IMP

Process View

Mus musculus

18 genes annotated in mouse

morphogenesis of an epithelial bud

The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "morphogenesis of an epithelial bud"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "morphogenesis of an epithelial bud" (in gray)

Name	Description	Probability	Func Analog Organism
Gli3	GLI-Kruppel family member GLI3	0.997	Mouse
Shh	sonic hedgehog	0.997
Fgfr3	fibroblast growth factor receptor 3	0.989	Mouse
Fgf8	fibroblast growth factor 8	0.987
Fgfr2	fibroblast growth factor receptor 2	0.938
Bmp7	bone morphogenetic protein 7	0.927
Pax2	paired box gene 2	0.926
Wnt3a	wingless-related MMTV integration site 3A	0.834	Mouse
Nog	noggin	0.813
Gli2	GLI-Kruppel family member GLI2	0.801
Nodal	nodal	0.793	Mouse
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.773
Sox9	SRY-box containing gene 9	0.757
Foxc1	forkhead box C1	0.748
Bmp4	bone morphogenetic protein 4	0.706
Fgf10	fibroblast growth factor 10	0.652
Hoxa13	homeobox A13	0.506
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.505
Meox2	mesenchyme homeobox 2	0.470
Chrd	chordin	0.438
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.425
Gdf1	growth differentiation factor 1	0.405	Mouse
Trp53	transformation related protein 53	0.398	Mouse
Fgf18	fibroblast growth factor 18	0.367
Trp63	transformation related protein 63	0.333
Hoxd13	homeobox D13	0.333
Ptch1	patched homolog 1	0.318
Lmx1a	LIM homeobox transcription factor 1 alpha	0.294
Otx2	orthodenticle homolog 2 (Drosophila)	0.289
Pten	phosphatase and tensin homolog	0.281
Amhr2	anti-Mullerian hormone type 2 receptor	0.262
Lrp6	low density lipoprotein receptor-related protein 6	0.251
Gdf5	growth differentiation factor 5	0.221	Mouse
Pax3	paired box gene 3	0.219
Tbx15	T-box 15	0.204
Tcf21	transcription factor 21	0.202
Ctnnb1	catenin (cadherin associated protein), beta 1	0.196
Gli1	GLI-Kruppel family member GLI1	0.192	Mouse
Rarg	retinoic acid receptor, gamma	0.187
Pax8	paired box gene 8	0.179
Tbx3	T-box 3	0.166
Foxc2	forkhead box C2	0.147
Ar	androgen receptor	0.146
Lhx1	LIM homeobox protein 1	0.144
Msx2	homeobox, msh-like 2	0.140
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.139
Hoxa11	homeobox A11	0.138
Rarb	retinoic acid receptor, beta	0.133
Apc	adenomatosis polyposis coli	0.125
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.120
Wnt3	wingless-related MMTV integration site 3	0.116	Mouse
Twist2	twist homolog 2 (Drosophila)	0.113
Pthlh	parathyroid hormone-like peptide	0.112
Emx2	empty spiracles homolog 2 (Drosophila)	0.110
Angpt4	angiopoietin 4	0.105
Wnt6	wingless-related MMTV integration site 6	0.101	Mouse
Acan	aggrecan	0.099
Tdgf1	teratocarcinoma-derived growth factor 1	0.098
Prrx1	paired related homeobox 1	0.097
Wnt4	wingless-related MMTV integration site 4	0.092	Mouse
T	brachyury	0.090
Fgf5	fibroblast growth factor 5	0.090	Mouse
Alx4	aristaless-like homeobox 4	0.080
Fgf9	fibroblast growth factor 9	0.074	Mouse
Pax7	paired box gene 7	0.073
Skor1	SKI family transcriptional corepressor 1	0.070
Otx1	orthodenticle homolog 1 (Drosophila)	0.068
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.067
Fgf15	fibroblast growth factor 15	0.062
Sh3pxd2a	SH3 and PX domains 2A	0.061
Smad3	MAD homolog 3 (Drosophila)	0.059
Gdf3	growth differentiation factor 3	0.058	Mouse
Neurog3	neurogenin 3	0.057
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.056
En1	engrailed 1	0.055
Wnt10b	wingless related MMTV integration site 10b	0.054	Mouse
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.054
Psen1	presenilin 1	0.051
Chrdl2	chordin-like 2	0.048
Foxd3	forkhead box D3	0.048
Gata5	GATA binding protein 5	0.048
Smo	smoothened homolog (Drosophila)	0.046
Bmper	BMP-binding endothelial regulator	0.046
Gdf6	growth differentiation factor 6	0.046	Mouse
Sox17	SRY-box containing gene 17	0.046
Foxf1a	forkhead box F1a	0.044
Hoxd11	homeobox D11	0.044
Wnt11	wingless-related MMTV integration site 11	0.043	Mouse
Epha1	Eph receptor A1	0.043
Gas1	growth arrest specific 1	0.043
Col13a1	collagen, type XIII, alpha 1	0.042
Fzd10	frizzled homolog 10 (Drosophila)	0.041
Nkx2-1	NK2 homeobox 1	0.041
Ptch2	patched homolog 2	0.040
Ret	ret proto-oncogene	0.040
Kl	klotho	0.040
Esr2	estrogen receptor 2 (beta)	0.040
Prrx2	paired related homeobox 2	0.040
Eda	ectodysplasin-A	0.040
Bnc1	basonuclin 1	0.039
Wnt9b	wingless-type MMTV integration site 9B	0.039	Mouse
Msx1	homeobox, msh-like 1	0.039
Zeb1	zinc finger E-box binding homeobox 1	0.038
Spry4	sprouty homolog 4 (Drosophila)	0.038
Edn3	endothelin 3	0.037
Pkdcc	protein kinase domain containing, cytoplasmic	0.037
Foxf2	forkhead box F2	0.036
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.036
Hoxb6	homeobox B6	0.036
Rspo1	R-spondin homolog (Xenopus laevis)	0.036
Acvr1	activin A receptor, type 1	0.035
Wnt2b	wingless related MMTV integration site 2b	0.035
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.035
Tcf15	transcription factor 15	0.034
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.034
Col2a1	collagen, type II, alpha 1	0.034
Foxh1	forkhead box H1	0.032
Sox2	SRY-box containing gene 2	0.031
Mylk2	myosin, light polypeptide kinase 2, skeletal muscle	0.031
Sulf2	sulfatase 2	0.031	Mouse
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.031
Fgf17	fibroblast growth factor 17	0.031
Hoxd9	homeobox D9	0.030
Bmp2	bone morphogenetic protein 2	0.030	Mouse
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.029
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.029
Gbx2	gastrulation brain homeobox 2	0.029
Gja3	gap junction protein, alpha 3	0.028
Hes1	hairy and enhancer of split 1 (Drosophila)	0.028
Npr3	natriuretic peptide receptor 3	0.028
Bmp5	bone morphogenetic protein 5	0.028	Mouse
Kcnk4	potassium channel, subfamily K, member 4	0.028
Hoxb9	homeobox B9	0.028
Adrb1	adrenergic receptor, beta 1	0.027
Crhr2	corticotropin releasing hormone receptor 2	0.027
Hoxa10	homeobox A10	0.027
Lrp2	low density lipoprotein receptor-related protein 2	0.026
Sox7	SRY-box containing gene 7	0.026
Omp	olfactory marker protein	0.026
Fgfrl1	fibroblast growth factor receptor-like 1	0.026
Spry2	sprouty homolog 2 (Drosophila)	0.026
Foxb1	forkhead box B1	0.026
Runx2	runt related transcription factor 2	0.025
Hoxc9	homeobox C9	0.025
Cdx1	caudal type homeobox 1	0.025
Rem1	rad and gem related GTP binding protein 1	0.024
Gdnf	glial cell line derived neurotrophic factor	0.024
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.024
Wnt5a	wingless-related MMTV integration site 5A	0.024
Tgfa	transforming growth factor alpha	0.023
Tecta	tectorin alpha	0.023
Oprd1	opioid receptor, delta 1	0.023
Smad6	MAD homolog 6 (Drosophila)	0.023
Zfpm2	zinc finger protein, multitype 2	0.022
Rgnef	Rho-guanine nucleotide exchange factor	0.022
Bdkrb2	bradykinin receptor, beta 2	0.022
Smad2	MAD homolog 2 (Drosophila)	0.022
Tbx1	T-box 1	0.022
Lmx1b	LIM homeobox transcription factor 1 beta	0.021
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.021
Rara	retinoic acid receptor, alpha	0.021
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.021
Npr2	natriuretic peptide receptor 2	0.020
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.020
Efna4	ephrin A4	0.020
Trp73	transformation related protein 73	0.020	Mouse
Tbx2	T-box 2	0.020
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.020
Pou3f1	POU domain, class 3, transcription factor 1	0.020
Fgf23	fibroblast growth factor 23	0.020
Jag2	jagged 2	0.020
Barx1	BarH-like homeobox 1	0.020
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.019
Amh	anti-Mullerian hormone	0.019
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.019
Foxa2	forkhead box A2	0.019
Tcfap2c	transcription factor AP-2, gamma	0.018
Foxn1	forkhead box N1	0.018
Hand1	heart and neural crest derivatives expressed transcript 1	0.018
Hoxb3	homeobox B3	0.018
Tcl1	T-cell lymphoma breakpoint 1	0.017
Wisp2	WNT1 inducible signaling pathway protein 2	0.017
Krt72-ps	keratin 72, pseudogene	0.017
Lmna	lamin A	0.017
Ptk2	PTK2 protein tyrosine kinase 2	0.017
Padi3	peptidyl arginine deiminase, type III	0.017
Otp	orthopedia homolog (Drosophila)	0.017
Pax9	paired box gene 9	0.017
Figla	folliculogenesis specific basic helix-loop-helix	0.016
Fmn1	formin 1	0.016
Fgfr1	fibroblast growth factor receptor 1	0.016	Mouse
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.016
Pgap1	post-GPI attachment to proteins 1	0.016
Bcam	basal cell adhesion molecule	0.016
Otog	otogelin	0.016
Dlx5	distal-less homeobox 5	0.016
Btbd17	BTB (POZ) domain containing 17	0.015
Pax6	paired box gene 6	0.015
Rhbdl3	rhomboid, veinlet-like 3 (Drosophila)	0.015
Cpxm2	carboxypeptidase X 2 (M14 family)	0.015
Hand2	heart and neural crest derivatives expressed transcript 2	0.015
Fgfbp1	fibroblast growth factor binding protein 1	0.015
Pou3f3	POU domain, class 3, transcription factor 3	0.015
Otos	otospiralin	0.015
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.015
Lef1	lymphoid enhancer binding factor 1	0.015
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.015
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.015
Gata4	GATA binding protein 4	0.015
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.015
Porcn	porcupine homolog (Drosophila)	0.015
Zic3	zinc finger protein of the cerebellum 3	0.015
Sim2	single-minded homolog 2 (Drosophila)	0.014
Ihh	Indian hedgehog	0.014	Mouse
Lrp5	low density lipoprotein receptor-related protein 5	0.014
Irf6	interferon regulatory factor 6	0.014
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.014
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.014
Hoxd3	homeobox D3	0.014
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.014
Fzd1	frizzled homolog 1 (Drosophila)	0.014
Axin2	axin2	0.014
Pitx2	paired-like homeodomain transcription factor 2	0.014
Hoxa7	homeobox A7	0.014
Smyd1	SET and MYND domain containing 1	0.014
Hoxa9	homeobox A9	0.013
Slurp1	secreted Ly6/Plaur domain containing 1	0.013
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.013
Lyzl4	lysozyme-like 4	0.013
Chuk	conserved helix-loop-helix ubiquitous kinase	0.013
Tcfap2a	transcription factor AP-2, alpha	0.013
Pth1r	parathyroid hormone 1 receptor	0.013
Ptgfr	prostaglandin F receptor	0.013
Krt35	keratin 35	0.013
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.013
Hoxa5	homeobox A5	0.013
BC021891	cDNA sequence BC021891	0.013
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.013
Gja1	gap junction protein, alpha 1	0.013
Ppyr1	pancreatic polypeptide receptor 1	0.013
Hoxd1	homeobox D1	0.013
Gsc	goosecoid homeobox	0.012
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.012
Card10	caspase recruitment domain family, member 10	0.012
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.012
Barx2	BarH-like homeobox 2	0.012
Dlx4	distal-less homeobox 4	0.012
Cldn4	claudin 4	0.012
Moxd2	monooxygenase, DBH-like 2	0.012
Hesx1	homeobox gene expressed in ES cells	0.012
Fzd8	frizzled homolog 8 (Drosophila)	0.012
Npas3	neuronal PAS domain protein 3	0.012
Syt9	synaptotagmin IX	0.012
Sp6	trans-acting transcription factor 6	0.012
Wnt7a	wingless-related MMTV integration site 7A	0.012	Mouse
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.012
Socs5	suppressor of cytokine signaling 5	0.012
Tbx20	T-box 20	0.011
Sost	sclerostin	0.011	Mouse
Fzd7	frizzled homolog 7 (Drosophila)	0.011
Adra2b	adrenergic receptor, alpha 2b	0.011
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.011
Gata6	GATA binding protein 6	0.011
Cbln3	cerebellin 3 precursor protein	0.011
Myl3	myosin, light polypeptide 3	0.011
Sfn	stratifin	0.011
Emx1	empty spiracles homolog 1 (Drosophila)	0.011
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.011
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.011
Npas1	neuronal PAS domain protein 1	0.011
Gjb4	gap junction protein, beta 4	0.011
Hmx3	H6 homeobox 3	0.011
Cdh13	cadherin 13	0.011
Fut7	fucosyltransferase 7	0.011
Des	desmin	0.011
Tenc1	tensin like C1 domain-containing phosphatase	0.011
Xpnpep2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.011
Krtap8-1	keratin associated protein 8-1	0.011
Wnt2	wingless-related MMTV integration site 2	0.011
Prdm6	PR domain containing 6	0.011
She	src homology 2 domain-containing transforming protein E	0.011
Ano1	anoctamin 1, calcium activated chloride channel	0.010
Art5	ADP-ribosyltransferase 5	0.010
Fgf6	fibroblast growth factor 6	0.010	Mouse
Irx4	Iroquois related homeobox 4 (Drosophila)	0.010
Lama3	laminin, alpha 3	0.010
Ptprb	protein tyrosine phosphatase, receptor type, B	0.010
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.010
Lbx2	ladybird homeobox homolog 2 (Drosophila)	0.010	Mouse
Adra1a	adrenergic receptor, alpha 1a	0.010
A530016L24Rik	RIKEN cDNA A530016L24 gene	0.010
Evx1	even skipped homeotic gene 1 homolog	0.010
Sfrp5	secreted frizzled-related sequence protein 5	0.010
Sulf1	sulfatase 1	0.010
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.010