IMP

Process View

Mus musculus

3 genes annotated in mouse

negative regulation of ligase activity

Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of ligase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of ligase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Notch1	Notch gene homolog 1 (Drosophila)	0.830
Rpgrip1l	Rpgrip1-like	0.699
Lrrk2	leucine-rich repeat kinase 2	0.669
Trp53	transformation related protein 53	0.495
Notch2	Notch gene homolog 2 (Drosophila)	0.418
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.288
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.276
Psen1	presenilin 1	0.271
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.198
Cdk2	cyclin-dependent kinase 2	0.196
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.159	Yeast
Ccne1	cyclin E1	0.134	Fly
Axin1	axin 1	0.112
Ptk2	PTK2 protein tyrosine kinase 2	0.112
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.101
Sgol1	shugoshin-like 1 (S. pombe)	0.096
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.089
Sgol2	shugoshin-like 2 (S. pombe)	0.068
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.053
Ncstn	nicastrin	0.049
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.049
H2afz	H2A histone family, member Z	0.048
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.047
Trp73	transformation related protein 73	0.046
Mdm2	transformed mouse 3T3 cell double minute 2	0.046
Irf6	interferon regulatory factor 6	0.045
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.045
Cops6	COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)	0.040
Ccne2	cyclin E2	0.040	Fly
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.039
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.035	Yeast
Immt	inner membrane protein, mitochondrial	0.032
Tbc1d4	TBC1 domain family, member 4	0.032
Tsc1	tuberous sclerosis 1	0.032
Tsc2	tuberous sclerosis 2	0.032
Mdm4	transformed mouse 3T3 cell double minute 4	0.032
Rb1	retinoblastoma 1	0.031
Skp2	S-phase kinase-associated protein 2 (p45)	0.031
Trp63	transformation related protein 63	0.031
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.031
Ptch1	patched homolog 1	0.030
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.030
Clpp	caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)	0.028
Ccna2	cyclin A2	0.026
App	amyloid beta (A4) precursor protein	0.025
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.025
Ripk4	receptor-interacting serine-threonine kinase 4	0.025
Ect2	ect2 oncogene	0.025
Scoc	short coiled-coil protein	0.024
Dok2	docking protein 2	0.024
Rxra	retinoid X receptor alpha	0.024
Psmc5	protease (prosome, macropain) 26S subunit, ATPase 5	0.024
Bad	BCL2-associated agonist of cell death	0.023
Abl2	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	0.022
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.022
Psen2	presenilin 2	0.022
Erlin2	ER lipid raft associated 2	0.021
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.021
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.020
Spint1	serine protease inhibitor, Kunitz type 1	0.019
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.019
E2f1	E2F transcription factor 1	0.019
Efnb2	ephrin B2	0.018
Nf2	neurofibromatosis 2	0.018
Acly	ATP citrate lyase	0.017
Ppard	peroxisome proliferator activator receptor delta	0.016
Psenen	presenilin enhancer 2 homolog (C. elegans)	0.016
Rps16	ribosomal protein S16	0.016
H2-Ke2	H2-K region expressed gene 2	0.016
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.016
2410089E03Rik	RIKEN cDNA 2410089E03 gene	0.016
Dok1	docking protein 1	0.016
Gen1	Gen homolog 1, endonuclease (Drosophila)	0.015
Psmd11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.015
Raf1	v-raf-leukemia viral oncogene 1	0.015
Hdgf	hepatoma-derived growth factor	0.015
Itga3	integrin alpha 3	0.015
Ncapg2	non-SMC condensin II complex, subunit G2	0.015
2610039C10Rik	RIKEN cDNA 2610039C10 gene	0.015
Hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.015
Rpl7a	ribosomal protein L7A	0.015
Dll1	delta-like 1 (Drosophila)	0.014
Msh2	mutS homolog 2 (E. coli)	0.014
Slc25a4	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4	0.014
Mapk13	mitogen-activated protein kinase 13	0.014
Rint1	RAD50 interactor 1	0.014
Cbl	Casitas B-lineage lymphoma	0.014
Muted	muted	0.014
Trim32	tripartite motif-containing 32	0.014
Actr1a	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	0.014
Enoph1	enolase-phosphatase 1	0.014
Ubqln4	ubiquilin 4	0.013
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.013
Fkbp1a	FK506 binding protein 1a	0.013
Prdm16	PR domain containing 16	0.013
Zbtb7a	zinc finger and BTB domain containing 7a	0.013
Lasp1	LIM and SH3 protein 1	0.013
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.013
Htatip2	HIV-1 tat interactive protein 2, homolog (human)	0.013
Xpa	xeroderma pigmentosum, complementation group A	0.013
Tsn	translin	0.013
Eef1g	eukaryotic translation elongation factor 1 gamma	0.013
Haus6	HAUS augmin-like complex, subunit 6	0.013
Phlda2	pleckstrin homology-like domain, family A, member 2	0.013
Impa1	inositol (myo)-1(or 4)-monophosphatase 1	0.012
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.012
Purb	purine rich element binding protein B	0.012
Vat1	vesicle amine transport protein 1 homolog (T californica)	0.012
Pax5	paired box gene 5	0.012
Otud6b	OTU domain containing 6B	0.012
4930579G24Rik	RIKEN cDNA 4930579G24 gene	0.012
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.011
Tacstd2	tumor-associated calcium signal transducer 2	0.011
Pkp3	plakophilin 3	0.011
Ercc1	excision repair cross-complementing rodent repair deficiency, complementation group 1	0.011
Crabp2	cellular retinoic acid binding protein II	0.011
Fbxo47	F-box protein 47	0.011
Gpr44	G protein-coupled receptor 44	0.011
Prkce	protein kinase C, epsilon	0.011
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.011
Hspa8	heat shock protein 8	0.011
Dtx2	deltex 2 homolog (Drosophila)	0.011
Hoxd13	homeobox D13	0.011
Tmem223	transmembrane protein 223	0.011
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.011
Rps4x	ribosomal protein S4, X-linked	0.011
Chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.011
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.011
E2f7	E2F transcription factor 7	0.011
Nf1	neurofibromatosis 1	0.011
Nefh	neurofilament, heavy polypeptide	0.010
Dusp9	dual specificity phosphatase 9	0.010
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.010
Id1	inhibitor of DNA binding 1	0.010
Stk11	serine/threonine kinase 11	0.010