The network for 'negative regulation of fibroblast growth factor receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of fibroblast growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.

Homo sapiens
Name Description Probability Func Analog Organism
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.968
SPRY2 sprouty homolog 2 (Drosophila) 0.816
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.786
TESK1 testis-specific kinase 1 0.687
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.514
SH3KBP1 SH3-domain kinase binding protein 1 0.452
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.436
STMN2 stathmin-like 2 0.280
FN1 fibronectin 1 0.191
ZFYVE9 zinc finger, FYVE domain containing 9 0.153
PSEN1 presenilin 1 0.143
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.095
HIC1 hypermethylated in cancer 1 0.094
JUP junction plakoglobin 0.088
TGFB1 transforming growth factor, beta 1 0.085
TIMP2 TIMP metallopeptidase inhibitor 2 0.080
SCARB2 scavenger receptor class B, member 2 0.074
VCAN versican 0.070
TCF4 transcription factor 4 0.068
SFRP4 secreted frizzled-related protein 4 0.065
FZD1 frizzled homolog 1 (Drosophila) 0.061
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.058
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.055
DUSP6 dual specificity phosphatase 6 0.050
SPRY4 sprouty homolog 4 (Drosophila) 0.048
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.047
THBS2 thrombospondin 2 0.047
NGF nerve growth factor (beta polypeptide) 0.047
C9orf25 chromosome 9 open reading frame 25 0.046
TIMP3 TIMP metallopeptidase inhibitor 3 0.046
MARCKS myristoylated alanine-rich protein kinase C substrate 0.046
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.044
BGN biglycan 0.043
SALL2 sal-like 2 (Drosophila) 0.043
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.043
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.041
SH2B2 SH2B adaptor protein 2 0.041
COMP cartilage oligomeric matrix protein 0.041
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.041
NTM neurotrimin 0.040
ANGPTL2 angiopoietin-like 2 0.039
GLIS2 GLIS family zinc finger 2 0.039
TPP1 tripeptidyl peptidase I 0.039
TNIK TRAF2 and NCK interacting kinase 0.039
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.038
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.037
THY1 Thy-1 cell surface antigen 0.036
MXRA5 matrix-remodelling associated 5 0.035
FAP fibroblast activation protein, alpha 0.035
CYR61 cysteine-rich, angiogenic inducer, 61 0.035
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.034
GSK3B glycogen synthase kinase 3 beta 0.033
CPD carboxypeptidase D 0.032
CTNNBIP1 catenin, beta interacting protein 1 0.031
ETV5 ets variant 5 0.030
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.029
RET ret proto-oncogene 0.029
RHOQ ras homolog gene family, member Q 0.028
COL11A1 collagen, type XI, alpha 1 0.028
WISP1 WNT1 inducible signaling pathway protein 1 0.027
HEXB hexosaminidase B (beta polypeptide) 0.027
ITSN1 intersectin 1 (SH3 domain protein) 0.027
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.026
AR androgen receptor 0.026
FGF2 fibroblast growth factor 2 (basic) 0.026
COL1A1 collagen, type I, alpha 1 0.026
COL5A1 collagen, type V, alpha 1 0.026
SFRP2 secreted frizzled-related protein 2 0.025
PRRX1 paired related homeobox 1 0.025
INHBA inhibin, beta A 0.025
AEBP1 AE binding protein 1 0.024
FAM198B family with sequence similarity 198, member B 0.023
ADAM12 ADAM metallopeptidase domain 12 0.023
SDC2 syndecan 2 0.022
POSTN periostin, osteoblast specific factor 0.022
CTSB cathepsin B 0.021
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.021
WNT4 wingless-type MMTV integration site family, member 4 0.020
FBN1 fibrillin 1 0.020
LOXL2 lysyl oxidase-like 2 0.020
THBS4 thrombospondin 4 0.019
DPYSL2 dihydropyrimidinase-like 2 0.019
COL16A1 collagen, type XVI, alpha 1 0.019
CRIP2 cysteine-rich protein 2 0.019
BMP1 bone morphogenetic protein 1 0.019
LAMP1 lysosomal-associated membrane protein 1 0.019
EDNRA endothelin receptor type A 0.019
EMD emerin 0.019
MET met proto-oncogene (hepatocyte growth factor receptor) 0.019
TMEM127 transmembrane protein 127 0.019
JAG1 jagged 1 0.019
TTR transthyretin 0.018
FSTL1 follistatin-like 1 0.018
ASPN asporin 0.017
TWIST1 twist homolog 1 (Drosophila) 0.017
WDYHV1 WDYHV motif containing 1 0.017
IGFBP5 insulin-like growth factor binding protein 5 0.017
FERMT2 fermitin family member 2 0.017
LUM lumican 0.017
CALD1 caldesmon 1 0.017
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
fgf3 fibroblast growth factor 3 0.239
wnt11r wingless-type MMTV integration site family, member 11, related 0.162
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.139
efnb2a ephrin B2a 0.115
robo3 roundabout homolog 3 0.102
foxd3 forkhead box D3 0.100
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.091
igf1rb insulin-like growth factor 1b receptor 0.089
spry2 sprouty homolog 2 0.078
twist1a twist1a 0.070
frzb frizzled-related protein 0.065
col5a1 procollagen, type V, alpha 1 0.053
flh floating head 0.049
appa amyloid beta (A4) precursor protein a 0.045
pea3 ETS-domain transcription factor pea3 0.044
axin2 axin 2 (conductin, axil) 0.044
sulf1 sulfatase 1 0.042
brd4 bromodomain containing 4 0.041
sulf2l sulfatase 2, like 0.041
dusp6 dual specificity phosphatase 6 0.038
sox2 SRY-box containing gene 2 0.037
lmo4a LIM domain only 4a 0.037
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.034
fzd7a frizzled homolog 7a 0.034
spry1 sprouty homolog 1 (Drosophila) 0.033
irx5a iroquois homeobox protein 5a 0.032
dkk1b dickkopf 1b 0.031
zgc:158603 zgc:158603 0.030
ntla no tail a 0.029
sfrp1a secreted frizzled-related protein 1a 0.028
otx1b orthodenticle homolog 1b 0.028
rarga retinoic acid receptor gamma a 0.028
nkd1 naked cuticle homolog 1 (Drosophila) 0.028
ephb4b eph receptor B4b 0.028
tp63 tumor protein p63 0.027
gpc4 glypican 4 0.026
nog1 noggin 1 0.024
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.022
dlx3b distal-less homeobox gene 3b 0.022
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.022
alcama activated leukocyte cell adhesion molecule a 0.022
boc brother of CDO 0.021
zbtb4 zinc finger and BTB domain containing 4 0.021
fgfr2 fibroblast growth factor receptor 2 0.021
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.020
aplp2 amyloid beta (A4) precursor-like protein 2 0.020
lef1 lymphocyte enhancer binding factor 1 0.020
tbx24 T-box 24 0.018
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.018
lama5 laminin, alpha 5 0.017
tob1a transducer of ERBB2, 1a 0.017
pax2b paired box gene 2b 0.017
rnd1l Rho family GTPase 1 like 0.017
acvr1b activin A receptor, type IB 0.017
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.016
znf609 zinc finger protein 609 0.015
foxo3b forkhead box O3b 0.015
bmp4 bone morphogenetic protein 4 0.015
gbx2 gastrulation brain homeo box 2 0.015
rx3 retinal homeobox gene 3 0.015
foxa2 forkhead box A2 0.014
bmp2b bone morphogenetic protein 2b 0.014
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.014
irx3a iroquois homeobox protein 3a 0.014
ihha Indian hedgehog homolog a 0.014
enc1 ectodermal-neural cortex (with BTB-like domain) 0.013
fzd10 frizzled homolog 10 0.013
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.013
alcamb activated leukocyte cell adhesion molecule b 0.013
wnt11 wingless-type MMTV integration site family, member 11 0.013
fgfrl1a fibroblast growth factor receptor-like 1a 0.013
pcdh8 protocadherin 8 0.012
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.012
auts2 autism susceptibility candidate 2 0.012
cntfr ciliary neurotrophic factor receptor 0.012
matn4 matrilin 4 0.012
clstn1 calsyntenin 1 0.012
atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 0.012
gata2a GATA-binding protein 2a 0.012
pcdh18a protocadherin 18a 0.012
cx43 connexin 43 0.012
spry4 sprouty (Drosophila) homolog 4 0.012
foxo3a forkhead box O3A 0.012
prickle1a prickle-like 1 (Drosophila) a 0.012
grhl2b grainyhead-like 2b (Drosophila) 0.011
dag1 dystroglycan 1 0.011
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.011
fzd9b frizzled homolog 9b 0.010
appb amyloid beta (A4) precursor protein b 0.010
ved ventrally expressed dharma/bozozok antagonist 0.010
zgc:63947 zgc:63947 0.010
fgfr1a fibroblast growth factor receptor 1a 0.010
robo1 roundabout homolog 1 0.010
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.010
inka1a induced in neural crest by AP2, 1a 0.010
skia nuclear oncoprotein skia 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
stumps CG31317 gene product from transcript CG31317-RC 0.261
Hs6st Heparan sulfate 6-O-sulfotransferase 0.161
htl heartless 0.156
sr stripe 0.153
ena enabled 0.153
nkd naked cuticle 0.144
Eip75B Ecdysone-induced protein 75B 0.118
fz frizzled 0.103
sfl sulfateless 0.102
Trh Tryptophan hydroxylase 0.095
krz kurtz 0.095
sd scalloped 0.091
Timp Tissue inhibitor of metalloproteases 0.084
Sdc Syndecan 0.075
spen split ends 0.070
step steppke 0.067
pck pickel 0.059
18w 18 wheeler 0.051
kon kon-tiki 0.050
Stim Stromal interaction molecule 0.044
fz2 frizzled 2 0.037
rost rolling stone 0.037
dbr debra 0.035
nmo nemo 0.031
Ubqn Ubiquilin 0.030
Eip93F CG18389 gene product from transcript CG18389-RB 0.029
Hr39 Hormone receptor-like in 39 0.029
dlp dally-like 0.028
bowl brother of odd with entrails limited 0.028
Fas3 Fasciclin 3 0.028
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.027
Ptp61F Protein tyrosine phosphatase 61F 0.023
flfl falafel 0.022
cv crossveinless 0.022
NFAT NFAT homolog 0.022
stwl stonewall 0.021
zfh1 Zn finger homeodomain 1 0.021
Rab23 CG2108 gene product from transcript CG2108-RA 0.021
hipk homeodomain interacting protein kinase 0.021
in inturned 0.020
Tom Twin of m4 0.020
blow blown fuse 0.020
Sulf1 Sulfated 0.019
Cam Calmodulin 0.019
sw short wing 0.019
bon bonus 0.019
Irk2 Inwardly rectifying potassium channel 2 0.018
Rac2 CG8556 gene product from transcript CG8556-RA 0.018
esg escargot 0.017
jumu jumeau 0.017
schlank CG3576 gene product from transcript CG3576-RB 0.017
bnl branchless 0.017
Vrp1 Verprolin 1 0.016
svp seven up 0.016
Ctr1B Copper transporter 1B 0.015
Krn Keren 0.015
wit wishful thinking 0.015
tok tolkin 0.014
wun2 wunen-2 0.014
par-1 CG8201 gene product from transcript CG8201-RA 0.014
NijA Ninjurin A 0.014
sbb scribbler 0.014
Spn77Ba Serpin 77Ba 0.014
egr eiger 0.014
bib big brain 0.013
sls sallimus 0.013
Mmp2 Matrix metalloproteinase 2 0.013
cln3 CG5582 gene product from transcript CG5582-RA 0.013
dan distal antenna 0.013
CycC Cyclin C 0.013
Hmgcr HMG Coenzyme A reductase 0.013
kermit CG11546 gene product from transcript CG11546-RB 0.012
wun wunen 0.012
dgo diego 0.012
rl rolled 0.012
inx3 innexin 3 0.012
dys dysfusion 0.012
CG3194 CG3194 gene product from transcript CG3194-RB 0.011
east enhanced adult sensory threshold 0.011
lmg lemming 0.011
sina seven in absentia 0.011
CG9650 CG9650 gene product from transcript CG9650-RG 0.011
C3G CG42328 gene product from transcript CG42328-RC 0.011
sno strawberry notch 0.011
Ten-m Tenascin major 0.011
Grip Glutamate receptor binding protein 0.011
DAAM Dishevelled Associated Activator of Morphogenesis 0.011
Ptp10D Protein tyrosine phosphatase 10D 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism