The network for 'regulation of endodermal cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of endodermal cell differentiation

Any process that modulates the frequency, rate or extent of endodermal cell differentiation.

Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.957
bmp4 bone morphogenetic protein 4 0.638
vent ventral expressed homeobox 0.623
emx3 empty spiracles homeobox 3 0.589
pcdh8 protocadherin 8 0.548
flh floating head 0.546
notch2 notch homolog 2 0.488
her7 hairy and enhancer of split related-7 0.461
fgf3 fibroblast growth factor 3 0.459
pax2a paired box gene 2a 0.458
etv2 ets variant gene 2 0.450
ndr2 nodal-related 2 0.420
fgfr1a fibroblast growth factor receptor 1a 0.390
wif1 wnt inhibitory factor 1 0.375
chd chordin 0.315
fgfr2 fibroblast growth factor receptor 2 0.292
junbl jun B proto-oncogene, like 0.245
gbx2 gastrulation brain homeo box 2 0.238
dlc deltaC 0.233
junb jun B proto-oncogene 0.232
foxd5 forkhead box D5 0.219
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.219
hoxa2b homeo box A2b 0.216
efnb2a ephrin B2a 0.212
sox32 SRY-box containing gene 32 0.208
tbx20 T-box 20 0.195
hnf1ba HNF1 homeobox Ba 0.192
hmx4 H6 family homeobox 4 0.188
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.185
gli1 GLI-Kruppel family member 1 0.162
jag1b jagged 1b 0.159
tll1 tolloid-like 1 0.156
foxi1 forkhead box I1 0.154
tbx16 T-box gene 16 0.150
aplnra apelin receptor a 0.149
irx3b iroquois homeobox protein 3b 0.146
foxh1 forkhead box H1 0.129
dkk1b dickkopf 1b 0.125
hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.122
mecom MDS1 and EVI1 complex locus 0.122
foxg1a forkhead box G1a 0.120
notch1a notch homolog 1a 0.119
wu:fv91b12 wu:fv91b12 0.118
pitx3 paired-like homeodomain transcription factor 3 0.112
ndr1 nodal-related 1 0.110
cdx4 caudal type homeo box transcription factor 4 0.109
wnt5b wingless-type MMTV integration site family, member 5b 0.108
eya1 eyes absent homolog 1 0.108
bmp7a bone morphogenetic protein 7a 0.107
lhx1b LIM homeobox 1b 0.107
pax6b paired box gene 6b 0.105
ved ventrally expressed dharma/bozozok antagonist 0.101
egr2a early growth response 2a 0.097
mespb mesoderm posterior b 0.096
mab21l2 mab-21-like 2 0.084
bmp2a bone morphogenetic protein 2a 0.082
her1 hairy-related 1 0.080
jag2 jagged 2 0.078
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.078
dmrta2 doublesex and mab-3 related transcription factor like family A2 0.077
chsy1 chondroitin sulfate synthase 1 0.076
her12 hairy-related 12 0.076
sall4 sal-like 4 (Drosophila) 0.075
oep one-eyed pinhead 0.075
spry2 sprouty homolog 2 0.073
lhx1a LIM homeobox 1a 0.073
col1a1a collagen, type I, alpha 1a 0.073
col5a1 procollagen, type V, alpha 1 0.071
atf3 activating transcription factor 3 0.070
pax2b paired box gene 2b 0.070
ephb4b eph receptor B4b 0.069
vax2 ventral anterior homeobox 2 0.069
btg2 B-cell translocation gene 2 0.063
mespa mesoderm posterior a 0.062
fn1 fibronectin 1 0.062
gdf6b growth differentiation factor 6b 0.061
boc brother of CDO 0.060
admp anti-dorsalizing morphogenic protein 0.059
otpb orthopedia homolog b 0.059
ascl1a achaete-scute complex-like 1a (Drosophila) 0.059
tbx1 T-box 1 0.057
hapln3 hyaluronan and proteoglycan link protein 3 0.057
socs3a suppressor of cytokine signaling 3a 0.056
si:ch211-235f6.2 si:ch211-235f6.2 0.054
sox1a SRY-box containing gene 1a 0.054
fgfr3 fibroblast growth factor receptor 3 0.054
lft1 lefty1 0.054
LOC100331484 hypothetical protein LOC100331484 0.053
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.052
cdh2 cadherin 2, neuronal 0.051
fosl2 fos-like antigen 2 0.051
osr2 odd-skipped related 2 (Drosophila) 0.051
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.051
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.050
her5 hairy-related 5 0.050
fgfr4 fibroblast growth factor receptor 4 0.049
etv5a ets variant 5a 0.049
sox9a SRY-box containing gene 9a 0.048
gpr126 G protein-coupled receptor 126 0.048
spry4 sprouty (Drosophila) homolog 4 0.048
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 1.000
COL1A2 collagen, type I, alpha 2 0.998
COL4A1 collagen, type IV, alpha 1 0.995
COL3A1 collagen, type III, alpha 1 0.990
COL5A1 collagen, type V, alpha 1 0.983
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.981
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.951
COL4A2 collagen, type IV, alpha 2 0.897
BMPR1A bone morphogenetic protein receptor, type IA 0.802
COL5A2 collagen, type V, alpha 2 0.744
FSTL1 follistatin-like 1 0.706
COL6A1 collagen, type VI, alpha 1 0.683
JAG1 jagged 1 0.538
PXDN peroxidasin homolog (Drosophila) 0.461
DDR2 discoidin domain receptor tyrosine kinase 2 0.436
NOTCH3 notch 3 0.415
LOX lysyl oxidase 0.408
COL6A2 collagen, type VI, alpha 2 0.391
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.301
MAML1 mastermind-like 1 (Drosophila) 0.268
POSTN periostin, osteoblast specific factor 0.260
MXRA5 matrix-remodelling associated 5 0.247
BGN biglycan 0.220
COL18A1 collagen, type XVIII, alpha 1 0.219
COL11A1 collagen, type XI, alpha 1 0.216
ADAM12 ADAM metallopeptidase domain 12 0.183
COL6A3 collagen, type VI, alpha 3 0.179
NID1 nidogen 1 0.171
COL16A1 collagen, type XVI, alpha 1 0.142
THY1 Thy-1 cell surface antigen 0.133
PLCG1 phospholipase C, gamma 1 0.132
NID2 nidogen 2 (osteonidogen) 0.126
FGF1 fibroblast growth factor 1 (acidic) 0.088
MFAP2 microfibrillar-associated protein 2 0.088
LAMB1 laminin, beta 1 0.087
FNDC1 fibronectin type III domain containing 1 0.087
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.086
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.085
PDGFA platelet-derived growth factor alpha polypeptide 0.072
BMP7 bone morphogenetic protein 7 0.070
IGFBP3 insulin-like growth factor binding protein 3 0.064
NOG noggin 0.062
FGF2 fibroblast growth factor 2 (basic) 0.057
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.056
CTHRC1 collagen triple helix repeat containing 1 0.055
HSPG2 heparan sulfate proteoglycan 2 0.051
PCOLCE procollagen C-endopeptidase enhancer 0.048
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.048
XIAP X-linked inhibitor of apoptosis 0.046
PLXDC1 plexin domain containing 1 0.044
LRP6 low density lipoprotein receptor-related protein 6 0.043
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.042
THBS1 thrombospondin 1 0.042
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.038
COL10A1 collagen, type X, alpha 1 0.036
FRS2 fibroblast growth factor receptor substrate 2 0.036
FKBP10 FK506 binding protein 10, 65 kDa 0.036
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.035
FBLN2 fibulin 2 0.033
COL7A1 collagen, type VII, alpha 1 0.031
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.030
COL12A1 collagen, type XII, alpha 1 0.030
SFRP2 secreted frizzled-related protein 2 0.029
UNC5B unc-5 homolog B (C. elegans) 0.029
MDFI MyoD family inhibitor 0.028
ZFYVE9 zinc finger, FYVE domain containing 9 0.028
WISP1 WNT1 inducible signaling pathway protein 1 0.028
BMP1 bone morphogenetic protein 1 0.028
ANGPTL2 angiopoietin-like 2 0.027
FGFR2 fibroblast growth factor receptor 2 0.026
GLT8D2 glycosyltransferase 8 domain containing 2 0.026
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.025
THBS2 thrombospondin 2 0.024
TNC tenascin C 0.023
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.023
COL5A3 collagen, type V, alpha 3 0.023
LRRC17 leucine rich repeat containing 17 0.023
COL2A1 collagen, type II, alpha 1 0.022
JAG2 jagged 2 0.022
NOSTRIN nitric oxide synthase trafficker 0.020
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.020
LOXL1 lysyl oxidase-like 1 0.019
AEBP1 AE binding protein 1 0.019
TGFB3 transforming growth factor, beta 3 0.018
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.018
SULF1 sulfatase 1 0.018
FAP fibroblast activation protein, alpha 0.017
COL8A2 collagen, type VIII, alpha 2 0.016
SPON2 spondin 2, extracellular matrix protein 0.016
MCAM melanoma cell adhesion molecule 0.016
MXRA8 matrix-remodelling associated 8 0.016
PMEPA1 prostate transmembrane protein, androgen induced 1 0.015
SFRP4 secreted frizzled-related protein 4 0.015
PPIC peptidylprolyl isomerase C (cyclophilin C) 0.015
FBN1 fibrillin 1 0.015
MSX1 msh homeobox 1 0.014
TGFB2 transforming growth factor, beta 2 0.014
TWIST1 twist homolog 1 (Drosophila) 0.014
OLFML2B olfactomedin-like 2B 0.013
DACT1 dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) 0.013
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Prrx1 paired related homeobox 1 0.999
Fgfr2 fibroblast growth factor receptor 2 0.999
Foxc1 forkhead box C1 0.999
Fgf8 fibroblast growth factor 8 0.998
Otx2 orthodenticle homolog 2 (Drosophila) 0.997
Hand2 heart and neural crest derivatives expressed transcript 2 0.996
Gli3 GLI-Kruppel family member GLI3 0.995
Pitx2 paired-like homeodomain transcription factor 2 0.995
Bmp4 bone morphogenetic protein 4 0.993
Foxc2 forkhead box C2 0.993
Smo smoothened homolog (Drosophila) 0.993
Tcfap2a transcription factor AP-2, alpha 0.990
Tgfb2 transforming growth factor, beta 2 0.989
Hand1 heart and neural crest derivatives expressed transcript 1 0.986
Tbx1 T-box 1 0.983
Pax3 paired box gene 3 0.979
Jag1 jagged 1 0.973
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.956
Hes1 hairy and enhancer of split 1 (Drosophila) 0.945
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.931
Chrd chordin 0.922
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.921
Eya1 eyes absent 1 homolog (Drosophila) 0.919
Ctnnb1 catenin (cadherin associated protein), beta 1 0.907
Sox9 SRY-box containing gene 9 0.907
Msx1 homeobox, msh-like 1 0.901
Prrx2 paired related homeobox 2 0.862
Gata4 GATA binding protein 4 0.854
Gbx2 gastrulation brain homeobox 2 0.838
Nodal nodal 0.836
Chd7 chromodomain helicase DNA binding protein 7 0.828
Msx2 homeobox, msh-like 2 0.827
Ednra endothelin receptor type A 0.747
Isl1 ISL1 transcription factor, LIM/homeodomain 0.731
Foxg1 forkhead box G1 0.729
Acvr1 activin A receptor, type 1 0.696
Vangl2 vang-like 2 (van gogh, Drosophila) 0.682
Pax2 paired box gene 2 0.679
Dlx5 distal-less homeobox 5 0.674
Fgfr1 fibroblast growth factor receptor 1 0.649
Wnt3a wingless-related MMTV integration site 3A 0.637
Rarg retinoic acid receptor, gamma 0.619
Vegfa vascular endothelial growth factor A 0.616
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.614
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.572
Gsc goosecoid homeobox 0.560
Psen1 presenilin 1 0.536
Rara retinoic acid receptor, alpha 0.508
Meox2 mesenchyme homeobox 2 0.508
Hoxa1 homeobox A1 0.475
Gli2 GLI-Kruppel family member GLI2 0.442
Fgfr3 fibroblast growth factor receptor 3 0.440
Alx4 aristaless-like homeobox 4 0.436
Lmx1b LIM homeobox transcription factor 1 beta 0.433
Ptch1 patched homolog 1 0.413
Rarb retinoic acid receptor, beta 0.399
Lrp6 low density lipoprotein receptor-related protein 6 0.344
Dll1 delta-like 1 (Drosophila) 0.342
Col1a1 collagen, type I, alpha 1 0.323
En1 engrailed 1 0.279
Efnb2 ephrin B2 0.267
Emx1 empty spiracles homolog 1 (Drosophila) 0.221
Foxa2 forkhead box A2 0.211
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.211
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.210
Sox11 SRY-box containing gene 11 0.196
Tgfbr2 transforming growth factor, beta receptor II 0.195
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.185
Emx2 empty spiracles homolog 2 (Drosophila) 0.179
Pax6 paired box gene 6 0.176
Nog noggin 0.174
Gata6 GATA binding protein 6 0.166
Bicc1 bicaudal C homolog 1 (Drosophila) 0.163
Sox2 SRY-box containing gene 2 0.148
Rxra retinoid X receptor alpha 0.133
Nkx3-2 NK3 homeobox 2 0.133
Pkd1 polycystic kidney disease 1 homolog 0.132
T brachyury 0.129
Fbn1 fibrillin 1 0.121
Runx2 runt related transcription factor 2 0.120
Fgf10 fibroblast growth factor 10 0.115
Bmp7 bone morphogenetic protein 7 0.111
Fgf3 fibroblast growth factor 3 0.110
Notch2 Notch gene homolog 2 (Drosophila) 0.110
Sox4 SRY-box containing gene 4 0.108
Ntf3 neurotrophin 3 0.106
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.104
Ece1 endothelin converting enzyme 1 0.104
Thbs1 thrombospondin 1 0.102
Pax8 paired box gene 8 0.101
Dlx6 distal-less homeobox 6 0.100
Col3a1 collagen, type III, alpha 1 0.098
Pitx1 paired-like homeodomain transcription factor 1 0.096
Sall4 sal-like 4 (Drosophila) 0.096
Mesp1 mesoderm posterior 1 0.095
Ptk7 PTK7 protein tyrosine kinase 7 0.093
Otx1 orthodenticle homolog 1 (Drosophila) 0.091
Alx3 aristaless-like homeobox 3 0.089
Hhex hematopoietically expressed homeobox 0.088
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism