IMP
Process View
The network for 'endocardial cushion to mesenchymal transition involved in heart valve formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
endocardial cushion to mesenchymal transition involved in heart valve formation
A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 1.000 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 1.000 | |
| Foxc2 | forkhead box C2 | 1.000 | |
| Efnb2 | ephrin B2 | 1.000 | |
| Gata4 | GATA binding protein 4 | 1.000 | |
| Tgfb2 | transforming growth factor, beta 2 | 1.000 | |
| Fgf8 | fibroblast growth factor 8 | 1.000 | |
| Shh | sonic hedgehog | 1.000 | |
| Foxc1 | forkhead box C1 | 1.000 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 1.000 | |
| Gli3 | GLI-Kruppel family member GLI3 | 1.000 | |
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.999 | |
| Msx1 | homeobox, msh-like 1 | 0.999 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.999 | |
| Jag1 | jagged 1 | 0.999 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.999 | |
| Sox9 | SRY-box containing gene 9 | 0.999 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.999 | |
| Pax3 | paired box gene 3 | 0.998 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.997 | |
| Hoxa1 | homeobox A1 | 0.997 | |
| Tbx1 | T-box 1 | 0.997 | |
| Ntf3 | neurotrophin 3 | 0.996 | |
| Ephb2 | Eph receptor B2 | 0.995 | |
| Neurod1 | neurogenic differentiation 1 | 0.994 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.992 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.989 | |
| Pax6 | paired box gene 6 | 0.987 | |
| Prrx1 | paired related homeobox 1 | 0.985 | |
| Chrd | chordin | 0.985 | |
| Gsc | goosecoid homeobox | 0.983 | |
| Bmp4 | bone morphogenetic protein 4 | 0.977 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.977 | |
| Efna2 | ephrin A2 | 0.972 | |
| En1 | engrailed 1 | 0.962 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.952 | |
| Smo | smoothened homolog (Drosophila) | 0.947 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.946 | |
| Sox11 | SRY-box containing gene 11 | 0.931 | |
| Pax2 | paired box gene 2 | 0.931 | |
| Neurog2 | neurogenin 2 | 0.925 | |
| Prrx2 | paired related homeobox 2 | 0.921 | |
| Dlx5 | distal-less homeobox 5 | 0.908 | |
| Ednra | endothelin receptor type A | 0.905 | |
| Foxg1 | forkhead box G1 | 0.904 | |
| Nhlh1 | nescient helix loop helix 1 | 0.903 | |
| Ptf1a | pancreas specific transcription factor, 1a | 0.899 | |
| Gata6 | GATA binding protein 6 | 0.882 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.867 | |
| Dlx2 | distal-less homeobox 2 | 0.866 | |
| Zfpm2 | zinc finger protein, multitype 2 | 0.866 | |
| Onecut1 | one cut domain, family member 1 | 0.861 | |
| Mesp1 | mesoderm posterior 1 | 0.857 | |
| Gpr50 | G-protein-coupled receptor 50 | 0.848 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.846 | |
| Foxd2 | forkhead box D2 | 0.838 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.819 | |
| Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.814 | |
| Igdcc3 | immunoglobulin superfamily, DCC subclass, member 3 | 0.809 | |
| Bmp7 | bone morphogenetic protein 7 | 0.801 | |
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.796 | |
| Neurog1 | neurogenin 1 | 0.795 | |
| Msx2 | homeobox, msh-like 2 | 0.795 | |
| Hoxd13 | homeobox D13 | 0.794 | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.768 | |
| Adam19 | a disintegrin and metallopeptidase domain 19 (meltrin beta) | 0.767 | |
| Alx3 | aristaless-like homeobox 3 | 0.762 | |
| Six6 | sine oculis-related homeobox 6 homolog (Drosophila) | 0.761 | |
| Hoxa2 | homeobox A2 | 0.760 | |
| Insm1 | insulinoma-associated 1 | 0.752 | |
| Efnb1 | ephrin B1 | 0.726 | |
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.705 | |
| Epha4 | Eph receptor A4 | 0.700 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.698 | |
| Nkx3-2 | NK3 homeobox 2 | 0.687 | |
| Pdx1 | pancreatic and duodenal homeobox 1 | 0.676 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.673 | |
| Snai1 | snail homolog 1 (Drosophila) | 0.664 | |
| Hoxb1 | homeobox B1 | 0.659 | |
| Dock1 | dedicator of cytokinesis 1 | 0.654 | |
| Hoxd3 | homeobox D3 | 0.641 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.610 | |
| Tbx3 | T-box 3 | 0.593 | |
| Mecom | MDS1 and EVI1 complex locus | 0.579 | |
| Tlx3 | T-cell leukemia, homeobox 3 | 0.564 | |
| Uncx | UNC homeobox | 0.561 | |
| Col2a1 | collagen, type II, alpha 1 | 0.559 | |
| Sox2 | SRY-box containing gene 2 | 0.555 | |
| Lhx5 | LIM homeobox protein 5 | 0.540 | |
| Nkx1-2 | NK1 transcription factor related, locus 2 (Drosophila) | 0.538 | |
| Bnc1 | basonuclin 1 | 0.522 | |
| Lhx3 | LIM homeobox protein 3 | 0.521 | |
| Hoxd1 | homeobox D1 | 0.518 | |
| Col22a1 | collagen, type XXII, alpha 1 | 0.490 | |
| Gata1 | GATA binding protein 1 | 0.489 | |
| Fbn2 | fibrillin 2 | 0.484 | |
| Dlx1 | distal-less homeobox 1 | 0.476 | |
| Tcf15 | transcription factor 15 | 0.472 | |
| Hoxd11 | homeobox D11 | 0.470 | |
| Neurog3 | neurogenin 3 | 0.466 |
