The network for 'detection of mechanical stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

detection of mechanical stimulus

The series of events by which a mechanical stimulus is received and converted into a molecular signal.

Mus musculus
Name Description Probability Func Analog Organism
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.991
Ush1g Usher syndrome 1G homolog (human) 0.975
Pcdh15 protocadherin 15 0.956
Meox2 mesenchyme homeobox 2 0.904
Cdh23 cadherin 23 (otocadherin) 0.832
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.799
Grxcr1 glutaredoxin, cysteine rich 1 0.768
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.652
Ush1c Usher syndrome 1C homolog (human) 0.596
Thrb thyroid hormone receptor beta 0.513
Ptprq protein tyrosine phosphatase, receptor type, Q 0.513
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.498
Cdh5 cadherin 5 0.487
Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 0.418
Pou4f3 POU domain, class 4, transcription factor 3 0.394
Myo15 myosin XV 0.351
Tmprss3 transmembrane protease, serine 3 0.338
Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 0.325
Myo6 myosin VI 0.297
Flt1 FMS-like tyrosine kinase 1 0.272
Fyn Fyn proto-oncogene 0.228
Ikzf1 IKAROS family zinc finger 1 0.206
Fgfr2 fibroblast growth factor receptor 2 0.203
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.197
Myo7a myosin VIIA 0.181
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.180
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.180
Dcc deleted in colorectal carcinoma 0.162
Plcg2 phospholipase C, gamma 2 0.143
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.125
Hand1 heart and neural crest derivatives expressed transcript 1 0.122
Tyrobp TYRO protein tyrosine kinase binding protein 0.119
Fgfr3 fibroblast growth factor receptor 3 0.117
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.114
Vegfc vascular endothelial growth factor C 0.103
Espn espin 0.100
Csf1 colony stimulating factor 1 (macrophage) 0.094
Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit 0.094
Cd247 CD247 antigen 0.089
Clrn1 clarin 1 0.085
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.084
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.083
Efnb2 ephrin B2 0.083
Pten phosphatase and tensin homolog 0.081
Slc12a2 solute carrier family 12, member 2 0.074
Vdr vitamin D receptor 0.072
Tgfb2 transforming growth factor, beta 2 0.071
Ptf1a pancreas specific transcription factor, 1a 0.070
Col1a1 collagen, type I, alpha 1 0.069
Max Max protein 0.068
Sox2 SRY-box containing gene 2 0.065
Sox9 SRY-box containing gene 9 0.063
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.063
Cd19 CD19 antigen 0.063
Pax6 paired box gene 6 0.060
Ret ret proto-oncogene 0.060
Vegfa vascular endothelial growth factor A 0.059
Whrn whirlin 0.057
Sox17 SRY-box containing gene 17 0.057
Sox4 SRY-box containing gene 4 0.056
Cel carboxyl ester lipase 0.050
Diras1 DIRAS family, GTP-binding RAS-like 1 0.050
Emx2 empty spiracles homolog 2 (Drosophila) 0.049
Lyz2 lysozyme 2 0.049
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.048
Thbd thrombomodulin 0.048
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.046
Nos3 nitric oxide synthase 3, endothelial cell 0.046
Cxcl12 chemokine (C-X-C motif) ligand 12 0.046
Lcn8 lipocalin 8 0.045
Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 0.044
Pdgfb platelet derived growth factor, B polypeptide 0.043
Il2 interleukin 2 0.042
Epas1 endothelial PAS domain protein 1 0.042
LOC100503041 PDZ domain-containing protein 7-like 0.042
Neto1 neuropilin (NRP) and tolloid (TLL)-like 1 0.042
Fgfr1 fibroblast growth factor receptor 1 0.042
Esrrb estrogen related receptor, beta 0.042
Mas1 MAS1 oncogene 0.042
Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10 0.042
Ptprc protein tyrosine phosphatase, receptor type, C 0.039
Pramel7 preferentially expressed antigen in melanoma like 7 0.039
Trp53 transformation related protein 53 0.039
She src homology 2 domain-containing transforming protein E 0.038
Cd40 CD40 antigen 0.038
Prkce protein kinase C, epsilon 0.037
Ccr6 chemokine (C-C motif) receptor 6 0.037
Nrp1 neuropilin 1 0.036
Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 0.036
Pkd1 polycystic kidney disease 1 homolog 0.036
Lhx6 LIM homeobox protein 6 0.036
Myog myogenin 0.035
Il2rg interleukin 2 receptor, gamma chain 0.035
Onecut1 one cut domain, family member 1 0.035
Tnni1 troponin I, skeletal, slow 1 0.035
Prf1 perforin 1 (pore forming protein) 0.035
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.035
Ednrb endothelin receptor type B 0.034
Atcay ataxia, cerebellar, Cayman type homolog (human) 0.034
Cys1 cystin 1 0.034
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
cdh23 cadherin-like 23 0.956
cacna1da calcium channel, voltage-dependent, L type, alpha 1D subunit, a 0.889
slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 0.744
ap1b1 adaptor-related protein complex 1, beta 1 subunit 0.656
cyfip2 cytoplasmic FMR1 interacting protein 2 0.654
myo6b myosin VIb 0.602
myo7aa myosin VIIAa 0.501
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.424
ush1c Usher syndrome 1C (autosomal recessive, severe) 0.380
pcdh15a protocadherin 15a 0.336
eya4 eyes absent homolog 4 (Drosophila) 0.264
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.190
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.184
synj1 synaptojanin 1 0.156
scn1bb sodium channel, voltage-gated, type I, beta b 0.122
trpc6 transient receptor potential cation channel, subfamily C, member 6 0.098
ift88 intraflagellar transport 88 homolog 0.084
sox3 SRY-box containing gene 3 0.084
gpr126 G protein-coupled receptor 126 0.073
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.072
cdh4 cadherin 4, retinal 0.064
cc2d2a coiled-coil and C2 domain containing 2A 0.063
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.055
xylt1 xylosyltransferase 1 0.054
tp63 tumor protein p63 0.053
mapk6 mitogen-activated protein kinase 6 0.053
trpa1b transient receptor potential cation channel, subfamily A, member 1b 0.052
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.051
clrn1 clarin 1 0.050
robo3 roundabout homolog 3 0.049
hmx2 H6 family homeobox 2 0.047
bbs4 Bardet-Biedl syndrome 4 0.046
myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.046
ssrp1b structure specific recognition protein 1b 0.044
p2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.042
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.040
col11a1b collagen type XI alpha-1b and collagen, type XI, alpha 1b 0.040
scn2b sodium channel, voltage-gated, type II, beta 0.037
six1b sine oculis homeobox homolog 1b 0.032
ef1a elongation factor 1-alpha 0.031
tmie transmembrane inner ear 0.031
ugdh UDP-glucose dehydrogenase 0.029
rtn4rl2a reticulon 4 receptor-like 2 a 0.029
gfi1.2 growth factor independent 1.2 0.027
LOC100000934 hypothetical protein LOC100000934 0.026
ppp4cb protein phosphatase 4 (formerly X), catalytic subunit b 0.026
sh3gl1a SH3-domain GRB2-like 1a 0.025
flr fleer 0.025
spsb4a splA/ryanodine receptor domain and SOCS box containing 4a 0.024
dpf3 D4, zinc and double PHD fingers, family 3 0.023
slc15a1b solute carrier family 15 (oligopeptide transporter), member 1b 0.023
nppa natriuretic peptide precursor A 0.022
zmynd11 zinc finger, MYND domain containing 11 0.022
naa15b N(alpha)-acetyltransferase 15, NatA auxiliary subunit b 0.022
neu3.3 sialidase 3.3 0.021
flot1 flotillin 1 0.021
st14a suppression of tumorigenicity 14 (colon carcinoma) a 0.020
otomp otolith matrix protein 0.020
wu:fb01h12 wu:fb01h12 0.019
scn8ab sodium channel, voltage-gated, type VIII, alpha b 0.018
col5a3b collagen type V alpha-3b 0.018
fam20b family with sequence similarity 20, member B (H. sapiens) 0.018
prox1b prospero-related homeobox gene 1b 0.018
cluap1 clusterin associated protein 1 0.017
LOC557722 similar to transient receptor potential cation channel, subfamily M, member 5 0.017
esrp1 epithelial splicing regulatory protein 1 0.016
entpd3 ectonucleoside triphosphate diphosphohydrolase 3 0.016
smc1al structural maintenance of chromosomes 1A, like 0.016
zgc:162420 zgc:162420 0.016
appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.016
gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.015
mycl1b v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b 0.015
slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.015
rpz rapunzel 0.015
LOC572325 dymeclin-like 0.014
wu:fc31e07 wu:fc31e07 0.013
mylk3 myosin light chain kinase 3 0.013
eya1 eyes absent homolog 1 0.013
agpat9 1-acylglycerol-3-phosphate O-acyltransferase 9 0.013
pth2 parathyroid hormone 2 0.012
cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit 0.012
gsk3b glycogen synthase kinase 3 beta 0.012
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.012
sid4 secreted immunoglobulin domain 4 0.012
ahcyl2 S-adenosylhomocysteine hydrolase-like 2 0.012
dyrk1b dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.012
sec24c SEC24 family, member C (S. cerevisiae) 0.012
pho phoenix 0.011
ripk4 receptor-interacting serine-threonine kinase 4 0.011
mb myoglobin 0.011
kif3b kinesin family member 3B 0.011
itga7 integrin, alpha 7 0.011
si:ch211-166a6.5 si:ch211-166a6.5 0.011
cacna1bb calcium channel, voltage-dependent, N type, alpha 1B subunit, b 0.011
rag1 recombination activating gene 1 0.011
bmp10 bone morphogenetic protein 10 0.011
slc9a3.2 solute carrier family 9 (sodium/hydrogen exchanger), member 3.2 0.011
zgc:194112 zgc:194112 0.011
scn12ab sodium channel, voltage gated, type XII, alpha b 0.010
lrrc10 leucine rich repeat containing 10 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
btv beethoven 0.266
Nmdar2 NMDA receptor 2 0.085
ppk11 pickpocket 11 0.079
Ca-beta Ca2+-channel-protein-beta-subunit 0.041
Gr32a Gustatory receptor 32a 0.034
nompC no mechanoreceptor potential C 0.026
dsh dishevelled 0.025
CG32792 CG32792 gene product from transcript CG32792-RF 0.022
iav inactive 0.021
Nach CG8178 gene product from transcript CG8178-RA 0.018
ppk pickpocket 0.017
CG33289 CG33289 gene product from transcript CG33289-RA 0.017
amn amnesiac 0.015
nan nanchung 0.015
plx pollux 0.015
Irk3 Inwardly rectifying potassium channel 3 0.015
Gr33a Gustatory receptor 33a 0.014
Spn77Ba Serpin 77Ba 0.013
Gr59c Gustatory receptor 59c 0.013
rpk ripped pocket 0.012
Fad2 CG7923 gene product from transcript CG7923-RA 0.011
Ptp99A Protein tyrosine phosphatase 99A 0.011
l(2)k16918 lethal (2) k16918 0.010
Gr64c Gustatory receptor 64c 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 0.993
COL1A2 collagen, type I, alpha 2 0.989
COL3A1 collagen, type III, alpha 1 0.980
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.820
COL5A2 collagen, type V, alpha 2 0.808
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.790
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.776
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.732
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.594
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.542
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.540
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.501
COL4A1 collagen, type IV, alpha 1 0.490
FGFR1 fibroblast growth factor receptor 1 0.431
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.415
FBN1 fibrillin 1 0.384
POSTN periostin, osteoblast specific factor 0.379
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.315
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.279
DLG4 discs, large homolog 4 (Drosophila) 0.276
LOX lysyl oxidase 0.258
PTEN phosphatase and tensin homolog 0.252
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.239
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.234
COL6A1 collagen, type VI, alpha 1 0.220
NGF nerve growth factor (beta polypeptide) 0.208
THY1 Thy-1 cell surface antigen 0.205
MXRA5 matrix-remodelling associated 5 0.203
CTNNBIP1 catenin, beta interacting protein 1 0.197
AP1M1 adaptor-related protein complex 1, mu 1 subunit 0.194
KITLG KIT ligand 0.179
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.171
STAG2 stromal antigen 2 0.169
LAT linker for activation of T cells 0.163
DLG2 discs, large homolog 2 (Drosophila) 0.155
TRIM63 tripartite motif containing 63 0.154
LCK lymphocyte-specific protein tyrosine kinase 0.143
CALCA calcitonin-related polypeptide alpha 0.132
WDYHV1 WDYHV motif containing 1 0.129
COL5A1 collagen, type V, alpha 1 0.127
EPN1 epsin 1 0.126
ADAM12 ADAM metallopeptidase domain 12 0.126
COL6A3 collagen, type VI, alpha 3 0.122
TTN titin 0.113
BGN biglycan 0.110
FNDC1 fibronectin type III domain containing 1 0.109
SCNN1G sodium channel, nonvoltage-gated 1, gamma 0.106
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.104
CTNND1 catenin (cadherin-associated protein), delta 1 0.100
PXDN peroxidasin homolog (Drosophila) 0.097
APC adenomatous polyposis coli 0.096
COL6A2 collagen, type VI, alpha 2 0.093
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.090
RET ret proto-oncogene 0.087
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.087
ACTN2 actinin, alpha 2 0.086
COL11A1 collagen, type XI, alpha 1 0.086
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.082
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.081
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.080
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.075
COL5A3 collagen, type V, alpha 3 0.072
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.072
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.070
COL18A1 collagen, type XVIII, alpha 1 0.069
BTRC beta-transducin repeat containing 0.066
COL2A1 collagen, type II, alpha 1 0.066
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.065
CTHRC1 collagen triple helix repeat containing 1 0.064
NPHP1 nephronophthisis 1 (juvenile) 0.064
COL10A1 collagen, type X, alpha 1 0.064
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.061
THBS1 thrombospondin 1 0.060
SFRP4 secreted frizzled-related protein 4 0.060
LOXL1 lysyl oxidase-like 1 0.060
GLT8D2 glycosyltransferase 8 domain containing 2 0.056
IGFBP3 insulin-like growth factor binding protein 3 0.055
MYOZ1 myozenin 1 0.055
JUP junction plakoglobin 0.055
WISP1 WNT1 inducible signaling pathway protein 1 0.054
KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.053
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.052
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.051
SYK spleen tyrosine kinase 0.051
TDRD3 tudor domain containing 3 0.049
INSR insulin receptor 0.048
MYOD1 myogenic differentiation 1 0.048
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.048
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.048
LRRC17 leucine rich repeat containing 17 0.047
LAMB1 laminin, beta 1 0.047
CRIP1 cysteine-rich protein 1 (intestinal) 0.047
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.047
OLFML3 olfactomedin-like 3 0.046
SFRP2 secreted frizzled-related protein 2 0.046
IGF1R insulin-like growth factor 1 receptor 0.046
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.045
FLNA filamin A, alpha 0.045
GRB2 growth factor receptor-bound protein 2 0.045
LUM lumican 0.045
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism