IMP

Process View

Homo sapiens

18 genes annotated in human

regulation of dna templated transcription in response to stress

Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of dna templated transcription in response to stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of dna templated transcription in response to stress" (in gray)

Name	Description	Probability	Func Analog Organism
JUN	jun proto-oncogene	1.000
CREBBP	CREB binding protein	0.996
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.996
EP300	E1A binding protein p300	0.996
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.951
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.911
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.907	Human
SMAD3	SMAD family member 3	0.871
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.868	Human
SP1	Sp1 transcription factor	0.838
DUSP1	dual specificity phosphatase 1	0.747
KAT2B	K(lysine) acetyltransferase 2B	0.707
ZFYVE9	zinc finger, FYVE domain containing 9	0.531
HDAC4	histone deacetylase 4	0.513
NCOA1	nuclear receptor coactivator 1	0.507
SMAD2	SMAD family member 2	0.497
KLF4	Kruppel-like factor 4 (gut)	0.423	Human
ATF3	activating transcription factor 3	0.420
AHR	aryl hydrocarbon receptor	0.340
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.306
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.290
NCOR1	nuclear receptor corepressor 1	0.281
IER2	immediate early response 2	0.278
CREB1	cAMP responsive element binding protein 1	0.272
EPAS1	endothelial PAS domain protein 1	0.258	Human Mouse
YY1	YY1 transcription factor	0.240
NCOA2	nuclear receptor coactivator 2	0.237
AR	androgen receptor	0.228
NCOR2	nuclear receptor corepressor 2	0.224
JUNB	jun B proto-oncogene	0.211	Human
NCOA6	nuclear receptor coactivator 6	0.197
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.187
SMAD4	SMAD family member 4	0.174
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.173
AFF4	AF4/FMR2 family, member 4	0.157
KEAP1	kelch-like ECH-associated protein 1	0.155
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.144
PPARA	peroxisome proliferator-activated receptor alpha	0.138
SIRT1	sirtuin 1	0.135
ESR1	estrogen receptor 1	0.124
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.120
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.100
TRIB3	tribbles homolog 3 (Drosophila)	0.095
DDIT3	DNA-damage-inducible transcript 3	0.094	Mouse Rat
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.087
HIPK2	homeodomain interacting protein kinase 2	0.081
MAPK8	mitogen-activated protein kinase 8	0.081	Yeast
ATF2	activating transcription factor 2	0.080	Human
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.079
HDAC1	histone deacetylase 1	0.078
JAG1	jagged 1	0.076
NCOA3	nuclear receptor coactivator 3	0.069
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.061
COPS2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	0.061
TGIF1	TGFB-induced factor homeobox 1	0.058
FOSL2	FOS-like antigen 2	0.056
JUND	jun D proto-oncogene	0.052	Human
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.052
ARRB1	arrestin, beta 1	0.050
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.049
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.049
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.047
CPNE6	copine VI (neuronal)	0.044
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.044
EGLN1	egl nine homolog 1 (C. elegans)	0.043
KLF6	Kruppel-like factor 6	0.043	Human
CLOCK	clock homolog (mouse)	0.042
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.040
FBXL15	F-box and leucine-rich repeat protein 15	0.038
ZFAND5	zinc finger, AN1-type domain 5	0.037
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.037
SMAD1	SMAD family member 1	0.037
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.036
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.035
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.035
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.034
MAP2K4	mitogen-activated protein kinase kinase 4	0.034
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.034
CLSPN	claspin	0.034
ING2	inhibitor of growth family, member 2	0.034	Yeast
SNX9	sorting nexin 9	0.034
RUNX1	runt-related transcription factor 1	0.033
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.032	Yeast
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.030
E2F1	E2F transcription factor 1	0.029
LDLR	low density lipoprotein receptor	0.029
