The network for 'regulation of defense response to virus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of defense response to virus

Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.

Homo sapiens
Name Description Probability Func Analog Organism
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.998
IFI44 interferon-induced protein 44 0.988
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.985
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.983
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.980
SP110 SP110 nuclear body protein 0.922
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.909
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.908
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.903
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.861
ISG15 ISG15 ubiquitin-like modifier 0.811
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.808
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.798
SAMD9 sterile alpha motif domain containing 9 0.797
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.766
IFI44L interferon-induced protein 44-like 0.701
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.677
IFIH1 interferon induced with helicase C domain 1 0.660
STAT1 signal transducer and activator of transcription 1, 91kDa 0.639
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.636
SP100 SP100 nuclear antigen 0.551
EPSTI1 epithelial stromal interaction 1 (breast) 0.530
NMI N-myc (and STAT) interactor 0.513
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.486
MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.467
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.467
OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 0.415
NLRC4 NLR family, CARD domain containing 4 0.396
CREBBP CREB binding protein 0.392
SMAD4 SMAD family member 4 0.367
PILRA paired immunoglobin-like type 2 receptor alpha 0.365
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.354
RSAD2 radical S-adenosyl methionine domain containing 2 0.352
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.347
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.292
HERC5 hect domain and RLD 5 0.281
PLSCR1 phospholipid scramblase 1 0.258
IL4R interleukin 4 receptor 0.256
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.255
TMEM173 transmembrane protein 173 0.242
IL23A interleukin 23, alpha subunit p19 0.242
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.237
CHUK conserved helix-loop-helix ubiquitous kinase 0.235
OASL 2'-5'-oligoadenylate synthetase-like 0.227
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.222
TRIM22 tripartite motif containing 22 0.214
MED15 mediator complex subunit 15 0.203
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.197
MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.190
PARP9 poly (ADP-ribose) polymerase family, member 9 0.180
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.160
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.155
XAF1 XIAP associated factor 1 0.151
PCBP1 poly(rC) binding protein 1 0.149
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.146
TRIM21 tripartite motif containing 21 0.142
USP18 ubiquitin specific peptidase 18 0.131
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.128
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.113
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.111
GBP1 guanylate binding protein 1, interferon-inducible 0.107
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.106
APOL6 apolipoprotein L, 6 0.105
TRIM39 tripartite motif containing 39 0.100
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.098
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.094
MEFV Mediterranean fever 0.093
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.092
RTP4 receptor (chemosensory) transporter protein 4 0.090
IRF9 interferon regulatory factor 9 0.087
TRAF3 TNF receptor-associated factor 3 0.086
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.083
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.078
MAVS mitochondrial antiviral signaling protein 0.077
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.075
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.075
IRF7 interferon regulatory factor 7 0.071
RNF11 ring finger protein 11 0.070
TRIM5 tripartite motif containing 5 0.070
XIAP X-linked inhibitor of apoptosis 0.068
TRIM25 tripartite motif containing 25 0.067
DICER1 dicer 1, ribonuclease type III 0.067
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.066
DAXX death-domain associated protein 0.062
IL15 interleukin 15 0.062
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.057
NOD2 nucleotide-binding oligomerization domain containing 2 0.057
CYLD cylindromatosis (turban tumor syndrome) 0.056
TDRD7 tudor domain containing 7 0.055
ZNF263 zinc finger protein 263 0.055
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.054
CXCL10 chemokine (C-X-C motif) ligand 10 0.054
IFI27 interferon, alpha-inducible protein 27 0.053
CXCL11 chemokine (C-X-C motif) ligand 11 0.053
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.052
TYMP thymidine phosphorylase 0.052
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.052
SAMD9L sterile alpha motif domain containing 9-like 0.052
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.050
RANBP3 RAN binding protein 3 0.050
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
caspa caspase a 0.073
s100a10b S100 calcium binding protein A10b 0.040
ef1a elongation factor 1-alpha 0.033
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.025
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.025
prkar1aa protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a 0.022
snx4 sorting nexin 4 0.022
il6r interleukin 6 receptor 0.020
plk3 polo-like kinase 3 (Drosophila) 0.019
tlr21 toll-like receptor 21 0.018
unc5c unc-5 homolog C (C. elegans) 0.018
LOC557072 caspase recruitment domain-containing protein 11-like 0.017
rel v-rel reticuloendotheliosis viral oncogene homolog 0.017
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.017
myl1 myosin, light chain 1, alkali; skeletal, fast 0.017
arhgdig Rho GDP dissociation inhibitor (GDI) gamma 0.016
il6st interleukin 6 signal transducer 0.015
plekha1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.014
glceb glucuronyl C5-epimerase b 0.014
timp2a tissue inhibitor of metalloproteinase 2a 0.014
tfe3b transcription factor binding to IGHM enhancer 3b 0.014
LOC566020 Gig2-like protein DreO 0.014
xrn2 5'-3' exoribonuclease 2 0.014
zgc:63992 zgc:63992 0.013
atg13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.013
stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.013
acvr2a activin receptor IIa 0.013
zgc:66286 zgc:66286 0.013
zgc:55573 zgc:55573 0.012
polb polymerase (DNA directed), beta 0.012
capns1b calpain, small subunit 1 b 0.012
card14 caspase recruitment domain family, member 14 0.012
cdh5 cadherin 5 0.012
sec24c SEC24 family, member C (S. cerevisiae) 0.012
gabarapa GABA(A) receptor-associated protein a 0.011
styk1 serine/threonine/tyrosine kinase 1 0.011
mecp2 methyl CpG binding protein 2 0.011
acta1b actin, alpha 1b, skeletal muscle 0.011
zgc:101724 zgc:101724 0.011
anxa1b annexin A1b 0.011
wnt5a wingless-type MMTV integration site family, member 5a 0.011
nod1 nucleotide-binding oligomerization domain containing 1 0.011
flot2a flotillin 2a 0.011
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.011
pob partial optokinetic response b 0.011
mmp2 matrix metalloproteinase 2 0.011
anxa13 annexin A13 0.011
cdkn1a cyclin-dependent kinase inhibitor 1A 0.011
tfe3a transcription factor binding to IGHM enhancer 3a 0.011
ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.011
maf1 MAF1 homolog (S. cerevisiae) 0.011
hmgb2a high-mobility group box 2a 0.011
lrmp lymphoid-restricted membrane protein 0.010
actc1b actin, alpha, cardiac muscle 1b 0.010
ddr2b discoidin domain receptor family, member 2b 0.010
tnni2b.2 troponin I, skeletal, fast 2b.2 0.010
cd40lg CD40 ligand 0.010
tsen54 tRNA splicing endonuclease 54 homolog (S. cerevisiae) 0.010
pmp22a peripheral myelin protein 22a 0.010
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rel Relish 0.999
BG4 CG12297 gene product from transcript CG12297-RA 0.958
key kenny 0.957
ird5 immune response deficient 5 0.924
Dredd Death related ced-3/Nedd2-like protein 0.822
Tak1 TGF-beta activated kinase 1 0.750
Toll-7 CG8595 gene product from transcript CG8595-RA 0.741
Pli Pellino 0.658
imd immune deficiency 0.637
Mpk2 CG5475 gene product from transcript CG5475-RB 0.473
krz kurtz 0.313
Atg13 Autophagy-specific gene 13 0.285
18w 18 wheeler 0.275
Atg18 Autophagy-specific gene 18 0.260
CG16718 CG16718 gene product from transcript CG16718-RA 0.241
Myd88 CG2078 gene product from transcript CG2078-RA 0.224
Toll-6 CG7250 gene product from transcript CG7250-RA 0.168
Atg7 Autophagy-specific gene 7 0.163
Lis-1 Lissencephaly-1 0.156
ird1 immune response deficient 1 0.150
AGO2 Argonaute 2 0.135
Sox14 Sox box protein 14 0.104
Tollo CG6890 gene product from transcript CG6890-RA 0.075
ec echinus 0.070
th thread 0.070
p38b CG7393 gene product from transcript CG7393-RA 0.061
Vps16A Vacuolar protein sorting 16A 0.059
Cat Catalase 0.054
whd withered 0.051
CG7611 CG7611 gene product from transcript CG7611-RJ 0.051
RASSF8 CG5053 gene product from transcript CG5053-RA 0.050
ced-6 CG11804 gene product from transcript CG11804-RC 0.044
crp cropped 0.040
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.039
CG10650 CG10650 gene product from transcript CG10650-RA 0.034
Ark Apaf-1-related-killer 0.034
PGRP-LC Peptidoglycan recognition protein LC 0.033
PGRP-LE Peptidoglycan recognition protein LE 0.032
Traf6 TNF-receptor-associated factor 6 0.032
CG1021 CG1021 gene product from transcript CG1021-RE 0.028
egr eiger 0.028
nct nicastrin 0.025
CG5794 CG5794 gene product from transcript CG5794-RB 0.025
spz spatzle 0.024
Atg9 Autophagy-specific gene 9 0.024
Mekk1 CG7717 gene product from transcript CG7717-RB 0.023
Hsf Heat shock factor 0.023
Krn Keren 0.022
CG32185 CG32185 gene product from transcript CG32185-RA 0.020
Tsp29Fa Tetraspanin 29Fa 0.020
CG2924 CG2924 gene product from transcript CG2924-RA 0.019
Atg8a Autophagy-specific gene 8a 0.018
bib big brain 0.018
Atg2 Autophagy-specific gene 2 0.017
Parp Poly-(ADP-ribose) polymerase 0.017
l(3)05822 lethal (3) 05822 0.017
Mt2 Methyltransferase 2 0.016
NT1 Neurotrophin 1 0.015
CG13482 CG13482 gene product from transcript CG13482-RA 0.014
alphaTry alphaTrypsin 0.014
Patr-1 Protein associated with topo II related - 1 0.013
Tsp42Ec Tetraspanin 42Ec 0.013
CG17107 CG17107 gene product from transcript CG17107-RA 0.013
Duox Dual oxidase 0.013
Notum CG13076 gene product from transcript CG13076-RB 0.013
CG13323 CG13323 gene product from transcript CG13323-RA 0.013
yki yorkie 0.013
Stam Signal transducing adaptor molecule 0.012
unc79 CG5237 gene product from transcript CG5237-RB 0.012
egg eggless 0.012
Nipped-B CG17704 gene product from transcript CG17704-RI 0.012
cert ceramide transfer protein 0.012
CG12974 CG12974 gene product from transcript CG12974-RA 0.012
CG17746 CG17746 gene product from transcript CG17746-RA 0.011
lambdaTry CG12350 gene product from transcript CG12350-RA 0.011
Atg5 Autophagy-specific gene 5 0.011
CG15152 CG15152 gene product from transcript CG15152-RA 0.011
MESR6 Misexpression suppressor of ras 6 0.010
Hip1 Huntingtin interacting protein 1 0.010
Atf-2 Activating transcription factor-2 0.010
p53 CG33336 gene product from transcript CG33336-RB 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.997
Trim30a tripartite motif-containing 30A 0.984
Gbp7 guanylate binding protein 7 0.940
Iigp1 interferon inducible GTPase 1 0.833
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.820
Parp14 poly (ADP-ribose) polymerase family, member 14 0.788
Ikbkg inhibitor of kappaB kinase gamma 0.781
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.706
Trim21 tripartite motif-containing 21 0.689
Ikbkb inhibitor of kappaB kinase beta 0.684
Aim2 absent in melanoma 2 0.666
Ifi203 interferon activated gene 203 0.647
Irgm1 immunity-related GTPase family M member 1 0.612
Igh immunoglobulin heavy chain complex 0.607
Stat1 signal transducer and activator of transcription 1 0.599
Sp100 nuclear antigen Sp100 0.598
Stat3 signal transducer and activator of transcription 3 0.578
Gbp2 guanylate binding protein 2 0.550
Mavs mitochondrial antiviral signaling protein 0.526
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.516
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.487
Gbp3 guanylate binding protein 3 0.480
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.427
Usp18 ubiquitin specific peptidase 18 0.427
Traf6 TNF receptor-associated factor 6 0.424
Cd40 CD40 antigen 0.421
Uba7 ubiquitin-like modifier activating enzyme 7 0.412
Rsad2 radical S-adenosyl methionine domain containing 2 0.409
Mndal myeloid nuclear differentiation antigen like 0.407
Myd88 myeloid differentiation primary response gene 88 0.393
Pycard PYD and CARD domain containing 0.376
Tnf tumor necrosis factor 0.374
Stat5b signal transducer and activator of transcription 5B 0.366
Trim30d tripartite motif-containing 30D 0.327
Gbp10 guanylate-binding protein 10 0.310
Pyhin1 pyrin and HIN domain family, member 1 0.295
Irf9 interferon regulatory factor 9 0.290
Ifi44 interferon-induced protein 44 0.283
Rtp4 receptor transporter protein 4 0.274
Igtp interferon gamma induced GTPase 0.270
Irgm2 immunity-related GTPase family M member 2 0.262
Gbp5 guanylate binding protein 5 0.252
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.249
Irf1 interferon regulatory factor 1 0.237
Trp53 transformation related protein 53 0.231
Cyld cylindromatosis (turban tumor syndrome) 0.228
Ikzf1 IKAROS family zinc finger 1 0.216
Ifi47 interferon gamma inducible protein 47 0.213
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.212
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.196
Tgtp2 T-cell specific GTPase 2 0.189
Stat5a signal transducer and activator of transcription 5A 0.181
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.179
Unc93b1 unc-93 homolog B1 (C. elegans) 0.174
Birc3 baculoviral IAP repeat-containing 3 0.168
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.165
Irf7 interferon regulatory factor 7 0.163
Casp1 caspase 1 0.163
Samd9l sterile alpha motif domain containing 9-like 0.154
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.154
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.145
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.142
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.137
Ciita class II transactivator 0.133
Gbp6 guanylate binding protein 6 0.129
Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 0.125
Ifih1 interferon induced with helicase C domain 1 0.124
Mx1 myxovirus (influenza virus) resistance 1 0.113
Trim12a tripartite motif-containing 12A 0.111
Pml promyelocytic leukemia 0.103
D14Ertd668e DNA segment, Chr 14, ERATO Doi 668, expressed 0.103
Lyz2 lysozyme 2 0.102
Dock2 dedicator of cyto-kinesis 2 0.102
Fas Fas (TNF receptor superfamily member 6) 0.096
Ifit2 interferon-induced protein with tetratricopeptide repeats 2 0.096
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.093
Foxp3 forkhead box P3 0.092
Herc6 hect domain and RLD 6 0.086
Cd19 CD19 antigen 0.086
Sfpi1 SFFV proviral integration 1 0.085
Stat2 signal transducer and activator of transcription 2 0.079
Traf2 TNF receptor-associated factor 2 0.079
Traf3 TNF receptor-associated factor 3 0.078
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.078
Bcl3 B-cell leukemia/lymphoma 3 0.076
Slfn8 schlafen 8 0.075
Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 0.074
Samhd1 SAM domain and HD domain, 1 0.074
Csf1 colony stimulating factor 1 (macrophage) 0.072
Mnda myeloid cell nuclear differentiation antigen 0.070
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.069
Zbp1 Z-DNA binding protein 1 0.069
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.068
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.067
Skil SKI-like 0.066
Cmpk2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.060
Tor3a torsin family 3, member A 0.056
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.054
Cxcl10 chemokine (C-X-C motif) ligand 10 0.051
Gvin1 GTPase, very large interferon inducible 1 0.048
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rpl10a ribosomal protein L10A 0.013
LOC100359498 ribosomal protein L35a-like 0.012
Rpl7a ribosomal protein L7a 0.011
Rps11 ribosomal protein S11 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism