IMP

Process View

Mus musculus

18 genes annotated in mouse

negative regulation of protein kinase b signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein kinase b signaling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein kinase b signaling" (in gray)

Name	Description	Probability	Func Analog Organism
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.896
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.710
Grb2	growth factor receptor bound protein 2	0.552
Cav1	caveolin 1, caveolae protein	0.458
Nos1	nitric oxide synthase 1, neuronal	0.321
Esr1	estrogen receptor 1 (alpha)	0.290
Dlg4	discs, large homolog 4 (Drosophila)	0.274	Mouse
Emx1	empty spiracles homolog 1 (Drosophila)	0.253
Cd80	CD80 antigen	0.228
Ccl2	chemokine (C-C motif) ligand 2	0.207
Grb10	growth factor receptor bound protein 10	0.202
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.129
Tsc1	tuberous sclerosis 1	0.115
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.112
Irs2	insulin receptor substrate 2	0.100
Trp53	transformation related protein 53	0.095
Rb1	retinoblastoma 1	0.083
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.081
Pax2	paired box gene 2	0.073
Nf2	neurofibromatosis 2	0.070
Drd2	dopamine receptor D2	0.069
Il1rn	interleukin 1 receptor antagonist	0.069
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.066
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.065
Tlr4	toll-like receptor 4	0.057
Gab2	growth factor receptor bound protein 2-associated protein 2	0.056
Ghr	growth hormone receptor	0.053
Lmna	lamin A	0.053
Npc1	Niemann Pick type C1	0.053
Ccl3	chemokine (C-C motif) ligand 3	0.048
Sox2	SRY-box containing gene 2	0.042
Otx2	orthodenticle homolog 2 (Drosophila)	0.042
Cxcl2	chemokine (C-X-C motif) ligand 2	0.041
Lhx3	LIM homeobox protein 3	0.041
Cd44	CD44 antigen	0.040
Prop1	paired like homeodomain factor 1	0.039
Fzd7	frizzled homolog 7 (Drosophila)	0.038
Ccl4	chemokine (C-C motif) ligand 4	0.038
Bdnf	brain derived neurotrophic factor	0.036
Insr	insulin receptor	0.035	Mouse
Il6	interleukin 6	0.035
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.035
Ccr2	chemokine (C-C motif) receptor 2	0.034
Sgpl1	sphingosine phosphate lyase 1	0.034
Hrh1	histamine receptor H1	0.033
Lhx1	LIM homeobox protein 1	0.033
Clec4d	C-type lectin domain family 4, member d	0.032
Cbl	Casitas B-lineage lymphoma	0.030
Shc1	src homology 2 domain-containing transforming protein C1	0.029
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.029
Pax6	paired box gene 6	0.028
Pparg	peroxisome proliferator activated receptor gamma	0.027
Clip2	CAP-GLY domain containing linker protein 2	0.027
Wnt7b	wingless-related MMTV integration site 7B	0.026
Irg1	immunoresponsive gene 1	0.026
Pax8	paired box gene 8	0.026
Loxl1	lysyl oxidase-like 1	0.026
Sstr4	somatostatin receptor 4	0.026
Dmd	dystrophin, muscular dystrophy	0.025
Grm1	glutamate receptor, metabotropic 1	0.025
Gpr3	G-protein coupled receptor 3	0.025
Plau	plasminogen activator, urokinase	0.025
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.024
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.024
Phox2a	paired-like homeobox 2a	0.023
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.023
Fgf3	fibroblast growth factor 3	0.023
Slc17a1	solute carrier family 17 (sodium phosphate), member 1	0.023
Has1	hyaluronan synthase1	0.022
Htra3	HtrA serine peptidase 3	0.022
Sall3	sal-like 3 (Drosophila)	0.022
Timp3	tissue inhibitor of metalloproteinase 3	0.022
Hr	hairless	0.022
Pdcd1	programmed cell death 1	0.021
Nf1	neurofibromatosis 1	0.021
Klf3	Kruppel-like factor 3 (basic)	0.021
Otx1	orthodenticle homolog 1 (Drosophila)	0.021
Frs2	fibroblast growth factor receptor substrate 2	0.021
Cux2	cut-like homeobox 2	0.021
Fbn1	fibrillin 1	0.021
Arc	activity regulated cytoskeletal-associated protein	0.021
Dnm2	dynamin 2	0.020
Fzd4	frizzled homolog 4 (Drosophila)	0.020
Prkcc	protein kinase C, gamma	0.020
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.020
Tlr2	toll-like receptor 2	0.020
Sstr1	somatostatin receptor 1	0.020
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.020
Tnf	tumor necrosis factor	0.019
Schip1	schwannomin interacting protein 1	0.019
Msr1	macrophage scavenger receptor 1	0.018
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.018
Drd1a	dopamine receptor D1A	0.018
Il1b	interleukin 1 beta	0.018
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.018
Atoh1	atonal homolog 1 (Drosophila)	0.018
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.018
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.017
Gdf15	growth differentiation factor 15	0.017
Oprm1	opioid receptor, mu 1	0.017
Dlg1	discs, large homolog 1 (Drosophila)	0.017
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.017
Saa3	serum amyloid A 3	0.017
Cd5	CD5 antigen	0.017
Dlg3	discs, large homolog 3 (Drosophila)	0.017	Mouse
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.017
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.016
Csf1	colony stimulating factor 1 (macrophage)	0.016
Nanog	Nanog homeobox	0.016
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	0.016
Atoh7	atonal homolog 7 (Drosophila)	0.016
Wnt9b	wingless-type MMTV integration site 9B	0.016
Adam8	a disintegrin and metallopeptidase domain 8	0.015
Gdf11	growth differentiation factor 11	0.015
Lepr	leptin receptor	0.015
Fgf5	fibroblast growth factor 5	0.015
Sdc4	syndecan 4	0.015
Ccl7	chemokine (C-C motif) ligand 7	0.015
Clec4e	C-type lectin domain family 4, member e	0.015
Apc	adenomatosis polyposis coli	0.015
Col4a1	collagen, type IV, alpha 1	0.015
Amotl2	angiomotin-like 2	0.015
Bai1	brain-specific angiogenesis inhibitor 1	0.015
Insm1	insulinoma-associated 1	0.015
Sim1	single-minded homolog 1 (Drosophila)	0.015
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.015
Tbx10	T-box 10	0.015
B3gnt1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1	0.015
Thra	thyroid hormone receptor alpha	0.014
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.014
Dock9	dedicator of cytokinesis 9	0.014
Fgf13	fibroblast growth factor 13	0.014
Wwox	WW domain-containing oxidoreductase	0.014
Lzts2	leucine zipper, putative tumor suppressor 2	0.014
Gad2	glutamic acid decarboxylase 2	0.014
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.014
Nos3	nitric oxide synthase 3, endothelial cell	0.014
Gnao1	guanine nucleotide binding protein, alpha O	0.014
Npas1	neuronal PAS domain protein 1	0.014
Adora2a	adenosine A2a receptor	0.014
Olfr90	olfactory receptor 90	0.014
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.014
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.014
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.014
Fpr2	formyl peptide receptor 2	0.014
Clock	circadian locomotor output cycles kaput	0.014
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.014
Ret	ret proto-oncogene	0.014
Src	Rous sarcoma oncogene	0.013
Sh3kbp1	SH3-domain kinase binding protein 1	0.013
Nos2	nitric oxide synthase 2, inducible	0.013
Spnb2	spectrin beta 2	0.013
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.013
Ccl17	chemokine (C-C motif) ligand 17	0.013
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.012
Kalrn	kalirin, RhoGEF kinase	0.012
Sebox	SEBOX homeobox	0.012
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.012
Rhbdl3	rhomboid, veinlet-like 3 (Drosophila)	0.012
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.012
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.012
Kifc2	kinesin family member C2	0.012
Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.012
Gab1	growth factor receptor bound protein 2-associated protein 1	0.011
Snai1	snail homolog 1 (Drosophila)	0.011
Ltbp4	latent transforming growth factor beta binding protein 4	0.011
Mxd1	MAX dimerization protein 1	0.011
Dlg2	discs, large homolog 2 (Drosophila)	0.011	Mouse
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.011
Chd7	chromodomain helicase DNA binding protein 7	0.011
Mmp12	matrix metallopeptidase 12	0.011	Mouse
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.011
Rbl2	retinoblastoma-like 2	0.011
Tagln	transgelin	0.011
Fgf15	fibroblast growth factor 15	0.011
A930001N09Rik	RIKEN cDNA A930001N09 gene	0.011
Ccr5	chemokine (C-C motif) receptor 5	0.011
Rpl8	ribosomal protein L8	0.011
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.011
Robo3	roundabout homolog 3 (Drosophila)	0.011
Adora2b	adenosine A2b receptor	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.011
S1pr2	sphingosine-1-phosphate receptor 2	0.011
Tacr1	tachykinin receptor 1	0.011
Aebp1	AE binding protein 1	0.011
Cnih2	cornichon homolog 2 (Drosophila)	0.011
Gpr83	G protein-coupled receptor 83	0.011
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
Dll1	delta-like 1 (Drosophila)	0.011
Fzd1	frizzled homolog 1 (Drosophila)	0.011
Pou3f4	POU domain, class 3, transcription factor 4	0.010	Mouse
Mmp13	matrix metallopeptidase 13	0.010	Mouse
Rnf167	ring finger protein 167	0.010
Gml	GPI anchored molecule like protein	0.010
Kiss1	KiSS-1 metastasis-suppressor	0.010
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.010
Tirap	toll-interleukin 1 receptor (TIR) domain-containing adaptor protein	0.010
Fktn	fukutin	0.010
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.010
Ctnnb1	catenin (cadherin associated protein), beta 1	0.010
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.010