The network for 'eye morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized.

Danio rerio
Name Description Probability Func Analog Organism
cdh2 cadherin 2, neuronal 1.000
ndr2 nodal-related 2 0.998
shha sonic hedgehog a 0.996
bmp4 bone morphogenetic protein 4 0.996
pax6b paired box gene 6b 0.993
foxa2 forkhead box A2 0.991
eya1 eyes absent homolog 1 0.989
pax2a paired box gene 2a 0.987
otx2 orthodenticle homolog 2 0.985
gdf6a growth differentiation factor 6a 0.983
kif17 kinesin family member 17 0.980
hnf1ba HNF1 homeobox Ba 0.979
ift88 intraflagellar transport 88 homolog 0.978
rx2 retinal homeobox gene 2 0.973
six3b sine oculis homeobox homolog 3b 0.971
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.971
bmp2b bone morphogenetic protein 2b 0.970
chd chordin 0.968
crb2a crumbs homolog 2a 0.967
boc brother of CDO 0.962
jag2 jagged 2 0.958
tfap2a transcription factor AP-2 alpha 0.950
otpb orthopedia homolog b 0.948
fsta follistatin a 0.946
irx1a iroquois homeobox protein 1, a 0.940
wnt11 wingless-type MMTV integration site family, member 11 0.939
mib mind bomb 0.939
flh floating head 0.937
rx3 retinal homeobox gene 3 0.936
gli1 GLI-Kruppel family member 1 0.932
rx1 retinal homeobox gene 1 0.931
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.929
myod1 myogenic differentiation 1 0.928
lhx2b LIM homeobox 2b 0.917
bhlhe22 basic helix-loop-helix family, member e22 0.915
crx cone-rod homeobox 0.914
fgf3 fibroblast growth factor 3 0.906
tbx2b T-box 2b 0.892
sox9a SRY-box containing gene 9a 0.892
notch3 notch homolog 3 0.887
vax2 ventral anterior homeobox 2 0.885
shhb sonic hedgehog b 0.885
isl1 islet1 0.880
sox2 SRY-box containing gene 2 0.878
neurod neurogenic differentiation 0.875
dla deltaA 0.864
wnt8b wingless-type MMTV integration site family, member 8b 0.862
tal1 T-cell acute lymphocytic leukemia 1 0.858
gbx2 gastrulation brain homeo box 2 0.839
pcdh8 protocadherin 8 0.831
bmp2a bone morphogenetic protein 2a 0.830
fgf8a fibroblast growth factor 8 a 0.828
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.828
mab21l2 mab-21-like 2 0.820
tfe3b transcription factor binding to IGHM enhancer 3b 0.818
atoh7 atonal homolog 7 0.816
dctn1a dynactin 1a 0.806
tfeb transcription factor EB 0.805
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.788
prdm1a PR domain containing 1a, with ZNF domain 0.778
met met proto-oncogene (hepatocyte growth factor receptor) 0.775
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.771
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.765
otx5 orthodenticle homolog 5 0.753
irx4b iroquois homeobox protein 4b 0.749
dlx3b distal-less homeobox gene 3b 0.741
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.738
gli2a GLI-Kruppel family member GLI2a 0.716
lrrc6 leucine rich repeat containing 6 0.715
ptch1 patched 1 0.713
vsx1 visual system homeobox 1 homolog, chx10-like 0.706
vcana versican a 0.700
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.693
foxi1 forkhead box I1 0.690
gsc goosecoid 0.681
traf4a tnf receptor-associated factor 4a 0.675
fezf2 FEZ family zinc finger 2 0.666
pitx2 paired-like homeodomain transcription factor 2 0.665
hoxb1b homeo box B1b 0.662
isl2a islet2a 0.661
olfm2 olfactomedin 2 0.649
sox3 SRY-box containing gene 3 0.648
cdh6 cadherin 6 0.648
foxg1a forkhead box G1a 0.632
sox4a SRY-box containing gene 4a 0.630
rxraa retinoid X receptor, alpha a 0.627
runx1 runt-related transcription factor 1 0.622
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.620
fgf10a fibroblast growth factor 10a 0.609
tbx1 T-box 1 0.608
rho rhodopsin 0.607
lamb1a laminin, beta 1a 0.607
dharma dharma 0.605
fgfr4 fibroblast growth factor receptor 4 0.601
meis1 myeloid ecotropic viral integration 1 0.592
wnt4a wingless-type MMTV integration site family, member 4a 0.587
pcdh18b protocadherin 18b 0.585
ptf1a pancreas specific transcription factor, 1a 0.582
tp53 tumor protein p53 0.581
notch1a notch homolog 1a 0.573
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
nmo nemo 1.000
E(spl) Enhancer of split 0.998
hbs hibris 0.996
fz frizzled 0.996
eyg eyegone 0.995
shi shibire 0.992
HLHm7 E(spl) region transcript m7 0.991
N Notch 0.991
wg wingless 0.990
argos CG4531 gene product from transcript CG4531-RA 0.986
spen split ends 0.985
sty sprouty 0.985
sno strawberry notch 0.983
phl pole hole 0.980
Moe Moesin 0.979
Ras85D Ras oncogene at 85D 0.978
sd scalloped 0.978
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.973
amos absent MD neurons and olfactory sensilla 0.972
dsh dishevelled 0.971
usp ultraspiracle 0.970
pnt pointed 0.968
rst roughest 0.964
Akt1 CG4006 gene product from transcript CG4006-RA 0.962
hipk homeodomain interacting protein kinase 0.962
Rac1 CG2248 gene product from transcript CG2248-RA 0.961
Rab11 Rab-protein 11 0.960
sax saxophone 0.956
ci cubitus interruptus 0.954
dac dachshund 0.954
ex expanded 0.948
dpp decapentaplegic 0.948
ato atonal 0.945
rg rugose 0.944
vvl ventral veins lacking 0.943
dm diminutive 0.941
CG11347 CG11347 gene product from transcript CG11347-RE 0.939
sina seven in absentia 0.939
Chc Clathrin heavy chain 0.935
phyl phyllopod 0.930
so sine oculis 0.927
sev sevenless 0.924
Tsc1 CG6147 gene product from transcript CG6147-RA 0.923
Tom Twin of m4 0.922
gbb glass bottom boat 0.921
ttk tramtrack 0.918
bi bifid 0.917
S6kII RPS6-protein kinase-II 0.914
TBPH CG10327 gene product from transcript CG10327-RC 0.908
esg escargot 0.907
Kap-alpha3 karyopherin alpha3 0.906
emc extra macrochaetae 0.899
Ten-m Tenascin major 0.898
bun bunched 0.894
stan starry night 0.888
Gug Grunge 0.886
crb crumbs 0.881
drk downstream of receptor kinase 0.877
wts warts 0.875
Sra-1 specifically Rac1-associated protein 1 0.875
Mi-2 CG8103 gene product from transcript CG8103-RA 0.872
Vang Van Gogh 0.869
ds dachsous 0.859
hth homothorax 0.855
disco disconnected 0.852
Fas2 Fasciclin 2 0.851
ptc patched 0.838
Cdc42 CG12530 gene product from transcript CG12530-RA 0.838
trio CG18214 gene product from transcript CG18214-RA 0.834
sens senseless 0.833
jar jaguar 0.831
ro rough 0.825
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.824
exd extradenticle 0.824
Arr2 Arrestin 2 0.823
rok Rho-kinase 0.816
cutlet CG33122 gene product from transcript CG33122-RA 0.815
Snr1 Snf5-related 1 0.814
ac achaete 0.812
tkv thickveins 0.810
scrib scribbled 0.803
eya eyes absent 0.799
pyd polychaetoid 0.799
zfh1 Zn finger homeodomain 1 0.792
hyd hyperplastic discs 0.792
caz cabeza 0.790
elav embryonic lethal abnormal vision 0.779
Hop Hsp70/Hsp90 organizing protein homolog 0.770
Su(Tpl) CG32217 gene product from transcript CG32217-RB 0.769
tsh teashirt 0.765
Trf2 TATA box binding protein-related factor 2 0.765
klu klumpfuss 0.761
ara araucan 0.761
ik2 IkappaB kinase-like 2 0.756
Fmr1 CG6203 gene product from transcript CG6203-RC 0.753
grim CG4345 gene product from transcript CG4345-RA 0.752
hh hedgehog 0.748
ebi CG4063 gene product from transcript CG4063-RA 0.746
Eb1 CG3265 gene product from transcript CG3265-RF 0.745
spi spitz 0.743
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Homo sapiens
Name Description Probability Func Analog Organism
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.638
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.605
COL1A1 collagen, type I, alpha 1 0.581
SP1 Sp1 transcription factor 0.500
CREBBP CREB binding protein 0.447
BCOR BCL6 corepressor 0.412
BMI1 BMI1 polycomb ring finger oncogene 0.312
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.304
EGFR epidermal growth factor receptor 0.274
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.197
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.185
NCOR1 nuclear receptor corepressor 1 0.167
INADL InaD-like (Drosophila) 0.161
SMAD3 SMAD family member 3 0.155
NRP1 neuropilin 1 0.153
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.148
RUNX1 runt-related transcription factor 1 0.147
COL3A1 collagen, type III, alpha 1 0.145
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.136
BCL2L1 BCL2-like 1 0.124
PBX1 pre-B-cell leukemia homeobox 1 0.121
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.113
HDAC2 histone deacetylase 2 0.112
PCGF2 polycomb group ring finger 2 0.111
PIAS1 protein inhibitor of activated STAT, 1 0.111
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.108
MCM7 minichromosome maintenance complex component 7 0.105
YAP1 Yes-associated protein 1 0.102
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.097
NOTCH3 notch 3 0.097
TP53 tumor protein p53 0.092
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.090
BBS2 Bardet-Biedl syndrome 2 0.089
DDR2 discoidin domain receptor tyrosine kinase 2 0.088
EP300 E1A binding protein p300 0.087
SMAD4 SMAD family member 4 0.083
COL6A1 collagen, type VI, alpha 1 0.083
HCFC1 host cell factor C1 (VP16-accessory protein) 0.080
COL1A2 collagen, type I, alpha 2 0.079
APC adenomatous polyposis coli 0.078
MDFI MyoD family inhibitor 0.078
TP53BP2 tumor protein p53 binding protein, 2 0.077
SMO smoothened homolog (Drosophila) 0.075
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.075
CSNK1E casein kinase 1, epsilon 0.072
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.072
SUFU suppressor of fused homolog (Drosophila) 0.068
PXN paxillin 0.066
HTT huntingtin 0.064
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.063
NOTCH1 notch 1 0.060
PTCH1 patched 1 0.060
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.059
ENG endoglin 0.058
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.056
CDK19 cyclin-dependent kinase 19 0.056
RBBP4 retinoblastoma binding protein 4 0.055
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.055
PML promyelocytic leukemia 0.054
PVRL4 poliovirus receptor-related 4 0.053
HIPK2 homeodomain interacting protein kinase 2 0.053
C2orf65 chromosome 2 open reading frame 65 0.052
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.052
STK3 serine/threonine kinase 3 0.052
SOX11 SRY (sex determining region Y)-box 11 0.052
ESR1 estrogen receptor 1 0.049
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.049
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.049
TAL1 T-cell acute lymphocytic leukemia 1 0.047
CADM4 cell adhesion molecule 4 0.044
FGFR1 fibroblast growth factor receptor 1 0.043
COL11A1 collagen, type XI, alpha 1 0.042
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.040
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.039
COL2A1 collagen, type II, alpha 1 0.039
PAX2 paired box 2 0.038
BBS7 Bardet-Biedl syndrome 7 0.038
SETD8 SET domain containing (lysine methyltransferase) 8 0.037
BBS9 Bardet-Biedl syndrome 9 0.036
GRB7 growth factor receptor-bound protein 7 0.035
COL5A1 collagen, type V, alpha 1 0.035
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.035
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.034
BAD BCL2-associated agonist of cell death 0.034
BBS4 Bardet-Biedl syndrome 4 0.032
EFNA1 ephrin-A1 0.031
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.031
NKX2-1 NK2 homeobox 1 0.029
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.029
PVRL3 poliovirus receptor-related 3 0.029
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.028
SKIL SKI-like oncogene 0.028
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.028
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.028
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.028
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.027
MXRA5 matrix-remodelling associated 5 0.027
RB1 retinoblastoma 1 0.026
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.026
FGF1 fibroblast growth factor 1 (acidic) 0.026
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Postn periostin, osteoblast specific factor 0.266
Col1a2 collagen, type I, alpha 2 0.235
Fgfr2 fibroblast growth factor receptor 2 0.234
Col3a1 collagen, type III, alpha 1 0.231
Col1a1 collagen, type I, alpha 1 0.220
Colec12 collectin sub-family member 12 0.211
Cltc clathrin, heavy chain (Hc) 0.184
Cd48 Cd48 molecule 0.178
Col12a1 collagen, type XII, alpha 1 0.170
Copb2 coatomer protein complex, subunit beta 2 (beta prime) 0.167
Cp ceruloplasmin 0.144
Adam17 ADAM metallopeptidase domain 17 0.136
Col5a2 collagen, type V, alpha 2 0.133
Anxa1 annexin A1 0.131
Cdk2 cyclin dependent kinase 2 0.123
Cga glycoprotein hormones, alpha polypeptide 0.119
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.119
Lox lysyl oxidase 0.114
Chgb chromogranin B 0.114
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.110
Prph2 peripherin 2 0.108
Gucy2e guanylate cyclase 2E 0.106
Dcn decorin 0.104
Rtn1 reticulon 1 0.102
Mip major intrinsic protein of lens fiber 0.101
Rorb RAR-related orphan receptor B 0.098
Calcrl calcitonin receptor-like 0.094
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.090
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.090
Gipc1 GIPC PDZ domain containing family, member 1 0.090
Tcfe2a transcription factor E2a 0.089
Tnc tenascin C 0.089
Col14a1 collagen, type XIV, alpha 1 0.089
Rara retinoic acid receptor, alpha 0.088
Glra2 glycine receptor, alpha 2 0.085
Pspn persephin 0.084
Lphn2 latrophilin 2 0.084
Dab2 disabled homolog 2 (Drosophila) 0.081
Ddr2 discoidin domain receptor tyrosine kinase 2 0.080
Nradd neurotrophin receptor associated death domain 0.079
Lim2 lens intrinsic membrane protein 2 0.077
Nrl neural retina leucine zipper 0.076
Cpne3 copine III 0.074
Cfh complement factor H 0.072
Cpxm2 carboxypeptidase X (M14 family), member 2 0.072
Cdc2l6 cell division cycle 2-like 6 (CDK8-like) 0.071
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.071
Esr2 estrogen receptor 2 (ER beta) 0.071
Rbp3 retinol binding protein 3, interstitial 0.070
Cald1 caldesmon 1 0.070
Aspn asporin 0.068
Folr1 folate receptor 1 (adult) 0.068
Il6st interleukin 6 signal transducer 0.068
Gnat1 guanine nucleotide binding protein (G protein), alpha transducing 1 0.067
Bnip2 BCL2/adenovirus E1B interacting protein 2 0.067
Dnm1 dynamin 1 0.065
Lrrc59 leucine rich repeat containing 59 0.064
Syt6 synaptotagmin VI 0.064
Caprin1 cell cycle associated protein 1 0.064
Casp7 caspase 7 0.064
Fbn1 fibrillin 1 0.063
Ap3m1 adaptor-related protein complex 3, mu 1 subunit 0.061
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.061
Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 0.061
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.059
Cxcr5 chemokine (C-X-C motif) receptor 5 0.059
Ptprc protein tyrosine phosphatase, receptor type, C 0.059
Stk3 serine/threonine kinase 3 (STE20 homolog, yeast) 0.059
Tmem47 transmembrane protein 47 0.059
Camk1g calcium/calmodulin-dependent protein kinase IG 0.059
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.059
Crygs crystallin, gamma S 0.058
Megf10 multiple EGF-like domains 10 0.058
Adrb1 adrenergic, beta-1-, receptor 0.058
Tgfbr2 transforming growth factor, beta receptor II 0.057
Drd4 dopamine receptor D4 0.057
Loxl1 lysyl oxidase-like 1 0.057
Prl4a1 prolactin family 4, subfamily a, member 1 0.057
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.057
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.057
St18 suppression of tumorigenicity 18 0.057
LOC100360205 palladin 0.057
Ak2 adenylate kinase 2 0.056
Drd1a dopamine receptor D1A 0.056
Casp3 caspase 3 0.056
Hist1h1d histone cluster 1, H1d 0.056
Ogn osteoglycin 0.056
Drd2 dopamine receptor D2 0.056
C1s complement component 1, s subcomponent 0.055
Nefm neurofilament, medium polypeptide 0.055
Vcan versican 0.055
Mid1 midline 1 0.055
Mlana melan-A 0.055
Mycbp2 MYC binding protein 2 0.054
Ctsc cathepsin C 0.054
Lbp lipopolysaccharide binding protein 0.054
Bmpr1a bone morphogenetic protein receptor, type IA 0.053
Vgf VGF nerve growth factor inducible 0.053
Shmt1 serine hydroxymethyltransferase 1 (soluble) 0.052
Slit3 slit homolog 3 (Drosophila) 0.052
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism