IMP

Process View

Mus musculus

3 genes annotated in mouse

negative regulation of tyrosine phosphorylation of stat protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of tyrosine phosphorylation of stat protein"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of tyrosine phosphorylation of stat protein" (in gray)

Name	Description	Probability	Func Analog Organism
Lepr	leptin receptor	0.989
Jak2	Janus kinase 2	0.757
Stat3	signal transducer and activator of transcription 3	0.654
Ptrf	polymerase I and transcript release factor	0.635
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.547
Il6st	interleukin 6 signal transducer	0.424
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.206
Pparg	peroxisome proliferator activated receptor gamma	0.190
Egfr	epidermal growth factor receptor	0.135
Insr	insulin receptor	0.126
Apc	adenomatosis polyposis coli	0.118
Col1a1	collagen, type I, alpha 1	0.110
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.092
Cd44	CD44 antigen	0.088
Pim1	proviral integration site 1	0.082
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.080
Tsc1	tuberous sclerosis 1	0.074
Egr1	early growth response 1	0.073
Tsc2	tuberous sclerosis 2	0.065
Stat5a	signal transducer and activator of transcription 5A	0.060
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.056
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.053
Cul5	cullin 5	0.050
Ghr	growth hormone receptor	0.048
Smad3	MAD homolog 3 (Drosophila)	0.048
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.047
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.043
Ctnnb1	catenin (cadherin associated protein), beta 1	0.043
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.041
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.038
Fas	Fas (TNF receptor superfamily member 6)	0.036
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.029
Ncoa3	nuclear receptor coactivator 3	0.028
Stat5b	signal transducer and activator of transcription 5B	0.028
Lipe	lipase, hormone sensitive	0.028
Jak1	Janus kinase 1	0.025
Irs1	insulin receptor substrate 1	0.025
Hif1a	hypoxia inducible factor 1, alpha subunit	0.024
Vhl	von Hippel-Lindau tumor suppressor	0.023
Itga1	integrin alpha 1	0.023
Tgfb1	transforming growth factor, beta 1	0.023
Il1r1	interleukin 1 receptor, type I	0.022
Bcl2	B-cell leukemia/lymphoma 2	0.022
Skil	SKI-like	0.022
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.021
Nf1	neurofibromatosis 1	0.021
Pnpla2	patatin-like phospholipase domain containing 2	0.021
Cish	cytokine inducible SH2-containing protein	0.021	Mouse
Marcksl1	MARCKS-like 1	0.020
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.020
Ar	androgen receptor	0.019
Eif1a	eukaryotic translation initiation factor 1A	0.019
Rint1	RAD50 interactor 1	0.019
Gdf15	growth differentiation factor 15	0.019
Tceb1	transcription elongation factor B (SIII), polypeptide 1	0.018
Esr1	estrogen receptor 1 (alpha)	0.018
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.018
Bcl3	B-cell leukemia/lymphoma 3	0.018
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.017
Junb	Jun-B oncogene	0.017
Gna11	guanine nucleotide binding protein, alpha 11	0.017
Trp53	transformation related protein 53	0.017
Lrp1	low density lipoprotein receptor-related protein 1	0.016
Nsf	N-ethylmaleimide sensitive fusion protein	0.016
Plin1	perilipin 1	0.015
Kit	kit oncogene	0.015
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.015
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.015
Mapk8	mitogen-activated protein kinase 8	0.015
Socs2	suppressor of cytokine signaling 2	0.015	Mouse
Rapgef3	Rap guanine nucleotide exchange factor (GEF) 3	0.014
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.014
Gsk3b	glycogen synthase kinase 3 beta	0.014
Mib1	mindbomb homolog 1 (Drosophila)	0.013
Dmtf1	cyclin D binding myb-like transcription factor 1	0.013
Fos	FBJ osteosarcoma oncogene	0.013
Smad1	MAD homolog 1 (Drosophila)	0.013
Lmna	lamin A	0.013
Taf1d	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, D	0.013
Irf1	interferon regulatory factor 1	0.013
Inhbb	inhibin beta-B	0.013
Vegfa	vascular endothelial growth factor A	0.013
Sim1	single-minded homolog 1 (Drosophila)	0.013
Cav1	caveolin 1, caveolae protein	0.013
Cd36	CD36 antigen	0.013
Fosl2	fos-like antigen 2	0.013
Braf	Braf transforming gene	0.013
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.013
Pvr	poliovirus receptor	0.012
Foxa2	forkhead box A2	0.012
Nos3	nitric oxide synthase 3, endothelial cell	0.012
Htt	huntingtin	0.012
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.012
Hbegf	heparin-binding EGF-like growth factor	0.012
Kctd10	potassium channel tetramerisation domain containing 10	0.012
Il6	interleukin 6	0.012
Sh3pxd2a	SH3 and PX domains 2A	0.012
Icam1	intercellular adhesion molecule 1	0.012
Nfil3	nuclear factor, interleukin 3, regulated	0.012
Zeb1	zinc finger E-box binding homeobox 1	0.011
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.011
Ctnna1	catenin (cadherin associated protein), alpha 1	0.011
Fgf21	fibroblast growth factor 21	0.011
Plekhg2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	0.011
Nod2	nucleotide-binding oligomerization domain containing 2	0.011
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.011
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.011
Ccl2	chemokine (C-C motif) ligand 2	0.011
Cbl	Casitas B-lineage lymphoma	0.011
Lpin1	lipin 1	0.010
Arl4c	ADP-ribosylation factor-like 4C	0.010
Ifrd1	interferon-related developmental regulator 1	0.010
Tlr4	toll-like receptor 4	0.010
Ccnd1	cyclin D1	0.010
Vav2	vav 2 oncogene	0.010
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.010
Ubtd2	ubiquitin domain containing 2	0.010
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.010