The network for 'antigen processing and presentation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

antigen processing and presentation

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

Mus musculus
Name Description Probability Func Analog Organism
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.998
H2-Aa histocompatibility 2, class II antigen A, alpha 0.996
Lyz2 lysozyme 2 0.995
H2-Eb1 histocompatibility 2, class II antigen E beta 0.993
H2-K1 histocompatibility 2, K1, K region 0.991
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.988
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.964
H2-D1 histocompatibility 2, D region locus 1 0.956
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.954
Tapbp TAP binding protein 0.951
Cd40 CD40 antigen 0.939
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.932
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.925
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.923
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.912
B2m beta-2 microglobulin 0.872
Cd44 CD44 antigen 0.856
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.829
Psme1 proteasome (prosome, macropain) 28 subunit, alpha 0.822
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.787
Ciita class II transactivator 0.786
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.763
Ccr1 chemokine (C-C motif) receptor 1 0.739
Psme2 proteasome (prosome, macropain) 28 subunit, beta 0.727
H2-Q7 histocompatibility 2, Q region locus 7 0.723
Ccl8 chemokine (C-C motif) ligand 8 0.683
Ccl3 chemokine (C-C motif) ligand 3 0.683
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.664
Irf1 interferon regulatory factor 1 0.649
Ccr6 chemokine (C-C motif) receptor 6 0.639
C1qa complement component 1, q subcomponent, alpha polypeptide 0.635
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.628
Xcl1 chemokine (C motif) ligand 1 0.612
Itgax integrin alpha X 0.604
Cd7 CD7 antigen 0.509
Folr2 folate receptor 2 (fetal) 0.494
AF251705 cDNA sequence AF251705 0.493
H2-Ob histocompatibility 2, O region beta locus 0.482
Blk B lymphoid kinase 0.453
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.448
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.446
H2-DMa histocompatibility 2, class II, locus DMa 0.441
Xcr1 chemokine (C motif) receptor 1 0.421
Cd52 CD52 antigen 0.420
Lilrb3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.367
Cd209a CD209a antigen 0.365
Cxcl9 chemokine (C-X-C motif) ligand 9 0.347
Gzma granzyme A 0.337
Irf5 interferon regulatory factor 5 0.317
Ccl2 chemokine (C-C motif) ligand 2 0.308
Cd3g CD3 antigen, gamma polypeptide 0.302
Cd209b CD209b antigen 0.299
Ccl22 chemokine (C-C motif) ligand 22 0.297
Clec4n C-type lectin domain family 4, member n 0.296
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.286
Ctsw cathepsin W 0.286
Ctsb cathepsin B 0.282
Cd209d CD209d antigen 0.282
Ccl9 chemokine (C-C motif) ligand 9 0.278
Ncr1 natural cytotoxicity triggering receptor 1 0.276
Mavs mitochondrial antiviral signaling protein 0.250
H2-Q8 histocompatibility 2, Q region locus 8 0.244
Fcna ficolin A 0.232
C3ar1 complement component 3a receptor 1 0.225
Il27ra interleukin 27 receptor, alpha 0.221
Fcrla Fc receptor-like A 0.219
Cd180 CD180 antigen 0.212
H2-Oa histocompatibility 2, O region alpha locus 0.204
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.204
Itgb2 integrin beta 2 0.202
Fcgr1 Fc receptor, IgG, high affinity I 0.197
H2-Q6 histocompatibility 2, Q region locus 6 0.194
Ptprc protein tyrosine phosphatase, receptor type, C 0.192
Ccl12 chemokine (C-C motif) ligand 12 0.191
Ubd ubiquitin D 0.182
Mmp12 matrix metallopeptidase 12 0.180
Cd2 CD2 antigen 0.180
Ccr2 chemokine (C-C motif) receptor 2 0.179
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.176
Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide 0.173
Aif1 allograft inflammatory factor 1 0.173
Cd86 CD86 antigen 0.169
Irf8 interferon regulatory factor 8 0.168
Slamf8 SLAM family member 8 0.166
Birc3 baculoviral IAP repeat-containing 3 0.163
Ccl6 chemokine (C-C motif) ligand 6 0.160
Cybb cytochrome b-245, beta polypeptide 0.158
Bst2 bone marrow stromal cell antigen 2 0.157
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.153
Ccl5 chemokine (C-C motif) ligand 5 0.145
Cd22 CD22 antigen 0.143
Bicd2 bicaudal D homolog 2 (Drosophila) 0.142
Itk IL2-inducible T-cell kinase 0.139
Ccl7 chemokine (C-C motif) ligand 7 0.138
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.137
Sh2d2a SH2 domain protein 2A 0.135
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.134
Ctsz cathepsin Z 0.134
Dnase1l3 deoxyribonuclease 1-like 3 0.130
Unc93b1 unc-93 homolog B1 (C. elegans) 0.129
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-DRA major histocompatibility complex, class II, DR alpha 1.000
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.999
HLA-DMA major histocompatibility complex, class II, DM alpha 0.990
TAPBP TAP binding protein (tapasin) 0.982
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.977
HLA-B major histocompatibility complex, class I, B 0.977
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.974
HLA-C major histocompatibility complex, class I, C 0.973
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.972
HLA-G major histocompatibility complex, class I, G 0.966
HLA-DMB major histocompatibility complex, class II, DM beta 0.961
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.958
B2M beta-2-microglobulin 0.893
HLA-A major histocompatibility complex, class I, A 0.889
HLA-F major histocompatibility complex, class I, F 0.870
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.850
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.807
OCRL oculocerebrorenal syndrome of Lowe 0.802
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.800
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.749
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.734
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.717
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.643
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.621
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.604
GOLGA2 golgin A2 0.518
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.431
PILRA paired immunoglobin-like type 2 receptor alpha 0.408
HLA-E major histocompatibility complex, class I, E 0.393
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.285
PSAP prosaposin 0.268
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.214
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.211
RAB1A RAB1A, member RAS oncogene family 0.172
GRN granulin 0.145
CD86 CD86 molecule 0.140
CLEC10A C-type lectin domain family 10, member A 0.139
SIGLEC7 sialic acid binding Ig-like lectin 7 0.123
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.123
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.122
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.122
PLEK pleckstrin 0.121
NUCB1 nucleobindin 1 0.119
CCR1 chemokine (C-C motif) receptor 1 0.112
RIPK2 receptor-interacting serine-threonine kinase 2 0.109
CTSA cathepsin A 0.102
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.100
NPC2 Niemann-Pick disease, type C2 0.097
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.096
GDI2 GDP dissociation inhibitor 2 0.088
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.086
MAN2B1 mannosidase, alpha, class 2B, member 1 0.083
CD33 CD33 molecule 0.082
HK3 hexokinase 3 (white cell) 0.082
RAB2A RAB2A, member RAS oncogene family 0.081
TPP1 tripeptidyl peptidase I 0.076
ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.074
PLD3 phospholipase D family, member 3 0.074
MLPH melanophilin 0.073
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.072
PTAFR platelet-activating factor receptor 0.071
C1orf38 chromosome 1 open reading frame 38 0.068
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.064
TYMP thymidine phosphorylase 0.063
CTSB cathepsin B 0.063
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.063
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.063
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.060
BTN3A3 butyrophilin, subfamily 3, member A3 0.059
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.059
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.058
SLC15A3 solute carrier family 15, member 3 0.057
LY86 lymphocyte antigen 86 0.056
CST3 cystatin C 0.050
IFI30 interferon, gamma-inducible protein 30 0.050
CD1A CD1a molecule 0.050
GAA glucosidase, alpha; acid 0.048
MEFV Mediterranean fever 0.045
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.044
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.041
NLRP3 NLR family, pyrin domain containing 3 0.041
RAB6A RAB6A, member RAS oncogene family 0.040
TAPBPL TAP binding protein-like 0.039
AIF1 allograft inflammatory factor 1 0.039
PDIA3 protein disulfide isomerase family A, member 3 0.038
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.038
IRF1 interferon regulatory factor 1 0.037
IGSF6 immunoglobulin superfamily, member 6 0.036
ARRB2 arrestin, beta 2 0.036
CCR2 chemokine (C-C motif) receptor 2 0.036
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.034
GM2A GM2 ganglioside activator 0.034
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.034
SYK spleen tyrosine kinase 0.034
PDIA4 protein disulfide isomerase family A, member 4 0.033
IRF8 interferon regulatory factor 8 0.033
HCK hemopoietic cell kinase 0.033
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.033
NLRC4 NLR family, CARD domain containing 4 0.032
TYROBP TYRO protein tyrosine kinase binding protein 0.032
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Da RT1 class II, locus Da 0.986
RT1-Db1 RT1 class II, locus Db1 0.954
RT1-EC2 RT1 class Ib, locus EC2 0.821
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.708
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.562
RT1-Bb RT1 class II, locus Bb 0.403
RT1-DMb RT1 class II, locus DMb 0.329
RT1-Ba RT1 class II, locus Ba 0.210
Ifitm3 interferon induced transmembrane protein 3 0.208
RT1-DMa RT1 class II, locus DMa 0.187
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.173
Irf1 interferon regulatory factor 1 0.159
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.112
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.104
Irf7 interferon regulatory factor 7 0.098
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.084
Lgals3 lectin, galactoside-binding, soluble, 3 0.082
Hck hemopoietic cell kinase 0.072
Psap prosaposin 0.072
Ftl ferritin, light polypeptide 0.059
Pdia3 protein disulfide isomerase family A, member 3 0.059
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.058
Il2rg interleukin 2 receptor, gamma 0.051
Ifi30 interferon gamma inducible protein 30 0.046
C1qc complement component 1, q subcomponent, C chain 0.044
Gbp2 guanylate binding protein 2 0.043
Ctsb cathepsin B 0.043
Ralb v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.043
Arhgap4 Rho GTPase activating protein 4 0.041
Cxcl10 chemokine (C-X-C motif) ligand 10 0.040
Ifi27l2b interferon, alpha-inducible protein 27 like 2B 0.040
P4hb prolyl 4-hydroxylase, beta polypeptide 0.039
LOC100365106 rCG32755-like 0.036
Cd37 CD37 molecule 0.035
Nmi N-myc (and STAT) interactor 0.034
RT1-Cl RT1 class Ib, locus Cl 0.033
Pdia4 protein disulfide isomerase family A, member 4 0.031
Pigq phosphatidylinositol glycan anchor biosynthesis, class Q 0.029
Fn3k fructosamine 3 kinase 0.027
Lyz2 lysozyme 2 0.026
C1qb complement component 1, q subcomponent, B chain 0.026
Aif1 allograft inflammatory factor 1 0.026
Plcb2 phospholipase C, beta 2 0.025
Slfn2 schlafen 2 0.025
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.025
Btd biotinidase 0.025
Sel1l sel-1 suppressor of lin-12-like (C. elegans) 0.025
Carhsp1 calcium regulated heat stable protein 1 0.025
C2 complement component 2 0.023
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.023
Ifi35 interferon-induced protein 35 0.023
Syngr2 synaptogyrin 2 0.023
Cxcl16 chemokine (C-X-C motif) ligand 16 0.022
Acp5 acid phosphatase 5, tartrate resistant 0.022
Hmox1 heme oxygenase (decycling) 1 0.022
RT1-N3 RT1 class Ib, locus N3 0.022
Ccl5 chemokine (C-C motif) ligand 5 0.022
Cd82 Cd82 molecule 0.021
Coro1b coronin, actin-binding protein, 1B 0.021
Clec10a C-type lectin domain family 10, member A 0.021
Alox5ap arachidonate 5-lipoxygenase activating protein 0.021
Cd53 Cd53 molecule 0.020
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.020
Crybb1 crystallin, beta B1 0.020
Nr1h2 nuclear receptor subfamily 1, group H, member 2 0.019
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.019
Tifa TRAF-interacting protein with forkhead-associated domain 0.019
Asah1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.019
Xdh xanthine dehydrogenase 0.019
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.019
Smad1 SMAD family member 1 0.018
LOC100362108 poly (ADP-ribose) polymerase family, member 10 0.018
Mvp major vault protein 0.018
Bst2 bone marrow stromal cell antigen 2 0.018
Fgd2 FYVE, RhoGEF and PH domain containing 2 0.018
Gpr4 G protein-coupled receptor 4 0.018
Cd14 CD14 molecule 0.018
Akt1s1 AKT1 substrate 1 (proline-rich) 0.018
Lhx1 LIM homeobox 1 0.018
Esr2 estrogen receptor 2 (ER beta) 0.017
Bcam basal cell adhesion molecule 0.017
LOC680711 hypothetical protein LOC680711 0.017
Irgm immunity-related GTPase family, M 0.017
Cfb complement factor B 0.017
Pyy peptide YY (mapped) 0.016
Cyba cytochrome b-245, alpha polypeptide 0.016
Rhog ras homolog gene family, member G (rho G) 0.016
LOC100362727 ubiquitin carboxyl-terminal hydrolase CYLD 0.016
Parp14 poly (ADP-ribose) polymerase family, member 14 0.016
Stat1 signal transducer and activator of transcription 1 0.016
C3 complement component 3 0.016
Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.016
Rab13 RAB13, member RAS oncogene family 0.016
Junb jun B proto-oncogene 0.016
Lrrk2 leucine-rich repeat kinase 2 0.015
C4-2 complement component 4, gene 2 0.015
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.015
Plaur plasminogen activator, urokinase receptor 0.015
Ms4a6b membrane-spanning 4-domains, subfamily A, member 6B 0.015
RGD1566001 similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed 0.015
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism