IMP

Process View

Homo sapiens

9 genes annotated in human

positive regulation of transcription from rna polymerase ii promoter in response to stress

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of transcription from rna polymerase ii promoter in response to stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of transcription from rna polymerase ii promoter in response to stress" (in gray)

Name	Description	Probability	Func Analog Organism
JUN	jun proto-oncogene	1.000
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.997
EP300	E1A binding protein p300	0.996
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.986
SMAD3	SMAD family member 3	0.977
CREBBP	CREB binding protein	0.977
DUSP1	dual specificity phosphatase 1	0.974
ATF2	activating transcription factor 2	0.971
ATF3	activating transcription factor 3	0.962
ARID1A	AT rich interactive domain 1A (SWI-like)	0.955
TRIB3	tribbles homolog 3 (Drosophila)	0.852
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.850
HDAC4	histone deacetylase 4	0.837
SP1	Sp1 transcription factor	0.816
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.803
KAT2B	K(lysine) acetyltransferase 2B	0.764
NCOR1	nuclear receptor corepressor 1	0.754
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.716
ESR1	estrogen receptor 1	0.695
DDIT3	DNA-damage-inducible transcript 3	0.686	Mouse Rat
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.684
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.636
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.587
SMAD2	SMAD family member 2	0.572
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.543	Yeast
HDAC1	histone deacetylase 1	0.534
KLF4	Kruppel-like factor 4 (gut)	0.509	Human
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.474
NCOA1	nuclear receptor coactivator 1	0.459
JUNB	jun B proto-oncogene	0.453
KLF6	Kruppel-like factor 6	0.450	Human
HIPK2	homeodomain interacting protein kinase 2	0.440
ZFYVE9	zinc finger, FYVE domain containing 9	0.431
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.404
PML	promyelocytic leukemia	0.397
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.394
NRP1	neuropilin 1	0.392
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.379
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.373
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.321	Yeast
CHD7	chromodomain helicase DNA binding protein 7	0.314	Human
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.310
RUNX1	runt-related transcription factor 1	0.288
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.285
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.281
NCOA3	nuclear receptor coactivator 3	0.271
CHD8	chromodomain helicase DNA binding protein 8	0.261	Human
VEGFA	vascular endothelial growth factor A	0.256
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.252
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.227
TGIF1	TGFB-induced factor homeobox 1	0.201
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.196
NCOA6	nuclear receptor coactivator 6	0.185
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.184
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.169
JAG1	jagged 1	0.164
MAPK14	mitogen-activated protein kinase 14	0.158	Yeast
MEF2C	myocyte enhancer factor 2C	0.158	Yeast
JUND	jun D proto-oncogene	0.156
EGR1	early growth response 1	0.154
SIRT1	sirtuin 1	0.123
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.121	Yeast
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.106
NCOR2	nuclear receptor corepressor 2	0.101
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.099	Human
MAP2K4	mitogen-activated protein kinase kinase 4	0.097
PBRM1	polybromo 1	0.091
NCOA2	nuclear receptor coactivator 2	0.091
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.078
ING2	inhibitor of growth family, member 2	0.075	Yeast
SMAD4	SMAD family member 4	0.073
MAPK8	mitogen-activated protein kinase 8	0.069	Yeast
AR	androgen receptor	0.068
MEF2A	myocyte enhancer factor 2A	0.068	Yeast
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.063	Human
BCL6	B-cell CLL/lymphoma 6	0.062
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.061
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.057
FOSL2	FOS-like antigen 2	0.055
IER2	immediate early response 2	0.052
PPARA	peroxisome proliferator-activated receptor alpha	0.052
CREB1	cAMP responsive element binding protein 1	0.048
CHD4	chromodomain helicase DNA binding protein 4	0.046
CARM1	coactivator-associated arginine methyltransferase 1	0.041
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.041
EGLN3	egl nine homolog 3 (C. elegans)	0.040
MAP2K5	mitogen-activated protein kinase kinase 5	0.039
PGF	placental growth factor	0.039	Human
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.038
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.038
GADD45B	growth arrest and DNA-damage-inducible, beta	0.037
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.036
RB1	retinoblastoma 1	0.036
TCF12	transcription factor 12	0.035
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.034
TTR	transthyretin	0.034
HDAC9	histone deacetylase 9	0.034
AHR	aryl hydrocarbon receptor	0.034
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.033
MAML1	mastermind-like 1 (Drosophila)	0.032
TP53	tumor protein p53	0.031
FOXO1	forkhead box O1	0.031
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.030
DAXX	death-domain associated protein	0.030
ARRB1	arrestin, beta 1	0.029
CTBP1	C-terminal binding protein 1	0.029
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.029
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.028
LDLR	low density lipoprotein receptor	0.028
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.027
CPNE6	copine VI (neuronal)	0.026
YY1	YY1 transcription factor	0.025
NOTCH3	notch 3	0.025
PDGFA	platelet-derived growth factor alpha polypeptide	0.025	Human
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.025
ARNT	aryl hydrocarbon receptor nuclear translocator	0.024
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.024
TNRC6B	trinucleotide repeat containing 6B	0.023
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.023
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.023
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.023
SOCS3	suppressor of cytokine signaling 3	0.022
ZFAND5	zinc finger, AN1-type domain 5	0.022
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.020
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.019
NFIL3	nuclear factor, interleukin 3 regulated	0.019
SAP30	Sin3A-associated protein, 30kDa	0.019
EGLN1	egl nine homolog 1 (C. elegans)	0.018
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.017
FOXO3	forkhead box O3	0.017
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.017
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.017
RHOB	ras homolog gene family, member B	0.017
CNOT4	CCR4-NOT transcription complex, subunit 4	0.016
CUX1	cut-like homeobox 1	0.016
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.015
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.015
NQO1	NAD(P)H dehydrogenase, quinone 1	0.014
SP3	Sp3 transcription factor	0.014
MAPK1	mitogen-activated protein kinase 1	0.013
KDM2A	lysine (K)-specific demethylase 2A	0.013
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.013
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.013
CUL7	cullin 7	0.013
PKN1	protein kinase N1	0.012
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.012
SREBF2	sterol regulatory element binding transcription factor 2	0.012
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.012
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.012
POU2F1	POU class 2 homeobox 1	0.011
TAL1	T-cell acute lymphocytic leukemia 1	0.011
KEAP1	kelch-like ECH-associated protein 1	0.011
PLCG1	phospholipase C, gamma 1	0.011
BHLHE40	basic helix-loop-helix family, member e40	0.011
BTG2	BTG family, member 2	0.011
BCL3	B-cell CLL/lymphoma 3	0.011
HCFC1	host cell factor C1 (VP16-accessory protein)	0.011
VHL	von Hippel-Lindau tumor suppressor	0.011
KLF2	Kruppel-like factor 2 (lung)	0.011
EPAS1	endothelial PAS domain protein 1	0.010	Human
PTPRB	protein tyrosine phosphatase, receptor type, B	0.010
MED13L	mediator complex subunit 13-like	0.010