The network for 'response to nicotine' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to nicotine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 0.976
BCL2L1 BCL2-like 1 0.974
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.774
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.557
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.285
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.265
DRD2 dopamine receptor D2 0.260
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.193
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.183
VAC14 Vac14 homolog (S. cerevisiae) 0.155
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.146
APAF1 apoptotic peptidase activating factor 1 0.113
ADORA2A adenosine A2a receptor 0.111
PLAU plasminogen activator, urokinase 0.102
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.084
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.082
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.078
PRSS2 protease, serine, 2 (trypsin 2) 0.068
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.068
NCOR2 nuclear receptor corepressor 2 0.064
ITGB1BP3 integrin beta 1 binding protein 3 0.054
CHD9 chromodomain helicase DNA binding protein 9 0.053
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.051
TGFB1 transforming growth factor, beta 1 0.048
PLAUR plasminogen activator, urokinase receptor 0.046
TNIP2 TNFAIP3 interacting protein 2 0.042
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.040
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.039
BCL3 B-cell CLL/lymphoma 3 0.037
IGF2R insulin-like growth factor 2 receptor 0.037
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.036
NGF nerve growth factor (beta polypeptide) 0.034
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.031
PLAT plasminogen activator, tissue 0.031
BAK1 BCL2-antagonist/killer 1 0.029
TRADD TNFRSF1A-associated via death domain 0.024
PICK1 protein interacting with PRKCA 1 0.024
TIMP2 TIMP metallopeptidase inhibitor 2 0.022
TRAF1 TNF receptor-associated factor 1 0.019
THBS1 thrombospondin 1 0.019
RNF144B ring finger protein 144B 0.018
XIAP X-linked inhibitor of apoptosis 0.017
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.017
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.016
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.015
TRAF2 TNF receptor-associated factor 2 0.015
RNR2 l-rRNA 0.014
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.014
WT1 Wilms tumor 1 0.014
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.013
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.012
TNIP1 TNFAIP3 interacting protein 1 0.012
ORM1 orosomucoid 1 0.011
MSN moesin 0.011
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.011
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.011
LAT linker for activation of T cells 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.704
uts1 urotensin 1 0.580
drd2b dopamine receptor D2b 0.532
dab1a disabled homolog 1a (Drosophila) 0.522
avpl arginine vasopressin-like 0.415
drd2l dopamine receptor D2 like 0.336
tfe3b transcription factor binding to IGHM enhancer 3b 0.292
wnt9b wingless-type MMTV integration site family, member 9B 0.252
wnt10a wingless-type MMTV integration site family, member 10a 0.225
drd3 dopamine receptor D3 0.213
gfra1b gdnf family receptor alpha 1b 0.210
sim1a single-minded homolog 1a (Drosophila) 0.208
dbh dopamine beta hydroxylase 0.197
pgd phosphogluconate hydrogenase 0.171
satb2 SATB homeobox 2 0.169
chrna4 cholinergic receptor, nicotinic, alpha 4 0.168
gria2b glutamate receptor, ionotropic, AMPA 2b 0.158
ins preproinsulin 0.156
gdnf glial cell derived neurotrophic factor 0.138
sst2 somatostatin 2 0.131
prl prolactin 0.127
snapc1b small nuclear RNA activating complex, polypeptide 1b 0.119
ctsz cathepsin Z 0.118
lhx3 LIM homeobox 3 0.113
efna5b ephrin A5b 0.110
crestin crestin 0.109
oxtl oxytocin-like 0.096
spon1a spondin 1a 0.091
gh1 growth hormone 1 0.088
arx aristaless related homeobox 0.082
wnt9a wingless-type MMTV integration site family, member 9A 0.077
si:ch211-212m21.5 si:ch211-212m21.5 0.076
pou4f2 POU domain, class 4, transcription factor 2 0.075
glra1 glycine receptor, alpha 1 0.069
mnx1 motor neuron and pancreas homeobox 1 0.069
per2 period homolog 2 (Drosophila) 0.066
gli2b GLI-Kruppel family member GLI2b 0.063
adra2c adrenergic, alpha-2C-, receptor 0.062
tgfb3 transforming growth factor, beta 3 0.062
nadl1.2 neural adhesion molecule L1.2 0.060
gad2 glutamate decarboxylase 2 0.057
nkx6.2 NK6 transcription factor related, locus 2 0.056
mc4r melanocortin 4 receptor 0.055
ctrb1 chymotrypsinogen B1 0.054
stc1l stanniocalcin 1, like 0.053
pax7a paired box gene 7a 0.049
gfra1a gdnf family receptor alpha 1a 0.048
wu:fc31g04 wu:fc31g04 0.048
chpf chondroitin polymerizing factor 0.048
tfeb transcription factor EB 0.047
npas2 neuronal PAS domain protein 2 0.046
ncam1b neural cell adhesion molecule 1b 0.045
th tyrosine hydroxylase 0.045
ela2l elastase 2 like 0.044
ryr2a ryanodine receptor 2a (cardiac) 0.043
fgf20a fibroblast growth factor 20a 0.041
nog3 noggin 3 0.040
hlxb9la homeo box HB9 like a 0.040
sst1.1 somatostatin 1, tandem duplicate 1 0.038
hcrt hypocretin (orexin) neuropeptide precursor 0.038
adipor1b adiponectin receptor 1b 0.038
flj13639 flj13639 0.037
otpa orthopedia homolog a 0.037
nadl1.1 neural adhesion molecule L1.1 0.037
pax4 paired box 4 0.036
stap2b signal transducing adaptor family member 2b 0.036
ctgf connective tissue growth factor 0.035
rel v-rel reticuloendotheliosis viral oncogene homolog 0.035
cnr1 cannabinoid receptor 1 0.035
th2 tyrosine hydroxylase 2 0.035
tln1 talin 1 0.033
mchr1a melanin-concentrating hormone receptor 1a 0.033
rhogb ras homolog gene family, member Gb 0.033
rx1 retinal homeobox gene 1 0.033
drd1 dopamine receptor D1 0.033
sox4b SRY-box containing gene 4b 0.033
gcga glucagon a and glucagon a-like 0.033
sema3ab semaphorin 3ab 0.032
prkcz protein kinase C, zeta 0.032
LOC790901 glucose-dependent insulinotropic polypeptide 0.031
cbr1l carbonyl reductase 1-like 0.031
adra2a adrenergic, alpha-2A-, receptor 0.031
grin1a glutamate receptor, ionotropic, N-methyl D-aspartate 1a 0.030
rpl9 ribosomal protein L9 0.030
gdf6b growth differentiation factor 6b 0.030
pcp4a Purkinje cell protein 4a 0.030
si:dkey-78p20.2 si:dkey-78p20.2 0.029
ela3l elastase 3 like 0.029
tbx15 T-box 15 0.028
cldnk claudin k 0.027
ncam2 neural cell adhesion molecule 2 0.027
chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 0.027
zgc:66382 zgc:66382 0.027
ca2 carbonic anhydrase II 0.026
caspa caspase a 0.026
slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.026
bmp7b bone morphogenetic protein 7b 0.026
cx27.5 connexin 27.5 0.026
mtnr1ba melatonin receptor type 1B a 0.025
nrp1b neuropilin 1b 0.025
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Drd2 dopamine receptor D2 0.770
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.687
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.352
Gpi1 glucose phosphate isomerase 1 0.328
Col1a1 collagen, type I, alpha 1 0.306
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.266
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.265
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.261
Gm5506 predicted gene 5506 0.252
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.232
Plat plasminogen activator, tissue 0.221
Pitx3 paired-like homeodomain transcription factor 3 0.185
Cd44 CD44 antigen 0.164
Tpi1 triosephosphate isomerase 1 0.145
Nos2 nitric oxide synthase 2, inducible 0.143
Nos3 nitric oxide synthase 3, endothelial cell 0.135
Ache acetylcholinesterase 0.134
Stat3 signal transducer and activator of transcription 3 0.129
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.106
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.095
Ldha lactate dehydrogenase A 0.091
Csf1 colony stimulating factor 1 (macrophage) 0.073
Grm1 glutamate receptor, metabotropic 1 0.071
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.065
Irf1 interferon regulatory factor 1 0.065
Gcgr glucagon receptor 0.063
Pkm2 pyruvate kinase, muscle 0.062
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.060
Onecut1 one cut domain, family member 1 0.055
Mybph myosin binding protein H 0.054
Dbh dopamine beta hydroxylase 0.051
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.050
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.050
Npy1r neuropeptide Y receptor Y1 0.047
Insm1 insulinoma-associated 1 0.047
Grb10 growth factor receptor bound protein 10 0.046
Vdr vitamin D receptor 0.045
Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) 0.045
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.043
Ccl2 chemokine (C-C motif) ligand 2 0.042
Fbn1 fibrillin 1 0.042
Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 0.040
Lhx3 LIM homeobox protein 3 0.039
Esr1 estrogen receptor 1 (alpha) 0.039
Adam17 a disintegrin and metallopeptidase domain 17 0.038
Pomc pro-opiomelanocortin-alpha 0.037
Snca synuclein, alpha 0.036
Gal galanin 0.035
Ins2 insulin II 0.034
C1ql1 complement component 1, q subcomponent-like 1 0.033
Il10 interleukin 10 0.032
Stat6 signal transducer and activator of transcription 6 0.032
Dcc deleted in colorectal carcinoma 0.031
Apoe apolipoprotein E 0.031
Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10 0.031
Icam1 intercellular adhesion molecule 1 0.030
Cplx1 complexin 1 0.030
Myog myogenin 0.029
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.028
Ctrb1 chymotrypsinogen B1 0.028
Prop1 paired like homeodomain factor 1 0.028
En1 engrailed 1 0.028
Gabbr2 gamma-aminobutyric acid (GABA) B receptor, 2 0.027
Oprm1 opioid receptor, mu 1 0.027
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.025
Gzmm granzyme M (lymphocyte met-ase 1) 0.024
Slc18a3 solute carrier family 18 (vesicular monoamine), member 3 0.023
Il13 interleukin 13 0.023
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.022
Timp3 tissue inhibitor of metalloproteinase 3 0.022
Ldlr low density lipoprotein receptor 0.021
Lox lysyl oxidase 0.021
Ebf3 early B-cell factor 3 0.020
Egfr epidermal growth factor receptor 0.020
Gdnf glial cell line derived neurotrophic factor 0.020
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.018
Opn1mw opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) 0.018
Fas Fas (TNF receptor superfamily member 6) 0.018
Phox2a paired-like homeobox 2a 0.018
Ifng interferon gamma 0.018
Myod1 myogenic differentiation 1 0.017
Adora2a adenosine A2a receptor 0.017
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.016
Iqgap1 IQ motif containing GTPase activating protein 1 0.016
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.015
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.015
Nxnl2 nucleoredoxin-like 2 0.015
Ecel1 endothelin converting enzyme-like 1 0.015
Mab21l2 mab-21-like 2 (C. elegans) 0.015
Osmr oncostatin M receptor 0.015
Rapsn receptor-associated protein of the synapse 0.014
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.014
Try5 trypsin 5 0.014
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.014
Grid1 glutamate receptor, ionotropic, delta 1 0.014
Sema5b sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.014
Oc90 otoconin 90 0.014
Pax1 paired box gene 1 0.014
Smyd1 SET and MYND domain containing 1 0.014
Trpm5 transient receptor potential cation channel, subfamily M, member 5 0.014
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Rattus norvegicus
Name Description Probability Func Analog Organism
Mag myelin-associated glycoprotein 0.661
Col3a1 collagen, type III, alpha 1 0.348
Ephx1 epoxide hydrolase 1, microsomal 0.328
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.314
Gstm1 glutathione S-transferase mu 1 0.307
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.296
Gsta3 glutathione S-transferase A3 0.237
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.234
Col1a1 collagen, type I, alpha 1 0.229
Trhr2 thyrotropin releasing hormone receptor 2 0.220
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.214
Mgst1 microsomal glutathione S-transferase 1 0.204
Ppard peroxisome proliferator-activated receptor delta 0.204
Mobp myelin-associated oligodendrocyte basic protein 0.185
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.182
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.173
Scnn1g sodium channel, nonvoltage-gated 1, gamma 0.165
Gabbr1 gamma-aminobutyric acid (GABA) B receptor 1 0.158
Gpr12 G protein-coupled receptor 12 0.157
Gzmf granzyme F 0.157
Mos Moloney sarcoma oncogene 0.154
Psp parotid secretory protein 0.152
Prss1 protease, serine, 1 (trypsin 1) 0.141
Gja6 gap junction protein, alpha 6 0.134
Nlgn3 neuroligin 3 0.132
Col5a2 collagen, type V, alpha 2 0.131
Chrna3 cholinergic receptor, nicotinic, alpha 3 0.130
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.130
Acaa1b acetyl-Coenzyme A acyltransferase 1B 0.128
Mstn myostatin 0.126
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.125
Lep leptin 0.125
LOC494499 LOC494499 protein 0.123
Tmem79 transmembrane protein 79 0.123
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.123
Sprr3 small proline-rich protein 3 0.122
Slc22a25 solute carrier family 22, member 25 0.110
COX3 cytochrome c oxidase subunit 3 0.108
Dio2 deiodinase, iodothyronine, type II 0.108
Prl8a2 prolactin family 8, subfamily a, member 2 0.108
Loxl1 lysyl oxidase-like 1 0.106
Grid1 glutamate receptor, ionotropic, delta 1 0.104
Nrg1 neuregulin 1 0.102
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.101
Reg3g regenerating islet-derived 3 gamma 0.101
Prm3 protamine 3 0.097
Vip vasoactive intestinal peptide 0.095
Fev FEV (ETS oncogene family) 0.094
Dpys dihydropyrimidinase 0.093
Faim2 Fas apoptotic inhibitory molecule 2 0.093
Tac1 tachykinin 1 0.092
Megf6 multiple EGF-like-domains 6 0.092
Slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.091
Lim2 lens intrinsic membrane protein 2 0.089
Cela2a chymotrypsin-like elastase family, member 2A 0.089
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.089
Gja1 gap junction protein, alpha 1 0.087
Esr2 estrogen receptor 2 (ER beta) 0.087
Cxcl2 chemokine (C-X-C motif) ligand 2 0.084
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.084
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.082
Pdyn prodynorphin 0.082
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.081
Kcnd3 potassium voltage-gated channel, Shal-related subfamily, member 3 0.080
Hap1 huntingtin-associated protein 1 0.079
Col1a2 collagen, type I, alpha 2 0.079
Sycn syncollin 0.079
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.078
Gfra2 GDNF family receptor alpha 2 0.077
Rgs8 regulator of G-protein signaling 8 0.077
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.077
Impg2 interphotoreceptor matrix proteoglycan 2 0.076
LOC60591 calcium-activated potassium channel beta subunit 0.076
Fgf17 fibroblast growth factor 17 0.076
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.076
Irx1 iroquois homeobox 1 0.075
Arc activity-regulated cytoskeleton-associated protein 0.075
Acan aggrecan 0.074
Olr1361 olfactory receptor 1361 0.074
Sstr1 somatostatin receptor 1 0.073
Hnmt histamine N-methyltransferase 0.072
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.072
Pkm2 pyruvate kinase, muscle 0.072
Catsper2 cation channel, sperm associated 2 0.071
Mycs myc-like oncogene, s-myc protein 0.070
Gzmc granzyme C 0.070
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.070
Dlg4 discs, large homolog 4 (Drosophila) 0.070
Pde3a phosphodiesterase 3A, cGMP inhibited 0.070
Lcn5 lipocalin 5 0.069
Mrgprf MAS-related GPR, member F 0.068
Fut1 fucosyltransferase 1 0.068
Ccl20 chemokine (C-C motif) ligand 20 0.068
Defb4 defensin beta 4 0.068
Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 0.068
Calca calcitonin-related polypeptide alpha 0.067
Slc22a6 solute carrier family 22 (organic anion transporter), member 6 0.067
LOC687536 similar to Forkhead box protein F1 (Forkhead-related protein FKHL5) (Forkhead-related transcription factor 1) (FREAC-1) (Hepatocyte nuclear factor 3 forkhead homolog 8) (HFH-8) 0.067
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.066
Foxd3 forkhead box D3 0.066
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism