IMP
Process View
negative regulation of release of cytochrome c from mitochondria
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of release of cytochrome c from mitochondria"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Trp53 | transformation related protein 53 | 0.910 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.906 | ||
| Egfr | epidermal growth factor receptor | 0.846 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.842 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.837 | ||
| Lepr | leptin receptor | 0.830 | ||
| Pparg | peroxisome proliferator activated receptor gamma | 0.775 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.730 | ||
| Akt1 | thymoma viral proto-oncogene 1 | 0.715 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.559 | ||
| Cav1 | caveolin 1, caveolae protein | 0.536 | ||
| Smn1 | survival motor neuron 1 | 0.475 | ||
| Lmnb1 | lamin B1 | 0.405 | Mouse | |
| Igf1r | insulin-like growth factor I receptor | 0.395 | ||
| Lep | leptin | 0.381 | ||
| Vegfa | vascular endothelial growth factor A | 0.337 | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.318 | ||
| Insr | insulin receptor | 0.250 | ||
| Apoe | apolipoprotein E | 0.230 | ||
| Nos1 | nitric oxide synthase 1, neuronal | 0.228 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.209 | ||
| Ldb3 | LIM domain binding 3 | 0.196 | ||
| Ghr | growth hormone receptor | 0.178 | ||
| Lmnb2 | lamin B2 | 0.170 | Mouse | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.150 | ||
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.147 | ||
| Lmna | lamin A | 0.147 | ||
| Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 0.118 | ||
| Akt2 | thymoma viral proto-oncogene 2 | 0.111 | Mouse | |
| Ins2 | insulin II | 0.109 | Mouse | |
| Gja1 | gap junction protein, alpha 1 | 0.092 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.092 | ||
| Kl | klotho | 0.082 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.080 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.078 | ||
| Stim2 | stromal interaction molecule 2 | 0.068 | ||
| Irs2 | insulin receptor substrate 2 | 0.059 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.057 | ||
| Pten | phosphatase and tensin homolog | 0.057 | ||
| Itga1 | integrin alpha 1 | 0.053 | ||
| Cdkn1c | cyclin-dependent kinase inhibitor 1C (P57) | 0.053 | ||
| Grin2b | glutamate receptor, ionotropic, NMDA2B (epsilon 2) | 0.051 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.049 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.049 | ||
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.045 | ||
| Tagln2 | transgelin 2 | 0.045 | ||
| Ins1 | insulin I | 0.040 | Mouse | |
| Ilk | integrin linked kinase | 0.040 | ||
| Igf2r | insulin-like growth factor 2 receptor | 0.037 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.035 | ||
| Psma4 | proteasome (prosome, macropain) subunit, alpha type 4 | 0.035 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.034 | ||
| Axl | AXL receptor tyrosine kinase | 0.033 | ||
| Thrb | thyroid hormone receptor beta | 0.033 | ||
| Pard3 | par-3 (partitioning defective 3) homolog (C. elegans) | 0.032 | ||
| Scd1 | stearoyl-Coenzyme A desaturase 1 | 0.031 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.030 | ||
| Myo1c | myosin IC | 0.028 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.028 | ||
| Cd44 | CD44 antigen | 0.027 | ||
| Cd151 | CD151 antigen | 0.027 | ||
| Pnpla2 | patatin-like phospholipase domain containing 2 | 0.026 | ||
| Rxra | retinoid X receptor alpha | 0.025 | ||
| Wrn | Werner syndrome homolog (human) | 0.025 | ||
| Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b | 0.025 | ||
| Cd28 | CD28 antigen | 0.024 | ||
| Apc | adenomatosis polyposis coli | 0.024 | ||
| Mapk8 | mitogen-activated protein kinase 8 | 0.024 | ||
| Idua | iduronidase, alpha-L- | 0.023 | ||
| Lif | leukemia inhibitory factor | 0.023 | ||
| Mapkapk2 | MAP kinase-activated protein kinase 2 | 0.023 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.022 | ||
| Plcb1 | phospholipase C, beta 1 | 0.022 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.021 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.021 | ||
| Mfn2 | mitofusin 2 | 0.020 | ||
| Efnb2 | ephrin B2 | 0.020 | ||
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.020 | ||
| Sh3pxd2b | SH3 and PX domains 2B | 0.018 | ||
| Nphs2 | nephrosis 2 homolog, podocin (human) | 0.018 | ||
| Psmb7 | proteasome (prosome, macropain) subunit, beta type 7 | 0.018 | ||
| Ptrf | polymerase I and transcript release factor | 0.017 | ||
| 2310046A06Rik | RIKEN cDNA 2310046A06 gene | 0.017 | ||
| E2f1 | E2F transcription factor 1 | 0.017 | ||
| Sema6d | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 0.017 | ||
| Pomp | proteasome maturation protein | 0.017 | ||
| Fbn1 | fibrillin 1 | 0.016 | ||
| Pthlh | parathyroid hormone-like peptide | 0.016 | ||
| Foxo1 | forkhead box O1 | 0.016 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.016 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.016 | ||
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.015 | ||
| Wdr1 | WD repeat domain 1 | 0.015 | ||
| Nf1 | neurofibromatosis 1 | 0.015 | ||
| Mrpl9 | mitochondrial ribosomal protein L9 | 0.014 | ||
| Atp5b | ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit | 0.014 | ||
| Prkce | protein kinase C, epsilon | 0.014 | ||
| Coq7 | demethyl-Q 7 | 0.014 | ||
| Kctd20 | potassium channel tetramerisation domain containing 20 | 0.014 | ||
| Myh9 | myosin, heavy polypeptide 9, non-muscle | 0.014 | ||
| Supv3l1 | suppressor of var1, 3-like 1 (S. cerevisiae) | 0.014 | ||
| Coro1c | coronin, actin binding protein 1C | 0.014 | ||
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.014 | ||
| Gtf2ird1 | general transcription factor II I repeat domain-containing 1 | 0.014 | ||
| Tyro3 | TYRO3 protein tyrosine kinase 3 | 0.014 | ||
| Npy1r | neuropeptide Y receptor Y1 | 0.014 | ||
| Myl2 | myosin, light polypeptide 2, regulatory, cardiac, slow | 0.014 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.013 | ||
| Trp63 | transformation related protein 63 | 0.013 | ||
| Ppargc1a | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | 0.013 | ||
| Kif3b | kinesin family member 3B | 0.013 | ||
| Bbc3 | BCL2 binding component 3 | 0.013 | ||
| Ate1 | arginyltransferase 1 | 0.013 | ||
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.012 | ||
| Ar | androgen receptor | 0.012 | ||
| Braf | Braf transforming gene | 0.012 | ||
| Smu1 | smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) | 0.012 | ||
| Bax | BCL2-associated X protein | 0.011 | ||
| Alkbh1 | alkB, alkylation repair homolog 1 (E. coli) | 0.011 | ||
| Sfn | stratifin | 0.011 | ||
| Clock | circadian locomotor output cycles kaput | 0.011 | ||
| Parl | presenilin associated, rhomboid-like | 0.011 | ||
| Ctnnd1 | catenin (cadherin associated protein), delta 1 | 0.011 | ||
| Esr2 | estrogen receptor 2 (beta) | 0.011 | ||
| Homer1 | homer homolog 1 (Drosophila) | 0.010 | ||
| Vasp | vasodilator-stimulated phosphoprotein | 0.010 | ||
| a | nonagouti | 0.010 | ||
| Mrpl50 | mitochondrial ribosomal protein L50 | 0.010 | ||
| Kit | kit oncogene | 0.010 |