IMP
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negative regulation of b cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of b cell differentiation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Vegfa | vascular endothelial growth factor A | 0.902 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.712 | ||
| Tcf4 | transcription factor 4 | 0.330 | ||
| Cdh5 | cadherin 5 | 0.325 | ||
| Kdr | kinase insert domain protein receptor | 0.210 | Mouse | |
| Ptma | prothymosin alpha | 0.199 | ||
| Kitl | kit ligand | 0.167 | ||
| Ptch1 | patched homolog 1 | 0.167 | ||
| Slc9a3r2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.162 | ||
| Tie1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 0.154 | ||
| Sfrp1 | secreted frizzled-related protein 1 | 0.128 | ||
| Tcf3 | transcription factor 3 | 0.118 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.110 | ||
| Trp53 | transformation related protein 53 | 0.108 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.107 | ||
| Pten | phosphatase and tensin homolog | 0.104 | ||
| Sfrp2 | secreted frizzled-related protein 2 | 0.103 | Mouse | |
| Prrx1 | paired related homeobox 1 | 0.095 | ||
| H3f3b | H3 histone, family 3B | 0.093 | ||
| Tyrobp | TYRO protein tyrosine kinase binding protein | 0.088 | ||
| Ednrb | endothelin receptor type B | 0.083 | ||
| Vegfc | vascular endothelial growth factor C | 0.082 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.081 | ||
| Hmgb1 | high mobility group box 1 | 0.077 | Mouse | |
| Anp32e | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.073 | ||
| Cdh11 | cadherin 11 | 0.067 | ||
| Plxnd1 | plexin D1 | 0.066 | ||
| Esam | endothelial cell-specific adhesion molecule | 0.063 | ||
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.061 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.060 | ||
| Tmpo | thymopoietin | 0.056 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.052 | ||
| Cbl | Casitas B-lineage lymphoma | 0.050 | ||
| Gja1 | gap junction protein, alpha 1 | 0.049 | ||
| Fbln1 | fibulin 1 | 0.046 | ||
| Cxcl12 | chemokine (C-X-C motif) ligand 12 | 0.043 | ||
| Fyn | Fyn proto-oncogene | 0.043 | ||
| H2afz | H2A histone family, member Z | 0.043 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.042 | ||
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.041 | ||
| Dck | deoxycytidine kinase | 0.040 | ||
| Foxc2 | forkhead box C2 | 0.039 | ||
| Hnrnpa1 | heterogeneous nuclear ribonucleoprotein A1 | 0.038 | ||
| Mylk | myosin, light polypeptide kinase | 0.038 | ||
| Ptprb | protein tyrosine phosphatase, receptor type, B | 0.036 | ||
| Ect2 | ect2 oncogene | 0.036 | ||
| Tek | endothelial-specific receptor tyrosine kinase | 0.036 | ||
| Ldlr | low density lipoprotein receptor | 0.036 | ||
| Sox18 | SRY-box containing gene 18 | 0.035 | ||
| Meis2 | Meis homeobox 2 | 0.034 | ||
| Tmem204 | transmembrane protein 204 | 0.034 | ||
| Ptn | pleiotrophin | 0.033 | ||
| Plcg1 | phospholipase C, gamma 1 | 0.031 | ||
| Pcna | proliferating cell nuclear antigen | 0.031 | ||
| Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.030 | ||
| Meox2 | mesenchyme homeobox 2 | 0.029 | ||
| Nr2f2 | nuclear receptor subfamily 2, group F, member 2 | 0.029 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.028 | ||
| Smad6 | MAD homolog 6 (Drosophila) | 0.028 | ||
| Epor | erythropoietin receptor | 0.028 | ||
| Npr3 | natriuretic peptide receptor 3 | 0.027 | ||
| Col4a2 | collagen, type IV, alpha 2 | 0.026 | ||
| S1pr3 | sphingosine-1-phosphate receptor 3 | 0.026 | ||
| Lbr | lamin B receptor | 0.026 | ||
| Cdkn1c | cyclin-dependent kinase inhibitor 1C (P57) | 0.025 | ||
| Foxo3 | forkhead box O3 | 0.025 | ||
| Gas1 | growth arrest specific 1 | 0.025 | ||
| Dab2 | disabled homolog 2 (Drosophila) | 0.025 | ||
| She | src homology 2 domain-containing transforming protein E | 0.025 | ||
| Apoe | apolipoprotein E | 0.024 | ||
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.023 | ||
| Flt4 | FMS-like tyrosine kinase 4 | 0.022 | Mouse | |
| Gpc3 | glypican 3 | 0.022 | ||
| Eng | endoglin | 0.022 | ||
| Rasip1 | Ras interacting protein 1 | 0.022 | ||
| Id3 | inhibitor of DNA binding 3 | 0.022 | Mouse | |
| Sgpl1 | sphingosine phosphate lyase 1 | 0.021 | ||
| Id1 | inhibitor of DNA binding 1 | 0.021 | Mouse | |
| Tgfb2 | transforming growth factor, beta 2 | 0.020 | ||
| Jun | Jun oncogene | 0.020 | ||
| Plvap | plasmalemma vesicle associated protein | 0.020 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.020 | ||
| Dpysl3 | dihydropyrimidinase-like 3 | 0.020 | ||
| Gfra3 | glial cell line derived neurotrophic factor family receptor alpha 3 | 0.020 | ||
| Ddah2 | dimethylarginine dimethylaminohydrolase 2 | 0.019 | ||
| Trp73 | transformation related protein 73 | 0.019 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.019 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.019 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.019 | ||
| Pdgfb | platelet derived growth factor, B polypeptide | 0.019 | ||
| Nucks1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.018 | ||
| Cldn5 | claudin 5 | 0.018 | ||
| Hmgn1 | high mobility group nucleosomal binding domain 1 | 0.018 | ||
| Rbbp4 | retinoblastoma binding protein 4 | 0.018 | ||
| Emcn | endomucin | 0.018 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.018 | ||
| Arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | 0.018 | ||
| Id2 | inhibitor of DNA binding 2 | 0.018 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.017 | ||
| Mitf | microphthalmia-associated transcription factor | 0.017 | ||
| Cbx3 | chromobox homolog 3 (Drosophila HP1 gamma) | 0.017 | ||
| Stmn1 | stathmin 1 | 0.017 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.017 | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.017 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.017 | ||
| Lrp1 | low density lipoprotein receptor-related protein 1 | 0.017 | ||
| Cadm1 | cell adhesion molecule 1 | 0.016 | ||
| Rad21 | RAD21 homolog (S. pombe) | 0.016 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.016 | ||
| Lpar1 | lysophosphatidic acid receptor 1 | 0.016 | ||
| Fzd2 | frizzled homolog 2 (Drosophila) | 0.016 | ||
| Gmnn | geminin | 0.016 | ||
| Hmgb3 | high mobility group box 3 | 0.016 | ||
| Adcy4 | adenylate cyclase 4 | 0.015 | ||
| Mfap2 | microfibrillar-associated protein 2 | 0.015 | ||
| Nrp1 | neuropilin 1 | 0.015 | ||
| Hnrnpd | heterogeneous nuclear ribonucleoprotein D | 0.015 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.015 | ||
| Apaf1 | apoptotic peptidase activating factor 1 | 0.015 | ||
| Topbp1 | topoisomerase (DNA) II binding protein 1 | 0.015 | ||
| Stab1 | stabilin 1 | 0.015 | ||
| Sema3f | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 0.014 | ||
| Hdac2 | histone deacetylase 2 | 0.014 | ||
| Slc25a45 | solute carrier family 25, member 45 | 0.014 | ||
| Smc2 | structural maintenance of chromosomes 2 | 0.014 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.014 | ||
| Sox4 | SRY-box containing gene 4 | 0.014 | ||
| Casp3 | caspase 3 | 0.014 | ||
| H3f3a | H3 histone, family 3A | 0.013 | ||
| Rbp1 | retinol binding protein 1, cellular | 0.013 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.013 | ||
| Lyst | lysosomal trafficking regulator | 0.013 | ||
| Tdp2 | tyrosyl-DNA phosphodiesterase 2 | 0.013 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.013 | ||
| Adamts20 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 | 0.013 | ||
| Hnrnpm | heterogeneous nuclear ribonucleoprotein M | 0.013 | ||
| Amotl2 | angiomotin-like 2 | 0.013 | ||
| Wnt5a | wingless-related MMTV integration site 5A | 0.013 | ||
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.013 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.013 | ||
| Arid5b | AT rich interactive domain 5B (MRF1-like) | 0.013 | ||
| Egfl7 | EGF-like domain 7 | 0.013 | ||
| Dact1 | dapper homolog 1, antagonist of beta-catenin (xenopus) | 0.013 | ||
| Heg1 | HEG homolog 1 (zebrafish) | 0.013 | ||
| Cachd1 | cache domain containing 1 | 0.013 | ||
| Runx1t1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.013 | ||
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.012 | ||
| Vwf | Von Willebrand factor homolog | 0.012 | ||
| Ppap2b | phosphatidic acid phosphatase type 2B | 0.012 | ||
| Cd19 | CD19 antigen | 0.012 | ||
| Psapl1 | prosaposin-like 1 | 0.012 | ||
| Cks2 | CDC28 protein kinase regulatory subunit 2 | 0.012 | ||
| Ldb2 | LIM domain binding 2 | 0.012 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.012 | ||
| Eltd1 | EGF, latrophilin seven transmembrane domain containing 1 | 0.012 | ||
| Pecam1 | platelet/endothelial cell adhesion molecule 1 | 0.012 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.012 | ||
| Kiss1r | KISS1 receptor | 0.012 | ||
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.012 | ||
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.012 | ||
| Smc4 | structural maintenance of chromosomes 4 | 0.012 | ||
| Efnb1 | ephrin B1 | 0.012 | ||
| Fos | FBJ osteosarcoma oncogene | 0.012 | ||
| Peg3 | paternally expressed 3 | 0.012 | ||
| U2af1 | U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 | 0.012 | ||
| Yap1 | yes-associated protein 1 | 0.012 | ||
| Slamf1 | signaling lymphocytic activation molecule family member 1 | 0.012 | ||
| Dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | 0.011 | ||
| Tcf7l1 | transcription factor 7-like 1 (T-cell specific, HMG box) | 0.011 | ||
| Dek | DEK oncogene (DNA binding) | 0.011 | ||
| Efnb2 | ephrin B2 | 0.011 | ||
| Dcbld2 | discoidin, CUB and LCCL domain containing 2 | 0.011 | ||
| Mapre1 | microtubule-associated protein, RP/EB family, member 1 | 0.011 | ||
| Mertk | c-mer proto-oncogene tyrosine kinase | 0.011 | ||
| Runx2 | runt related transcription factor 2 | 0.011 | ||
| Trim59 | tripartite motif-containing 59 | 0.011 | ||
| Sox17 | SRY-box containing gene 17 | 0.011 | ||
| Olig2 | oligodendrocyte transcription factor 2 | 0.011 | ||
| Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | 0.011 | ||
| Nfib | nuclear factor I/B | 0.011 | ||
| Spnb2 | spectrin beta 2 | 0.011 | ||
| Fzd1 | frizzled homolog 1 (Drosophila) | 0.011 | ||
| Rbm3 | RNA binding motif protein 3 | 0.011 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.011 | ||
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.011 | ||
| Dkk3 | dickkopf homolog 3 (Xenopus laevis) | 0.011 | ||
| Epas1 | endothelial PAS domain protein 1 | 0.011 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.011 | ||
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.011 | ||
| Ltb | lymphotoxin B | 0.010 | ||
| Stmn2 | stathmin-like 2 | 0.010 | ||
| Ets1 | E26 avian leukemia oncogene 1, 5' domain | 0.010 | ||
| Ccnd1 | cyclin D1 | 0.010 | ||
| Atp2a2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.010 | ||
| Nrarp | Notch-regulated ankyrin repeat protein | 0.010 | ||
| Lyz2 | lysozyme 2 | 0.010 | ||
| Sumo2 | SMT3 suppressor of mif two 3 homolog 2 (yeast) | 0.010 | ||
| Twist1 | twist homolog 1 (Drosophila) | 0.010 | ||
| Fgd5 | FYVE, RhoGEF and PH domain containing 5 | 0.010 | ||
| Ramp2 | receptor (calcitonin) activity modifying protein 2 | 0.010 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.010 | ||
| Slbp | stem-loop binding protein | 0.010 | ||
| Klf7 | Kruppel-like factor 7 (ubiquitous) | 0.010 |