IMP

Process View

Mus musculus

4 genes annotated in mouse

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

GO:0021938

The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
Gli3	GLI-Kruppel family member GLI3	1.000	Mouse
Shh	sonic hedgehog	1.000
Fgfr2	fibroblast growth factor receptor 2	1.000
Gli2	GLI-Kruppel family member GLI2	0.999
Sox9	SRY-box containing gene 9	0.996
Smo	smoothened homolog (Drosophila)	0.992
Foxc1	forkhead box C1	0.991
Bmp4	bone morphogenetic protein 4	0.986
Bmp7	bone morphogenetic protein 7	0.974
Msx1	homeobox, msh-like 1	0.960
Fgfr1	fibroblast growth factor receptor 1	0.945
Fgf8	fibroblast growth factor 8	0.923
Pax2	paired box gene 2	0.918
Tcfap2a	transcription factor AP-2, alpha	0.912
Foxc2	forkhead box C2	0.908
Fgfr3	fibroblast growth factor receptor 3	0.888
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.882
Prrx1	paired related homeobox 1	0.870
Rarg	retinoic acid receptor, gamma	0.854
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.850
Pitx2	paired-like homeodomain transcription factor 2	0.836
Pax3	paired box gene 3	0.807
Tgfb2	transforming growth factor, beta 2	0.773
Eya1	eyes absent 1 homolog (Drosophila)	0.767
Chrd	chordin	0.754
Otx2	orthodenticle homolog 2 (Drosophila)	0.724
Tbx1	T-box 1	0.699
Dlx5	distal-less homeobox 5	0.681
Msx2	homeobox, msh-like 2	0.660
Prrx2	paired related homeobox 2	0.592
Col2a1	collagen, type II, alpha 1	0.529
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.523
Fgf10	fibroblast growth factor 10	0.501
Rarb	retinoic acid receptor, beta	0.467
Hand1	heart and neural crest derivatives expressed transcript 1	0.464
Hand2	heart and neural crest derivatives expressed transcript 2	0.348
Twist2	twist homolog 2 (Drosophila)	0.332
Zeb1	zinc finger E-box binding homeobox 1	0.330
Ctnnb1	catenin (cadherin associated protein), beta 1	0.328
Ptch1	patched homolog 1	0.305
Nog	noggin	0.295
Meox2	mesenchyme homeobox 2	0.285
Hoxa1	homeobox A1	0.275
Runx2	runt related transcription factor 2	0.261
Foxg1	forkhead box G1	0.238
Efna4	ephrin A4	0.230
Vangl2	vang-like 2 (van gogh, Drosophila)	0.222
Gbx2	gastrulation brain homeobox 2	0.188
Jag1	jagged 1	0.179
Alx4	aristaless-like homeobox 4	0.174
Chd7	chromodomain helicase DNA binding protein 7	0.163
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.144
Pax6	paired box gene 6	0.141
Isl1	ISL1 transcription factor, LIM/homeodomain	0.140
Pbx1	pre B-cell leukemia transcription factor 1	0.132
Emx2	empty spiracles homolog 2 (Drosophila)	0.132
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.130
Mn1	meningioma 1	0.129
Rara	retinoic acid receptor, alpha	0.127
En1	engrailed 1	0.126
Ednra	endothelin receptor type A	0.125
Lmx1b	LIM homeobox transcription factor 1 beta	0.122
Sox2	SRY-box containing gene 2	0.118
Otx1	orthodenticle homolog 1 (Drosophila)	0.111
Pitx1	paired-like homeodomain transcription factor 1	0.104
Hoxa2	homeobox A2	0.103
Fgf9	fibroblast growth factor 9	0.094
Pthlh	parathyroid hormone-like peptide	0.093
Efnb2	ephrin B2	0.084
Bmper	BMP-binding endothelial regulator	0.084
Tbx15	T-box 15	0.081
Hoxa3	homeobox A3	0.081
Hoxa11	homeobox A11	0.081
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.079
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.077
Gli1	GLI-Kruppel family member GLI1	0.077
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.070
Hoxd13	homeobox D13	0.068
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.068
Ptk7	PTK7 protein tyrosine kinase 7	0.065
Lmx1a	LIM homeobox transcription factor 1 alpha	0.065
Bmp2	bone morphogenetic protein 2	0.063
Sox11	SRY-box containing gene 11	0.062
Gata4	GATA binding protein 4	0.062
Wt1	Wilms tumor 1 homolog	0.061
Pax8	paired box gene 8	0.059
Obsl1	obscurin-like 1	0.055
Hoxb3	homeobox B3	0.055
Lhx1	LIM homeobox protein 1	0.054
Wnt5a	wingless-related MMTV integration site 5A	0.052
Alx1	ALX homeobox 1	0.052
Hoxd11	homeobox D11	0.051
Gsc	goosecoid homeobox	0.050
Ihh	Indian hedgehog	0.049	Mouse
Hoxd3	homeobox D3	0.048
Wnt6	wingless-related MMTV integration site 6	0.047
Vegfa	vascular endothelial growth factor A	0.046
Col13a1	collagen, type XIII, alpha 1	0.046
Foxd2	forkhead box D2	0.045
Lrp6	low density lipoprotein receptor-related protein 6	0.044
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.044
Pten	phosphatase and tensin homolog	0.044
Rxra	retinoid X receptor alpha	0.043
Efna2	ephrin A2	0.042
Lef1	lymphoid enhancer binding factor 1	0.038
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.037
Gdnf	glial cell line derived neurotrophic factor	0.037
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.036
Trp63	transformation related protein 63	0.036
Wnt3a	wingless-related MMTV integration site 3A	0.035
Ephb2	Eph receptor B2	0.034
Bnc1	basonuclin 1	0.034
Tbx2	T-box 2	0.033
Acvr1	activin A receptor, type 1	0.032
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.032
Hoxd9	homeobox D9	0.031
Nkx3-2	NK3 homeobox 2	0.030
Tcf21	transcription factor 21	0.029
Hoxb6	homeobox B6	0.029
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.028
Col1a1	collagen, type I, alpha 1	0.027
Gja1	gap junction protein, alpha 1	0.027
Gas1	growth arrest specific 1	0.027
Hes1	hairy and enhancer of split 1 (Drosophila)	0.027
Ar	androgen receptor	0.027
Sox4	SRY-box containing gene 4	0.027
Emid2	EMI domain containing 2	0.027
Tbx3	T-box 3	0.026
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.026
Npr2	natriuretic peptide receptor 2	0.026
Fzd2	frizzled homolog 2 (Drosophila)	0.025
Ece1	endothelin converting enzyme 1	0.024
Tgfbr2	transforming growth factor, beta receptor II	0.024
Trp53	transformation related protein 53	0.024
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.024
Apln	apelin	0.024
Ptch2	patched homolog 2	0.023
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.023
Lrp2	low density lipoprotein receptor-related protein 2	0.022
Efnb1	ephrin B1	0.022
Pax9	paired box gene 9	0.022
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.022
Mesp1	mesoderm posterior 1	0.021
Wnt1	wingless-related MMTV integration site 1	0.021
Disp1	dispatched homolog 1 (Drosophila)	0.020
Ret	ret proto-oncogene	0.020
Hoxa13	homeobox A13	0.020
Hoxa5	homeobox A5	0.019
Meox1	mesenchyme homeobox 1	0.019
Nodal	nodal	0.019
Tead3	TEA domain family member 3	0.019
Sox3	SRY-box containing gene 3	0.019
Gata6	GATA binding protein 6	0.018
Hoxc8	homeobox C8	0.018
Nynrin	NYN domain and retroviral integrase containing	0.018
Nf1	neurofibromatosis 1	0.018
Notch3	Notch gene homolog 3 (Drosophila)	0.017
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.017
Twist1	twist homolog 1 (Drosophila)	0.017
Hoxd10	homeobox D10	0.017
Pax1	paired box gene 1	0.017
Hoxd4	homeobox D4	0.016
Hoxa10	homeobox A10	0.016
Tead2	TEA domain family member 2	0.016
Efs	embryonal Fyn-associated substrate	0.016
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.016
Col6a2	collagen, type VI, alpha 2	0.016
Insm1	insulinoma-associated 1	0.016
Gata3	GATA binding protein 3	0.015
Pkdcc	protein kinase domain containing, cytoplasmic	0.015
Alx3	aristaless-like homeobox 3	0.015
Neurog3	neurogenin 3	0.015
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.015
Smad6	MAD homolog 6 (Drosophila)	0.015
Fbn2	fibrillin 2	0.015
Hoxd8	homeobox D8	0.014
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.014
Amhr2	anti-Mullerian hormone type 2 receptor	0.014
Pkd1	polycystic kidney disease 1 homolog	0.014
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.014
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.014
Emx1	empty spiracles homolog 1 (Drosophila)	0.014
Bik	BCL2-interacting killer	0.014
Foxn1	forkhead box N1	0.014
Prx	periaxin	0.013
Sim2	single-minded homolog 2 (Drosophila)	0.013
Col4a3	collagen, type IV, alpha 3	0.013
Fgf3	fibroblast growth factor 3	0.013
Nrtn	neurturin	0.013
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.013
Col11a1	collagen, type XI, alpha 1	0.013
Rdh10	retinol dehydrogenase 10 (all-trans)	0.013
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.013
Capn6	calpain 6	0.012
Egfr	epidermal growth factor receptor	0.012
Tcfap2c	transcription factor AP-2, gamma	0.012
Sult5a1	sulfotransferase family 5A, member 1	0.012
Fgfrl1	fibroblast growth factor receptor-like 1	0.012
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.012
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.011
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.011
Pitx3	paired-like homeodomain transcription factor 3	0.011
Wnt9b	wingless-type MMTV integration site 9B	0.011
Amh	anti-Mullerian hormone	0.011
Nrk	Nik related kinase	0.011
Lhx3	LIM homeobox protein 3	0.011
Mks1	Meckel syndrome, type 1	0.011
Snai1	snail homolog 1 (Drosophila)	0.011
Pla2g2c	phospholipase A2, group IIC	0.011
Padi3	peptidyl arginine deiminase, type III	0.011
Ntf3	neurotrophin 3	0.011
Fbln1	fibulin 1	0.011
Fgf18	fibroblast growth factor 18	0.011
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.011
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.010
Wnt4	wingless-related MMTV integration site 4	0.010
Nos3	nitric oxide synthase 3, endothelial cell	0.010
Unc5c	unc-5 homolog C (C. elegans)	0.010
Hoxb1	homeobox B1	0.010
Gata5	GATA binding protein 5	0.010