.835
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.734
MON1B	MON1 homolog B (yeast)	0.516
VPS33B	vacuolar protein sorting 33 homolog B (yeast)	0.497
GDI2	GDP dissociation inhibitor 2	0.329
SNX33	sorting nexin 33	0.203
OCRL	oculocerebrorenal syndrome of Lowe	0.191
SNX6	sorting nexin 6	0.167
VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)	0.158
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.136
FKBP8	FK506 binding protein 8, 38kDa	0.131
AMBRA1	autophagy/beclin-1 regulator 1	0.129
GOLGA2	golgin A2	0.124
BCL2L1	BCL2-like 1	0.088
BCL2	B-cell CLL/lymphoma 2	0.087
HOOK2	hook homolog 2 (Drosophila)	0.085
ATF2	activating transcription factor 2	0.082
FNBP1	formin binding protein 1	0.081
SH3KBP1	SH3-domain kinase binding protein 1	0.075
USP22	ubiquitin specific peptidase 22	0.074
RAB5A	RAB5A, member RAS oncogene family	0.072
MAPK8	mitogen-activated protein kinase 8	0.067
ITSN1	intersectin 1 (SH3 domain protein)	0.057
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.048
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.048
RAB1A	RAB1A, member RAS oncogene family	0.046
GLB1	galactosidase, beta 1	0.040
GM2A	GM2 ganglioside activator	0.039
STX12	syntaxin 12	0.039
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.038
BIK	BCL2-interacting killer (apoptosis-inducing)	0.037
WASL	Wiskott-Aldrich syndrome-like	0.037
DZIP3	DAZ interacting protein 3, zinc finger	0.037
C5orf54	chromosome 5 open reading frame 54	0.036
MFSD1	major facilitator superfamily domain containing 1	0.036
PSAP	prosaposin	0.036
MAN2B1	mannosidase, alpha, class 2B, member 1	0.035
SNX1	sorting nexin 1	0.035	Worm
APPBP2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	0.033
UVRAG	UV radiation resistance associated gene	0.032
TYK2	tyrosine kinase 2	0.031
PLD3	phospholipase D family, member 3	0.031
PIK3C3	phosphoinositide-3-kinase, class 3	0.031
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.030
CTTN	cortactin	0.030
RAB6A	RAB6A, member RAS oncogene family	0.029
DNM2	dynamin 2	0.028
EIF1B	eukaryotic translation initiation factor 1B	0.027
SS18	synovial sarcoma translocation, chromosome 18	0.025
AMPH	amphiphysin	0.025
REEP6	receptor accessory protein 6	0.025
STAMBP	STAM binding protein	0.025
GRN	granulin	0.025
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.024
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.024
BAD	BCL2-associated agonist of cell death	0.022
PICALM	phosphatidylinositol binding clathrin assembly protein	0.022
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.022
DAPK1	death-associated protein kinase 1	0.022
HEXB	hexosaminidase B (beta polypeptide)	0.021	Mouse
KIAA1377	KIAA1377	0.020
TP53BP2	tumor protein p53 binding protein, 2	0.020
ABLIM1	actin binding LIM protein 1	0.020
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.020
EEA1	early endosome antigen 1	0.019
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.019
NEU1	sialidase 1 (lysosomal sialidase)	0.018
CANX	calnexin	0.018
WASH1	WAS protein family homolog 1	0.017
HOOK3	hook homolog 3 (Drosophila)	0.017
BAX	BCL2-associated X protein	0.017
RTN1	reticulon 1	0.017
MAN1B1	mannosidase, alpha, class 1B, member 1	0.017
POLD4	polymerase (DNA-directed), delta 4	0.017
GOLGA7	golgin A7	0.016
ZFYVE1	zinc finger, FYVE domain containing 1	0.016
RAB7A	RAB7A, member RAS oncogene family	0.016
VPS33A	vacuolar protein sorting 33 homolog A (S. cerevisiae)	0.016
UNC45A	unc-45 homolog A (C. elegans)	0.016
P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	0.016
ZFYVE26	zinc finger, FYVE domain containing 26	0.015
M6PR	mannose-6-phosphate receptor (cation dependent)	0.015
LRP10	low density lipoprotein receptor-related protein 10	0.015
MANBA	mannosidase, beta A, lysosomal	0.015
BBC3	BCL2 binding component 3	0.015
MAPK14	mitogen-activated protein kinase 14	0.014
TMCO1	transmembrane and coiled-coil domains 1	0.014
CTBP2	C-terminal binding protein 2	0.014
SPHAR	S-phase response (cyclin related)	0.014
CLTC	clathrin, heavy chain (Hc)	0.014
LTA4H	leukotriene A4 hydrolase	0.014
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.014
RAB11A	RAB11A, member RAS oncogene family	0.014
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.014
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.014
ARHGAP4	Rho GTPase activating protein 4	0.014
RUFY1	RUN and FYVE domain containing 1	0.014
NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	0.014
PEX2	peroxisomal biogenesis factor 2	0.013
C14orf101	chromosome 14 open reading frame 101	0.013
FLOT2	flotillin 2	0.013
WDR48	WD repeat domain 48	0.013
GNS	glucosamine (N-acetyl)-6-sulfatase	0.013
HPS1	Hermansky-Pudlak syndrome 1	0.013
SH3GL2	SH3-domain GRB2-like 2	0.013
UNC50	unc-50 homolog (C. elegans)	0.013
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.013
TM9SF2	transmembrane 9 superfamily member 2	0.013
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.013
GATAD1	GATA zinc finger domain containing 1	0.012
TMEM50B	transmembrane protein 50B	0.012
COX15	COX15 homolog, cytochrome c oxidase assembly protein (yeast)	0.012
SIGMAR1	sigma non-opioid intracellular receptor 1	0.012
CTSL1	cathepsin L1	0.012
HOOK1	hook homolog 1 (Drosophila)	0.012
VAMP7	vesicle-associated membrane protein 7	0.012
CTSA	cathepsin A	0.012
TPP1	tripeptidyl peptidase I	0.012	Mouse
SH3GL1	SH3-domain GRB2-like 1	0.012
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.011
MYST2	MYST histone acetyltransferase 2	0.011
PGRMC1	progesterone receptor membrane component 1	0.011
C5orf15	chromosome 5 open reading frame 15	0.011
TMEM50A	transmembrane protein 50A	0.011
AP3B1	adaptor-related protein complex 3, beta 1 subunit	0.011	Worm
SCAMP2	secretory carrier membrane protein 2	0.011
GOLGA1	golgin A1	0.011
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.011
PXN	paxillin	0.011
GGA3	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	0.011
ILVBL	ilvB (bacterial acetolactate synthase)-like	0.011
NBR1	neighbor of BRCA1 gene 1	0.011
ZDHHC24	zinc finger, DHHC-type containing 24	0.011
MMGT1	membrane magnesium transporter 1	0.011
TBC1D17	TBC1 domain family, member 17	0.011
BID	BH3 interacting domain death agonist	0.011
RGS19	regulator of G-protein signaling 19	0.011
RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	0.011
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.011
SGSH	N-sulfoglucosamine sulfohydrolase	0.011
VPS16	vacuolar protein sorting 16 homolog (S. cerevisiae)	0.011
SCARB2	scavenger receptor class B, member 2	0.010
PEX19	peroxisomal biogenesis factor 19	0.010
TMC6	transmembrane channel-like 6	0.010
ATRN	attractin	0.010
MYO1E	myosin IE	0.010
GNPDA1	glucosamine-6-phosphate deaminase 1	0.010
LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	0.010