The network for 'neural tube formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neural tube formation

The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Pax3 paired box gene 3 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Pax2 paired box gene 2 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Pbx1 pre B-cell leukemia transcription factor 1 1.000
Tcfap2a transcription factor AP-2, alpha 1.000
Pitx2 paired-like homeodomain transcription factor 2 0.999
Bmp4 bone morphogenetic protein 4 0.999
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.999
Eya1 eyes absent 1 homolog (Drosophila) 0.999
Fgf8 fibroblast growth factor 8 0.998
Smo smoothened homolog (Drosophila) 0.997
Hoxa1 homeobox A1 0.997
Gli2 GLI-Kruppel family member GLI2 0.997
Hand1 heart and neural crest derivatives expressed transcript 1 0.997
Sox2 SRY-box containing gene 2 0.997
Msx1 homeobox, msh-like 1 0.997
Prrx1 paired related homeobox 1 0.997
Bmp7 bone morphogenetic protein 7 0.996
Sall4 sal-like 4 (Drosophila) 0.995
Fgfr1 fibroblast growth factor receptor 1 0.995
Pax6 paired box gene 6 0.994
Rarg retinoic acid receptor, gamma 0.993
Tbx1 T-box 1 0.990
Zic3 zinc finger protein of the cerebellum 3 0.988
Lhx1 LIM homeobox protein 1 0.986
Foxc1 forkhead box C1 0.985
Vegfa vascular endothelial growth factor A 0.984
Chrd chordin 0.983
Ctnnb1 catenin (cadherin associated protein), beta 1 0.982
Gbx2 gastrulation brain homeobox 2 0.978
Nodal nodal 0.975
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.972
Nog noggin 0.967
Pax9 paired box gene 9 0.967
Wnt5a wingless-related MMTV integration site 5A 0.966
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.957
Foxc2 forkhead box C2 0.954
Fgf10 fibroblast growth factor 10 0.953
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.953
Apc adenomatosis polyposis coli 0.949
Sfrp2 secreted frizzled-related protein 2 0.948
Dlx5 distal-less homeobox 5 0.941
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.940
Emx2 empty spiracles homolog 2 (Drosophila) 0.940
Rarb retinoic acid receptor, beta 0.939
Msx2 homeobox, msh-like 2 0.936
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.926
Wnt3a wingless-related MMTV integration site 3A 0.924
Hes1 hairy and enhancer of split 1 (Drosophila) 0.921
En1 engrailed 1 0.916
Chd7 chromodomain helicase DNA binding protein 7 0.913
Foxg1 forkhead box G1 0.909
Hoxd13 homeobox D13 0.905
Prrx2 paired related homeobox 2 0.901
Emx1 empty spiracles homolog 1 (Drosophila) 0.888
Mks1 Meckel syndrome, type 1 0.886
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.886
Hoxa2 homeobox A2 0.883
Acvr1 activin A receptor, type 1 0.882
Hand2 heart and neural crest derivatives expressed transcript 2 0.881
Pax8 paired box gene 8 0.879
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.878
Rara retinoic acid receptor, alpha 0.876
Pitx1 paired-like homeodomain transcription factor 1 0.876
Wt1 Wilms tumor 1 homolog 0.869
Hoxa13 homeobox A13 0.859
Ednra endothelin receptor type A 0.853
Fzd1 frizzled homolog 1 (Drosophila) 0.838
Meox2 mesenchyme homeobox 2 0.834
Smad6 MAD homolog 6 (Drosophila) 0.831
Alx4 aristaless-like homeobox 4 0.830
Ptch1 patched homolog 1 0.818
Lrp2 low density lipoprotein receptor-related protein 2 0.815
Mn1 meningioma 1 0.814
Foxh1 forkhead box H1 0.798
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.796
Jag1 jagged 1 0.796
Efna2 ephrin A2 0.795
Tbx2 T-box 2 0.793
Smad3 MAD homolog 3 (Drosophila) 0.768
Tbx15 T-box 15 0.767
Arid1a AT rich interactive domain 1A (SWI-like) 0.767
Isl1 ISL1 transcription factor, LIM/homeodomain 0.760
Ret ret proto-oncogene 0.759
Lrp6 low density lipoprotein receptor-related protein 6 0.756
Tbx3 T-box 3 0.747
Yap1 yes-associated protein 1 0.744
Hoxa5 homeobox A5 0.743
Otx1 orthodenticle homolog 1 (Drosophila) 0.736
Smad1 MAD homolog 1 (Drosophila) 0.729
Ift88 intraflagellar transport 88 homolog (Chlamydomonas) 0.728
Pou5f1 POU domain, class 5, transcription factor 1 0.716
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.712
Gas1 growth arrest specific 1 0.708
Tcfap2c transcription factor AP-2, gamma 0.704
Axin1 axin 1 0.703
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nkd1 naked cuticle homolog 1 (Drosophila) 0.953
foxd3 forkhead box D3 0.750
hoxb1b homeo box B1b 0.735
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.721
sox9a SRY-box containing gene 9a 0.605
ift88 intraflagellar transport 88 homolog 0.549
crb2a crumbs homolog 2a 0.549
rarga retinoic acid receptor gamma a 0.457
egr2b early growth response 2b 0.443
dla deltaA 0.419
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.383
kif17 kinesin family member 17 0.373
scrib scribbled homolog (Drosophila) 0.348
zeb2a zinc finger E-box binding homeobox 2a 0.338
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.324
gbx2 gastrulation brain homeo box 2 0.311
raraa retinoic acid receptor, alpha a 0.303
hoxb1a homeo box B1a 0.279
meis2.2 myeloid ecotropic viral integration site 2.2 0.267
eng2b engrailed 2b 0.257
hoxb3a homeo box B3a 0.256
six3a sine oculis homeobox homolog 3a 0.246
msxc muscle segment homeobox C 0.237
zic4 zic family member 4 0.234
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.212
otx2 orthodenticle homolog 2 0.187
shha sonic hedgehog a 0.167
meis3 myeloid ecotropic viral integration site 3 0.162
spry2 sprouty homolog 2 0.162
fzd7a frizzled homolog 7a 0.161
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.153
boc brother of CDO 0.152
foxg1a forkhead box G1a 0.140
irx7 iroquois homeobox protein 7 0.134
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.133
wnt5b wingless-type MMTV integration site family, member 5b 0.121
alcamb activated leukocyte cell adhesion molecule b 0.118
pou3f3b POU class 3 homeobox 3b 0.118
sulf2 sulfatase 2 0.117
oc90 otoconin 90 0.112
crabp2a cellular retinoic acid binding protein 2, a 0.109
irx3a iroquois homeobox protein 3a 0.107
dctn1a dynactin 1a 0.106
robo1 roundabout homolog 1 0.104
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.102
gdf6a growth differentiation factor 6a 0.102
gpr98 G protein-coupled receptor 98 0.099
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.098
col2a1a collagen type II, alpha-1a 0.097
fgfr2 fibroblast growth factor receptor 2 0.096
skia nuclear oncoprotein skia 0.096
spry1 sprouty homolog 1 (Drosophila) 0.096
plekhg4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.095
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.095
fgf3 fibroblast growth factor 3 0.094
odz4 odd Oz/ten-m homolog 4 0.094
sox19a SRY-box containing gene 19a 0.093
hmx3 homeo box (H6 family) 3 0.089
hoxb2a homeo box B2a 0.087
lfng lunatic fringe homolog 0.087
hoxb5a homeo box B5a 0.087
gyltl1b glycosyltransferase-like 1b 0.086
etv5b ets variant 5b 0.084
pax6a paired box gene 6a 0.083
guca1c guanylate cyclase activator 1C 0.082
tfap2a transcription factor AP-2 alpha 0.082
sox3 SRY-box containing gene 3 0.081
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.081
meis2.1 myeloid ecotropic viral integration site 2.1 0.081
mab21l2 mab-21-like 2 0.077
mib mind bomb 0.076
irx1a iroquois homeobox protein 1, a 0.073
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.072
axin2 axin 2 (conductin, axil) 0.070
mdkb midkine-related growth factor b 0.069
lhx5 LIM homeobox 5 0.068
prkci protein kinase C, iota 0.067
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.066
wnt11 wingless-type MMTV integration site family, member 11 0.066
dlx3b distal-less homeobox gene 3b 0.064
dync1h1 dynein, cytoplasmic 1, heavy chain 1 0.063
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.058
dpysl5a dihydropyrimidinase-like 5a 0.057
fgfr1b fibroblast growth factor receptor 1b 0.054
twist1a twist1a 0.052
olig3 oligodendrocyte transcription factor 3 0.052
hoxa3a homeo box A3a 0.051
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.050
bmp2b bone morphogenetic protein 2b 0.050
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.049
sox1a SRY-box containing gene 1a 0.048
tbx2b T-box 2b 0.048
pcdh19 protocadherin 19 0.046
neurod neurogenic differentiation 0.046
eng2a engrailed 2a 0.046
pcdh18a protocadherin 18a 0.045
gbx1 gastrulation brain homeobox 1 0.045
eng1a engrailed 1a 0.043
lrrtm1 leucine rich repeat transmembrane neuronal 1 0.043
vangl2 vang-like 2 (van gogh, Drosophila) 0.043
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
SMAD3 SMAD family member 3 0.999
APC adenomatous polyposis coli 0.999
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.999
TSC2 tuberous sclerosis 2 0.994
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.991
LRRK2 leucine-rich repeat kinase 2 0.988
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.986
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.981
SQSTM1 sequestosome 1 0.971
STRN3 striatin, calmodulin binding protein 3 0.970
STK3 serine/threonine kinase 3 0.966
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.955
MEOX2 mesenchyme homeobox 2 0.953
XIAP X-linked inhibitor of apoptosis 0.952
PRKCZ protein kinase C, zeta 0.948
TRAF6 TNF receptor-associated factor 6 0.948
TRRAP transformation/transcription domain-associated protein 0.947
CREBBP CREB binding protein 0.942
ESR1 estrogen receptor 1 0.932
SMAD2 SMAD family member 2 0.920
ACTB actin, beta 0.899
ZRANB1 zinc finger, RAN-binding domain containing 1 0.886
GSK3B glycogen synthase kinase 3 beta 0.876
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.876
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.862
EP300 E1A binding protein p300 0.859
STK4 serine/threonine kinase 4 0.849
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.846
ACTG1 actin, gamma 1 0.840
USP9X ubiquitin specific peptidase 9, X-linked 0.831
AXIN1 axin 1 0.828
SMAD4 SMAD family member 4 0.798
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.777
RXRA retinoid X receptor, alpha 0.772
SOX10 SRY (sex determining region Y)-box 10 0.772
CSNK1E casein kinase 1, epsilon 0.767
BAIAP2 BAI1-associated protein 2 0.751
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.744
SLMAP sarcolemma associated protein 0.736
SETD8 SET domain containing (lysine methyltransferase) 8 0.735
SEC23A Sec23 homolog A (S. cerevisiae) 0.713
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.711
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.707
BCOR BCL6 corepressor 0.694
BBS1 Bardet-Biedl syndrome 1 0.683
PPP1R16A protein phosphatase 1, regulatory (inhibitor) subunit 16A 0.682
KIF5B kinesin family member 5B 0.667
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.648
ZFYVE9 zinc finger, FYVE domain containing 9 0.639
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.632
INADL InaD-like (Drosophila) 0.631
PCM1 pericentriolar material 1 0.608
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.606
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.604
CTBP2 C-terminal binding protein 2 0.598
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.595
SAV1 salvador homolog 1 (Drosophila) 0.581
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.570
ZFX zinc finger protein, X-linked 0.551
RPL18A ribosomal protein L18a 0.539
BBS2 Bardet-Biedl syndrome 2 0.519
ERBB2IP erbb2 interacting protein 0.504
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.503
SEC24D SEC24 family, member D (S. cerevisiae) 0.489
LMAN1 lectin, mannose-binding, 1 0.477
SASS6 spindle assembly 6 homolog (C. elegans) 0.468
MTA1 metastasis associated 1 0.467
ATXN1 ataxin 1 0.466
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.465
EXOC7 exocyst complex component 7 0.464
SKI v-ski sarcoma viral oncogene homolog (avian) 0.454
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.451
PSEN1 presenilin 1 0.450
MED25 mediator complex subunit 25 0.449
NCOR1 nuclear receptor corepressor 1 0.425
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.424
STRN striatin, calmodulin binding protein 0.412
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.405
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.396
DLG5 discs, large homolog 5 (Drosophila) 0.378
PRKCI protein kinase C, iota 0.373
SP1 Sp1 transcription factor 0.365
CTBP1 C-terminal binding protein 1 0.357
ANKRD28 ankyrin repeat domain 28 0.355
YAP1 Yes-associated protein 1 0.353
BBS10 Bardet-Biedl syndrome 10 0.350
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.341
NCOA6 nuclear receptor coactivator 6 0.337
PUM1 pumilio homolog 1 (Drosophila) 0.334
EPAS1 endothelial PAS domain protein 1 0.326
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.322
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.320
NCOA1 nuclear receptor coactivator 1 0.318
SORBS3 sorbin and SH3 domain containing 3 0.317
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.317
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.316
ARID1B AT rich interactive domain 1B (SWI1-like) 0.315
IQGAP1 IQ motif containing GTPase activating protein 1 0.314
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.312
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Rattus norvegicus
Name Description Probability Func Analog Organism
Actb actin, beta 0.066
Ptov1 prostate tumor overexpressed 1 0.036
Atf2 activating transcription factor 2 0.029
Pfn1 profilin 1 0.025
Ireb2 iron responsive element binding protein 2 0.023
Ptms parathymosin 0.023
Scaf1 SR-related CTD-associated factor 1 0.020
Csnk1g3 casein kinase 1, gamma 3 0.019
Pgm2 phosphoglucomutase 2 0.019
Uba1 ubiquitin-like modifier activating enzyme 1 0.019
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.018
Dcakd dephospho-CoA kinase domain containing 0.018
Mapk9 mitogen-activated protein kinase 9 0.017
Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 0.016
Tuba1c tubulin, alpha 1C 0.016
Cyfip1 cytoplasmic FMR1 interacting protein 1 0.016
Ect2 epithelial cell transforming sequence 2 oncogene 0.015
Fat1 FAT tumor suppressor homolog 1 (Drosophila) 0.015
Actg1 actin, gamma 1 0.015
G3bp2 GTPase activating protein (SH3 domain) binding protein 2 0.015
Ncdn neurochondrin 0.015
Fkbp1a FK506 binding protein 1a 0.015
Loxl1 lysyl oxidase-like 1 0.014
Calr calreticulin 0.014
Tmem168 transmembrane protein 168 0.013
Tubb5 tubulin, beta 5 0.013
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.013
Skiv2l2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 0.013
Pfkl phosphofructokinase, liver 0.013
Cxxc4 CXXC finger 4 0.013
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.012
Fmr1 fragile X mental retardation 1 0.012
Smc2 structural maintenance of chromosomes 2 0.012
Tgoln1 trans-golgi network protein 0.012
Dmd dystrophin 0.012
RGD1309414 similar to KIAA0913 protein 0.012
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.012
Clptm1 cleft lip and palate associated transmembrane protein 1 0.012
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.012
Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 0.012
Pcbp4 poly(rC) binding protein 4 0.012
Dact1 dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) 0.011
Zfp260 zinc finger protein 260 0.011
Gosr1 golgi SNAP receptor complex member 1 0.011
Vegfa vascular endothelial growth factor A 0.011
Dctn1 dynactin 1 0.011
Nnat neuronatin 0.011
Mlf2 myeloid leukemia factor 2 0.011
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.011
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.011
Foxs1 forkhead box S1 0.011
Sc65 synaptonemal complex protein SC65 0.010
Cenpf centromere protein F 0.010
Acvr1 activin A receptor, type I 0.010
Arpc4 actin related protein 2/3 complex, subunit 4 0.010
Neurl4 neuralized homolog 4 (Drosophila) 0.010
Casp3 caspase 3 0.010
Fzd2 frizzled homolog 2 (Drosophila) 0.010
Best2 bestrophin 2 0.010
Man2c1 mannosidase, alpha, class 2C, member 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism