IMP

Process View

Mus musculus

21 genes annotated in mouse

negative regulation of protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein import into nucleus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein import into nucleus" (in gray)

Name	Description	Probability	Func Analog Organism
Ctnnb1	catenin (cadherin associated protein), beta 1	0.957
Trp53	transformation related protein 53	0.953	Fly
Pten	phosphatase and tensin homolog	0.716	Worm
Apc	adenomatosis polyposis coli	0.684
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.627
Gli3	GLI-Kruppel family member GLI3	0.448
Fgfr2	fibroblast growth factor receptor 2	0.382
Trp63	transformation related protein 63	0.381	Fly
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.352
Grb10	growth factor receptor bound protein 10	0.286
Rara	retinoic acid receptor, alpha	0.280	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.272
Casp1	caspase 1	0.270
Gopc	golgi associated PDZ and coiled-coil motif containing	0.253
Smad3	MAD homolog 3 (Drosophila)	0.152
Yap1	yes-associated protein 1	0.147
Pbx1	pre B-cell leukemia transcription factor 1	0.127
Bcl2	B-cell leukemia/lymphoma 2	0.124
Iigp1	interferon inducible GTPase 1	0.121
Pycard	PYD and CARD domain containing	0.108
Gli2	GLI-Kruppel family member GLI2	0.100
Aim2	absent in melanoma 2	0.079
Smo	smoothened homolog (Drosophila)	0.077
Rxra	retinoid X receptor alpha	0.076
Pax8	paired box gene 8	0.064
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.054
Htt	huntingtin	0.053
Gbp2	guanylate binding protein 2	0.051	Mouse
Wnt5a	wingless-related MMTV integration site 5A	0.051
Ghr	growth hormone receptor	0.050
Ifit2	interferon-induced protein with tetratricopeptide repeats 2	0.049
Gbp3	guanylate binding protein 3	0.049	Mouse
Fzd1	frizzled homolog 1 (Drosophila)	0.048
Sox9	SRY-box containing gene 9	0.046
Irgm2	immunity-related GTPase family M member 2	0.044
Sap18	Sin3-associated polypeptide 18	0.044
Meox2	mesenchyme homeobox 2	0.043
Prrx1	paired related homeobox 1	0.041
Axin1	axin 1	0.040
Stat6	signal transducer and activator of transcription 6	0.040
Il6st	interleukin 6 signal transducer	0.039
Rnh1	ribonuclease/angiogenin inhibitor 1	0.039
Ptk7	PTK7 protein tyrosine kinase 7	0.039
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.038
Rb1	retinoblastoma 1	0.035
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.034
Per2	period homolog 2 (Drosophila)	0.034
Bmp4	bone morphogenetic protein 4	0.034
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.034
Fzd8	frizzled homolog 8 (Drosophila)	0.033	Mouse
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.033
Ncoa3	nuclear receptor coactivator 3	0.033
Notch2	Notch gene homolog 2 (Drosophila)	0.031
Kitl	kit ligand	0.030
Hoxa2	homeobox A2	0.030
F2r	coagulation factor II (thrombin) receptor	0.030
Shh	sonic hedgehog	0.029
Dlg2	discs, large homolog 2 (Drosophila)	0.028
Rarg	retinoic acid receptor, gamma	0.028	Mouse
Ikbkb	inhibitor of kappaB kinase beta	0.027
Bicc1	bicaudal C homolog 1 (Drosophila)	0.027
Tef	thyrotroph embryonic factor	0.026
Casp12	caspase 12	0.026
Bcl3	B-cell leukemia/lymphoma 3	0.026
Ifi203	interferon activated gene 203	0.025
Rnf115	ring finger protein 115	0.025
Bmp5	bone morphogenetic protein 5	0.024
Dlg4	discs, large homolog 4 (Drosophila)	0.024
Eya1	eyes absent 1 homolog (Drosophila)	0.024
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.024
Ar	androgen receptor	0.024
Mapkap1	mitogen-activated protein kinase associated protein 1	0.024
Tbx3	T-box 3	0.024
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.023
Mdm2	transformed mouse 3T3 cell double minute 2	0.023
Phldb2	pleckstrin homology-like domain, family B, member 2	0.023
Nr1d2	nuclear receptor subfamily 1, group D, member 2	0.023	Mouse
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.023
Btbd3	BTB (POZ) domain containing 3	0.022
Ptch1	patched homolog 1	0.022
Rptor	regulatory associated protein of MTOR, complex 1	0.022
Gbp7	guanylate binding protein 7	0.022	Mouse
Pax2	paired box gene 2	0.022
Lepr	leptin receptor	0.022
Hr	hairless	0.021
Hoxb3	homeobox B3	0.021
Gbp6	guanylate binding protein 6	0.021	Mouse
Tsc1	tuberous sclerosis 1	0.021
Per1	period homolog 1 (Drosophila)	0.021
Mpdz	multiple PDZ domain protein	0.020
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.020
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.020
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.020
Per3	period homolog 3 (Drosophila)	0.020
Igbp1	immunoglobulin (CD79A) binding protein 1	0.020
Zfp358	zinc finger protein 358	0.020
Col4a5	collagen, type IV, alpha 5	0.020
Vhl	von Hippel-Lindau tumor suppressor	0.020
Rhoq	ras homolog gene family, member Q	0.020
Wnt9b	wingless-type MMTV integration site 9B	0.019
Kit	kit oncogene	0.019
Dbp	D site albumin promoter binding protein	0.019
Emx2	empty spiracles homolog 2 (Drosophila)	0.019
Invs	inversin	0.019
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.019
Hoxa9	homeobox A9	0.019
Lrp6	low density lipoprotein receptor-related protein 6	0.019
Lef1	lymphoid enhancer binding factor 1	0.019
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.018
Nmi	N-myc (and STAT) interactor	0.018
Ifih1	interferon induced with helicase C domain 1	0.018
Dlg1	discs, large homolog 1 (Drosophila)	0.018
Fgf10	fibroblast growth factor 10	0.018
Hes1	hairy and enhancer of split 1 (Drosophila)	0.018
Nf2	neurofibromatosis 2	0.018
Irs1	insulin receptor substrate 1	0.018
Rab5a	RAB5A, member RAS oncogene family	0.018
Duox2	dual oxidase 2	0.018
Marveld1	MARVEL (membrane-associating) domain containing 1	0.017
Anxa7	annexin A7	0.017
Mcl1	myeloid cell leukemia sequence 1	0.017
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.017
Efnb1	ephrin B1	0.017
Vegfa	vascular endothelial growth factor A	0.017
Cys1	cystin 1	0.017
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.016
Rarb	retinoic acid receptor, beta	0.016	Mouse
Gbp10	guanylate-binding protein 10	0.016	Mouse
Tgfb2	transforming growth factor, beta 2	0.016
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.016
Zeb1	zinc finger E-box binding homeobox 1	0.016
Smoc2	SPARC related modular calcium binding 2	0.016
Zfp651	zinc finger protein 651	0.016
Slc12a6	solute carrier family 12, member 6	0.016
Igf2r	insulin-like growth factor 2 receptor	0.016
Fzd2	frizzled homolog 2 (Drosophila)	0.016	Mouse
Nkx2-1	NK2 homeobox 1	0.016
Setdb1	SET domain, bifurcated 1	0.015
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.015
Mdm4	transformed mouse 3T3 cell double minute 4	0.015
Sox4	SRY-box containing gene 4	0.015
Ece1	endothelin converting enzyme 1	0.015
Bmp7	bone morphogenetic protein 7	0.015
Wwtr1	WW domain containing transcription regulator 1	0.015	Human
Acvr1	activin A receptor, type 1	0.015
Mndal	myeloid nuclear differentiation antigen like	0.015
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.015
Lrp5	low density lipoprotein receptor-related protein 5	0.015
Card11	caspase recruitment domain family, member 11	0.014
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.014
Esr1	estrogen receptor 1 (alpha)	0.014
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.014
Cdh23	cadherin 23 (otocadherin)	0.014
Siah2	seven in absentia 2	0.014
AW112010	expressed sequence AW112010	0.014
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.014
Mapk3	mitogen-activated protein kinase 3	0.014
Cry2	cryptochrome 2 (photolyase-like)	0.014
Flot1	flotillin 1	0.014
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.013
Plxna1	plexin A1	0.013
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.013
Tgfbr3	transforming growth factor, beta receptor III	0.013
Tead2	TEA domain family member 2	0.013
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.013
Wwc2	WW, C2 and coiled-coil domain containing 2	0.013
Rab34	RAB34, member of RAS oncogene family	0.013
Smad6	MAD homolog 6 (Drosophila)	0.013
Rras	Harvey rat sarcoma oncogene, subgroup R	0.013
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.013
Srgn	serglycin	0.013
Gbp9	guanylate-binding protein 9	0.013	Mouse
Lgals3	lectin, galactose binding, soluble 3	0.012
S100a11	S100 calcium binding protein A11 (calgizzarin)	0.012
Telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.012
Apoe	apolipoprotein E	0.012
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.012
Erg	avian erythroblastosis virus E-26 (v-ets) oncogene related	0.012
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.012
S1pr2	sphingosine-1-phosphate receptor 2	0.012
Irf8	interferon regulatory factor 8	0.012
Anxa5	annexin A5	0.012
S1pr3	sphingosine-1-phosphate receptor 3	0.012
Msx1	homeobox, msh-like 1	0.012
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.012
Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.012
Gas1	growth arrest specific 1	0.011
Megf8	multiple EGF-like-domains 8	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.011
Lipe	lipase, hormone sensitive	0.011
Ret	ret proto-oncogene	0.011
Fabp4	fatty acid binding protein 4, adipocyte	0.011
Sqstm1	sequestosome 1	0.011
Trim30a	tripartite motif-containing 30A	0.011
Ccnd1	cyclin D1	0.011
Ednrb	endothelin receptor type B	0.011
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.011
Fzd7	frizzled homolog 7 (Drosophila)	0.011	Mouse
Tcf21	transcription factor 21	0.011
Smad7	MAD homolog 7 (Drosophila)	0.011
Gpc3	glypican 3	0.011
Sat1	spermidine/spermine N1-acetyl transferase 1	0.011
Mks1	Meckel syndrome, type 1	0.011
Ifi44	interferon-induced protein 44	0.011
H2-M3	histocompatibility 2, M region locus 3	0.011
Parp14	poly (ADP-ribose) polymerase family, member 14	0.011
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.011
Mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae)	0.011
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.011
Qk	quaking	0.010
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.010
Rhbdf1	rhomboid family 1 (Drosophila)	0.010
Gimap4	GTPase, IMAP family member 4	0.010
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.010
Ep300	E1A binding protein p300	0.010
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.010
Vldlr	very low density lipoprotein receptor	0.010
Plin2	perilipin 2	0.010