The network for 'positive regulation of purine nucleotide catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of purine nucleotide catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.

Mus musculus
Name Description Probability Func Analog Organism
Rac1 RAS-related C3 botulinum substrate 1 0.962
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.907
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.865
Braf Braf transforming gene 0.843
Arrb2 arrestin, beta 2 0.833
Grb2 growth factor receptor bound protein 2 0.811
Nf1 neurofibromatosis 1 0.735
Dnm1 dynamin 1 0.714
Bcl2 B-cell leukemia/lymphoma 2 0.696
Hmha1 histocompatibility (minor) HA-1 0.690
Vav1 vav 1 oncogene 0.656
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.617
Git1 G protein-coupled receptor kinase-interactor 1 0.600
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.567
Kl klotho 0.565
Plxna1 plexin A1 0.543
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.504
Selplg selectin, platelet (p-selectin) ligand 0.471
Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent 0.457
Adrbk1 adrenergic receptor kinase, beta 1 0.452
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.442
Sox10 SRY-box containing gene 10 0.391
Epha4 Eph receptor A4 0.361
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.355
Cd37 CD37 antigen 0.354
Arhgap21 Rho GTPase activating protein 21 0.352
Hdac7 histone deacetylase 7 0.324
Arrb1 arrestin, beta 1 0.316
Tmem123 transmembrane protein 123 0.313
Tsc2 tuberous sclerosis 2 0.309
Bax BCL2-associated X protein 0.302
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.294
Tsc1 tuberous sclerosis 1 0.292
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.292
Eps15 epidermal growth factor receptor pathway substrate 15 0.291
Cbl Casitas B-lineage lymphoma 0.289
Ltb lymphotoxin B 0.288
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.284
Rpgrip1l Rpgrip1-like 0.280
Adrb1 adrenergic receptor, beta 1 0.278
Rasgrp1 RAS guanyl releasing protein 1 0.278
Gpsm3 G-protein signalling modulator 3 (AGS3-like, C. elegans) 0.276
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.274
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.272
Stag2 stromal antigen 2 0.270
Nrp1 neuropilin 1 0.269
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.269
Parva parvin, alpha 0.268
Plxnb1 plexin B1 0.268
Ntf3 neurotrophin 3 0.261
Prkcc protein kinase C, gamma 0.260
Itga3 integrin alpha 3 0.259
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.256
Arhgap30 Rho GTPase activating protein 30 0.256
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.248
Akt1 thymoma viral proto-oncogene 1 0.240
Prkcd protein kinase C, delta 0.234
Nrbp2 nuclear receptor binding protein 2 0.233
Dlg4 discs, large homolog 4 (Drosophila) 0.232
Plxna3 plexin A3 0.229
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.224
Elmo1 engulfment and cell motility 1, ced-12 homolog (C. elegans) 0.218
Rhob ras homolog gene family, member B 0.216
Cacnb3 calcium channel, voltage-dependent, beta 3 subunit 0.216
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.215
Nf2 neurofibromatosis 2 0.211
Scn5a sodium channel, voltage-gated, type V, alpha 0.210
Arpc4 actin related protein 2/3 complex, subunit 4 0.210
Actb actin, beta 0.207
Rtkn rhotekin 0.206
Laptm5 lysosomal-associated protein transmembrane 5 0.202
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.195
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.194
Mobp myelin-associated oligodendrocytic basic protein 0.189
Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.185
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.185
Ksr1 kinase suppressor of ras 1 0.181
Epha1 Eph receptor A1 0.181
Cfl1 cofilin 1, non-muscle 0.181
Ptprc protein tyrosine phosphatase, receptor type, C 0.177
Rasgrp2 RAS, guanyl releasing protein 2 0.176
Zfr2 zinc finger RNA binding protein 2 0.175
Atp13a2 ATPase type 13A2 0.174
Mast3 microtubule associated serine/threonine kinase 3 0.171
Fmnl1 formin-like 1 0.170
Bicd2 bicaudal D homolog 2 (Drosophila) 0.169
Ehmt2 euchromatic histone lysine N-methyltransferase 2 0.165
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.165
Rasal3 RAS protein activator like 3 0.163
Bcr breakpoint cluster region 0.162
Ccl7 chemokine (C-C motif) ligand 7 0.161
Sirpa signal-regulatory protein alpha 0.161
Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 0.160
Efna1 ephrin A1 0.160
Tcfcp2l1 transcription factor CP2-like 1 0.160
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.157
P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 0.156
Sh3bp1 SH3-domain binding protein 1 0.154
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.152
ND6 NADH dehydrogenase subunit 6 0.152
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
let-60 Protein LET-60 0.338
lag-1 Protein LAG-1 0.227
F52G3.1 Protein F52G3.1 0.144
rig-6 Protein RIG-6 0.132
sem-5 Protein SEM-5 0.127
goa-1 Protein GOA-1 0.126
unc-79 Protein UNC-79 0.124
C11E4.6 Protein C11E4.6 0.118
zfp-3 Protein ZFP-3 0.113
rpm-1 Protein RPM-1 0.107
mpk-1 Protein MPK-1 0.095
CELE_F47G4.4 Protein F47G4.4 0.083
plc-3 Protein PLC-3 0.077
flh-2 Protein FLH-2 0.058
unc-71 Protein UNC-71 0.056
abl-1 Protein ABL-1 0.054
eor-2 Protein EOR-2 0.053
egrh-1 Protein EGRH-1 0.052
egl-18 Protein EGL-18 0.052
coh-3 Protein COH-3 0.052
smp-1 Protein SMP-1 0.050
cgef-2 Protein CGEF-2 0.049
sup-17 Protein SUP-17 0.048
rme-4 Protein RME-4 0.047
ptp-4 Protein PTP-4 0.047
etr-1 Protein ETR-1 0.046
lin-45 Protein LIN-45 0.044
afd-1 Protein AFD-1 0.044
cam-1 Protein CAM-1 0.042
rgl-1 Protein RGL-1 0.042
egl-44 Protein EGL-44 0.042
abts-1 Protein ABTS-1 0.040
zfp-1 Protein ZFP-1 0.039
T23F2.2 Protein T23F2.2 0.039
F28B3.1 Protein F28B3.1 0.038
bet-2 Protein BET-2 0.038
sax-3 Protein SAX-3 0.037
aha-1 Protein AHA-1 0.036
C53C9.2 Protein C53C9.2 0.036
magi-1 Protein MAGI-1 0.035
itr-1 Protein ITR-1 0.035
egl-8 Protein EGL-8 0.035
ykt-6 Protein YKT-6 0.035
sto-4 Protein STO-4 0.034
kin-25 Protein KIN-25 0.034
snf-1 Protein SNF-1 0.033
pkg-1 Protein PKG-1 0.032
gar-3 Protein GAR-3 0.032
ist-1 Protein IST-1 0.032
mbk-1 Protein MBK-1 0.031
cah-6 Protein CAH-6 0.030
ddr-2 Protein DDR-2 0.029
rpb-7 Protein RPB-7 0.029
myo-3 Protein MYO-3 0.028
cpt-1 Protein CPT-1 0.028
sma-6 Protein SMA-6 0.028
stau-1 Protein STAU-1 0.028
pat-3 Protein PAT-3 0.027
daf-19 Protein DAF-19 0.027
unc-115 Protein UNC-115 0.027
nck-1 Protein NCK-1 0.027
cdh-9 Protein CDH-9 0.027
ptp-1 Protein PTP-1 0.027
zoo-1 Protein ZOO-1 0.027
CELE_Y60A3A.9 Protein Y60A3A.9 0.026
par-6 Protein PAR-6 0.026
lin-40 Protein LIN-40 0.026
larp-5 Protein LARP-5 0.026
exc-5 Protein EXC-5 0.025
atg-11 Protein ATG-11 0.025
CELE_K08E7.6 Protein K08E7.6 0.025
ced-10 Protein CED-10 0.025
magu-3 Protein MAGU-3 0.025
ubr-1 Protein UBR-1 0.025
T23F11.1 Protein T23F11.1 0.025
pdk-1 Protein PDK-1 0.024
C15H9.5 Protein C15H9.5 0.024
nrx-1 Protein NRX-1 0.024
unc-26 Protein UNC-26 0.024
rab-5 Protein RAB-5 0.023
sav-1 Protein SAV-1 0.023
pak-1 Protein PAK-1 0.023
crt-1 Protein CRT-1 0.023
mpz-1 Protein MPZ-1 0.023
acr-2 Protein ACR-2 0.023
Y55B1AL.2 Protein Y55B1AL.2 0.022
hpk-1 Protein HPK-1 0.022
Y55F3BR.2 Protein Y55F3BR.2 0.022
T14B1.1 Protein T14B1.1 0.022
F13H6.1 Protein F13H6.1 0.021
gap-2 Protein GAP-2 0.021
lin-7 Protein LIN-7 0.021
frm-10 Protein FRM-10 0.021
CELE_Y43F8B.19 Protein Y43F8B.19 0.021
sel-12 Protein SEL-12 0.021
git-1 Protein GIT-1 0.021
C49A1.10 Protein C49A1.10 0.020
clr-1 Protein CLR-1 0.020
rpn-6.1 Protein RPN-6.1 0.020
CELE_T10D4.6 Protein T10D4.6 0.020
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Danio rerio
Name Description Probability Func Analog Organism
tpm4 tropomyosin 4 0.689
hspa4a heat shock protein 4a 0.378
rtcd1 RNA terminal phosphate cyclase domain 1 0.346
bcl2 B-cell leukemia/lymphoma 2 0.340
bida BH3 interacting domain death agonist 0.331
pparg peroxisome proliferator activated receptor gamma 0.317
nf1a neurofibromin 1a 0.242
dnaja1l DnaJ (Hsp40) homolog, subfamily A, member 1, like 0.230
hsp90a.2 heat shock protein 90-alpha 2 0.208
mcl1b myeloid cell leukemia sequence 1b 0.171
adrb2a adrenergic receptor, beta 2a 0.167
sox4a SRY-box containing gene 4a 0.166
rtn1a reticulon 1a 0.155
cfl2l cofilin 2, like 0.149
si:ch211-232m7.1 si:ch211-232m7.1 0.146
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.146
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.133
s1pr1 sphingosine-1-phosphate receptor 1 0.129
icn ictacalcin 0.128
zgc:100838 zgc:100838 0.127
pdlim1 PDZ and LIM domain 1 (elfin) 0.119
ndel1a nudE nuclear distribution gene E homolog like 1 (A. nidulans) A 0.117
nf1b neurofibromin 1b 0.116
baxa bcl2-associated X protein, a 0.115
mcl1a myeloid cell leukemia sequence 1a 0.115
cnn2 calponin 2 0.112
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.110
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.106
msna moesin a 0.104
pole2 polymerase (DNA directed), epsilon 2 0.099
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.099
b3gnt5a UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a 0.097
LOC565839 tumor necrosis factor alpha-induced protein 2-like 0.096
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.095
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.094
scinlb scinderin like b 0.094
adrb2b adrenergic receptor, beta 2b 0.093
s100v2 S100 calcium binding protein V2 0.093
pvalb4 parvalbumin 4 0.092
dzip1 DAZ interacting protein 1 0.091
pak2a p21 (CDKN1A)-activated kinase 2a 0.090
phf21a PHD finger protein 21A 0.090
rab5c RAB5C, member RAS oncogene family 0.090
acsl4a acyl-CoA synthetase long-chain family member 4a 0.089
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.089
gclc glutamate-cysteine ligase, catalytic subunit 0.088
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.087
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.087
gro2 groucho 2 0.086
boka BCL2-related ovarian killer a 0.085
actc1a actin, alpha, cardiac muscle 1a 0.084
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.083
mcm6 MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae) 0.082
tomm34 translocase of outer mitochondrial membrane 34 0.080
elf2b E74-like factor 2b (ets domain transcription factor) 0.080
zgc:77517 zgc:77517 0.080
rhoaa ras homolog gene family, member Aa 0.080
rcn1 reticulocalbin 1, EF-hand calcium binding domain 0.078
sncb synuclein, beta 0.078
zgc:73142 zgc:73142 0.077
ilk integrin linked kinase 0.077
tpm3 tropomyosin 3 0.076
gsna gelsolin a 0.076
epha2 eph receptor A2 0.076
mat2a methionine adenosyltransferase II, alpha 0.075
depdc1a DEP domain containing 1a 0.074
wu:fb39a06 wu:fb39a06 0.074
zgc:112329 zgc:112329 0.071
neb nebulin 0.071
nras neuroblastoma RAS viral (v-ras) oncogene homolog 0.071
tnni2a.4 troponin I, skeletal, fast 2a.4 0.070
sox19a SRY-box containing gene 19a 0.070
cldnk claudin k 0.070
s100z S100 calcium binding protein Z 0.070
adrb3a adrenergic receptor, beta 3a 0.069
phlda2 pleckstrin homology-like domain, family A, member 2 0.069
mycbp2 MYC binding protein 2 0.068
dnajb1b DnaJ (Hsp40) homolog, subfamily B, member 1b 0.068
rpsa ribosomal protein SA 0.067
ache acetylcholinesterase 0.067
gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a 0.067
tsc22d3 TSC22 domain family, member 3 0.066
nfe2l3 nuclear factor (erythroid-derived 2)-like 3 0.066
wu:fc23b05 wu:fc23b05 0.065
zgc:92851 zgc:92851 0.065
ccnb2 cyclin B2 0.065
ccna2 cyclin A2 0.065
melk maternal embryonic leucine zipper kinase 0.064
rras related RAS viral (r-ras) oncogene homolog 0.064
chac1 ChaC, cation transport regulator-like 1 0.064
atp6v1al ATPase, H+ transporting, lysosomal V1 subunit A, like 0.064
ahnak AHNAK nucleoprotein 0.064
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.063
bad BCL2-antagonist of cell death 0.063
yap1 Yes-associated protein 1 0.062
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.062
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.062
hmgb3a high-mobility group box 3a 0.062
yrk Yes-related kinase 0.062
junb jun B proto-oncogene 0.061
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Drosophila melanogaster
Name Description Probability Func Analog Organism
rok Rho-kinase 0.626
drpr draper 0.572
Wnk CG7177 gene product from transcript CG7177-RA 0.431
Pkn Protein kinase related to protein kinase N 0.363
Pten CG5671 gene product from transcript CG5671-RB 0.344
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.331
plexB plexin B 0.307
mbc myoblast city 0.283
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.271
puc puckered 0.260
Dap160 Dynamin associated protein 160 0.257
NaCP60E Na channel protein 60E 0.242
stai stathmin 0.236
Rheb CG1081 gene product from transcript CG1081-RA 0.231
jumu jumeau 0.217
stg string 0.207
Hem HEM-protein 0.206
drk downstream of receptor kinase 0.184
CG7158 CG7158 gene product from transcript CG7158-RA 0.171
Gug Grunge 0.163
unc-104 CG8566 gene product from transcript CG8566-RB 0.158
raps rapsynoid 0.145
nwk nervous wreck 0.142
cno canoe 0.135
Plc21C Phospholipase C at 21C 0.125
Abi Abelson interacting protein 0.116
cenG1A centaurin gamma 1A 0.112
Fak56D Focal Adhesion Kinase 0.112
siz schizo 0.111
synj synaptojanin 0.109
Sos Son of sevenless 0.102
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.101
Cf2 Chorion factor 2 0.100
Pk61C Protein kinase 61C 0.098
mbt mushroom bodies tiny 0.096
dys dysfusion 0.088
Myo31DF Myosin 31DF 0.088
Act88F Actin 88F 0.087
kuz kuzbanian 0.087
Smg1 CG32743 gene product from transcript CG32743-RA 0.084
l(2)k16918 lethal (2) k16918 0.079
Tsc1 CG6147 gene product from transcript CG6147-RA 0.076
CG3573 CG3573 gene product from transcript CG3573-RA 0.075
DAAM Dishevelled Associated Activator of Morphogenesis 0.075
Khc Kinesin heavy chain 0.074
CG8155 CG8155 gene product from transcript CG8155-RA 0.074
dos daughter of sevenless 0.073
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.071
mask multiple ankyrin repeats single KH domain 0.070
sima similar 0.069
Mlc2 Myosin light chain 2 0.068
pod1 CG4532 gene product from transcript CG4532-RF 0.067
Klc Kinesin light chain 0.064
Mad Mothers against dpp 0.062
Ephrin CG1862 gene product from transcript CG1862-RA 0.062
flw flapwing 0.060
CG9426 CG9426 gene product from transcript CG9426-RA 0.060
tmod tropomodulin 0.059
Hnf4 Hepatocyte nuclear factor 4 0.057
Tre1 trapped in endoderm-1 0.054
Shaw Shaker cognate w 0.054
Rbsn-5 Rabenosyn-5 0.054
Dab Disabled 0.054
CG11033 CG11033 gene product from transcript CG11033-RB 0.053
Vps45 Vacuolar protein sorting 45 0.053
neur neuralized 0.053
baz bazooka 0.052
Stat92E Signal-transducer and activator of transcription protein at 92E 0.052
Su(H) Suppressor of Hairless 0.052
CG7231 CG7231 gene product from transcript CG7231-RE 0.052
Dcr-2 Dicer-2 0.052
car carnation 0.051
neuroligin CG13772 gene product from transcript CG13772-RA 0.051
p120ctn Adherens junction protein p120 0.051
gcl germ cell-less 0.050
pcx pecanex 0.049
Ced-12 CG5336 gene product from transcript CG5336-RA 0.048
CG17233 CG17233 gene product from transcript CG17233-RA 0.048
klar klarsicht 0.047
trio CG18214 gene product from transcript CG18214-RA 0.047
G-ialpha65A G protein alphai subunit 65A 0.046
Vps35 Vacuolar protein sorting 35 0.046
CalpB Calpain-B 0.045
Su(Tpl) CG32217 gene product from transcript CG32217-RB 0.045
RhoBTB CG5701 gene product from transcript CG5701-RA 0.044
CG8334 CG8334 gene product from transcript CG8334-RA 0.044
gfA giant fibre A 0.044
UBL3 CG9038 gene product from transcript CG9038-RC 0.044
ken ken and barbie 0.043
Sbf SET domain binding factor 0.043
pkaap CG4132 gene product from transcript CG4132-RA 0.043
CG9941 CG9941 gene product from transcript CG9941-RA 0.043
phl pole hole 0.043
Mlp84B Muscle LIM protein at 84B 0.043
Dlic Dynein light intermediate chain 0.042
pgant3 polypeptide GalNAc transferase 3 0.042
Mtl Mig-2-like 0.042
pie pineapple eye 0.042
Mbs Myosin binding subunit 0.040
CG6454 CG6454 gene product from transcript CG6454-RC 0.040
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Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.993
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.987
SFN stratifin 0.984
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.976
EGFR epidermal growth factor receptor 0.969
FGFR2 fibroblast growth factor receptor 2 0.947
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.917
PTK2 PTK2 protein tyrosine kinase 2 0.912
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.902
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.890
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.890
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.880
BCAR1 breast cancer anti-estrogen resistance 1 0.876
GRB7 growth factor receptor-bound protein 7 0.873
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.860
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.819
OCRL oculocerebrorenal syndrome of Lowe 0.817
ARRB1 arrestin, beta 1 0.813
RIN3 Ras and Rab interactor 3 0.810
NCF2 neutrophil cytosolic factor 2 0.804
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.803
SNX9 sorting nexin 9 0.790
DNM1 dynamin 1 0.769
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.766
BCL2L1 BCL2-like 1 0.735
GSK3B glycogen synthase kinase 3 beta 0.729
PLCG1 phospholipase C, gamma 1 0.725
BBS10 Bardet-Biedl syndrome 10 0.725
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.707
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.703
S100A8 S100 calcium binding protein A8 0.702
SH3RF1 SH3 domain containing ring finger 1 0.702
EXOSC10 exosome component 10 0.696
DOCK1 dedicator of cytokinesis 1 0.683
GRB2 growth factor receptor-bound protein 2 0.634
NCKAP1 NCK-associated protein 1 0.620
ITSN1 intersectin 1 (SH3 domain protein) 0.613
PTPRJ protein tyrosine phosphatase, receptor type, J 0.610
TSC2 tuberous sclerosis 2 0.606
RICTOR RPTOR independent companion of MTOR, complex 2 0.605
SH3BP2 SH3-domain binding protein 2 0.597
FGF1 fibroblast growth factor 1 (acidic) 0.597
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.586
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.586
FGFR1 fibroblast growth factor receptor 1 0.585
RGS2 regulator of G-protein signaling 2, 24kDa 0.585
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.580
ILK integrin-linked kinase 0.567
RHOA ras homolog gene family, member A 0.554
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.538
S100B S100 calcium binding protein B 0.538
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.529
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.515
VAV1 vav 1 guanine nucleotide exchange factor 0.505
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.504
S100A6 S100 calcium binding protein A6 0.503
ADRBK1 adrenergic, beta, receptor kinase 1 0.500
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.498
S100A9 S100 calcium binding protein A9 0.487
STAT5A signal transducer and activator of transcription 5A 0.470
PKN3 protein kinase N3 0.467
HSPA1B heat shock 70kDa protein 1B 0.465
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.457
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.456
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.455
CCR5 chemokine (C-C motif) receptor 5 0.449
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.447
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.443
ZYX zyxin 0.431
S100A1 S100 calcium binding protein A1 0.430
DSP desmoplakin 0.429
S100A11 S100 calcium binding protein A11 0.414
FMNL1 formin-like 1 0.399
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.393
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 0.376
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 0.371
RHOC ras homolog gene family, member C 0.369
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.368
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.364
AGAP7 ArfGAP with GTPase domain, ankyrin repeat and PH domain 7 0.362
TRAF5 TNF receptor-associated factor 5 0.358
MARK3 MAP/microtubule affinity-regulating kinase 3 0.349
ADAM15 ADAM metallopeptidase domain 15 0.346
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.339
PNPLA6 patatin-like phospholipase domain containing 6 0.338
SH3KBP1 SH3-domain kinase binding protein 1 0.335
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.333
ANKRD28 ankyrin repeat domain 28 0.333
TOR1A torsin family 1, member A (torsin A) 0.331
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.330
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 0.330
VASP vasodilator-stimulated phosphoprotein 0.322
C7orf59 chromosome 7 open reading frame 59 0.321
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.319
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.315
LIMS1 LIM and senescent cell antigen-like domains 1 0.314
TFG TRK-fused gene 0.314
TNK2 tyrosine kinase, non-receptor, 2 0.308
ABI1 abl-interactor 1 0.300
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Copb1 coatomer protein complex, subunit beta 1 0.234
Tagln transgelin 0.156
Pja2 praja 2, RING-H2 motif containing 0.128
Arpc2 actin related protein 2/3 complex, subunit 2 0.102
Epas1 endothelial PAS domain protein 1 0.091
Ptafr platelet-activating factor receptor 0.090
Arl1 ADP-ribosylation factor-like 1 0.088
Actg2 actin, gamma 2, smooth muscle, enteric 0.087
Myl9 myosin, light chain 9, regulatory 0.085
Adora2a adenosine A2a receptor 0.083
Dgkg diacylglycerol kinase, gamma 0.083
Myo1c myosin IC 0.077
Acta2 smooth muscle alpha-actin 0.072
Rap1b RAP1B, member of RAS oncogene family 0.071
Picalm phosphatidylinositol binding clathrin assembly protein 0.068
Apc adenomatous polyposis coli 0.068
Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.068
Myo1d myosin ID 0.066
Chrm1 cholinergic receptor, muscarinic 1 0.065
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.065
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.064
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.064
Cyth1 cytohesin 1 0.062
Copb2 coatomer protein complex, subunit beta 2 (beta prime) 0.062
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.061
Scn3b sodium channel, voltage-gated, type III, beta 0.059
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.058
Homer1 homer homolog 1 (Drosophila) 0.057
Sirpa signal-regulatory protein alpha 0.056
Anxa2 annexin A2 0.056
Kitlg KIT ligand 0.053
Ddr1 discoidin domain receptor tyrosine kinase 1 0.053
Serp1 stress-associated endoplasmic reticulum protein 1 0.053
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.053
Gria2 glutamate receptor, ionotropic, AMPA 2 0.052
Lcp2 lymphocyte cytosolic protein 2 0.051
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.050
Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.049
Inpp5d inositol polyphosphate-5-phosphatase D 0.049
Adcy5 adenylate cyclase 5 0.049
Strn striatin, calmodulin binding protein 0.049
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.048
Dstn destrin 0.048
Cmklr1 chemokine-like receptor 1 0.047
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.047
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.047
Zmym4 zinc finger, MYM-type 4 0.046
Hand2 heart and neural crest derivatives expressed 2 0.046
Cfp complement factor properdin 0.044
Amph amphiphysin 0.043
Prkch protein kinase C, eta 0.043
Mcam melanoma cell adhesion molecule 0.043
Hk1 hexokinase 1 0.043
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.043
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.042
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.042
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.041
Sox17 SRY (sex determining region Y)-box 17 0.041
Shank2 SH3 and multiple ankyrin repeat domains 2 0.041
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.040
Fgfr1 Fibroblast growth factor receptor 1 0.039
Camk4 calcium/calmodulin-dependent protein kinase IV 0.039
Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.039
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.039
Sel1l sel-1 suppressor of lin-12-like (C. elegans) 0.039
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.038
Kremen1 kringle containing transmembrane protein 1 0.037
Ddn dendrin 0.037
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.037
Atrn attractin 0.037
Clcn7 chloride channel 7 0.035
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.035
Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 0.035
Hpca hippocalcin 0.035
Pld2 phospholipase D2 0.035
Adrbk1 adrenergic, beta, receptor kinase 1 0.035
Braf v-raf murine sarcoma viral oncogene homolog B1 0.034
Alb albumin 0.034
Sstr1 somatostatin receptor 1 0.033
Utrn utrophin 0.033
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.033
Gpr182 G protein-coupled receptor 182 0.032
Plcg1 phospholipase C, gamma 1 0.032
Rab5a RAB5A, member RAS oncogene family 0.032
Snca synuclein, alpha (non A4 component of amyloid precursor) 0.032
Smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.031
Unc5b unc-5 homolog B (C. elegans) 0.031
Anxa1 annexin A1 0.031
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.031
Arf4 ADP-ribosylation factor 4 0.031
Btg1 B-cell translocation gene 1, anti-proliferative 0.030
Dlg3 discs, large homolog 3 (Drosophila) 0.030
LOC293989 cytochrome P450-like 0.029
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.029
Timp1 TIMP metallopeptidase inhibitor 1 0.029
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.029
Gria1 glutamate receptor, ionotropic, AMPA 1 0.029
Necap1 NECAP endocytosis associated 1 0.029
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.028
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.028
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GYL1 Gyl1p 0.362
MKK1 Mkk1p 0.354
GCD6 Gcd6p 0.242
STE11 Ste11p 0.221
PKC1 Pkc1p 0.155
RHO1 Rho1p 0.135
STE5 Ste5p 0.131
YPT53 Ypt53p 0.110
SPA2 Spa2p 0.110
ROM2 Rom2p 0.103
BEM3 Bem3p 0.100
VPS15 Vps15p 0.099
CDC24 Cdc24p 0.094
PTP2 Ptp2p 0.087
TUS1 Tus1p 0.078
TOM1 Tom1p 0.076
SAC7 Sac7p 0.073
PEA2 Pea2p 0.067
SUI3 Sui3p 0.066
SSA4 Ssa4p 0.065
SUI2 Sui2p 0.064
RPG1 Rpg1p 0.054
STE4 Ste4p 0.054
AVO1 Avo1p 0.051
YCR007C hypothetical protein 0.050
CRZ1 Crz1p 0.048
CHS1 Chs1p 0.047
KEL1 Kel1p 0.046
SSK2 Ssk2p 0.044
MKK2 Mkk2p 0.042
CCT4 Cct4p 0.042
APM3 Apm3p 0.042
TOF2 Tof2p 0.041
TRR1 Trr1p 0.039
MNN9 Mnn9p 0.038
RGD1 Rgd1p 0.038
ACK1 Ack1p 0.038
KSS1 Kss1p 0.038
VTA1 Vta1p 0.037
PKH2 Pkh2p 0.037
SEC16 Sec16p 0.037
BFR1 Bfr1p 0.036
TSC11 Tsc11p 0.036
STI1 Sti1p 0.036
CYK3 Cyk3p 0.035
YDR186C hypothetical protein 0.035
MDS3 Mds3p 0.035
GCD1 Gcd1p 0.034
URA4 Ura4p 0.034
CDC50 Cdc50p 0.034
MSG5 Msg5p 0.034
AKL1 Akl1p 0.033
GPB2 Gpb2p 0.033
SPR6 Spr6p 0.033
RGA2 Rga2p 0.032
MOB2 Mob2p 0.032
PRS2 Prs2p 0.032
GCD7 Gcd7p 0.032
INP52 Inp52p 0.032
NUP49 Nup49p 0.032
GGA2 Gga2p 0.031
YOL087C hypothetical protein 0.031
CHC1 Chc1p 0.031
FAA2 Faa2p 0.030
YNL108C hypothetical protein 0.030
NEO1 Neo1p 0.030
SET1 Set1p 0.030
SWC7 Swc7p 0.029
FKH1 Fkh1p 0.029
HRP1 Hrp1p 0.029
MRE11 Mre11p 0.029
NGL3 Ngl3p 0.029
CRG1 Crg1p 0.029
NVJ1 Nvj1p 0.029
TSC10 Tsc10p 0.029
YML002W hypothetical protein 0.029
ATG20 Atg20p 0.028
STT4 Stt4p 0.028
CDC12 Cdc12p 0.028
SOG2 Sog2p 0.028
SLG1 Slg1p 0.027
YGR012W hypothetical protein 0.027
URA3 Ura3p 0.026
PPE1 Ppe1p 0.026
GCD2 Gcd2p 0.026
CMK2 Cmk2p 0.026
BRN1 Brn1p 0.026
YGK3 Ygk3p 0.026
ITR2 Itr2p 0.026
YPR148C hypothetical protein 0.026
KTR4 Ktr4p 0.026
FUS2 Fus2p 0.025
SRD1 Srd1p 0.025
LEU2 Leu2p 0.025
CUR1 Cur1p 0.025
BUL1 Bul1p 0.025
DCD1 Dcd1p 0.025
CUP1-1 Cup1-1p 0.024
PEP7 Pep7p 0.024
BUD2 Bud2p 0.024