EGLN3	egl nine homolog 3 (C. elegans)	0.029
JDP2	Jun dimerization protein 2	0.029
HDAC9	histone deacetylase 9	0.028
RB1	retinoblastoma 1	0.028
EAF1	ELL associated factor 1	0.027
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.026
TLK1	tousled-like kinase 1	0.024
ARNT	aryl hydrocarbon receptor nuclear translocator	0.024
CDAN1	congenital dyserythropoietic anemia, type I	0.024
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.024
MAP2K5	mitogen-activated protein kinase kinase 5	0.023
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.022	Yeast
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.022
NRP1	neuropilin 1	0.021
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.021
SMAD7	SMAD family member 7	0.020
MEF2C	myocyte enhancer factor 2C	0.020	Yeast
MAML1	mastermind-like 1 (Drosophila)	0.020
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.020	Human
TTR	transthyretin	0.020
RHOA	ras homolog gene family, member A	0.020
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.020
HMGA1	high mobility group AT-hook 1	0.019
FOXO1	forkhead box O1	0.019	Worm
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.019
NBN	nibrin	0.019
AFF1	AF4/FMR2 family, member 1	0.019
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.018	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.018
VEGFA	vascular endothelial growth factor A	0.018
RBBP4	retinoblastoma binding protein 4	0.018
WDR5	WD repeat domain 5	0.018
BCL6	B-cell CLL/lymphoma 6	0.018
DTX1	deltex homolog 1 (Drosophila)	0.018
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.017
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.017
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.017
CUX1	cut-like homeobox 1	0.017
FOXO3	forkhead box O3	0.016
PKN1	protein kinase N1	0.016
XIAP	X-linked inhibitor of apoptosis	0.016
RHOB	ras homolog gene family, member B	0.016
MMS22L	MMS22-like, DNA repair protein	0.016
SMAD5	SMAD family member 5	0.016
BCL3	B-cell CLL/lymphoma 3	0.015
FHL2	four and a half LIM domains 2	0.015
HDAC6	histone deacetylase 6	0.015
TP73	tumor protein p73	0.014
ARID1A	AT rich interactive domain 1A (SWI-like)	0.014
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.014
ZRANB1	zinc finger, RAN-binding domain containing 1	0.014
MEF2A	myocyte enhancer factor 2A	0.014	Yeast
ADRBK1	adrenergic, beta, receptor kinase 1	0.014
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.014
SNW1	SNW domain containing 1	0.014
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.014
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.013
POU2F1	POU class 2 homeobox 1	0.013
SAP30	Sin3A-associated protein, 30kDa	0.013
TRAF4	TNF receptor-associated factor 4	0.012
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.012
SOCS3	suppressor of cytokine signaling 3	0.012
PER1	period homolog 1 (Drosophila)	0.012
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.012
ELL2	elongation factor, RNA polymerase II, 2	0.012	Fly
RNF11	ring finger protein 11	0.011
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.011
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.011
THRAP3	thyroid hormone receptor associated protein 3	0.011
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.011
HCFC1	host cell factor C1 (VP16-accessory protein)	0.011
RFWD2	ring finger and WD repeat domain 2	0.011
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.011
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.011
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.011
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.011
VHL	von Hippel-Lindau tumor suppressor	0.011
FGFR1	fibroblast growth factor receptor 1	0.011
SNAI1	snail homolog 1 (Drosophila)	0.011
HTT	huntingtin	0.011
TCF12	transcription factor 12	0.011
INO80D	INO80 complex subunit D	0.010
EGR3	early growth response 3	0.010
DAXX	death-domain associated protein	0.010
OCIAD1	OCIA domain containing 1	0.010
PML	promyelocytic leukemia	0.010
KLF5	Kruppel-like factor 5 (intestinal)	0.010	Human
EIF1	eukaryotic translation initiation factor 1	0.010
CDK2	cyclin-dependent kinase 2	0.010
TSC22D3	TSC22 domain family, member 3	0.010
ACTR8	ARP8 actin-related protein 8 homolog (yeast)	0.010
MEF2D	myocyte enhancer factor 2D	0.010	Yeast
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.010
PLCG1	phospholipase C, gamma 1	0.010
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.010
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.010