The network for 'regulation of cartilage development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cartilage development

Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Prrx1 paired related homeobox 1 0.996
Sox9 SRY-box containing gene 9 0.994
Prrx2 paired related homeobox 2 0.993
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.983
Fgfr3 fibroblast growth factor receptor 3 0.976
Bmp4 bone morphogenetic protein 4 0.973
Bmp7 bone morphogenetic protein 7 0.972
Isl1 ISL1 transcription factor, LIM/homeodomain 0.962
Smad3 MAD homolog 3 (Drosophila) 0.954
Hoxd11 homeobox D11 0.950
Twist2 twist homolog 2 (Drosophila) 0.947
Fzd8 frizzled homolog 8 (Drosophila) 0.944
Tgfb2 transforming growth factor, beta 2 0.943
Nog noggin 0.942
Acvr1 activin A receptor, type 1 0.940
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.939
Hoxa10 homeobox A10 0.934
Smad6 MAD homolog 6 (Drosophila) 0.932
Pax6 paired box gene 6 0.928
Rarg retinoic acid receptor, gamma 0.926
Hoxd13 homeobox D13 0.925
Wnt5a wingless-related MMTV integration site 5A 0.916
En1 engrailed 1 0.890
Tcfap2a transcription factor AP-2, alpha 0.886
Gas1 growth arrest specific 1 0.884
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.879
Fgf8 fibroblast growth factor 8 0.878
Nodal nodal 0.875
Gata4 GATA binding protein 4 0.872
Fgf10 fibroblast growth factor 10 0.859
Snai1 snail homolog 1 (Drosophila) 0.854
Hoxa13 homeobox A13 0.851
Pthlh parathyroid hormone-like peptide 0.850
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.840
Pax3 paired box gene 3 0.825
Msx1 homeobox, msh-like 1 0.823
Wnt3a wingless-related MMTV integration site 3A 0.818
Hand1 heart and neural crest derivatives expressed transcript 1 0.794
Foxc1 forkhead box C1 0.794
Pax2 paired box gene 2 0.791
Neurod1 neurogenic differentiation 1 0.783
Tbx15 T-box 15 0.775
Tgfbr2 transforming growth factor, beta receptor II 0.768
Pbx1 pre B-cell leukemia transcription factor 1 0.766
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.745
Bmpr1a bone morphogenetic protein receptor, type 1A 0.727
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.715
Pax8 paired box gene 8 0.710
Fbn1 fibrillin 1 0.708
Col5a1 collagen, type V, alpha 1 0.706
Dlx5 distal-less homeobox 5 0.697
Smad7 MAD homolog 7 (Drosophila) 0.685
Chrd chordin 0.681
Smo smoothened homolog (Drosophila) 0.673
Meox2 mesenchyme homeobox 2 0.667
Eya1 eyes absent 1 homolog (Drosophila) 0.663
Gata6 GATA binding protein 6 0.656
Fgf18 fibroblast growth factor 18 0.650
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.636
Lhx1 LIM homeobox protein 1 0.617
Hoxa11 homeobox A11 0.608
Runx2 runt related transcription factor 2 0.591
Otx2 orthodenticle homolog 2 (Drosophila) 0.582
Tbx3 T-box 3 0.569
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.550
Emx2 empty spiracles homolog 2 (Drosophila) 0.545
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.542
Twist1 twist homolog 1 (Drosophila) 0.542
Rarb retinoic acid receptor, beta 0.541
Fgfr1 fibroblast growth factor receptor 1 0.538
Mrc2 mannose receptor, C type 2 0.535
Fzd1 frizzled homolog 1 (Drosophila) 0.524
Alx4 aristaless-like homeobox 4 0.523
Pax9 paired box gene 9 0.501
Hand2 heart and neural crest derivatives expressed transcript 2 0.497
Sox11 SRY-box containing gene 11 0.489
Col2a1 collagen, type II, alpha 1 0.482
Alx3 aristaless-like homeobox 3 0.476
Lmx1a LIM homeobox transcription factor 1 alpha 0.470
Ptf1a pancreas specific transcription factor, 1a 0.462
Foxf1a forkhead box F1a 0.461
Pitx1 paired-like homeodomain transcription factor 1 0.451
Ntf3 neurotrophin 3 0.450
Tbx2 T-box 2 0.435
Apc adenomatosis polyposis coli 0.427
Hoxa1 homeobox A1 0.426
Ret ret proto-oncogene 0.424
Tcf21 transcription factor 21 0.422
Msx2 homeobox, msh-like 2 0.405
Kiss1 KiSS-1 metastasis-suppressor 0.405
Rara retinoic acid receptor, alpha 0.402
Col1a1 collagen, type I, alpha 1 0.401
Fgf9 fibroblast growth factor 9 0.394
Neurog3 neurogenin 3 0.394
Fst follistatin 0.393
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.755
bmp2b bone morphogenetic protein 2b 0.476
runx2b runt-related transcription factor 2b 0.441
rarga retinoic acid receptor gamma a 0.386
hapln1a hyaluronan and proteoglycan link protein 1a 0.211
fgf3 fibroblast growth factor 3 0.204
tbx16 T-box gene 16 0.182
fgf10a fibroblast growth factor 10a 0.173
runx2a runt-related transcription factor 2a 0.135
twist3 twist3 0.132
gpr126 G protein-coupled receptor 126 0.124
col2a1a collagen type II, alpha-1a 0.124
flh floating head 0.121
sox9a SRY-box containing gene 9a 0.117
bmper BMP binding endothelial regulator 0.105
shha sonic hedgehog a 0.102
tgfbi transforming growth factor, beta-induced 0.098
rarab retinoic acid receptor, alpha b 0.096
s1pr2 sphingosine-1-phosphate receptor 2 0.092
ndr2 nodal-related 2 0.090
prdm1a PR domain containing 1a, with ZNF domain 0.086
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.084
fgfrl1b fibroblast growth factor receptor-like 1b 0.084
chd chordin 0.082
fgfr1a fibroblast growth factor receptor 1a 0.079
cx30.3 connexin 30.3 0.076
hand2 heart and neural crest derivatives expressed transcript 2 0.070
gsc goosecoid 0.070
hoxa13b homeo box A13b 0.069
lft1 lefty1 0.068
osr1 odd-skipped related 1 (Drosophila) 0.065
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.064
gli2a GLI-Kruppel family member GLI2a 0.061
dlx4a distal-less homeobox gene 4a 0.056
snai1b snail homolog 1b (Drosophila) 0.053
prrx1a paired related homeobox 1a 0.053
bmp2a bone morphogenetic protein 2a 0.051
twist1a twist1a 0.050
wu:fv91b12 wu:fv91b12 0.050
sox2 SRY-box containing gene 2 0.049
rxrbb retinoid x receptor, beta b 0.049
col10a1 collagen, type X, alpha 1 0.049
gdf6a growth differentiation factor 6a 0.048
dlx2a distal-less homeobox gene 2a 0.046
hoxa11b homeo box A11b 0.045
msxc muscle segment homeobox C 0.045
hoxd10a homeo box D10a 0.044
hoxd12a homeo box D12a 0.043
si:ch211-173b8.2 si:ch211-173b8.2 0.043
hoxa9b homeo box A9b 0.041
hoxd13a homeo box D13a 0.041
foxa3 forkhead box A3 0.041
jag1b jagged 1b 0.040
fgf4 fibroblast growth factor 4 0.038
sec24d SEC24 family, member D (S. cerevisiae) 0.037
pax9 paired box gene 9 0.037
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.035
wnt5b wingless-type MMTV integration site family, member 5b 0.034
spry2 sprouty homolog 2 0.034
sall4 sal-like 4 (Drosophila) 0.034
hoxa10b homeo box A10b 0.034
ptch1 patched 1 0.033
col1a1a collagen, type I, alpha 1a 0.033
foxi1 forkhead box I1 0.033
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.030
dlx5a distal-less homeobox gene 5a 0.030
spns2 spinster homolog 2 (Drosophila) 0.029
loxl3b lysyl oxidase-like 3b 0.029
ctgf connective tissue growth factor 0.029
znf703 zinc finger protein 703 0.028
fn1 fibronectin 1 0.028
sparc secreted acidic cysteine rich glycoprotein 0.028
tcf12 transcription factor 12 0.027
fgfr2 fibroblast growth factor receptor 2 0.027
kita kit receptor a 0.027
hsp47 heat shock protein 47 0.027
ptch2 patched 2 0.026
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.026
loxl2b lysyl oxidase-like 2b 0.026
twist2 twist2 0.025
efnb1 ephrin B1 0.025
shhb sonic hedgehog b 0.025
ldb2a LIM-domain binding factor 2a 0.024
boc brother of CDO 0.024
pcdh18a protocadherin 18a 0.023
dlx3b distal-less homeobox gene 3b 0.023
spon2a spondin 2a, extracellular matrix protein 0.022
mab21l2 mab-21-like 2 0.021
hoxa11a homeo box A11a 0.021
prrx1b paired related homeobox 1b 0.021
frem3 Fras1 related extracellular matrix 3 0.021
barx1 BarH-like homeobox 1 0.020
srf serum response factor 0.020
rxraa retinoid X receptor, alpha a 0.020
sh3gl1b SH3-domain GRB2-like 1b 0.020
bmp4 bone morphogenetic protein 4 0.020
hoxb5a homeo box B5a 0.020
sp7 Sp7 transcription factor 0.019
dkk1b dickkopf 1b 0.019
admp anti-dorsalizing morphogenic protein 0.019
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD7 SMAD family member 7 0.967
LTBP2 latent transforming growth factor beta binding protein 2 0.886
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.827
ELN elastin 0.769
SMAD2 SMAD family member 2 0.767
FBLN1 fibulin 1 0.638
SMAD4 SMAD family member 4 0.605
SMAD1 SMAD family member 1 0.555
SMAD5 SMAD family member 5 0.551
BMPR1A bone morphogenetic protein receptor, type IA 0.504
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.489
ATN1 atrophin 1 0.486
CTGF connective tissue growth factor 0.469
FSTL1 follistatin-like 1 0.459
POU3F2 POU class 3 homeobox 2 0.456
COL1A1 collagen, type I, alpha 1 0.352
COL6A1 collagen, type VI, alpha 1 0.342
LOXL1 lysyl oxidase-like 1 0.337
SMAD3 SMAD family member 3 0.321
PAX3 paired box 3 0.320
LOX lysyl oxidase 0.255
FN1 fibronectin 1 0.246
FBN1 fibrillin 1 0.227
TGFB1 transforming growth factor, beta 1 0.221
CHRD chordin 0.200
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.199
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.168
COL6A2 collagen, type VI, alpha 2 0.167
FBLN5 fibulin 5 0.152
RXRA retinoid X receptor, alpha 0.138
TGFB3 transforming growth factor, beta 3 0.132
SKI v-ski sarcoma viral oncogene homolog (avian) 0.114
NCOA1 nuclear receptor coactivator 1 0.111
BMPR1B bone morphogenetic protein receptor, type IB 0.107
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.096
BMP7 bone morphogenetic protein 7 0.095
COL5A1 collagen, type V, alpha 1 0.090
BGN biglycan 0.090
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.090
MEOX2 mesenchyme homeobox 2 0.088
ENG endoglin 0.088
ZFYVE9 zinc finger, FYVE domain containing 9 0.086
BMP2 bone morphogenetic protein 2 0.083
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.078
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.078
CYR61 cysteine-rich, angiogenic inducer, 61 0.078
EGR1 early growth response 1 0.074
MED25 mediator complex subunit 25 0.074
BTRC beta-transducin repeat containing 0.072
THBS1 thrombospondin 1 0.060
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.059
TGFBR1 transforming growth factor, beta receptor 1 0.058
PCOLCE procollagen C-endopeptidase enhancer 0.057
PML promyelocytic leukemia 0.056
COL1A2 collagen, type I, alpha 2 0.055
HSPG2 heparan sulfate proteoglycan 2 0.051
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.048
SMAD6 SMAD family member 6 0.045
TNC tenascin C 0.045
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.041
COL3A1 collagen, type III, alpha 1 0.035
DCN decorin 0.034
COL18A1 collagen, type XVIII, alpha 1 0.033
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.033
MRC2 mannose receptor, C type 2 0.032
SUFU suppressor of fused homolog (Drosophila) 0.031
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.031
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.030
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.030
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.030
COL2A1 collagen, type II, alpha 1 0.028
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.027
CALD1 caldesmon 1 0.027
MFAP2 microfibrillar-associated protein 2 0.027
CTBP2 C-terminal binding protein 2 0.025
AXIN1 axin 1 0.025
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.025
WISP1 WNT1 inducible signaling pathway protein 1 0.023
CREBBP CREB binding protein 0.023
SOX11 SRY (sex determining region Y)-box 11 0.023
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.023
BMP1 bone morphogenetic protein 1 0.022
FZD1 frizzled homolog 1 (Drosophila) 0.022
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.022
LAMB2 laminin, beta 2 (laminin S) 0.021
IGFBP5 insulin-like growth factor binding protein 5 0.021
LTBP4 latent transforming growth factor beta binding protein 4 0.021
CHAC1 ChaC, cation transport regulator homolog 1 (E. coli) 0.021
COMP cartilage oligomeric matrix protein 0.020
TGFB2 transforming growth factor, beta 2 0.020
AMOTL2 angiomotin like 2 0.020
NRP2 neuropilin 2 0.020
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.020
HOXA10 homeobox A10 0.019
MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 0.019
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.019
CD248 CD248 molecule, endosialin 0.019
MXRA8 matrix-remodelling associated 8 0.018
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.018
PRKD2 protein kinase D2 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism