The network for 'regulation of epidermal cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of epidermal cell differentiation

Any process that modulates the frequency, rate or extent of epidermal cell differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Notch1 Notch gene homolog 1 (Drosophila) 1.000
Shh sonic hedgehog 0.999
Pax6 paired box gene 6 0.994
Foxc1 forkhead box C1 0.992
Neurod1 neurogenic differentiation 1 0.989
Emx1 empty spiracles homolog 1 (Drosophila) 0.985
Pten phosphatase and tensin homolog 0.978
Otx2 orthodenticle homolog 2 (Drosophila) 0.963
Hand2 heart and neural crest derivatives expressed transcript 2 0.961
Trp63 transformation related protein 63 0.959
Gli3 GLI-Kruppel family member GLI3 0.933
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.921
Sox2 SRY-box containing gene 2 0.906
Jag1 jagged 1 0.902
Lhx3 LIM homeobox protein 3 0.902
Egfr epidermal growth factor receptor 0.899
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.862
Ldb3 LIM domain binding 3 0.862
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.862
Fgfr2 fibroblast growth factor receptor 2 0.852
Gata4 GATA binding protein 4 0.852
Isl1 ISL1 transcription factor, LIM/homeodomain 0.844
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.841
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.820
Foxg1 forkhead box G1 0.809
Dlx3 distal-less homeobox 3 0.805
Krt14 keratin 14 0.801
Pitx2 paired-like homeodomain transcription factor 2 0.779
Hes1 hairy and enhancer of split 1 (Drosophila) 0.774
Hes5 hairy and enhancer of split 5 (Drosophila) 0.764
Trp53 transformation related protein 53 0.698
Rpgrip1l Rpgrip1-like 0.682
En1 engrailed 1 0.681
Tcfap2a transcription factor AP-2, alpha 0.676
Krt71 keratin 71 0.656
Efnb2 ephrin B2 0.655
Sprr1a small proline-rich protein 1A 0.652
Krt5 keratin 5 0.635
Rb1 retinoblastoma 1 0.622
Krt8 keratin 8 0.604
Notch2 Notch gene homolog 2 (Drosophila) 0.597
Krt35 keratin 35 0.596
Prrx1 paired related homeobox 1 0.593
Psen1 presenilin 1 0.572
Krt85 keratin 85 0.553
Pkp1 plakophilin 1 0.543
Pitx1 paired-like homeodomain transcription factor 1 0.517
Eya1 eyes absent 1 homolog (Drosophila) 0.513
Wnt3a wingless-related MMTV integration site 3A 0.510
Padi3 peptidyl arginine deiminase, type III 0.508
Foxc2 forkhead box C2 0.502
Neurog2 neurogenin 2 0.490
Psapl1 prosaposin-like 1 0.486
Krt33b keratin 33B 0.484
Fgf8 fibroblast growth factor 8 0.471
Pax3 paired box gene 3 0.468
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.466
Kiss1 KiSS-1 metastasis-suppressor 0.465
Chd7 chromodomain helicase DNA binding protein 7 0.443
Ptf1a pancreas specific transcription factor, 1a 0.443
Krt17 keratin 17 0.422
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.416
Krtap8-1 keratin associated protein 8-1 0.407
Irf6 interferon regulatory factor 6 0.402
Tlx3 T-cell leukemia, homeobox 3 0.383
Dlx5 distal-less homeobox 5 0.373
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.372
Twist2 twist homolog 2 (Drosophila) 0.368
Krt6a keratin 6A 0.364
Krt36 keratin 36 0.350
Nhlh1 nescient helix loop helix 1 0.342
Krtdap keratinocyte differentiation associated protein 0.341
Krt15 keratin 15 0.340
Fshr follicle stimulating hormone receptor 0.336
Etv4 ets variant gene 4 (E1A enhancer binding protein, E1AF) 0.329
Hand1 heart and neural crest derivatives expressed transcript 1 0.318
Krt27 keratin 27 0.316
S100a14 S100 calcium binding protein A14 0.315
Dll1 delta-like 1 (Drosophila) 0.310
Cdsn corneodesmosin 0.304
Hr hairless 0.292
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.286
Tgfb2 transforming growth factor, beta 2 0.286
Dlx2 distal-less homeobox 2 0.277
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.275
Dsc3 desmocollin 3 0.275
Krt13 keratin 13 0.254
Ctnnb1 catenin (cadherin associated protein), beta 1 0.249
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.245
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.240
Lgals7 lectin, galactose binding, soluble 7 0.232
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.227
Epha2 Eph receptor A2 0.227
Krt31 keratin 31 0.220
Ptch2 patched homolog 2 0.220
Krt19 keratin 19 0.211
Krtap3-1 keratin associated protein 3-1 0.208
Lhx5 LIM homeobox protein 5 0.206
Msx2 homeobox, msh-like 2 0.202
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.196
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
C15C7.5 Protein C15C7.5 0.014
C18D11.1 Protein C18D11.1 0.013
gta-1 Protein GTA-1 0.013
ain-1 Protein AIN-1 0.012
grl-7 Protein GRL-7 0.012
erd-2 Protein ERD-2 0.011
dre-1 Protein DRE-1 0.011
dhs-28 Protein DHS-28 0.011
F56A8.5 Protein F56A8.5 0.010
F36A2.2 Protein F36A2.2 0.010
nkb-3 Protein NKB-3 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Dl Delta 0.657
E(spl) Enhancer of split 0.203
Nrx-IV Neurexin IV 0.176
CycE Cyclin E 0.146
sens senseless 0.111
Moe Moesin 0.087
ed echinoid 0.083
CG12424 CG12424 gene product from transcript CG12424-RC 0.076
Tak1 TGF-beta activated kinase 1 0.075
hh hedgehog 0.068
arm armadillo 0.060
Su(H) Suppressor of Hairless 0.053
ro rough 0.049
Mad Mothers against dpp 0.048
Pk61C Protein kinase 61C 0.048
l(2)gl lethal (2) giant larvae 0.044
spo spook 0.043
wg wingless 0.041
brk brinker 0.041
Atx2 Ataxin-2 0.039
rl rolled 0.038
east enhanced adult sensory threshold 0.038
lz lozenge 0.035
Dcr-1 Dicer-1 0.035
mi minus 0.035
dlt discs lost 0.034
drosha CG8730 gene product from transcript CG8730-RA 0.034
shg shotgun 0.033
Notum CG13076 gene product from transcript CG13076-RB 0.032
ase asense 0.031
hpo hippo 0.030
stg string 0.030
RpII215 RNA polymerase II 215kD subunit 0.029
dm diminutive 0.029
ham hamlet 0.028
Rac1 CG2248 gene product from transcript CG2248-RA 0.027
MTF-1 Metal response element-binding Transcription Factor-1 0.027
Ubx Ultrabithorax 0.026
CG9772 CG9772 gene product from transcript CG9772-RB 0.026
ptc patched 0.026
N Notch 0.026
Rab23 CG2108 gene product from transcript CG2108-RA 0.025
JhI-1 Juvenile hormone-inducible protein 1 0.025
Ras85D Ras oncogene at 85D 0.025
klar klarsicht 0.025
Rho1 CG8416 gene product from transcript CG8416-RB 0.025
Parp Poly-(ADP-ribose) polymerase 0.025
Ric Ras which interacts with Calmodulin 0.025
unc uncoordinated 0.024
H Hairless 0.023
trbl tribbles 0.023
bou boudin 0.022
Elongin-C Elongin C 0.021
Gef26 CG9491 gene product from transcript CG9491-RB 0.021
Crag Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein 0.021
CG6770 CG6770 gene product from transcript CG6770-RA 0.021
tll tailless 0.020
pxb CG33207 gene product from transcript CG33207-RB 0.020
ssh slingshot 0.020
Pten CG5671 gene product from transcript CG5671-RB 0.020
btsz bitesize 0.020
pan pangolin 0.020
Rab11 Rab-protein 11 0.020
wdb widerborst 0.020
Lam Lamin 0.020
spir spire 0.019
dib disembodied 0.019
Tsc1 CG6147 gene product from transcript CG6147-RA 0.019
poly CG9829 gene product from transcript CG9829-RB 0.019
luna CG33473 gene product from transcript CG33473-RB 0.019
CG11055 CG11055 gene product from transcript CG11055-RB 0.019
CG17059 CG17059 gene product from transcript CG17059-RA 0.019
Akt1 CG4006 gene product from transcript CG4006-RA 0.019
m4 E(spl) region transcript m4 0.019
sna snail 0.018
ac achaete 0.018
ex expanded 0.018
pyd polychaetoid 0.018
Mekk1 CG7717 gene product from transcript CG7717-RB 0.018
in inturned 0.018
CG18316 CG18316 gene product from transcript CG18316-RA 0.018
sgl sugarless 0.018
Peb Protein ejaculatory bulb 0.018
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.017
Tom Twin of m4 0.017
ovo CG6824 gene product from transcript CG6824-RE 0.017
Mt2 Methyltransferase 2 0.017
Acyp2 Acylphosphatase 2 0.017
Hcf Host cell factor 0.017
comm commissureless 0.017
jim CG11352 gene product from transcript CG11352-RB 0.017
CG5741 CG5741 gene product from transcript CG5741-RC 0.017
lqfR liquid facets-Related 0.017
sav salvador 0.017
eyg eyegone 0.016
noc no ocelli 0.016
CG31531 CG31531 gene product from transcript CG31531-RC 0.016
HLHm5 E(spl) region transcript m5 0.016
klu klumpfuss 0.016
zen zerknullt 0.016
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Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 0.876
NCOA1 nuclear receptor coactivator 1 0.735
NME2 non-metastatic cells 2, protein (NM23B) expressed in 0.689
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.510
HOXB5 homeobox B5 0.448
CREBBP CREB binding protein 0.349
ZNF746 zinc finger protein 746 0.280
BMPR1A bone morphogenetic protein receptor, type IA 0.201
NCOR2 nuclear receptor corepressor 2 0.156
NCOA3 nuclear receptor coactivator 3 0.153
HOXA5 homeobox A5 0.133
TJP1 tight junction protein 1 (zona occludens 1) 0.131
HOXA10 homeobox A10 0.106
BBS10 Bardet-Biedl syndrome 10 0.105
RXRA retinoid X receptor, alpha 0.099
EP300 E1A binding protein p300 0.097
JAG1 jagged 1 0.096
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.094
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.092
PTK2 PTK2 protein tyrosine kinase 2 0.091
HNF4A hepatocyte nuclear factor 4, alpha 0.080
HOXA7 homeobox A7 0.074
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.057
NCL nucleolin 0.052
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.051
HOXB6 homeobox B6 0.051
HOXB3 homeobox B3 0.049
NCOR1 nuclear receptor corepressor 1 0.048
FSTL1 follistatin-like 1 0.048
NOTCH3 notch 3 0.048
HOXA11 homeobox A11 0.045
RARA retinoic acid receptor, alpha 0.043
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.035
HOXC6 homeobox C6 0.035
HOXA4 homeobox A4 0.034
HOXB9 homeobox B9 0.033
AR androgen receptor 0.032
KRT5 keratin 5 0.029
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.027
HOXC10 homeobox C10 0.026
RUNX1 runt-related transcription factor 1 0.024
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.024
GADD45A growth arrest and DNA-damage-inducible, alpha 0.023
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.023
WNT3A wingless-type MMTV integration site family, member 3A 0.022
MED25 mediator complex subunit 25 0.022
NOTCH1 notch 1 0.022
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 0.020
HOXB7 homeobox B7 0.020
SRRM1 serine/arginine repetitive matrix 1 0.020
NCOA6 nuclear receptor coactivator 6 0.020
HOXA2 homeobox A2 0.019
ZMYND11 zinc finger, MYND-type containing 11 0.018
MSX1 msh homeobox 1 0.017
HOXA1 homeobox A1 0.017
FOXO1 forkhead box O1 0.017
HOXA6 homeobox A6 0.017
CABLES1 Cdk5 and Abl enzyme substrate 1 0.016
SATB2 SATB homeobox 2 0.015
PGR progesterone receptor 0.015
HR hairless homolog (mouse) 0.015
NME3 non-metastatic cells 3, protein expressed in 0.015
NME4 non-metastatic cells 4, protein expressed in 0.015
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.014
HOXA3 homeobox A3 0.014
HIPK2 homeodomain interacting protein kinase 2 0.013
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.013
KAT2B K(lysine) acetyltransferase 2B 0.013
ZFYVE9 zinc finger, FYVE domain containing 9 0.012
WNT5A wingless-type MMTV integration site family, member 5A 0.012
TNS4 tensin 4 0.012
DDIT3 DNA-damage-inducible transcript 3 0.012
SFN stratifin 0.012
HOXC5 homeobox C5 0.012
TGS1 trimethylguanosine synthase 1 0.012
WDYHV1 WDYHV motif containing 1 0.011
NOTCH2 notch 2 0.011
SKIL SKI-like oncogene 0.011
NDP Norrie disease (pseudoglioma) 0.011
ESRRG estrogen-related receptor gamma 0.011
HOXC4 homeobox C4 0.011
GJA1 gap junction protein, alpha 1, 43kDa 0.011
ATF3 activating transcription factor 3 0.010
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.010
SRSF7 serine/arginine-rich splicing factor 7 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism