The network for 'aortic valve morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

aortic valve morphogenesis

The process in which the structure of the aortic valve is generated and organized.

Mus musculus
Name Description Probability Func Analog Organism
Gata4 GATA binding protein 4 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Jag1 jagged 1 0.999
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.996
Shh sonic hedgehog 0.995
Hand2 heart and neural crest derivatives expressed transcript 2 0.989
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.986
Neurod1 neurogenic differentiation 1 0.985
Gata6 GATA binding protein 6 0.983
Pitx2 paired-like homeodomain transcription factor 2 0.969
Notch1 Notch gene homolog 1 (Drosophila) 0.965
Hoxa1 homeobox A1 0.960
Foxc2 forkhead box C2 0.958
Ntf3 neurotrophin 3 0.954
Fgf8 fibroblast growth factor 8 0.940
Neurog2 neurogenin 2 0.923
Nhlh1 nescient helix loop helix 1 0.914
Zfpm2 zinc finger protein, multitype 2 0.906
Tal1 T-cell acute lymphocytic leukemia 1 0.891
Kiss1 KiSS-1 metastasis-suppressor 0.875
Pax2 paired box gene 2 0.862
Isl1 ISL1 transcription factor, LIM/homeodomain 0.856
Ptf1a pancreas specific transcription factor, 1a 0.850
Tcfap2a transcription factor AP-2, alpha 0.847
Gli3 GLI-Kruppel family member GLI3 0.846
Otx2 orthodenticle homolog 2 (Drosophila) 0.841
Gpr50 G-protein-coupled receptor 50 0.824
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.817
Tbx3 T-box 3 0.808
Klf3 Kruppel-like factor 3 (basic) 0.790
Efnb2 ephrin B2 0.788
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.767
Rxra retinoid X receptor alpha 0.734
Hes1 hairy and enhancer of split 1 (Drosophila) 0.715
Smad6 MAD homolog 6 (Drosophila) 0.705
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.701
Foxd2 forkhead box D2 0.699
Ephb2 Eph receptor B2 0.695
Pax6 paired box gene 6 0.692
Gata1 GATA binding protein 1 0.691
Hoxd13 homeobox D13 0.684
En1 engrailed 1 0.684
Tcf15 transcription factor 15 0.674
Neurog3 neurogenin 3 0.664
Tgfb2 transforming growth factor, beta 2 0.661
Mecom MDS1 and EVI1 complex locus 0.652
Gata5 GATA binding protein 5 0.650
Pitx1 paired-like homeodomain transcription factor 1 0.642
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.639
Hand1 heart and neural crest derivatives expressed transcript 1 0.602
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.588
Sim2 single-minded homolog 2 (Drosophila) 0.576
Prox1 prospero-related homeobox 1 0.568
Snai1 snail homolog 1 (Drosophila) 0.538
Chd7 chromodomain helicase DNA binding protein 7 0.535
Neurod4 neurogenic differentiation 4 0.533
Foxg1 forkhead box G1 0.532
Bnc1 basonuclin 1 0.509
Efnb1 ephrin B1 0.507
Sox7 SRY-box containing gene 7 0.493
Tbx20 T-box 20 0.483
Lmx1a LIM homeobox transcription factor 1 alpha 0.483
Dll1 delta-like 1 (Drosophila) 0.481
Cxcr4 chemokine (C-X-C motif) receptor 4 0.479
Tbx5 T-box 5 0.475
Gbx2 gastrulation brain homeobox 2 0.469
Mesp1 mesoderm posterior 1 0.446
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.443
Lhx9 LIM homeobox protein 9 0.440
Pax3 paired box gene 3 0.440
Onecut1 one cut domain, family member 1 0.427
Hoxc5 homeobox C5 0.424
Lmx1b LIM homeobox transcription factor 1 beta 0.418
Notch2 Notch gene homolog 2 (Drosophila) 0.409
Hoxd1 homeobox D1 0.409
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.390
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.388
Tal2 T-cell acute lymphocytic leukemia 2 0.383
Ank1 ankyrin 1, erythroid 0.380
Efna2 ephrin A2 0.362
Tlx3 T-cell leukemia, homeobox 3 0.361
T brachyury 0.358
Sox11 SRY-box containing gene 11 0.356
Tead3 TEA domain family member 3 0.356
Ebf3 early B-cell factor 3 0.343
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.334
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.332
Hoxa10 homeobox A10 0.331
Hif3a hypoxia inducible factor 3, alpha subunit 0.327
Lhx5 LIM homeobox protein 5 0.321
Hoxc8 homeobox C8 0.321
Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex 0.307
Shox2 short stature homeobox 2 0.294
Foxc1 forkhead box C1 0.293
Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 0.292
Hoxa13 homeobox A13 0.291
Tbx2 T-box 2 0.285
Pou4f2 POU domain, class 4, transcription factor 2 0.284
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.284
Hoxa4 homeobox A4 0.281
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
JAG1 jagged 1 1.000
NOTCH1 notch 1 0.981
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.974
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.949
NOTCH3 notch 3 0.919
SETD8 SET domain containing (lysine methyltransferase) 8 0.754
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.672
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.549
GATA2 GATA binding protein 2 0.491
TAL1 T-cell acute lymphocytic leukemia 1 0.432
DLL1 delta-like 1 (Drosophila) 0.361
GATA4 GATA binding protein 4 0.330
RUNX1 runt-related transcription factor 1 0.320
MAML1 mastermind-like 1 (Drosophila) 0.245
JAG2 jagged 2 0.237
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.237
XIAP X-linked inhibitor of apoptosis 0.231
SPEN spen homolog, transcriptional regulator (Drosophila) 0.115
TCF12 transcription factor 12 0.097
MYOD1 myogenic differentiation 1 0.081
EGFL7 EGF-like-domain, multiple 7 0.081
LMO2 LIM domain only 2 (rhombotin-like 1) 0.062
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.057
TBX5 T-box 5 0.054
GATA3 GATA binding protein 3 0.052
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.048
SOX18 SRY (sex determining region Y)-box 18 0.048
PHOX2A paired-like homeobox 2a 0.040
DLL4 delta-like 4 (Drosophila) 0.039
NOTCH2NL notch 2 N-terminal like 0.037
FGF3 fibroblast growth factor 3 0.037
LRRN2 leucine rich repeat neuronal 2 0.036
HIPK2 homeodomain interacting protein kinase 2 0.034
LMO1 LIM domain only 1 (rhombotin 1) 0.034
SMAD1 SMAD family member 1 0.033
SIX6 SIX homeobox 6 0.032
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.030
FOXF2 forkhead box F2 0.029
HEYL hairy/enhancer-of-split related with YRPW motif-like 0.029
MSX1 msh homeobox 1 0.028
RUNX3 runt-related transcription factor 3 0.028
SOX1 SRY (sex determining region Y)-box 1 0.026
NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) 0.026
GFI1B growth factor independent 1B transcription repressor 0.026
TBX21 T-box 21 0.026
HAND2 heart and neural crest derivatives expressed 2 0.025
POU4F2 POU class 4 homeobox 2 0.025
HOXD11 homeobox D11 0.024
ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 0.024
ACAN aggrecan 0.024
PML promyelocytic leukemia 0.023
HOXD12 homeobox D12 0.023
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.023
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.022
WNT6 wingless-type MMTV integration site family, member 6 0.022
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.022
LTK leukocyte receptor tyrosine kinase 0.022
NKG7 natural killer cell group 7 sequence 0.022
FEV FEV (ETS oncogene family) 0.021
ATXN1L ataxin 1-like 0.020
HOXB9 homeobox B9 0.020
ELF4 E74-like factor 4 (ets domain transcription factor) 0.020
FOXF1 forkhead box F1 0.020
LHX5 LIM homeobox 5 0.020
GLP1R glucagon-like peptide 1 receptor 0.019
PKNOX2 PBX/knotted 1 homeobox 2 0.019
HOXD13 homeobox D13 0.019
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.019
FGF8 fibroblast growth factor 8 (androgen-induced) 0.019
HOXC11 homeobox C11 0.019
HOXD9 homeobox D9 0.019
TBX2 T-box 2 0.019
HOXA3 homeobox A3 0.019
TBX1 T-box 1 0.018
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.018
FBLN1 fibulin 1 0.018
S1PR4 sphingosine-1-phosphate receptor 4 0.018
NEUROG2 neurogenin 2 0.018
GATA5 GATA binding protein 5 0.018
SFRP5 secreted frizzled-related protein 5 0.018
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.017
LHX3 LIM homeobox 3 0.017
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B 0.017
FOXB1 forkhead box B1 0.017
BMP6 bone morphogenetic protein 6 0.017
SMAD6 SMAD family member 6 0.017
POU2F2 POU class 2 homeobox 2 0.017
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.017
PHOX2B paired-like homeobox 2b 0.017
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.017
SLITRK3 SLIT and NTRK-like family, member 3 0.017
HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) 0.017
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.017
TLX1 T-cell leukemia homeobox 1 0.016
MAGED1 melanoma antigen family D, 1 0.016
OAF OAF homolog (Drosophila) 0.016
CXCR6 chemokine (C-X-C motif) receptor 6 0.016
HAP1 huntingtin-associated protein 1 0.016
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E 0.016
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism