The network for 'negative regulation of endodermal cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of endodermal cell fate specification

Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.

Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.969
chd chordin 0.901
mespa mesoderm posterior a 0.492
bmp2a bone morphogenetic protein 2a 0.348
fgf3 fibroblast growth factor 3 0.217
gli1 GLI-Kruppel family member 1 0.202
fgfr2 fibroblast growth factor receptor 2 0.186
flh floating head 0.184
bmp4 bone morphogenetic protein 4 0.182
hmx4 H6 family homeobox 4 0.168
mespb mesoderm posterior b 0.165
dkk1b dickkopf 1b 0.152
wnt5b wingless-type MMTV integration site family, member 5b 0.141
pcdh8 protocadherin 8 0.106
msxc muscle segment homeobox C 0.102
foxa3 forkhead box A3 0.099
her7 hairy and enhancer of split related-7 0.099
lama5 laminin, alpha 5 0.094
notch2 notch homolog 2 0.092
nkd1 naked cuticle homolog 1 (Drosophila) 0.091
pea3 ETS-domain transcription factor pea3 0.083
shha sonic hedgehog a 0.083
sparc secreted acidic cysteine rich glycoprotein 0.079
her5 hairy-related 5 0.078
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.077
sox9a SRY-box containing gene 9a 0.075
gbx2 gastrulation brain homeo box 2 0.070
msxd muscle segment homeobox D 0.067
etv5b ets variant 5b 0.062
wif1 wnt inhibitory factor 1 0.062
fstl1b follistatin-like 1b 0.059
nkx2.5 NK2 transcription factor related 5 0.059
sox17 SRY-box containing gene 17 0.059
sp5l Sp5 transcription factor-like 0.059
her1 hairy-related 1 0.058
pnx posterior neuron-specific homeobox 0.058
foxi1 forkhead box I1 0.057
myod1 myogenic differentiation 1 0.055
spry4 sprouty (Drosophila) homolog 4 0.051
sfrp1a secreted frizzled-related protein 1a 0.048
tbx6 T-box gene 6 0.048
foxd5 forkhead box D5 0.047
twist3 twist3 0.047
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.046
fgfrl1a fibroblast growth factor receptor-like 1a 0.045
meis2.2 myeloid ecotropic viral integration site 2.2 0.038
il17rd interleukin 17 receptor D 0.037
otx1a orthodenticle homolog 1a 0.037
pitx3 paired-like homeodomain transcription factor 3 0.037
cdx1a caudal type homeo box transcription factor 1 a 0.036
tbx16 T-box gene 16 0.036
tll1 tolloid-like 1 0.036
lft1 lefty1 0.035
eve1 even-skipped-like1 0.035
has2 hyaluronan synthase 2 0.034
snai1b snail homolog 1b (Drosophila) 0.033
wnt8b wingless-type MMTV integration site family, member 8b 0.033
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.033
col14a1 collagen, type XIV, alpha 1 0.032
twist1b twist1b 0.031
fgfr4 fibroblast growth factor receptor 4 0.030
dusp6 dual specificity phosphatase 6 0.029
twist1a twist1a 0.029
nanos3 nanos homolog 3 0.029
tbx18 T-box 18 0.027
gpr126 G protein-coupled receptor 126 0.027
sox9b SRY-box containing gene 9b 0.027
gdf6a growth differentiation factor 6a 0.026
tbx24 T-box 24 0.026
ptch1 patched 1 0.025
frem3 Fras1 related extracellular matrix 3 0.025
spry2 sprouty homolog 2 0.024
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.024
pax2a paired box gene 2a 0.023
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.023
her6 hairy-related 6 0.023
chsy1 chondroitin sulfate synthase 1 0.023
fgf8b fibroblast growth factor 8 b 0.023
tbpl2 TATA box binding protein like 2 0.021
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.021
hhip hedgehog interacting protein 0.021
neo1 neogenin 1 0.021
dlx2a distal-less homeobox gene 2a 0.021
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.020
hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.020
fgf24 fibroblast growth factor 24 0.020
fgf17 fibroblast growth factor 17 0.020
dlx3b distal-less homeobox gene 3b 0.020
boc brother of CDO 0.020
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.019
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.019
zgc:110712 zgc:110712 0.019
dlx5a distal-less homeobox gene 5a 0.019
sox32 SRY-box containing gene 32 0.019
fsta follistatin a 0.018
ephb3a eph receptor B3a 0.018
tgfb2 transforming growth factor, beta 2 0.018
fibin fin bud initiation factor 0.018
wnt10a wingless-type MMTV integration site family, member 10a 0.018
ved ventrally expressed dharma/bozozok antagonist 0.018
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Fgf8 fibroblast growth factor 8 1.000
Shh sonic hedgehog 0.999
Fgfr1 fibroblast growth factor receptor 1 0.998
Fgfr2 fibroblast growth factor receptor 2 0.996
Gli3 GLI-Kruppel family member GLI3 0.988
Foxc1 forkhead box C1 0.987
Smo smoothened homolog (Drosophila) 0.981
Foxc2 forkhead box C2 0.981
Bmp7 bone morphogenetic protein 7 0.968
Pax3 paired box gene 3 0.961
Tbx1 T-box 1 0.959
Hand2 heart and neural crest derivatives expressed transcript 2 0.959
Sox9 SRY-box containing gene 9 0.955
Chrd chordin 0.953
Prrx1 paired related homeobox 1 0.950
Msx1 homeobox, msh-like 1 0.945
Tgfb2 transforming growth factor, beta 2 0.938
Tcfap2a transcription factor AP-2, alpha 0.935
Rarg retinoic acid receptor, gamma 0.868
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.864
Otx2 orthodenticle homolog 2 (Drosophila) 0.861
Eya1 eyes absent 1 homolog (Drosophila) 0.831
Dlx5 distal-less homeobox 5 0.801
Hand1 heart and neural crest derivatives expressed transcript 1 0.792
Pitx2 paired-like homeodomain transcription factor 2 0.756
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.748
Ednra endothelin receptor type A 0.727
Gli2 GLI-Kruppel family member GLI2 0.679
Prrx2 paired related homeobox 2 0.665
Gsc goosecoid homeobox 0.445
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.394
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.372
Fgfr3 fibroblast growth factor receptor 3 0.357
Rarb retinoic acid receptor, beta 0.347
Msx2 homeobox, msh-like 2 0.315
Efnb2 ephrin B2 0.306
Rara retinoic acid receptor, alpha 0.285
Foxg1 forkhead box G1 0.281
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.277
Acvr1 activin A receptor, type 1 0.264
Pax2 paired box gene 2 0.259
Mesp1 mesoderm posterior 1 0.246
Gbx2 gastrulation brain homeobox 2 0.222
Isl1 ISL1 transcription factor, LIM/homeodomain 0.203
Vangl2 vang-like 2 (van gogh, Drosophila) 0.170
Vegfa vascular endothelial growth factor A 0.166
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.161
Alx4 aristaless-like homeobox 4 0.161
Lmx1b LIM homeobox transcription factor 1 beta 0.147
Ece1 endothelin converting enzyme 1 0.144
Nodal nodal 0.137
Hoxa1 homeobox A1 0.114
Meox2 mesenchyme homeobox 2 0.103
Ctnnb1 catenin (cadherin associated protein), beta 1 0.100
Wnt3a wingless-related MMTV integration site 3A 0.097
Tgfbr2 transforming growth factor, beta receptor II 0.097
Gja1 gap junction protein, alpha 1 0.090
Bmp2 bone morphogenetic protein 2 0.089
Nog noggin 0.088
Gata4 GATA binding protein 4 0.086
Jag1 jagged 1 0.082
Rxra retinoid X receptor alpha 0.074
Hoxa3 homeobox A3 0.074
Zeb1 zinc finger E-box binding homeobox 1 0.073
Chd7 chromodomain helicase DNA binding protein 7 0.071
Bmper BMP-binding endothelial regulator 0.064
Fgf10 fibroblast growth factor 10 0.063
Dlx6 distal-less homeobox 6 0.063
Fgfrl1 fibroblast growth factor receptor-like 1 0.052
Runx2 runt related transcription factor 2 0.052
Pax9 paired box gene 9 0.048
Nkx3-2 NK3 homeobox 2 0.046
Ptch1 patched homolog 1 0.046
Lrp6 low density lipoprotein receptor-related protein 6 0.046
Pax6 paired box gene 6 0.041
Col2a1 collagen, type II, alpha 1 0.041
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.035
Fgf3 fibroblast growth factor 3 0.034
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.033
Lhx1 LIM homeobox protein 1 0.030
Sox4 SRY-box containing gene 4 0.024
Pitx1 paired-like homeodomain transcription factor 1 0.024
Otx1 orthodenticle homolog 1 (Drosophila) 0.021
Emx2 empty spiracles homolog 2 (Drosophila) 0.020
Alx1 ALX homeobox 1 0.019
Pbx1 pre B-cell leukemia transcription factor 1 0.019
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.019
Hoxa2 homeobox A2 0.018
Ptk7 PTK7 protein tyrosine kinase 7 0.018
Sox11 SRY-box containing gene 11 0.018
Bmp4 bone morphogenetic protein 4 0.018
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.018
Lmx1a LIM homeobox transcription factor 1 alpha 0.018
Twist2 twist homolog 2 (Drosophila) 0.017
Foxe3 forkhead box E3 0.016
Alx3 aristaless-like homeobox 3 0.016
En1 engrailed 1 0.015
Wnt6 wingless-related MMTV integration site 6 0.015
Fbln1 fibulin 1 0.015
Foxh1 forkhead box H1 0.015
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism