The network for 'embryonic skeletal system morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Foxc1 forkhead box C1 1.000
Tbx1 T-box 1 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Tcfap2a transcription factor AP-2, alpha 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Msx1 homeobox, msh-like 1 1.000
Dlx5 distal-less homeobox 5 1.000
Bmp7 bone morphogenetic protein 7 1.000
Sox9 SRY-box containing gene 9 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Prrx1 paired related homeobox 1 1.000
Pax3 paired box gene 3 1.000
Pax2 paired box gene 2 1.000
Pax6 paired box gene 6 1.000
Runx2 runt related transcription factor 2 1.000
Foxc2 forkhead box C2 1.000
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 1.000
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.999
Bmp4 bone morphogenetic protein 4 0.999
Tgfb2 transforming growth factor, beta 2 0.999
Eya1 eyes absent 1 homolog (Drosophila) 0.999
Rnf2 ring finger protein 2 0.999
Pbx1 pre B-cell leukemia transcription factor 1 0.998
Hoxa13 homeobox A13 0.998
Hoxa1 homeobox A1 0.998
Rarg retinoic acid receptor, gamma 0.998
Lhx1 LIM homeobox protein 1 0.998
Smo smoothened homolog (Drosophila) 0.998
Rarb retinoic acid receptor, beta 0.997
Pax9 paired box gene 9 0.997
Hoxd11 homeobox D11 0.997
Hoxa11 homeobox A11 0.997
Pitx1 paired-like homeodomain transcription factor 1 0.997
Fgf8 fibroblast growth factor 8 0.996
Fgf10 fibroblast growth factor 10 0.996
Twist2 twist homolog 2 (Drosophila) 0.996
Msx2 homeobox, msh-like 2 0.994
Hand1 heart and neural crest derivatives expressed transcript 1 0.993
Pax8 paired box gene 8 0.993
Col1a1 collagen, type I, alpha 1 0.991
Chrd chordin 0.991
Fgfr3 fibroblast growth factor receptor 3 0.991
Fgfr1 fibroblast growth factor receptor 1 0.990
Hoxd13 homeobox D13 0.988
Col2a1 collagen, type II, alpha 1 0.988
Hoxa5 homeobox A5 0.988
Tbx15 T-box 15 0.986
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.985
Emx2 empty spiracles homolog 2 (Drosophila) 0.983
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.982
Hoxb3 homeobox B3 0.982
Apc adenomatosis polyposis coli 0.981
Nodal nodal 0.980
Gbx2 gastrulation brain homeobox 2 0.980
Hand2 heart and neural crest derivatives expressed transcript 2 0.980
Prrx2 paired related homeobox 2 0.978
Wnt3a wingless-related MMTV integration site 3A 0.977
Hoxd3 homeobox D3 0.974
Hoxa2 homeobox A2 0.974
Hoxa9 homeobox A9 0.973
Lmx1a LIM homeobox transcription factor 1 alpha 0.969
Smad4 MAD homolog 4 (Drosophila) 0.969
Ctnnb1 catenin (cadherin associated protein), beta 1 0.967
Hoxa10 homeobox A10 0.961
Ptch1 patched homolog 1 0.957
Gdnf glial cell line derived neurotrophic factor 0.954
Tgfbr2 transforming growth factor, beta receptor II 0.953
Hoxa3 homeobox A3 0.943
Foxg1 forkhead box G1 0.942
Sox2 SRY-box containing gene 2 0.942
Lef1 lymphoid enhancer binding factor 1 0.937
Nkx2-1 NK2 homeobox 1 0.936
Smad6 MAD homolog 6 (Drosophila) 0.929
Meox2 mesenchyme homeobox 2 0.929
Gas1 growth arrest specific 1 0.923
Pthlh parathyroid hormone-like peptide 0.923
Pten phosphatase and tensin homolog 0.922
Rybp RING1 and YY1 binding protein 0.921
Pkd1 polycystic kidney disease 1 homolog 0.919
Ptf1a pancreas specific transcription factor, 1a 0.916
Dlx2 distal-less homeobox 2 0.916
Rara retinoic acid receptor, alpha 0.915
Tcfcp2l1 transcription factor CP2-like 1 0.914
Fgf3 fibroblast growth factor 3 0.914
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.913
Gsc goosecoid homeobox 0.905
Vegfa vascular endothelial growth factor A 0.904
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.899
Emx1 empty spiracles homolog 1 (Drosophila) 0.898
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.886
Zeb1 zinc finger E-box binding homeobox 1 0.883
Isl1 ISL1 transcription factor, LIM/homeodomain 0.872
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.872
Hoxd9 homeobox D9 0.867
Dlx1 distal-less homeobox 1 0.858
Smad3 MAD homolog 3 (Drosophila) 0.855
Gdf11 growth differentiation factor 11 0.855
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
sox9a SRY-box containing gene 9a 0.999
prdm1a PR domain containing 1a, with ZNF domain 0.998
wu:fv91b12 wu:fv91b12 0.996
jag1b jagged 1b 0.996
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.996
foxi1 forkhead box I1 0.995
edn1 endothelin 1 0.990
barx1 BarH-like homeobox 1 0.988
brpf1 bromodomain and PHD finger containing, 1 0.985
sec24d SEC24 family, member D (S. cerevisiae) 0.983
hoxb5b homeo box B5b 0.970
hoxb3a homeo box B3a 0.956
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.951
hoxa3a homeo box A3a 0.939
bmp4 bone morphogenetic protein 4 0.938
hand2 heart and neural crest derivatives expressed transcript 2 0.938
foxd3 forkhead box D3 0.936
tbx1 T-box 1 0.936
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.935
boc brother of CDO 0.929
hoxb2a homeo box B2a 0.928
furina furin (paired basic amino acid cleaving enzyme) a 0.927
atoh1a atonal homolog 1a 0.927
uxs1 UDP-glucuronic acid decarboxylase 1 0.926
hoxa2b homeo box A2b 0.925
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.924
csnk1a1 casein kinase 1, alpha 1 0.921
twist1a twist1a 0.920
wnt5b wingless-type MMTV integration site family, member 5b 0.916
tbx5a T-box 5a 0.916
gata3 GATA-binding protein 3 0.914
mab21l2 mab-21-like 2 0.903
zgc:158603 zgc:158603 0.903
pitx2 paired-like homeodomain transcription factor 2 0.899
pax8 paired box gene 8 0.898
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.880
xylt1 xylosyltransferase 1 0.863
gbx2 gastrulation brain homeo box 2 0.855
col2a1a collagen type II, alpha-1a 0.848
nkx3.2 NK3 homeobox 2 0.848
hoxb6a homeo box B6a 0.834
six4b sine oculis homeobox homolog 4b 0.825
twist1b twist1b 0.820
myod1 myogenic differentiation 1 0.814
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.797
pax9 paired box gene 9 0.782
gli2a GLI-Kruppel family member GLI2a 0.781
hoxd3a homeo box D3a 0.776
crabp2a cellular retinoic acid binding protein 2, a 0.762
pbx4 pre-B-cell leukemia transcription factor 4 0.760
shhb sonic hedgehog b 0.757
meis3 myeloid ecotropic viral integration site 3 0.756
fn1 fibronectin 1 0.752
hmx4 H6 family homeobox 4 0.739
disc1 disrupted in schizophrenia 1 0.737
osr1 odd-skipped related 1 (Drosophila) 0.733
raraa retinoic acid receptor, alpha a 0.732
hoxb4a homeo box B4a 0.732
lhx5 LIM homeobox 5 0.731
six2a sine oculis-related homeobox 2a 0.719
disp1 dispatched homolog 1 (Drosophila) 0.708
s1pr2 sphingosine-1-phosphate receptor 2 0.708
bmp2a bone morphogenetic protein 2a 0.690
shha sonic hedgehog a 0.684
hoxa9b homeo box A9b 0.671
bmp2b bone morphogenetic protein 2b 0.669
hoxb1a homeo box B1a 0.662
nkx2.3 NK2 transcription factor related 3 0.656
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.647
tp53 tumor protein p53 0.644
ptch2 patched 2 0.638
mecom MDS1 and EVI1 complex locus 0.638
dlx2a distal-less homeobox gene 2a 0.634
eya1 eyes absent homolog 1 0.631
pcdh18a protocadherin 18a 0.622
pax6a paired box gene 6a 0.620
fgf3 fibroblast growth factor 3 0.617
runx2a runt-related transcription factor 2a 0.615
msxc muscle segment homeobox C 0.605
hoxa4a homeo box A4a 0.596
rargb retinoic acid receptor, gamma b 0.575
rarga retinoic acid receptor gamma a 0.572
frem2a Fras1 related extracellular matrix protein 2a 0.571
ptch1 patched 1 0.565
hoxa5a homeo box A5a 0.564
pcdh8 protocadherin 8 0.562
mef2ca myocyte enhancer factor 2ca 0.561
unc45b unc-45 homolog B (C. elegans) 0.561
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.559
wnt11r wingless-type MMTV integration site family, member 11, related 0.558
wif1 wnt inhibitory factor 1 0.551
hoxd4a homeo box D4a 0.545
tp63 tumor protein p63 0.544
hoxc4a homeo box C4a 0.535
msxd muscle segment homeobox D 0.532
LOC100000500 sclerostin-like 0.527
snai1b snail homolog 1b (Drosophila) 0.523
smad1 MAD homolog 1 (Drosophila) 0.521
unc45a unc-45 homolog A (C. elegans) 0.518
pax2a paired box gene 2a 0.518
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HOXB5 homeobox B5 0.894
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.848
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.821
COL1A1 collagen, type I, alpha 1 0.677
FGF1 fibroblast growth factor 1 (acidic) 0.608
SMAD3 SMAD family member 3 0.495
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.463
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.449
HOXA10 homeobox A10 0.396
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.394
COL1A2 collagen, type I, alpha 2 0.348
COL3A1 collagen, type III, alpha 1 0.337
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.331
COL6A1 collagen, type VI, alpha 1 0.247
HOXA5 homeobox A5 0.239
TAL1 T-cell acute lymphocytic leukemia 1 0.193
HOXA11 homeobox A11 0.172
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.148
TP53 tumor protein p53 0.145
HOXB9 homeobox B9 0.133
RUNX1 runt-related transcription factor 1 0.132
FSTL1 follistatin-like 1 0.122
HOXB3 homeobox B3 0.121
PBX1 pre-B-cell leukemia homeobox 1 0.103
HOXA4 homeobox A4 0.103
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.094
HOXB6 homeobox B6 0.094
SMAD7 SMAD family member 7 0.094
SMAD2 SMAD family member 2 0.089
RING1 ring finger protein 1 0.088
EP300 E1A binding protein p300 0.082
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.081
HOXA7 homeobox A7 0.078
HOXA6 homeobox A6 0.073
COL5A1 collagen, type V, alpha 1 0.072
HOXD9 homeobox D9 0.067
MDFI MyoD family inhibitor 0.062
CREBBP CREB binding protein 0.058
MEF2A myocyte enhancer factor 2A 0.058
BMI1 BMI1 polycomb ring finger oncogene 0.058
PTCH1 patched 1 0.057
HOXA3 homeobox A3 0.057
COL5A2 collagen, type V, alpha 2 0.054
COL4A1 collagen, type IV, alpha 1 0.052
RNF31 ring finger protein 31 0.049
HOXA9 homeobox A9 0.049
CABP1 calcium binding protein 1 0.046
PML promyelocytic leukemia 0.044
HOXC8 homeobox C8 0.044
TWIST1 twist homolog 1 (Drosophila) 0.043
HOXC6 homeobox C6 0.043
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.043
DAXX death-domain associated protein 0.041
BMP1 bone morphogenetic protein 1 0.039
TRIP6 thyroid hormone receptor interactor 6 0.039
CBX8 chromobox homolog 8 0.038
HOXD10 homeobox D10 0.038
HOXD13 homeobox D13 0.037
PAX3 paired box 3 0.035
GATA2 GATA binding protein 2 0.035
COL6A2 collagen, type VI, alpha 2 0.035
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.035
HOXA2 homeobox A2 0.034
COL2A1 collagen, type II, alpha 1 0.034
HOXB13 homeobox B13 0.032
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.032
FOXF2 forkhead box F2 0.031
MSX1 msh homeobox 1 0.031
PDGFA platelet-derived growth factor alpha polypeptide 0.031
APC adenomatous polyposis coli 0.029
HOXD3 homeobox D3 0.029
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.029
BARX1 BARX homeobox 1 0.029
TCF4 transcription factor 4 0.028
POSTN periostin, osteoblast specific factor 0.028
ELN elastin 0.027
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.027
ADAM17 ADAM metallopeptidase domain 17 0.026
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.026
HOXD11 homeobox D11 0.026
HOXC11 homeobox C11 0.026
HOXC10 homeobox C10 0.025
TJP1 tight junction protein 1 (zona occludens 1) 0.025
HOXB4 homeobox B4 0.024
NRP1 neuropilin 1 0.024
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.024
MEF2C myocyte enhancer factor 2C 0.024
TGFB1 transforming growth factor, beta 1 0.023
COL11A1 collagen, type XI, alpha 1 0.023
HOXA13 homeobox A13 0.023
PTEN phosphatase and tensin homolog 0.023
LUM lumican 0.023
FOXA2 forkhead box A2 0.022
COL16A1 collagen, type XVI, alpha 1 0.022
HOXC13 homeobox C13 0.021
USP11 ubiquitin specific peptidase 11 0.021
FOXC1 forkhead box C1 0.021
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.021
PRRX2 paired related homeobox 2 0.020
NRP2 neuropilin 2 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.711
Col12a1 collagen, type XII, alpha 1 0.541
Fos FBJ osteosarcoma oncogene 0.506
Lamc1 laminin, gamma 1 0.495
Twist2 twist homolog 2 (Drosophila) 0.408
Dusp6 dual specificity phosphatase 6 0.335
Tgfbr2 transforming growth factor, beta receptor II 0.312
Junb jun B proto-oncogene 0.287
Igfbp5 insulin-like growth factor binding protein 5 0.287
Prrx1 paired related homeobox 1 0.253
Dusp1 dual specificity phosphatase 1 0.236
Efna5 ephrin A5 0.234
Bgn biglycan 0.208
Vcan versican 0.205
Hoxc4 homeo box C4 0.200
Shox2 short stature homeobox 2 0.190
Tcfe2a transcription factor E2a 0.184
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.183
Aebp1 AE binding protein 1 0.176
Lox lysyl oxidase 0.169
Cercam cerebral endothelial cell adhesion molecule 0.167
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.154
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.153
Gdf11 growth differentiation factor 11 0.149
Mybpc2 myosin binding protein C, fast-type 0.147
Rest RE1-silencing transcription factor 0.142
Fgfr2 fibroblast growth factor receptor 2 0.140
Cyr61 cysteine-rich, angiogenic inducer, 61 0.140
Znf503 zinc finger protein 503 0.138
Ier2 immediate early response 2 0.135
Arnt aryl hydrocarbon receptor nuclear translocator 0.133
Mstn myostatin 0.130
Egr2 early growth response 2 0.126
Col5a1 collagen, type V, alpha 1 0.124
Slit3 slit homolog 3 (Drosophila) 0.124
Btg2 BTG family, member 2 0.115
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.115
Ptbp1 polypyrimidine tract binding protein 1 0.111
Prrx2 paired related homeobox 2 0.105
Ebf1 early B-cell factor 1 0.105
Foxc2 forkhead box C2 0.102
Scarf2 scavenger receptor class F, member 2 0.102
Baiap2 BAI1-associated protein 2 0.098
Pick1 protein interacting with PRKCA 1 0.098
Galr3 galanin receptor 3 0.098
Add3 adducin 3 (gamma) 0.090
Nfya nuclear transcription factor-Y alpha 0.086
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.082
Hand2 heart and neural crest derivatives expressed 2 0.082
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.082
Figf c-fos induced growth factor 0.080
Myh10 myosin, heavy chain 10, non-muscle 0.079
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 0.075
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.074
Dmd dystrophin 0.073
Tnc tenascin C 0.072
Bmp6 bone morphogenetic protein 6 0.072
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.070
Fn1 fibronectin 1 0.069
Gprc5c G protein-coupled receptor, family C, group 5, member C 0.069
Rnf138 ring finger protein 138 0.069
Galr2 galanin receptor 2 0.068
Ephb3 Eph receptor B3 0.066
Col9a1 collagen, type IX, alpha 1 0.065
Isl1 ISL LIM homeobox 1 0.064
Lef1 lymphoid enhancer binding factor 1 0.063
Unc5b unc-5 homolog B (C. elegans) 0.060
Jun Jun oncogene 0.060
Ntf4 neurotrophin 4 0.059
Six1 SIX homeobox 1 0.059
Grip1 glutamate receptor interacting protein 1 0.058
Kctd15 potassium channel tetramerisation domain containing 15 0.058
Col8a1 collagen, type VIII, alpha 1 0.057
Jak2 Janus kinase 2 0.057
Nppc natriuretic peptide precursor C 0.057
Ddr2 discoidin domain receptor tyrosine kinase 2 0.055
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.053
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.053
Sfrp4 secreted frizzled-related protein 4 0.052
Hist1h1d histone cluster 1, H1d 0.051
Arrb1 arrestin, beta 1 0.051
Adarb2 adenosine deaminase, RNA-specific, B2 0.050
Gal3st4 galactose-3-O-sulfotransferase 4 0.049
RGD1310262 hypothetical LOC304650 0.049
Dnah8 dynein, axonemal, heavy chain 8 0.048
Megf6 multiple EGF-like-domains 6 0.048
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.048
Snai2 snail homolog 2 (Drosophila) 0.047
Hoxb7 homeo box B7 0.047
Robo1 roundabout homolog 1 (Drosophila) 0.047
LOC100362331 rCG59612-like 0.046
Epha8 Eph receptor A8 0.046
Tgfb2 transforming growth factor, beta 2 0.043
Acan aggrecan 0.043
Ncam1 neural cell adhesion molecule 1 0.043
Mapk8 mitogen-activated protein kinase 8 0.042
Kl Klotho 0.042
Sirpa signal-regulatory protein alpha 0.041
Fkbp10 FK506 binding protein 10 0.041
Homer3 homer homolog 3 (Drosophila) 0.041
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism