IMP

Process View

Homo sapiens

12 genes annotated in human

fertilization

The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "fertilization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "fertilization" (in gray)

Name	Description	Probability	Func Analog Organism
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.992	Worm
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.959	Mouse
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.944	Worm
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.926	Worm
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.862	Mouse
TCP1	t-complex 1	0.818	Mouse
CKAP5	cytoskeleton associated protein 5	0.712	Worm Fly
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.641
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.614	Mouse
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.554	Mouse
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.364	Mouse
PRC1	protein regulator of cytokinesis 1	0.353
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.290
CDK2	cyclin-dependent kinase 2	0.250
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.203
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.202	Worm
KLK10	kallikrein-related peptidase 10	0.137	Human
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.129
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.122	Mouse
PRSS2	protease, serine, 2 (trypsin 2)	0.087
DYNLT3	dynein, light chain, Tctex-type 3	0.086
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.070
RAN	RAN, member RAS oncogene family	0.067
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.062
OCRL	oculocerebrorenal syndrome of Lowe	0.062
CCNB1	cyclin B1	0.061
TACC3	transforming, acidic coiled-coil containing protein 3	0.059	Fly
SNRPG	small nuclear ribonucleoprotein polypeptide G	0.059
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.058	Worm
SNRPF	small nuclear ribonucleoprotein polypeptide F	0.057
CCNA2	cyclin A2	0.057
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.056	Worm
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.048
KLK5	kallikrein-related peptidase 5	0.046	Human
CAND1	cullin-associated and neddylation-dissociated 1	0.044
PPP4C	protein phosphatase 4, catalytic subunit	0.043
CUL4B	cullin 4B	0.042
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.041
WDR77	WD repeat domain 77	0.041
TUBA3E	tubulin, alpha 3e	0.039
HSPA8	heat shock 70kDa protein 8	0.038
PTPRN	protein tyrosine phosphatase, receptor type, N	0.037
RACGAP1	Rac GTPase activating protein 1	0.036
AURKA	aurora kinase A	0.036
TDRD7	tudor domain containing 7	0.035
RNR2	l-rRNA	0.035
SNRNP40	small nuclear ribonucleoprotein 40kDa (U5)	0.033
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.032
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.032
UBAP2L	ubiquitin associated protein 2-like	0.032
DDX1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	0.031
CD63	CD63 molecule	0.031
CCNB2	cyclin B2	0.030
RPA1	replication protein A1, 70kDa	0.030
BCL2L1	BCL2-like 1	0.030	Mouse
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.029
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.029
KLK7	kallikrein-related peptidase 7	0.027	Human
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.026	Worm
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.025
HN1	hematological and neurological expressed 1	0.025
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.025
TRIP6	thyroid hormone receptor interactor 6	0.025
CKS2	CDC28 protein kinase regulatory subunit 2	0.025
PEF1	penta-EF-hand domain containing 1	0.025
C15orf63	chromosome 15 open reading frame 63	0.025
CAPNS1	calpain, small subunit 1	0.024
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	0.024
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.023
APPBP2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	0.022
KLK11	kallikrein-related peptidase 11	0.022	Human
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.022
CACYBP	calcyclin binding protein	0.021
TUBA1B	tubulin, alpha 1b	0.021
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.021
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.020
HSPA4	heat shock 70kDa protein 4	0.020
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.019
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.019	Worm
EMG1	EMG1 nucleolar protein homolog (S. cerevisiae)	0.018
CREBBP	CREB binding protein	0.018
EIF4A3	eukaryotic translation initiation factor 4A3	0.018
CDSN	corneodesmosin	0.018
SNAP25	synaptosomal-associated protein, 25kDa	0.017
PCBP1	poly(rC) binding protein 1	0.017
H2AFZ	H2A histone family, member Z	0.017
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.017
NCL	nucleolin	0.017
CD81	CD81 molecule	0.017	Human
BAK1	BCL2-antagonist/killer 1	0.017
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.016
CD9	CD9 molecule	0.016
PPP6C	protein phosphatase 6, catalytic subunit	0.016
C3orf34	chromosome 3 open reading frame 34	0.016
MCM3	minichromosome maintenance complex component 3	0.016
WDR20	WD repeat domain 20	0.016
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.016
SF3A1	splicing factor 3a, subunit 1, 120kDa	0.016
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.016
SRSF9	serine/arginine-rich splicing factor 9	0.016
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.015
NUP93	nucleoporin 93kDa	0.015
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.015
UBE2S	ubiquitin-conjugating enzyme E2S	0.015
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.015
KLK2	kallikrein-related peptidase 2	0.015	Human
DICER1	dicer 1, ribonuclease type III	0.015
STIP1	stress-induced-phosphoprotein 1	0.015
CAPRIN1	cell cycle associated protein 1	0.014
VDAC1	voltage-dependent anion channel 1	0.014
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.014
DYNLL1	dynein, light chain, LC8-type 1	0.014	Worm
TRIM37	tripartite motif containing 37	0.014
GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.014	Worm
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.014
ZMPSTE24	zinc metallopeptidase (STE24 homolog, S. cerevisiae)	0.014
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.014
ERH	enhancer of rudimentary homolog (Drosophila)	0.013
POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.013
RAB1A	RAB1A, member RAS oncogene family	0.013
SAE1	SUMO1 activating enzyme subunit 1	0.013
HOXA10	homeobox A10	0.013
SFN	stratifin	0.013
DYNC1LI1	dynein, cytoplasmic 1, light intermediate chain 1	0.013
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.013
HMGB2	high mobility group box 2	0.013
FBXW11	F-box and WD repeat domain containing 11	0.012
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.012
RNF144B	ring finger protein 144B	0.012
PSMA4	proteasome (prosome, macropain) subunit, alpha type, 4	0.012
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.012
TUBG1	tubulin, gamma 1	0.012
LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.012
FLNA	filamin A, alpha	0.012
FEN1	flap structure-specific endonuclease 1	0.012
BAD	BCL2-associated agonist of cell death	0.012
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.011
NCR2	natural cytotoxicity triggering receptor 2	0.011
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.011
KLK8	kallikrein-related peptidase 8	0.011	Human
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.011
POMP	proteasome maturation protein	0.011
CUL1	cullin 1	0.011
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.011
SEC61G	Sec61 gamma subunit	0.011
ZHX1	zinc fingers and homeoboxes 1	0.011
IGSF21	immunoglobin superfamily, member 21	0.011
MAPK15	mitogen-activated protein kinase 15	0.010
TUBB2C	tubulin, beta 2C	0.010
BMS1	BMS1 homolog, ribosome assembly protein (yeast)	0.010
PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	0.010
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.010
EPRS	glutamyl-prolyl-tRNA synthetase	0.010
MAPK1	mitogen-activated protein kinase 1	0.010