The network for 'determination of bilateral symmetry' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.996
pkd2 polycystic kidney disease 2 0.994
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.994
lrrc6 leucine rich repeat containing 6 0.992
ift88 intraflagellar transport 88 homolog 0.990
pax2a paired box gene 2a 0.988
cdh2 cadherin 2, neuronal 0.988
chd chordin 0.976
fzd10 frizzled homolog 10 0.973
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.972
bmp4 bone morphogenetic protein 4 0.969
etv5b ets variant 5b 0.958
ntla no tail a 0.954
hnf1ba HNF1 homeobox Ba 0.953
gata3 GATA-binding protein 3 0.953
neurod neurogenic differentiation 0.951
fgf8a fibroblast growth factor 8 a 0.939
zgc:100838 zgc:100838 0.934
wnt11r wingless-type MMTV integration site family, member 11, related 0.930
tbx20 T-box 20 0.923
smad9 MAD homolog 9 (Drosophila) 0.922
runx2b runt-related transcription factor 2b 0.909
lhx1a LIM homeobox 1a 0.903
fgf3 fibroblast growth factor 3 0.898
twist1a twist1a 0.898
flh floating head 0.898
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.893
bmp2b bone morphogenetic protein 2b 0.892
wnt11 wingless-type MMTV integration site family, member 11 0.858
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.851
tbx18 T-box 18 0.847
gro1 groucho 1 0.844
pax8 paired box gene 8 0.841
msxc muscle segment homeobox C 0.830
lrrc50 leucine rich repeat containing 50 0.821
gli1 GLI-Kruppel family member 1 0.812
sulf1 sulfatase 1 0.808
bmp2a bone morphogenetic protein 2a 0.808
shhb sonic hedgehog b 0.804
gata4 GATA-binding protein 4 0.774
sesn1 sestrin 1 0.769
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.764
snai1b snail homolog 1b (Drosophila) 0.764
arl13b ADP-ribosylation factor-like 13b 0.760
zic4 zic family member 4 0.752
dld deltaD 0.751
twist3 twist3 0.749
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.746
itgb1b integrin, beta 1b 0.744
tbx16 T-box gene 16 0.740
smad5 MAD homolog 5 (Drosophila) 0.702
fzd8a frizzled homolog 8a 0.702
notch1a notch homolog 1a 0.700
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.698
fgfrl1b fibroblast growth factor receptor-like 1b 0.685
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.683
ephb4b eph receptor B4b 0.681
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.681
gbx2 gastrulation brain homeo box 2 0.665
itgav integrin, alpha V 0.664
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.663
hand2 heart and neural crest derivatives expressed transcript 2 0.663
rarab retinoic acid receptor, alpha b 0.662
eya4 eyes absent homolog 4 (Drosophila) 0.654
gli2a GLI-Kruppel family member GLI2a 0.649
emx3 empty spiracles homeobox 3 0.638
dmrt2a doublesex and mab-3 related transcription factor 2a 0.627
cdx4 caudal type homeo box transcription factor 4 0.626
fgf4 fibroblast growth factor 4 0.621
twist1b twist1b 0.615
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.615
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.609
foxj1a forkhead box J1a 0.608
tfap2a transcription factor AP-2 alpha 0.606
lft1 lefty1 0.602
shha sonic hedgehog a 0.600
gdf6a growth differentiation factor 6a 0.585
notch1b notch homolog 1b 0.582
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.581
fgfr4 fibroblast growth factor receptor 4 0.576
wnt4a wingless-type MMTV integration site family, member 4a 0.576
six4b sine oculis homeobox homolog 4b 0.569
tnni1b troponin I, skeletal, slow b 0.565
lft2 lefty2 0.556
ext1a exostoses (multiple) 1a 0.549
nkx2.5 NK2 transcription factor related 5 0.547
mapk1 mitogen-activated protein kinase 1 0.546
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.546
pcdh8 protocadherin 8 0.541
cc2d2a coiled-coil and C2 domain containing 2A 0.539
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.537
igf1rb insulin-like growth factor 1b receptor 0.534
dbx1a developing brain homeobox 1a 0.523
pou3f2 POU class 3 homeobox 2 0.520
ndr2 nodal-related 2 0.519
olfm2 olfactomedin 2 0.514
smarcd3b SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b 0.506
fibin fin bud initiation factor 0.502
vmhc ventricular myosin heavy chain 0.502
robo3 roundabout homolog 3 0.498
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
che-2 Protein CHE-2 0.234
egl-18 Protein EGL-18 0.064
glp-1 Protein GLP-1 0.056
soc-2 Protein SOC-2 0.055
inx-4 Protein INX-4 0.048
che-3 Protein CHE-3 0.040
pdfr-1 Protein PDFR-1 0.035
unc-9 Protein UNC-9 0.033
lin-17 Protein LIN-17 0.032
mec-2 Protein MEC-2 0.027
inx-13 Protein INX-13 0.027
che-11 Protein CHE-11 0.026
bar-1 Protein BAR-1 0.025
hlh-1 Protein HLH-1 0.024
vab-3 Protein VAB-3 0.021
klp-15 Protein KLP-15 0.021
efn-2 Protein EFN-2 0.020
sdz-28 Protein SDZ-28 0.020
lin-29 Protein LIN-29 0.019
eat-4 Protein EAT-4 0.019
bli-1 Protein BLI-1 0.018
rig-6 Protein RIG-6 0.017
ina-1 Protein INA-1 0.016
che-14 Protein CHE-14 0.016
unc-7 Protein UNC-7 0.014
unc-53 Protein UNC-53 0.014
unc-73 Protein UNC-73 0.014
daf-12 Protein DAF-12 0.013
egl-19 Protein EGL-19 0.013
lin-11 Protein LIN-11 0.012
inx-5 Protein INX-5 0.012
osm-5 Protein OSM-5 0.012
unc-52 Protein UNC-52 0.012
unc-62 Protein UNC-62 0.012
cam-1 Protein CAM-1 0.012
pal-1 Protein PAL-1 0.012
syg-2 Protein SYG-2 0.012
unc-115 Protein UNC-115 0.011
mps-2 Protein MPS-2 0.011
nphp-1 Protein NPHP-1 0.010
ajm-1 Protein AJM-1 0.010
sel-8 Protein SEL-8 0.010
F49E2.5 Protein F49E2.5 0.010
daf-10 Protein DAF-10 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
tin tinman 0.644
Rac1 CG2248 gene product from transcript CG2248-RA 0.615
twi twist 0.557
mys myospheroid 0.489
dsh dishevelled 0.382
tkv thickveins 0.371
Acsl Acyl-CoA synthetase long-chain 0.332
wg wingless 0.275
ci cubitus interruptus 0.251
slou slouch 0.243
emc extra macrochaetae 0.227
baz bazooka 0.219
stumps CG31317 gene product from transcript CG31317-RC 0.219
en engrailed 0.215
htl heartless 0.213
fng fringe 0.211
rhea CG6831 gene product from transcript CG6831-RA 0.167
robo roundabout 0.159
LanB1 CG7123 gene product from transcript CG7123-RA 0.146
crb crumbs 0.139
ptc patched 0.126
HLH54F CG5005 gene product from transcript CG5005-RA 0.120
cact cactus 0.117
if inflated 0.115
shi shibire 0.103
Cdc42 CG12530 gene product from transcript CG12530-RA 0.103
ena enabled 0.093
Egfr Epidermal growth factor receptor 0.092
N Notch 0.091
eve even skipped 0.086
Pvr PDGF- and VEGF-receptor related 0.083
CG14869 CG14869 gene product from transcript CG14869-RB 0.082
arr arrow 0.079
kn knot 0.079
Rho1 CG8416 gene product from transcript CG8416-RB 0.076
mid midline 0.075
srp serpent 0.071
comt comatose 0.060
G-oalpha47A G protein oalpha 47A 0.058
Lim1 CG11354 gene product from transcript CG11354-RA 0.058
gbb glass bottom boat 0.054
kst karst 0.054
Ras85D Ras oncogene at 85D 0.051
Myo31DF Myosin 31DF 0.050
ovo CG6824 gene product from transcript CG6824-RE 0.049
LanB2 Laminin B2 0.049
Tsc1 CG6147 gene product from transcript CG6147-RA 0.047
dpp decapentaplegic 0.046
scb scab 0.045
sli slit 0.045
kug kugelei 0.044
pcx pecanex 0.044
sr stripe 0.044
zfh1 Zn finger homeodomain 1 0.043
bi bifid 0.042
Tl Toll 0.040
ap apterous 0.040
Cby Chibby 0.036
nct nicastrin 0.036
cv-c crossveinless c 0.035
nau nautilus 0.034
byn brachyenteron 0.034
sns sticks and stones 0.033
eya eyes absent 0.033
fru fruitless 0.032
ash2 absent, small, or homeotic discs 2 0.031
kirre kin of irre 0.031
fu fused 0.031
pb proboscipedia 0.030
hh hedgehog 0.030
WASp CG1520 gene product from transcript CG1520-RA 0.030
hkb huckebein 0.029
Cul-5 Cullin-5 0.028
wb wing blister 0.028
Sema-1a CG18405 gene product from transcript CG18405-RD 0.027
tum tumbleweed 0.027
robo3 CG5423 gene product from transcript CG5423-RA 0.027
TBPH CG10327 gene product from transcript CG10327-RC 0.027
kibra kibra ortholog 0.027
slp1 sloppy paired 1 0.026
unc-5 CG8166 gene product from transcript CG8166-RA 0.026
Wnt4 Wnt oncogene analog 4 0.025
fj four-jointed 0.025
neuroligin CG13772 gene product from transcript CG13772-RA 0.025
flw flapwing 0.025
Syx1A Syntaxin 1A 0.024
pnr pannier 0.024
rho rhomboid 0.024
Snap25 Synapse protein 25 0.023
LanA Laminin A 0.023
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.023
otk off-track 0.021
frtz fritz 0.021
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.020
p120ctn Adherens junction protein p120 0.019
ato atonal 0.019
G-salpha60A G protein salpha 60A 0.019
Med Medea 0.019
rempA reduced mechanoreceptor potential A 0.018
inv invected 0.018
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD3 SMAD family member 3 0.996
RHOA ras homolog gene family, member A 0.977
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.733
SMAD7 SMAD family member 7 0.702
TGFB1 transforming growth factor, beta 1 0.700
BMPR1A bone morphogenetic protein receptor, type IA 0.661
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.609
SMAD2 SMAD family member 2 0.585
SMAD1 SMAD family member 1 0.532
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.525
FSTL1 follistatin-like 1 0.465
ATF2 activating transcription factor 2 0.423
TBX5 T-box 5 0.406
FKBP1A FK506 binding protein 1A, 12kDa 0.403
NOTCH1 notch 1 0.375
GSK3B glycogen synthase kinase 3 beta 0.366
SMAD4 SMAD family member 4 0.325
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.284
SP1 Sp1 transcription factor 0.261
FGF10 fibroblast growth factor 10 0.233
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.216
ARHGAP1 Rho GTPase activating protein 1 0.214
FLNC filamin C, gamma 0.213
GATA4 GATA binding protein 4 0.175
PBX1 pre-B-cell leukemia homeobox 1 0.146
ENG endoglin 0.136
MAP2K4 mitogen-activated protein kinase kinase 4 0.132
EP300 E1A binding protein p300 0.127
BMP2 bone morphogenetic protein 2 0.127
JAG1 jagged 1 0.127
CHRD chordin 0.121
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.108
TJP1 tight junction protein 1 (zona occludens 1) 0.107
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.107
MAPK8 mitogen-activated protein kinase 8 0.085
YBX1 Y box binding protein 1 0.081
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.081
SMAD5 SMAD family member 5 0.080
TGFBR1 transforming growth factor, beta receptor 1 0.079
YY1 YY1 transcription factor 0.079
APC adenomatous polyposis coli 0.078
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.073
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.072
ARRB2 arrestin, beta 2 0.070
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.065
HDAC2 histone deacetylase 2 0.065
SIRT1 sirtuin 1 0.062
AXIN1 axin 1 0.061
LRP6 low density lipoprotein receptor-related protein 6 0.060
CXXC5 CXXC finger protein 5 0.059
CD44 CD44 molecule (Indian blood group) 0.050
ACVR1 activin A receptor, type I 0.049
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.049
SNIP1 Smad nuclear interacting protein 1 0.047
MKL1 megakaryoblastic leukemia (translocation) 1 0.047
HIPK2 homeodomain interacting protein kinase 2 0.046
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.046
PLXNB1 plexin B1 0.046
MAPK9 mitogen-activated protein kinase 9 0.045
CREB1 cAMP responsive element binding protein 1 0.044
PTCH1 patched 1 0.043
GLI1 GLI family zinc finger 1 0.041
MAML1 mastermind-like 1 (Drosophila) 0.040
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.040
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.038
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.037
FLNB filamin B, beta 0.037
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.036
SFPQ splicing factor proline/glutamine-rich 0.035
GDF5 growth differentiation factor 5 0.035
PML promyelocytic leukemia 0.035
ZFYVE9 zinc finger, FYVE domain containing 9 0.033
SMAD6 SMAD family member 6 0.033
PCM1 pericentriolar material 1 0.033
MARK3 MAP/microtubule affinity-regulating kinase 3 0.032
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.030
TP53 tumor protein p53 0.029
FGF7 fibroblast growth factor 7 0.029
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.028
PKP4 plakophilin 4 0.028
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.028
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.027
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.027
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.027
MKL2 MKL/myocardin-like 2 0.027
ATF3 activating transcription factor 3 0.027
FZD1 frizzled homolog 1 (Drosophila) 0.027
HMGA1 high mobility group AT-hook 1 0.026
SPEN spen homolog, transcriptional regulator (Drosophila) 0.026
CTBP2 C-terminal binding protein 2 0.026
CANX calnexin 0.025
BBS2 Bardet-Biedl syndrome 2 0.025
HDAC9 histone deacetylase 9 0.025
BMP1 bone morphogenetic protein 1 0.024
SASS6 spindle assembly 6 homolog (C. elegans) 0.024
NOG noggin 0.023
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0.023
EPAS1 endothelial PAS domain protein 1 0.023
DSP desmoplakin 0.023
MEIS2 Meis homeobox 2 0.022
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism