IMP
Process View
The network for 'bmp signaling pathway involved in heart development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
bmp signaling pathway involved in heart development
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| bmp2b | bone morphogenetic protein 2b | 1.000 | |
| shha | sonic hedgehog a | 0.999 | |
| chd | chordin | 0.998 | |
| tbx16 | T-box gene 16 | 0.995 | |
| bmp4 | bone morphogenetic protein 4 | 0.984 | |
| ndr2 | nodal-related 2 | 0.972 | |
| ntla | no tail a | 0.953 | |
| flh | floating head | 0.938 | |
| gli1 | GLI-Kruppel family member 1 | 0.900 | |
| ptch2 | patched 2 | 0.887 | |
| ptch1 | patched 1 | 0.887 | |
| has2 | hyaluronan synthase 2 | 0.883 | |
| sox32 | SRY-box containing gene 32 | 0.827 | |
| oep | one-eyed pinhead | 0.796 | |
| tbx1 | T-box 1 | 0.732 | |
| lft1 | lefty1 | 0.689 | |
| fgf8a | fibroblast growth factor 8 a | 0.673 | |
| foxh1 | forkhead box H1 | 0.664 | |
| her7 | hairy and enhancer of split related-7 | 0.646 | |
| tbx18 | T-box 18 | 0.637 | |
| tbx2b | T-box 2b | 0.603 | |
| fn1 | fibronectin 1 | 0.597 | |
| wnt5b | wingless-type MMTV integration site family, member 5b | 0.578 | |
| tbx20 | T-box 20 | 0.573 | |
| foxi1 | forkhead box I1 | 0.530 | |
| bmp7a | bone morphogenetic protein 7a | 0.444 | |
| foxd5 | forkhead box D5 | 0.433 | |
| sox17 | SRY-box containing gene 17 | 0.422 | |
| wnt11 | wingless-type MMTV integration site family, member 11 | 0.387 | |
| gsc | goosecoid | 0.383 | |
| nkx1.2la | NK1 transcription factor related 2-like,a | 0.364 | |
| lft2 | lefty2 | 0.364 | |
| sox9a | SRY-box containing gene 9a | 0.336 | |
| twist3 | twist3 | 0.326 | |
| dlx2a | distal-less homeobox gene 2a | 0.316 | |
| smo | smoothened homolog (Drosophila) | 0.313 | |
| snai1b | snail homolog 1b (Drosophila) | 0.291 | |
| cyp26c1 | cytochrome P450, family 26, subfamily C, polypeptide 1 | 0.288 | |
| hand2 | heart and neural crest derivatives expressed transcript 2 | 0.275 | |
| msxe | muscle segment homeobox E | 0.274 | |
| vent | ventral expressed homeobox | 0.269 | |
| pax9 | paired box gene 9 | 0.268 | |
| nkx3.2 | NK3 homeobox 2 | 0.238 | |
| smad9 | MAD homolog 9 (Drosophila) | 0.230 | |
| pou5f1 | POU domain, class 5, transcription factor 1 | 0.186 | |
| mib | mind bomb | 0.179 | |
| ephb4b | eph receptor B4b | 0.148 | |
| bon | bonnie and clyde | 0.147 | |
| tbx2a | T-box gene 2a | 0.141 | |
| gli2a | GLI-Kruppel family member GLI2a | 0.141 | |
| nkx2.5 | NK2 transcription factor related 5 | 0.135 | |
| dharma | dharma | 0.134 | |
| tll1 | tolloid-like 1 | 0.130 | |
| fgf10a | fibroblast growth factor 10a | 0.130 | |
| ihha | Indian hedgehog homolog a | 0.125 | |
| pcdh8 | protocadherin 8 | 0.122 | |
| myf5 | myogenic factor 5 | 0.116 | |
| gbx2 | gastrulation brain homeo box 2 | 0.115 | |
| eve1 | even-skipped-like1 | 0.107 | |
| vangl2 | vang-like 2 (van gogh, Drosophila) | 0.104 | |
| dact2 | dapper homolog 2, antagonist of beta-catenin (xenopus) | 0.104 | |
| mespa | mesoderm posterior a | 0.100 | |
| hoxa13b | homeo box A13b | 0.099 | |
| six4a | sine oculis homeobox homolog 4a | 0.099 | |
| msxc | muscle segment homeobox C | 0.096 | |
| her5 | hairy-related 5 | 0.096 | |
| bmp2a | bone morphogenetic protein 2a | 0.093 | |
| gdf6a | growth differentiation factor 6a | 0.092 | |
| runx2b | runt-related transcription factor 2b | 0.091 | |
| sp7 | Sp7 transcription factor | 0.091 | |
| spaw | southpaw | 0.088 | |
| foxa2 | forkhead box A2 | 0.082 | |
| cdh2 | cadherin 2, neuronal | 0.081 | |
| sim2 | single-minded homolog 2 (Drosophila) | 0.080 | |
| axin1 | axin 1 | 0.079 | |
| ndr1 | nodal-related 1 | 0.078 | |
| cdx4 | caudal type homeo box transcription factor 4 | 0.072 | |
| fgf4 | fibroblast growth factor 4 | 0.071 | |
| fezf2 | FEZ family zinc finger 2 | 0.071 | |
| lhx1b | LIM homeobox 1b | 0.070 | |
| fzd5 | frizzled homolog 5 | 0.068 | |
| rxrbb | retinoid x receptor, beta b | 0.068 | |
| hapln1a | hyaluronan and proteoglycan link protein 1a | 0.066 | |
| chsy1 | chondroitin sulfate synthase 1 | 0.063 | |
| snai1a | snail homolog 1a (Drosophila) | 0.062 | |
| col8a1a | collagen, type VIII, alpha 1a | 0.060 | |
| lmo4a | LIM domain only 4a | 0.060 | |
| fbn2b | fibrillin 2b | 0.059 | |
| rarab | retinoic acid receptor, alpha b | 0.057 | |
| mespb | mesoderm posterior b | 0.057 | |
| per3 | period homolog 3 (Drosophila) | 0.056 | |
| vox | ventral homeobox | 0.056 | |
| brd4 | bromodomain containing 4 | 0.055 | |
| bambia | BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a | 0.055 | |
| nkx2.3 | NK2 transcription factor related 3 | 0.053 | |
| msxb | muscle segment homeobox B | 0.053 | |
| gro1 | groucho 1 | 0.052 | |
| grem2 | gremlin 2, cysteine knot superfamily | 0.051 | |
| hmx4 | H6 family homeobox 4 | 0.050 | |
| mll | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 0.050 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| FOXD3 | forkhead box D3 | 1.000 | |
| SP1 | Sp1 transcription factor | 1.000 | |
| BMPR1A | bone morphogenetic protein receptor, type IA | 1.000 | |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 1.000 | |
| PAX3 | paired box 3 | 1.000 | |
| SOX10 | SRY (sex determining region Y)-box 10 | 1.000 | |
| SOX2 | SRY (sex determining region Y)-box 2 | 1.000 | |
| FSTL1 | follistatin-like 1 | 0.999 | |
| HTT | huntingtin | 0.997 | |
| HCFC1 | host cell factor C1 (VP16-accessory protein) | 0.987 | |
| SMAD3 | SMAD family member 3 | 0.984 | |
| ESR1 | estrogen receptor 1 | 0.961 | |
| HMGA1 | high mobility group AT-hook 1 | 0.950 | |
| GABPA | GA binding protein transcription factor, alpha subunit 60kDa | 0.935 | |
| MSX1 | msh homeobox 1 | 0.929 | |
| MSX2 | msh homeobox 2 | 0.904 | |
| SMAD7 | SMAD family member 7 | 0.898 | |
| EP300 | E1A binding protein p300 | 0.847 | |
| MEOX2 | mesenchyme homeobox 2 | 0.795 | |
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.770 | |
| WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 | 0.581 | |
| POU3F3 | POU class 3 homeobox 3 | 0.554 | |
| SOX1 | SRY (sex determining region Y)-box 1 | 0.492 | |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.488 | |
| POU3F2 | POU class 3 homeobox 2 | 0.468 | |
| ETS2 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | 0.467 | |
| SOX11 | SRY (sex determining region Y)-box 11 | 0.459 | |
| NOG | noggin | 0.454 | |
| OTP | orthopedia homeobox | 0.453 | |
| DLX2 | distal-less homeobox 2 | 0.439 | |
| NOVA2 | neuro-oncological ventral antigen 2 | 0.301 | |
| ATN1 | atrophin 1 | 0.300 | |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.289 | |
| SOX21 | SRY (sex determining region Y)-box 21 | 0.265 | |
| DLX5 | distal-less homeobox 5 | 0.217 | |
| POU3F1 | POU class 3 homeobox 1 | 0.208 | |
| LHX1 | LIM homeobox 1 | 0.198 | |
| SMAD4 | SMAD family member 4 | 0.193 | |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.186 | |
| BMP2 | bone morphogenetic protein 2 | 0.181 | |
| NEUROG3 | neurogenin 3 | 0.172 | |
| TP73 | tumor protein p73 | 0.160 | |
| SFRP5 | secreted frizzled-related protein 5 | 0.156 | |
| TBX2 | T-box 2 | 0.147 | |
| ATF7IP | activating transcription factor 7 interacting protein | 0.146 | |
| NKX2-1 | NK2 homeobox 1 | 0.136 | |
| FOXE1 | forkhead box E1 (thyroid transcription factor 2) | 0.128 | |
| HRK | harakiri, BCL2 interacting protein (contains only BH3 domain) | 0.121 | |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.114 | |
| HOXD12 | homeobox D12 | 0.110 | |
| POU4F1 | POU class 4 homeobox 1 | 0.108 | |
| BMPR1B | bone morphogenetic protein receptor, type IB | 0.107 | |
| NKX6-1 | NK6 homeobox 1 | 0.101 | |
| ASCL1 | achaete-scute complex homolog 1 (Drosophila) | 0.098 | |
| FOXA2 | forkhead box A2 | 0.097 | |
| TGFB1 | transforming growth factor, beta 1 | 0.087 | |
| DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila) | 0.085 | |
| ESR2 | estrogen receptor 2 (ER beta) | 0.085 | |
| NKX2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.084 | |
| TFAP2B | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) | 0.082 | |
| UTF1 | undifferentiated embryonic cell transcription factor 1 | 0.080 | |
| PAX6 | paired box 6 | 0.080 | |
| FOXC2 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 0.078 | |
| LHX2 | LIM homeobox 2 | 0.077 | |
| BMP7 | bone morphogenetic protein 7 | 0.074 | |
| GBX2 | gastrulation brain homeobox 2 | 0.072 | |
| VSX1 | visual system homeobox 1 | 0.070 | |
| OLIG2 | oligodendrocyte lineage transcription factor 2 | 0.070 | |
| LHX5 | LIM homeobox 5 | 0.066 | |
| PITX2 | paired-like homeodomain 2 | 0.065 | |
| NPAS1 | neuronal PAS domain protein 1 | 0.063 | |
| MYCN | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.063 | |
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | 0.063 | |
| HOXC8 | homeobox C8 | 0.062 | |
| NKX2-8 | NK2 homeobox 8 | 0.061 | |
| NEUROG1 | neurogenin 1 | 0.056 | |
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | 0.056 | |
| NCOA1 | nuclear receptor coactivator 1 | 0.055 | |
| FOXB1 | forkhead box B1 | 0.054 | |
| ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 0.052 | |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.052 | |
| HTR7 | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) | 0.051 | |
| POU4F2 | POU class 4 homeobox 2 | 0.050 | |
| SIX6 | SIX homeobox 6 | 0.049 | |
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.049 | |
| FGF3 | fibroblast growth factor 3 | 0.049 | |
| NFYA | nuclear transcription factor Y, alpha | 0.047 | |
| SOX18 | SRY (sex determining region Y)-box 18 | 0.047 | |
| LBX1 | ladybird homeobox 1 | 0.046 | |
| SMAD2 | SMAD family member 2 | 0.046 | |
| ALX1 | ALX homeobox 1 | 0.046 | |
| HOXD3 | homeobox D3 | 0.045 | |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.044 | |
| PDX1 | pancreatic and duodenal homeobox 1 | 0.044 | |
| GRIP1 | glutamate receptor interacting protein 1 | 0.044 | |
| BMP4 | bone morphogenetic protein 4 | 0.044 | |
| ZIC1 | Zic family member 1 (odd-paired homolog, Drosophila) | 0.042 | |
| HOXB13 | homeobox B13 | 0.042 | |
| PGR | progesterone receptor | 0.041 | |
| CRLF1 | cytokine receptor-like factor 1 | 0.040 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 0.999 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.999 | |
| Foxc1 | forkhead box C1 | 0.997 | |
| Prrx1 | paired related homeobox 1 | 0.996 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.996 | |
| Msx1 | homeobox, msh-like 1 | 0.992 | |
| Bmp4 | bone morphogenetic protein 4 | 0.985 | |
| Sox9 | SRY-box containing gene 9 | 0.984 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.978 | |
| Bmp7 | bone morphogenetic protein 7 | 0.972 | |
| Smo | smoothened homolog (Drosophila) | 0.970 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.969 | |
| Pax3 | paired box gene 3 | 0.967 | |
| Dlx5 | distal-less homeobox 5 | 0.952 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.952 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.934 | |
| Foxc2 | forkhead box C2 | 0.932 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.903 | |
| Tbx1 | T-box 1 | 0.877 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.877 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.869 | |
| Fgf8 | fibroblast growth factor 8 | 0.868 | |
| Prrx2 | paired related homeobox 2 | 0.832 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.813 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.798 | |
| Runx2 | runt related transcription factor 2 | 0.797 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.749 | |
| Chrd | chordin | 0.667 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.601 | |
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.534 | |
| Ednra | endothelin receptor type A | 0.519 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.470 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.466 | |
| Msx2 | homeobox, msh-like 2 | 0.392 | |
| Gsc | goosecoid homeobox | 0.353 | |
| Alx4 | aristaless-like homeobox 4 | 0.349 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.341 | |
| Rarb | retinoic acid receptor, beta | 0.329 | |
| Foxg1 | forkhead box G1 | 0.308 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.267 | |
| Rarg | retinoic acid receptor, gamma | 0.195 | |
| Ptch1 | patched homolog 1 | 0.194 | |
| Alx1 | ALX homeobox 1 | 0.175 | |
| Sall4 | sal-like 4 (Drosophila) | 0.164 | |
| Pax9 | paired box gene 9 | 0.158 | |
| Hoxa1 | homeobox A1 | 0.141 | |
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.138 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.121 | |
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.118 | |
| Acvr1 | activin A receptor, type 1 | 0.106 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.103 | |
| Hoxa2 | homeobox A2 | 0.098 | |
| Fgf10 | fibroblast growth factor 10 | 0.088 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.082 | |
| Jag1 | jagged 1 | 0.081 | |
| Meox2 | mesenchyme homeobox 2 | 0.081 | |
| Bmp2 | bone morphogenetic protein 2 | 0.079 | |
| Rara | retinoic acid receptor, alpha | 0.073 | |
| Pax6 | paired box gene 6 | 0.072 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.072 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.071 | |
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.069 | |
| Pax2 | paired box gene 2 | 0.067 | |
| Sox2 | SRY-box containing gene 2 | 0.058 | |
| Vegfa | vascular endothelial growth factor A | 0.056 | |
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.053 | |
| Gja1 | gap junction protein, alpha 1 | 0.052 | |
| Dlx2 | distal-less homeobox 2 | 0.048 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.047 | |
| Dlx6 | distal-less homeobox 6 | 0.045 | |
| Hoxa3 | homeobox A3 | 0.045 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.039 | |
| Ece1 | endothelin converting enzyme 1 | 0.036 | |
| Alx3 | aristaless-like homeobox 3 | 0.034 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.034 | |
| Bmper | BMP-binding endothelial regulator | 0.031 | |
| Nanog | Nanog homeobox | 0.030 | |
| Tbx15 | T-box 15 | 0.029 | |
| Col2a1 | collagen, type II, alpha 1 | 0.028 | |
| Nog | noggin | 0.028 | |
| Nodal | nodal | 0.027 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.025 | |
| Mn1 | meningioma 1 | 0.024 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.023 | |
| Sox11 | SRY-box containing gene 11 | 0.022 | |
| Egfr | epidermal growth factor receptor | 0.021 | |
| En1 | engrailed 1 | 0.018 | |
| Gata4 | GATA binding protein 4 | 0.017 | |
| Rxra | retinoid X receptor alpha | 0.017 | |
| Sox4 | SRY-box containing gene 4 | 0.017 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.016 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.015 | |
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.015 | |
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.015 | |
| Mesp1 | mesoderm posterior 1 | 0.014 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.013 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.013 | |
| Col1a1 | collagen, type I, alpha 1 | 0.013 | |
| Tcfcp2l1 | transcription factor CP2-like 1 | 0.012 | |
| Bmp5 | bone morphogenetic protein 5 | 0.012 |