The network for 'positive regulation of protein localization to plasma membrane' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein localization to plasma membrane

Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.

Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.998
FHL2 four and a half LIM domains 2 0.914
PRKCZ protein kinase C, zeta 0.461
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.377
SORBS3 sorbin and SH3 domain containing 3 0.362
FN1 fibronectin 1 0.353
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.284
SNAP23 synaptosomal-associated protein, 23kDa 0.271
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.206
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.198
PSEN2 presenilin 2 (Alzheimer disease 4) 0.181
PXN paxillin 0.169
NCF4 neutrophil cytosolic factor 4, 40kDa 0.151
FLNA filamin A, alpha 0.122
KLHL3 kelch-like 3 (Drosophila) 0.115
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.107
GDA guanine deaminase 0.103
PTPRC protein tyrosine phosphatase, receptor type, C 0.096
NOXA1 NADPH oxidase activator 1 0.095
SNAP25 synaptosomal-associated protein, 25kDa 0.086
PDIA3 protein disulfide isomerase family A, member 3 0.084
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.070
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.069
PLEC plectin 0.066
ENG endoglin 0.045
RANBP9 RAN binding protein 9 0.043
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.035
GRB7 growth factor receptor-bound protein 7 0.035
EFNA1 ephrin-A1 0.034
ADAM17 ADAM metallopeptidase domain 17 0.033
EZR ezrin 0.032
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.031
ILK integrin-linked kinase 0.030
MYO10 myosin X 0.029
ZNF746 zinc finger protein 746 0.028
CD63 CD63 molecule 0.027
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.026
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.026
EFNA5 ephrin-A5 0.026
FLNB filamin B, beta 0.025
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.025
LCK lymphocyte-specific protein tyrosine kinase 0.025
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.024
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.024
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.023
EPS8 epidermal growth factor receptor pathway substrate 8 0.023
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.023
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.023
ITGA6 integrin, alpha 6 0.022
SH3RF1 SH3 domain containing ring finger 1 0.022
MSN moesin 0.022
PVRL3 poliovirus receptor-related 3 0.022
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.022
EPHA7 EPH receptor A7 0.022
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.022
ITSN1 intersectin 1 (SH3 domain protein) 0.021
PTCH1 patched 1 0.021
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.018
PICK1 protein interacting with PRKCA 1 0.018
CARD11 caspase recruitment domain family, member 11 0.017
CDCP1 CUB domain containing protein 1 0.017
FHL3 four and a half LIM domains 3 0.017
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.017
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.017
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.017
SPAG9 sperm associated antigen 9 0.016
TSC22D4 TSC22 domain family, member 4 0.016
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.016
PRKCB protein kinase C, beta 0.016
NUMB numb homolog (Drosophila) 0.016
CD9 CD9 molecule 0.015
ITGB5 integrin, beta 5 0.015
RAB11FIP2 RAB11 family interacting protein 2 (class I) 0.014
ANGPTL4 angiopoietin-like 4 0.014
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.013
TLN1 talin 1 0.013
LGALS1 lectin, galactoside-binding, soluble, 1 0.013
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.013
JUP junction plakoglobin 0.012
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.012
RHOC ras homolog gene family, member C 0.012
F11R F11 receptor 0.012
SFN stratifin 0.012
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.012
LMO2 LIM domain only 2 (rhombotin-like 1) 0.012
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.012
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.011
PKP3 plakophilin 3 0.011
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.011
CTGF connective tissue growth factor 0.011
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.011
RDX radixin 0.011
ZNF71 zinc finger protein 71 0.011
DGCR14 DiGeorge syndrome critical region gene 14 0.010
ICAM1 intercellular adhesion molecule 1 0.010
OXSR1 oxidative-stress responsive 1 0.010
GRB10 growth factor receptor-bound protein 10 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.795
Rac1 CG2248 gene product from transcript CG2248-RA 0.367
mys myospheroid 0.287
crb crumbs 0.234
Pten CG5671 gene product from transcript CG5671-RB 0.190
Ras85D Ras oncogene at 85D 0.168
Cdc42 CG12530 gene product from transcript CG12530-RA 0.165
Rab11 Rab-protein 11 0.165
Pk61C Protein kinase 61C 0.150
scb scab 0.142
Dad Daughters against dpp 0.137
baz bazooka 0.132
Gug Grunge 0.127
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.125
G-oalpha47A G protein oalpha 47A 0.114
S6k RPS6-p70-protein kinase 0.109
par-1 CG8201 gene product from transcript CG8201-RA 0.100
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.091
Ephrin CG1862 gene product from transcript CG1862-RA 0.076
Rho1 CG8416 gene product from transcript CG8416-RB 0.069
slmb supernumerary limbs 0.068
Arp66B Actin-related protein 66B 0.068
Moe Moesin 0.068
InR Insulin-like receptor 0.061
Nrx-IV Neurexin IV 0.058
sxc super sex combs 0.057
Rab5 Rab-protein 5 0.055
put punt 0.053
Pkn Protein kinase related to protein kinase N 0.053
Rheb CG1081 gene product from transcript CG1081-RA 0.053
wun wunen 0.051
if inflated 0.050
aux auxillin 0.047
dia diaphanous 0.046
CaMKII Calcium/calmodulin-dependent protein kinase II 0.042
Rala Ras-related protein 0.042
Su(H) Suppressor of Hairless 0.041
Atg1 Autophagy-specific gene 1 0.039
rhea CG6831 gene product from transcript CG6831-RA 0.037
stai stathmin 0.036
tkv thickveins 0.034
arr arrow 0.034
hpo hippo 0.033
emc extra macrochaetae 0.031
Fak56D Focal Adhesion Kinase 0.031
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.030
gbb glass bottom boat 0.029
Syx1A Syntaxin 1A 0.029
gig gigas 0.029
wb wing blister 0.029
EcR Ecdysone receptor 0.028
fog folded gastrulation 0.027
ttk tramtrack 0.027
Lis-1 Lissencephaly-1 0.027
Akt1 CG4006 gene product from transcript CG4006-RA 0.026
cpa capping protein alpha 0.025
kuz kuzbanian 0.025
NetB Netrin-B 0.025
fng fringe 0.025
msn misshapen 0.024
Ank2 Ankyrin 2 0.024
dm diminutive 0.024
l(2)gl lethal (2) giant larvae 0.024
cdm cadmus 0.024
how held out wings 0.023
vri vrille 0.023
zip zipper 0.023
egl egalitarian 0.022
sgg shaggy 0.021
Cip4 CG15015 gene product from transcript CG15015-RA 0.020
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.020
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.019
chic chickadee 0.018
puc puckered 0.018
kon kon-tiki 0.018
vib vibrator 0.018
sd scalloped 0.018
Dlic Dynein light intermediate chain 0.018
shn schnurri 0.018
LanA Laminin A 0.017
endoA endophilin A 0.017
Nrg Neuroglian 0.016
CG15609 CG15609 gene product from transcript CG15609-RE 0.016
sr stripe 0.015
Stat92E Signal-transducer and activator of transcription protein at 92E 0.015
Tak1 TGF-beta activated kinase 1 0.015
bsk basket 0.015
Mef2 Myocyte enhancer factor 2 0.015
Vinc Vinculin 0.015
Btk29A Btk family kinase at 29A 0.015
Ank Ankyrin 0.015
NFAT NFAT homolog 0.014
frc fringe connection 0.014
shot short stop 0.014
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.014
Vrp1 Verprolin 1 0.014
Csp Cysteine string protein 0.014
Chc Clathrin heavy chain 0.014
Tao-1 CG14217 gene product from transcript CG14217-RF 0.014
Stam Signal transducing adaptor molecule 0.013
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Mus musculus
Name Description Probability Func Analog Organism
Nrxn3 neurexin III 0.852
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.655
Nrxn1 neurexin I 0.459
Nrxn2 neurexin II 0.259
Lama5 laminin, alpha 5 0.213
Gsk3b glycogen synthase kinase 3 beta 0.172
Ilk integrin linked kinase 0.111
Ptk2 PTK2 protein tyrosine kinase 2 0.110
Cd151 CD151 antigen 0.106
Itga3 integrin alpha 3 0.078
Psen1 presenilin 1 0.072
Nf1 neurofibromatosis 1 0.067
Kif3a kinesin family member 3A 0.061
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.060
Ctnnb1 catenin (cadherin associated protein), beta 1 0.057
Stx12 syntaxin 12 0.056
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.042
Dlg4 discs, large homolog 4 (Drosophila) 0.040
Spag9 sperm associated antigen 9 0.036
Cbln1 cerebellin 1 precursor protein 0.035
Itga6 integrin alpha 6 0.035
Ctnnd1 catenin (cadherin associated protein), delta 1 0.032
Gja1 gap junction protein, alpha 1 0.031
Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma 0.030
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.030
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.029
Prss8 protease, serine, 8 (prostasin) 0.027
Src Rous sarcoma oncogene 0.027
Grid2 glutamate receptor, ionotropic, delta 2 0.026
Akt1 thymoma viral proto-oncogene 1 0.026
Vasp vasodilator-stimulated phosphoprotein 0.024
Zeb1 zinc finger E-box binding homeobox 1 0.024
Ldb3 LIM domain binding 3 0.024
Txndc17 thioredoxin domain containing 17 0.023
Vhl von Hippel-Lindau tumor suppressor 0.022
Cdh1 cadherin 1 0.020
Ptch1 patched homolog 1 0.020
Rarg retinoic acid receptor, gamma 0.020
Tjap1 tight junction associated protein 1 0.018
Klc1 kinesin light chain 1 0.016
Vegfa vascular endothelial growth factor A 0.016
Ptp4a2 protein tyrosine phosphatase 4a2 0.016
Spint1 serine protease inhibitor, Kunitz type 1 0.016
Fgfr2 fibroblast growth factor receptor 2 0.016
Lmna lamin A 0.014
Ctnna1 catenin (cadherin associated protein), alpha 1 0.014
Adrbk1 adrenergic receptor kinase, beta 1 0.014
Fgfr1 fibroblast growth factor receptor 1 0.014
Blnk B-cell linker 0.014
Bcl2 B-cell leukemia/lymphoma 2 0.014
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.014
Krt7 keratin 7 0.014
Hif1a hypoxia inducible factor 1, alpha subunit 0.013
Efnb2 ephrin B2 0.013
Prr13 proline rich 13 0.013
Ltbr lymphotoxin B receptor 0.013
Sh3bgrl3 SH3 domain binding glutamic acid-rich protein-like 3 0.013
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.013
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.012
Mapkapk2 MAP kinase-activated protein kinase 2 0.012
Capn1 calpain 1 0.012
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.012
Cdc42se1 CDC42 small effector 1 0.012
Kcnk1 potassium channel, subfamily K, member 1 0.012
Arpc4 actin related protein 2/3 complex, subunit 4 0.012
Vangl2 vang-like 2 (van gogh, Drosophila) 0.012
Nrcam neuron-glia-CAM-related cell adhesion molecule 0.012
Rala v-ral simian leukemia viral oncogene homolog A (ras related) 0.011
Eea1 early endosome antigen 1 0.011
Stxbp2 syntaxin binding protein 2 0.011
Capn5 calpain 5 0.011
Tubb4 tubulin, beta 4 0.011
Apc adenomatosis polyposis coli 0.011
Prkce protein kinase C, epsilon 0.011
Wasf2 WAS protein family, member 2 0.011
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.011
Dlg1 discs, large homolog 1 (Drosophila) 0.011
Tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.010
Numb numb gene homolog (Drosophila) 0.010
Tln1 talin 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism