The network for 'regulation of humoral immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of humoral immune response

Any process that modulates the frequency, rate, or extent of a humoral immune response.

Homo sapiens
Name Description Probability Func Analog Organism
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.985
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.868
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.810
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.582
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.492
BCL3 B-cell CLL/lymphoma 3 0.422
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.363
C1S complement component 1, s subcomponent 0.339
C1R complement component 1, r subcomponent 0.194
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.140
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.139
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.130
C3 complement component 3 0.128
IL4R interleukin 4 receptor 0.104
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.087
RXRA retinoid X receptor, alpha 0.085
SYK spleen tyrosine kinase 0.081
HLA-DMB major histocompatibility complex, class II, DM beta 0.078
SOX10 SRY (sex determining region Y)-box 10 0.056
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.048
NLRC4 NLR family, CARD domain containing 4 0.044
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.038
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.032
LCK lymphocyte-specific protein tyrosine kinase 0.031
XIAP X-linked inhibitor of apoptosis 0.030
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.024
JUN jun proto-oncogene 0.024
CFH complement factor H 0.024
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.023
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.021
RARA retinoic acid receptor, alpha 0.021
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.021
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.021
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.019
STAP2 signal transducing adaptor family member 2 0.019
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.018
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.017
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.017
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.017
CPNE6 copine VI (neuronal) 0.016
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.016
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.016
CD22 CD22 molecule 0.015
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.014
CFHR1 complement factor H-related 1 0.014
CFI complement factor I 0.013
INSR insulin receptor 0.013
MASP2 mannan-binding lectin serine peptidase 2 0.013
APOE apolipoprotein E 0.012
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.012
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.012
BLNK B-cell linker 0.012
SOCS3 suppressor of cytokine signaling 3 0.012
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.012
HLA-DRA major histocompatibility complex, class II, DR alpha 0.011
IL2RB interleukin 2 receptor, beta 0.010
JUNB jun B proto-oncogene 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rel Relish 0.998
PGRP-LC Peptidoglycan recognition protein LC 0.995
Tl Toll 0.989
SPE Spatzle-Processing Enzyme 0.953
grass Gram-positive Specific Serine protease 0.869
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.857
Spn27A Serpin 27A 0.827
Spn28D Serpin 28D 0.794
AGO2 Argonaute 2 0.730
ird5 immune response deficient 5 0.716
AttA Attacin-A 0.693
Sp7 Serine protease 7 0.664
spz spatzle 0.646
Dredd Death related ced-3/Nedd2-like protein 0.612
ird1 immune response deficient 1 0.590
imd immune deficiency 0.566
PGRP-SA Peptidoglycan recognition protein SA 0.565
fon fondue 0.490
Glt Glutactin 0.431
Myd88 CG2078 gene product from transcript CG2078-RA 0.422
Mpk2 CG5475 gene product from transcript CG5475-RB 0.369
ush u-shaped 0.346
BG4 CG12297 gene product from transcript CG12297-RA 0.327
Nc Nedd2-like caspase 0.263
Mtk Metchnikowin 0.242
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.213
key kenny 0.209
psh persephone 0.208
kay kayak 0.198
nec necrotic 0.188
Spn1 Serine protease inhibitor 1 0.185
pirk poor Imd response upon knock-in 0.182
pnr pannier 0.177
amos absent MD neurons and olfactory sensilla 0.176
th thread 0.155
Irc Immune-regulated catalase 0.153
Ndae1 Na[+]-driven anion exchanger 1 0.142
modSP modular serine protease 0.140
egr eiger 0.139
r2d2 CG7138 gene product from transcript CG7138-RB 0.136
DptB Diptericin B 0.135
ac achaete 0.128
CG32185 CG32185 gene product from transcript CG32185-RA 0.127
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.116
CG9184 CG9184 gene product from transcript CG9184-RB 0.115
drk downstream of receptor kinase 0.112
CG18594 CG18594 gene product from transcript CG18594-RA 0.107
GNBP3 Gram-negative bacteria binding protein 3 0.103
aop anterior open 0.103
sub subito 0.096
CG12766 CG12766 gene product from transcript CG12766-RA 0.093
CG15917 CG15917 gene product from transcript CG15917-RA 0.093
IM18 Immune induced molecule 18 0.092
CG7910 CG7910 gene product from transcript CG7910-RA 0.088
tsl torso-like 0.081
RYBP Ring and YY1 Binding Protein 0.080
tamo CG4057 gene product from transcript CG4057-RA 0.078
spheroide CG9675 gene product from transcript CG9675-RA 0.077
sc scute 0.077
l(3)mbn lethal (3) malignant blood neoplasm 0.073
eater CG6124 gene product from transcript CG6124-RB 0.067
Tab2 TAK1-associated binding protein 2 0.066
Drs Drosomycin 0.065
Pvr PDGF- and VEGF-receptor related 0.064
Ark Apaf-1-related-killer 0.062
bcd bicoid 0.061
hb hunchback 0.059
grn grain 0.058
CG13641 CG13641 gene product from transcript CG13641-RA 0.057
CG17633 CG17633 gene product from transcript CG17633-RA 0.057
Abd-B Abdominal B 0.056
Tak1 TGF-beta activated kinase 1 0.054
dl dorsal 0.054
CG12943 CG12943 gene product from transcript CG12943-RA 0.053
HLHm7 E(spl) region transcript m7 0.053
Atg13 Autophagy-specific gene 13 0.052
GNBP1 Gram-negative bacteria binding protein 1 0.052
klu klumpfuss 0.051
Akt1 CG4006 gene product from transcript CG4006-RA 0.051
Lip3 CG8823 gene product from transcript CG8823-RA 0.050
PGRP-LB Peptidoglycan recognition protein LB 0.049
PGRP-LE Peptidoglycan recognition protein LE 0.049
Lmpt Limpet 0.048
CycD Cyclin D 0.046
HLHmbeta E(spl) region transcript mbeta 0.046
upd2 unpaired 2 0.045
Atg18 Autophagy-specific gene 18 0.044
rpr reaper 0.044
Mekk1 CG7717 gene product from transcript CG7717-RB 0.044
fz2 frizzled 2 0.043
foxo forkhead box, sub-group O 0.043
Duox Dual oxidase 0.042
MED15 Mediator complex subunit 15 0.040
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.040
Sucb CG10622 gene product from transcript CG10622-RA 0.040
gsb-n gooseberry-neuro 0.040
spirit Serine Protease Immune Response Integrator 0.039
upd3 unpaired 3 0.038
SoxN SoxNeuro 0.037
Ice CG7788 gene product from transcript CG7788-RA 0.037
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Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.990
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.951
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.906
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.857
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.764
Lyz2 lysozyme 2 0.682
Ccr2 chemokine (C-C motif) receptor 2 0.643
Ikzf1 IKAROS family zinc finger 1 0.639
Cd19 CD19 antigen 0.564
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.556
Igh immunoglobulin heavy chain complex 0.532
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.396
Lta lymphotoxin A 0.396
Cxcl13 chemokine (C-X-C motif) ligand 13 0.338
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.320
Il1r1 interleukin 1 receptor, type I 0.317
Cd28 CD28 antigen 0.305
Ccr1 chemokine (C-C motif) receptor 1 0.300
Ikbkg inhibitor of kappaB kinase gamma 0.289
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.275
Il2rg interleukin 2 receptor, gamma chain 0.230
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.217
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.199
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.196
Il4 interleukin 4 0.166
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.166
Ikbkb inhibitor of kappaB kinase beta 0.165
Cxcr5 chemokine (C-X-C motif) receptor 5 0.163
Ifng interferon gamma 0.154
Il2 interleukin 2 0.149
Foxp3 forkhead box P3 0.147
Xcr1 chemokine (C motif) receptor 1 0.144
Tcra T-cell receptor alpha chain 0.141
Cd22 CD22 antigen 0.137
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.134
Il10 interleukin 10 0.131
Ltb lymphotoxin B 0.117
Stat5b signal transducer and activator of transcription 5B 0.117
Cd40 CD40 antigen 0.115
Stat5a signal transducer and activator of transcription 5A 0.111
Saa4 serum amyloid A 4 0.110
Il1b interleukin 1 beta 0.109
Ptprc protein tyrosine phosphatase, receptor type, C 0.108
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.099
Cyld cylindromatosis (turban tumor syndrome) 0.098
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.096
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.093
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.091
Il7 interleukin 7 0.085
Fyn Fyn proto-oncogene 0.084
Ccl4 chemokine (C-C motif) ligand 4 0.084
F9 coagulation factor IX 0.080
Socs1 suppressor of cytokine signaling 1 0.078
H2-Eb1 histocompatibility 2, class II antigen E beta 0.076
Ccr5 chemokine (C-C motif) receptor 5 0.064
Ciita class II transactivator 0.064
Cxcr2 chemokine (C-X-C motif) receptor 2 0.063
C1qc complement component 1, q subcomponent, C chain 0.063
Fcgr2b Fc receptor, IgG, low affinity IIb 0.058
Fos FBJ osteosarcoma oncogene 0.056
Sfpi1 SFFV proviral integration 1 0.055
C3ar1 complement component 3a receptor 1 0.054
Akr1c6 aldo-keto reductase family 1, member C6 0.052
Folr2 folate receptor 2 (fetal) 0.051
Spna1 spectrin alpha 1 0.050
Apcs serum amyloid P-component 0.049
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.049
Selp selectin, platelet 0.048
Cdx2 caudal type homeobox 2 0.047
Hrg histidine-rich glycoprotein 0.047
Ccl2 chemokine (C-C motif) ligand 2 0.047
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.047
Pax2 paired box gene 2 0.046
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.046
Cd59a CD59a antigen 0.045
Stat3 signal transducer and activator of transcription 3 0.044
Tlr8 toll-like receptor 8 0.044
Nckap1l NCK associated protein 1 like 0.043
Rxra retinoid X receptor alpha 0.042
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.041
Ccl3 chemokine (C-C motif) ligand 3 0.041
Tnip1 TNFAIP3 interacting protein 1 0.040
Kif19a kinesin family member 19A 0.039
Il15 interleukin 15 0.038
Onecut1 one cut domain, family member 1 0.038
Ccr6 chemokine (C-C motif) receptor 6 0.037
Ifnar1 interferon (alpha and beta) receptor 1 0.037
Inhbe inhibin beta E 0.036
Itgb2 integrin beta 2 0.036
Cd59b CD59b antigen 0.036
Jak3 Janus kinase 3 0.036
Zeb1 zinc finger E-box binding homeobox 1 0.036
Ccr7 chemokine (C-C motif) receptor 7 0.035
Il27ra interleukin 27 receptor, alpha 0.035
Cfh complement component factor h 0.035
Ncr1 natural cytotoxicity triggering receptor 1 0.035
Gata5 GATA binding protein 5 0.034
Cybb cytochrome b-245, beta polypeptide 0.033
Cd44 CD44 antigen 0.031
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.031
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism