IMP
Process View
The network for 'regulation of mast cell degranulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
regulation of mast cell degranulation
Any process that modulates the frequency, rate, or extent of mast cell degranulation.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | 0.779 | |
| TFF1 | trefoil factor 1 | 0.750 | |
| IL4R | interleukin 4 receptor | 0.680 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.648 | |
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.608 | |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.547 | |
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.512 | |
| HCK | hemopoietic cell kinase | 0.506 | |
| SYK | spleen tyrosine kinase | 0.503 | |
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.464 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.400 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.381 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.352 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.338 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.303 | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.303 | |
| ZNF746 | zinc finger protein 746 | 0.283 | |
| IL4 | interleukin 4 | 0.277 | |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.230 | |
| IL2RG | interleukin 2 receptor, gamma | 0.225 | |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.193 | |
| PLCG1 | phospholipase C, gamma 1 | 0.152 | |
| CRH | corticotropin releasing hormone | 0.149 | |
| LCK | lymphocyte-specific protein tyrosine kinase | 0.140 | |
| BLNK | B-cell linker | 0.111 | |
| BAI1 | brain-specific angiogenesis inhibitor 1 | 0.111 | |
| GRB2 | growth factor receptor-bound protein 2 | 0.092 | |
| ZNF775 | zinc finger protein 775 | 0.072 | |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.069 | |
| LAT | linker for activation of T cells | 0.069 | |
| CARD11 | caspase recruitment domain family, member 11 | 0.064 | |
| IRS1 | insulin receptor substrate 1 | 0.057 | |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.055 | |
| SH3BP2 | SH3-domain binding protein 2 | 0.053 | |
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 0.050 | |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.045 | |
| PSTPIP1 | proline-serine-threonine phosphatase interacting protein 1 | 0.045 | |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.041 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.041 | |
| GAB1 | GRB2-associated binding protein 1 | 0.040 | |
| GRAP2 | GRB2-related adaptor protein 2 | 0.039 | |
| HK3 | hexokinase 3 (white cell) | 0.039 | |
| C1orf93 | chromosome 1 open reading frame 93 | 0.039 | |
| AIF1 | allograft inflammatory factor 1 | 0.037 | |
| SIRPB1 | signal-regulatory protein beta 1 | 0.037 | |
| ARAP1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 0.033 | |
| CD300C | CD300c molecule | 0.031 | |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.030 | |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 0.030 | |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.028 | |
| C15orf29 | chromosome 15 open reading frame 29 | 0.027 | |
| BCL10 | B-cell CLL/lymphoma 10 | 0.027 | |
| DLG4 | discs, large homolog 4 (Drosophila) | 0.025 | |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.023 | |
| CMIP | c-Maf-inducing protein | 0.023 | |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.022 | |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | 0.022 | |
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.020 | |
| ZC3HC1 | zinc finger, C3HC-type containing 1 | 0.020 | |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.019 | |
| SLA | Src-like-adaptor | 0.019 | |
| FYB | FYN binding protein | 0.018 | |
| NSF | N-ethylmaleimide-sensitive factor | 0.018 | |
| DUSP23 | dual specificity phosphatase 23 | 0.018 | |
| EZR | ezrin | 0.017 | |
| C5AR1 | complement component 5a receptor 1 | 0.017 | |
| SIGLEC9 | sialic acid binding Ig-like lectin 9 | 0.017 | |
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 | 0.017 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.017 | |
| EPHA8 | EPH receptor A8 | 0.017 | |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 0.016 | |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 0.016 | |
| CSF3R | colony stimulating factor 3 receptor (granulocyte) | 0.016 | |
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 0.016 | |
| FOXF2 | forkhead box F2 | 0.016 | |
| ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | 0.016 | |
| MTOR | mechanistic target of rapamycin (serine/threonine kinase) | 0.015 | |
| CR1 | complement component (3b/4b) receptor 1 (Knops blood group) | 0.015 | |
| DOK4 | docking protein 4 | 0.015 | |
| DOK1 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | 0.015 | |
| PIK3CB | phosphoinositide-3-kinase, catalytic, beta polypeptide | 0.015 | |
| CYTH4 | cytohesin 4 | 0.015 | |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.015 | |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.015 | |
| DOK3 | docking protein 3 | 0.015 | |
| SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | 0.015 | |
| HDC | histidine decarboxylase | 0.015 | |
| CD33 | CD33 molecule | 0.014 | |
| PIM1 | pim-1 oncogene | 0.014 | |
| TYROBP | TYRO protein tyrosine kinase binding protein | 0.014 | |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.014 | |
| PARK2 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.014 | |
| DENND1C | DENN/MADD domain containing 1C | 0.014 | |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.013 | |
| MYO1F | myosin IF | 0.013 | |
| CEACAM3 | carcinoembryonic antigen-related cell adhesion molecule 3 | 0.013 | |
| ABI3 | ABI family, member 3 | 0.013 | |
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.013 | |
| FGFR1 | fibroblast growth factor receptor 1 | 0.013 | |
| NFAM1 | NFAT activating protein with ITAM motif 1 | 0.013 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.992 | |
| Grb2 | growth factor receptor bound protein 2 | 0.979 | |
| Il4 | interleukin 4 | 0.974 | |
| Cd247 | CD247 antigen | 0.965 | |
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.951 | |
| Mefv | Mediterranean fever | 0.910 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.857 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.856 | |
| Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | 0.761 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.735 | |
| Lat | linker for activation of T cells | 0.721 | |
| Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | 0.620 | |
| Cd19 | CD19 antigen | 0.591 | |
| Ifng | interferon gamma | 0.495 | |
| Dok1 | docking protein 1 | 0.488 | |
| Cbl | Casitas B-lineage lymphoma | 0.485 | |
| Dok3 | docking protein 3 | 0.426 | |
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.402 | |
| Cd40 | CD40 antigen | 0.352 | |
| Igh | immunoglobulin heavy chain complex | 0.323 | |
| Nfam1 | Nfat activating molecule with ITAM motif 1 | 0.314 | |
| C5ar1 | complement component 5a receptor 1 | 0.276 | |
| Cd22 | CD22 antigen | 0.274 | |
| Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | 0.239 | |
| Clec4n | C-type lectin domain family 4, member n | 0.221 | |
| Msr1 | macrophage scavenger receptor 1 | 0.217 | |
| Met | met proto-oncogene | 0.188 | |
| Btk | Bruton agammaglobulinemia tyrosine kinase | 0.175 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.165 | |
| Il2 | interleukin 2 | 0.161 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.157 | |
| Shc1 | src homology 2 domain-containing transforming protein C1 | 0.148 | |
| Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.139 | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.130 | |
| Hcst | hematopoietic cell signal transducer | 0.130 | |
| Lck | lymphocyte protein tyrosine kinase | 0.130 | |
| Tcra | T-cell receptor alpha chain | 0.126 | |
| Was | Wiskott-Aldrich syndrome homolog (human) | 0.121 | |
| S1pr4 | sphingosine-1-phosphate receptor 4 | 0.116 | |
| Tyrobp | TYRO protein tyrosine kinase binding protein | 0.113 | |
| Snai1 | snail homolog 1 (Drosophila) | 0.110 | |
| Clec4d | C-type lectin domain family 4, member d | 0.107 | |
| Lyl1 | lymphoblastomic leukemia 1 | 0.106 | |
| Sykb | spleen tyrosine kinase | 0.103 | |
| Rag1 | recombination activating gene 1 | 0.100 | |
| Foxn1 | forkhead box N1 | 0.100 | |
| Fcgr2b | Fc receptor, IgG, low affinity IIb | 0.091 | |
| Plcg2 | phospholipase C, gamma 2 | 0.088 | |
| Cd4 | CD4 antigen | 0.087 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.085 | |
| Il2rg | interleukin 2 receptor, gamma chain | 0.082 | |
| Dok2 | docking protein 2 | 0.082 | |
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.082 | |
| Trem3 | triggering receptor expressed on myeloid cells 3 | 0.077 | |
| Fes | feline sarcoma oncogene | 0.076 | |
| Pik3cg | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 0.076 | |
| Galnt6 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 | 0.074 | |
| Tbxas1 | thromboxane A synthase 1, platelet | 0.071 | |
| Itgb3 | integrin beta 3 | 0.069 | |
| Spib | Spi-B transcription factor (Spi-1/PU.1 related) | 0.066 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.066 | |
| Csf2rb2 | colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) | 0.066 | |
| Kit | kit oncogene | 0.065 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.064 | |
| Csf3r | colony stimulating factor 3 receptor (granulocyte) | 0.063 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.062 | |
| Il10ra | interleukin 10 receptor, alpha | 0.062 | |
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.057 | |
| Pilra | paired immunoglobin-like type 2 receptor alpha | 0.057 | |
| Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.055 | |
| Pten | phosphatase and tensin homolog | 0.055 | |
| Il13 | interleukin 13 | 0.052 | |
| Il4ra | interleukin 4 receptor, alpha | 0.050 | |
| Mmp8 | matrix metallopeptidase 8 | 0.050 | |
| Hmox1 | heme oxygenase (decycling) 1 | 0.048 | |
| Slpi | secretory leukocyte peptidase inhibitor | 0.048 | |
| Siglece | sialic acid binding Ig-like lectin E | 0.045 | |
| P2rx7 | purinergic receptor P2X, ligand-gated ion channel, 7 | 0.044 | |
| Nos2 | nitric oxide synthase 2, inducible | 0.043 | |
| Csf1r | colony stimulating factor 1 receptor | 0.043 | |
| Pxn | paxillin | 0.042 | |
| Plcg1 | phospholipase C, gamma 1 | 0.041 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.041 | |
| Mvp | major vault protein | 0.041 | |
| Cmklr1 | chemokine-like receptor 1 | 0.041 | |
| Irg1 | immunoresponsive gene 1 | 0.041 | |
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.039 | |
| Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.038 | |
| Il1rn | interleukin 1 receptor antagonist | 0.038 | |
| Cd28 | CD28 antigen | 0.037 | |
| Rel | reticuloendotheliosis oncogene | 0.037 | |
| Gpr132 | G protein-coupled receptor 132 | 0.037 | |
| AF251705 | cDNA sequence AF251705 | 0.036 | |
| Gpr35 | G protein-coupled receptor 35 | 0.035 | |
| Marco | macrophage receptor with collagenous structure | 0.035 | |
| Fcgr4 | Fc receptor, IgG, low affinity IV | 0.034 | |
| Pou2f2 | POU domain, class 2, transcription factor 2 | 0.034 | |
| Hcls1 | hematopoietic cell specific Lyn substrate 1 | 0.034 | |
| Ptpre | protein tyrosine phosphatase, receptor type, E | 0.033 | |
| Ptpra | protein tyrosine phosphatase, receptor type, A | 0.033 |