IMP

Process View

Mus musculus

14 genes annotated in mouse

Multi-species View

convergent extension

GO:0060026

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "convergent extension"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "convergent extension" (in gray)

Name	Description	Probability	Func Analog Organism
Vangl2	vang-like 2 (van gogh, Drosophila)	0.999
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.998
Gli3	GLI-Kruppel family member GLI3	0.990
Fgfr2	fibroblast growth factor receptor 2	0.952
Wnt3a	wingless-related MMTV integration site 3A	0.948	Zebrafish Mouse
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.902	Mouse
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.841
Gli2	GLI-Kruppel family member GLI2	0.812
Shh	sonic hedgehog	0.793
Ptk7	PTK7 protein tyrosine kinase 7	0.785
Fgf8	fibroblast growth factor 8	0.730
Fyn	Fyn proto-oncogene	0.697	Zebrafish
Fzd1	frizzled homolog 1 (Drosophila)	0.690	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.634	Zebrafish
Lrp6	low density lipoprotein receptor-related protein 6	0.601
Foxc1	forkhead box C1	0.589
Fgfr1	fibroblast growth factor receptor 1	0.570
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.418
Slit3	slit homolog 3 (Drosophila)	0.366
Nodal	nodal	0.366
Hes1	hairy and enhancer of split 1 (Drosophila)	0.326
Meox2	mesenchyme homeobox 2	0.319
Fzd8	frizzled homolog 8 (Drosophila)	0.302	Mouse
Wnt5a	wingless-related MMTV integration site 5A	0.302
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.285
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.282
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.282
Tbx3	T-box 3	0.255
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.252
Sfrp2	secreted frizzled-related protein 2	0.250
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.242
Sfrp1	secreted frizzled-related protein 1	0.233
Nog	noggin	0.230
Twist2	twist homolog 2 (Drosophila)	0.225
Sox9	SRY-box containing gene 9	0.214
Dlg1	discs, large homolog 1 (Drosophila)	0.210
Pitx2	paired-like homeodomain transcription factor 2	0.202
Bbs2	Bardet-Biedl syndrome 2 (human)	0.200
Bmp4	bone morphogenetic protein 4	0.199
Fzd7	frizzled homolog 7 (Drosophila)	0.197	Zebrafish Mouse
Smad1	MAD homolog 1 (Drosophila)	0.190
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.188
Egfr	epidermal growth factor receptor	0.165
Fgfr3	fibroblast growth factor receptor 3	0.164
Smad6	MAD homolog 6 (Drosophila)	0.151
Msx1	homeobox, msh-like 1	0.149
Vangl1	vang-like 1 (van gogh, Drosophila)	0.135	Mouse
Tbx2	T-box 2	0.133
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.126
Acvr1	activin A receptor, type 1	0.125
Prrx1	paired related homeobox 1	0.121
Gata6	GATA binding protein 6	0.117
Smo	smoothened homolog (Drosophila)	0.112
Bmp7	bone morphogenetic protein 7	0.108
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.106
Wnt4	wingless-related MMTV integration site 4	0.104	Mouse
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.099
Foxc2	forkhead box C2	0.098
Axin1	axin 1	0.097
Slit1	slit homolog 1 (Drosophila)	0.095
Efna4	ephrin A4	0.089
Robo2	roundabout homolog 2 (Drosophila)	0.088
Rbms1	RNA binding motif, single stranded interacting protein 1	0.088
Pax1	paired box gene 1	0.086
Rarb	retinoic acid receptor, beta	0.081
Hand1	heart and neural crest derivatives expressed transcript 1	0.080
Dlg4	discs, large homolog 4 (Drosophila)	0.079
Tgfb2	transforming growth factor, beta 2	0.073
Rxra	retinoid X receptor alpha	0.070
Rara	retinoic acid receptor, alpha	0.069
Pax3	paired box gene 3	0.068
Gsk3b	glycogen synthase kinase 3 beta	0.067
Jak2	Janus kinase 2	0.062	Fly
Gopc	golgi associated PDZ and coiled-coil motif containing	0.062
Amhr2	anti-Mullerian hormone type 2 receptor	0.059
Tead2	TEA domain family member 2	0.058
Gas1	growth arrest specific 1	0.057
Foxh1	forkhead box H1	0.053
Trp63	transformation related protein 63	0.053
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.049
Lrp5	low density lipoprotein receptor-related protein 5	0.049	Mouse
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.047
Fgf10	fibroblast growth factor 10	0.046
Gli1	GLI-Kruppel family member GLI1	0.045
Lhx1	LIM homeobox protein 1	0.045
Ptch2	patched homolog 2	0.044
Zfp185	zinc finger protein 185	0.043
Chrd	chordin	0.041	Zebrafish
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.041
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.040
Alx4	aristaless-like homeobox 4	0.040
Fzd2	frizzled homolog 2 (Drosophila)	0.040	Zebrafish Mouse
Klf7	Kruppel-like factor 7 (ubiquitous)	0.037
Wdr1	WD repeat domain 1	0.036
Zfp503	zinc finger protein 503	0.035
Smad4	MAD homolog 4 (Drosophila)	0.034
Try10	trypsin 10	0.032
Invs	inversin	0.032
Fzd10	frizzled homolog 10 (Drosophila)	0.032
Ptpre	protein tyrosine phosphatase, receptor type, E	0.032	Zebrafish
App	amyloid beta (A4) precursor protein	0.031	Zebrafish
Rem1	rad and gem related GTP binding protein 1	0.030
Kif3a	kinesin family member 3A	0.030
Ptch1	patched homolog 1	0.030
Prrx2	paired related homeobox 2	0.030
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.029
Pitx1	paired-like homeodomain transcription factor 1	0.029
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.028
Epha1	Eph receptor A1	0.028
Runx2	runt related transcription factor 2	0.028
Smad3	MAD homolog 3 (Drosophila)	0.027
Zic3	zinc finger protein of the cerebellum 3	0.027
Fgf15	fibroblast growth factor 15	0.026
Lrp2	low density lipoprotein receptor-related protein 2	0.026	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.026
Gata4	GATA binding protein 4	0.025	Zebrafish
Pcdh18	protocadherin 18	0.025
Padi3	peptidyl arginine deiminase, type III	0.025
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.025
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.024
Rarg	retinoic acid receptor, gamma	0.024
Msx2	homeobox, msh-like 2	0.024
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.023
Sox4	SRY-box containing gene 4	0.023
Hdac2	histone deacetylase 2	0.023
Khdrbs1	KH domain containing, RNA binding, signal transduction associated 1	0.023
Tcfap2a	transcription factor AP-2, alpha	0.023
Wwtr1	WW domain containing transcription regulator 1	0.022
Cldn6	claudin 6	0.022
Gpc3	glypican 3	0.022
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.021
Nkx2-1	NK2 homeobox 1	0.021
Il6st	interleukin 6 signal transducer	0.021
Pick1	protein interacting with C kinase 1	0.021
Snai1	snail homolog 1 (Drosophila)	0.021
Mrc2	mannose receptor, C type 2	0.021
Wipf1	WAS/WASL interacting protein family, member 1	0.021
Gna13	guanine nucleotide binding protein, alpha 13	0.021	Zebrafish
Il2rg	interleukin 2 receptor, gamma chain	0.020
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.020	Zebrafish
Col2a1	collagen, type II, alpha 1	0.020
Pou3f3	POU domain, class 3, transcription factor 3	0.020
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.019
Nfe2l3	nuclear factor, erythroid derived 2, like 3	0.019
Wdr26	WD repeat domain 26	0.019
Mta2	metastasis-associated gene family, member 2	0.018
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.018
Efna2	ephrin A2	0.018
Wnt6	wingless-related MMTV integration site 6	0.018	Mouse
Fn1	fibronectin 1	0.018
Hoxa2	homeobox A2	0.018
Klf6	Kruppel-like factor 6	0.018
Adra2b	adrenergic receptor, alpha 2b	0.018
Tbx6	T-box 6	0.018
Wnt7b	wingless-related MMTV integration site 7B	0.018	Mouse
Tgfa	transforming growth factor alpha	0.018
Foxf1a	forkhead box F1a	0.017
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.017
Ptprc	protein tyrosine phosphatase, receptor type, C	0.017
Bmp1	bone morphogenetic protein 1	0.017
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.017
Kdm5b	lysine (K)-specific demethylase 5B	0.017
Apaf1	apoptotic peptidase activating factor 1	0.017
Trp53	transformation related protein 53	0.016
Psen1	presenilin 1	0.016
Rap2c	RAP2C, member of RAS oncogene family	0.016
Flnb	filamin, beta	0.016
Efnb1	ephrin B1	0.015
Dlg2	discs, large homolog 2 (Drosophila)	0.015
Hoxc9	homeobox C9	0.015
Timp3	tissue inhibitor of metalloproteinase 3	0.015
Trip12	thyroid hormone receptor interactor 12	0.015
Pax2	paired box gene 2	0.015
Npas1	neuronal PAS domain protein 1	0.015
Aif1l	allograft inflammatory factor 1-like	0.015
Nkd1	naked cuticle 1 homolog (Drosophila)	0.015
Cpd	carboxypeptidase D	0.015
Acan	aggrecan	0.015
Fgfrl1	fibroblast growth factor receptor-like 1	0.015
Lck	lymphocyte protein tyrosine kinase	0.015
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.015
Col13a1	collagen, type XIII, alpha 1	0.014
Ugcg	UDP-glucose ceramide glucosyltransferase	0.014
Socs1	suppressor of cytokine signaling 1	0.014
Barx1	BarH-like homeobox 1	0.014
Lefty1	left right determination factor 1	0.014
Wnt5b	wingless-related MMTV integration site 5B	0.014	Zebrafish Mouse
Foxn1	forkhead box N1	0.014
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.014
Ptk2	PTK2 protein tyrosine kinase 2	0.014
Lum	lumican	0.013
Rnd3	Rho family GTPase 3	0.013
Foxd3	forkhead box D3	0.013
T	brachyury	0.013	Zebrafish
Rnf111	ring finger 111	0.013
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.013
Tead3	TEA domain family member 3	0.013
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.013
Dsg2	desmoglein 2	0.013
Jag1	jagged 1	0.012
Tbx1	T-box 1	0.012
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.012
Unc5c	unc-5 homolog C (C. elegans)	0.012
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.012
Sult5a1	sulfotransferase family 5A, member 1	0.012
Bbs1	Bardet-Biedl syndrome 1 (human)	0.012
Ptp4a2	protein tyrosine phosphatase 4a2	0.012
Tnnt3	troponin T3, skeletal, fast	0.012
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.012
Hoxd9	homeobox D9	0.012
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.012
Wnt11	wingless-related MMTV integration site 11	0.012	Mouse
Fst	follistatin	0.012
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.012
Tspan12	tetraspanin 12	0.012
Hoxa3	homeobox A3	0.012
Vps54	vacuolar protein sorting 54 (yeast)	0.011
Klf3	Kruppel-like factor 3 (basic)	0.011
Rps3	ribosomal protein S3	0.011
She	src homology 2 domain-containing transforming protein E	0.011
Fndc3b	fibronectin type III domain containing 3B	0.011
Dll1	delta-like 1 (Drosophila)	0.011
Cald1	caldesmon 1	0.011
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.011
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.011
Tab3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.011
Lmx1b	LIM homeobox transcription factor 1 beta	0.011
Ret	ret proto-oncogene	0.011
Cldn4	claudin 4	0.011
Skor1	SKI family transcriptional corepressor 1	0.011
Dll3	delta-like 3 (Drosophila)	0.011
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.011
Fgfr4	fibroblast growth factor receptor 4	0.010
Gja5	gap junction protein, alpha 5	0.010
Fgf5	fibroblast growth factor 5	0.010
Fign	fidgetin	0.010
Lrp4	low density lipoprotein receptor-related protein 4	0.010	Mouse
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.010
Msn	moesin	0.010
Mylk2	myosin, light polypeptide kinase 2, skeletal muscle	0.010
Sox7	SRY-box containing gene 7	0.010
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.010
Trp73	transformation related protein 73	0.010
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.010
Wnt9b	wingless-type MMTV integration site 9B	0.010	Mouse
Hoxb2	homeobox B2	0.010