IMP

Process View

Homo sapiens

4 genes annotated in human

negative regulation of t cell receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of t cell receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of t cell receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
LAT	linker for activation of T cells	0.946
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.906
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.905
LCK	lymphocyte-specific protein tyrosine kinase	0.850
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.808
GHR	growth hormone receptor	0.794
CD2	CD2 molecule	0.750
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.750
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.549
VAV1	vav 1 guanine nucleotide exchange factor	0.469
CD247	CD247 molecule	0.438
MAPK1	mitogen-activated protein kinase 1	0.307
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.262
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.247
THAP2	THAP domain containing, apoptosis associated protein 2	0.229
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.170
CTNND1	catenin (cadherin-associated protein), delta 1	0.139
SYK	spleen tyrosine kinase	0.134
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.119
CD33	CD33 molecule	0.099
MAPK3	mitogen-activated protein kinase 3	0.092
SH3BP2	SH3-domain binding protein 2	0.087
PEA15	phosphoprotein enriched in astrocytes 15	0.082
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.080
MAP2K1	mitogen-activated protein kinase kinase 1	0.078
UTRN	utrophin	0.074
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.067
DNM1	dynamin 1	0.061
MICA	MHC class I polypeptide-related sequence A	0.061
PTPRC	protein tyrosine phosphatase, receptor type, C	0.054
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.054
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.051
PTPRB	protein tyrosine phosphatase, receptor type, B	0.050	Human
DUSP7	dual specificity phosphatase 7	0.047
PLCG1	phospholipase C, gamma 1	0.047
GAB1	GRB2-associated binding protein 1	0.043
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.041
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.041
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.040
PILRA	paired immunoglobin-like type 2 receptor alpha	0.040
MAPK14	mitogen-activated protein kinase 14	0.040
SOCS2	suppressor of cytokine signaling 2	0.039
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.038
BLNK	B-cell linker	0.037
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.036
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.035
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.034
PTK2	PTK2 protein tyrosine kinase 2	0.034
CD2AP	CD2-associated protein	0.032
GRB2	growth factor receptor-bound protein 2	0.029
PLK3	polo-like kinase 3	0.028
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.028
BTN3A1	butyrophilin, subfamily 3, member A1	0.027
DUSP1	dual specificity phosphatase 1	0.026
CDH5	cadherin 5, type 2 (vascular endothelium)	0.025
SH3GL3	SH3-domain GRB2-like 3	0.024
BTN2A1	butyrophilin, subfamily 2, member A1	0.024	Mouse
SH3KBP1	SH3-domain kinase binding protein 1	0.023
BTN2A2	butyrophilin, subfamily 2, member A2	0.022	Mouse
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.021
DPYSL4	dihydropyrimidinase-like 4	0.021
PTPN9	protein tyrosine phosphatase, non-receptor type 9	0.021
FHL1	four and a half LIM domains 1	0.020
BTN3A3	butyrophilin, subfamily 3, member A3	0.020
DBNL	drebrin-like	0.020
GAB2	GRB2-associated binding protein 2	0.019
PTPRR	protein tyrosine phosphatase, receptor type, R	0.019
RRAS2	related RAS viral (r-ras) oncogene homolog 2	0.019
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.018
HOXA1	homeobox A1	0.018
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.018
BTN3A2	butyrophilin, subfamily 3, member A2	0.017
ITGA1	integrin, alpha 1	0.017
RHOU	ras homolog gene family, member U	0.017
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.016
CRY1	cryptochrome 1 (photolyase-like)	0.016
DUSP3	dual specificity phosphatase 3	0.016
SIRPA	signal-regulatory protein alpha	0.015
SH2D2A	SH2 domain containing 2A	0.015
CD22	CD22 molecule	0.015
IQGAP1	IQ motif containing GTPase activating protein 1	0.015
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.015
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.015
NCK2	NCK adaptor protein 2	0.014
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.014	Mouse
REPS2	RALBP1 associated Eps domain containing 2	0.014
PXN	paxillin	0.014
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.014
TNK2	tyrosine kinase, non-receptor, 2	0.014
TRIM38	tripartite motif containing 38	0.014
APP	amyloid beta (A4) precursor protein	0.014
FTL	ferritin, light polypeptide	0.013
DUSP5	dual specificity phosphatase 5	0.013
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.013
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.013
CCDC85B	coiled-coil domain containing 85B	0.013
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.013
SCNM1	sodium channel modifier 1	0.013
PRKCQ	protein kinase C, theta	0.012
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.012
STX16	syntaxin 16	0.012
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.012
KIAA1033	KIAA1033	0.012
VEGFA	vascular endothelial growth factor A	0.012
INPPL1	inositol polyphosphate phosphatase-like 1	0.012
UBASH3B	ubiquitin associated and SH3 domain containing B	0.012
KIAA1191	KIAA1191	0.012
DUSP6	dual specificity phosphatase 6	0.012
RBM19	RNA binding motif protein 19	0.011
CFLAR	CASP8 and FADD-like apoptosis regulator	0.011
S100A6	S100 calcium binding protein A6	0.011
POU2F1	POU class 2 homeobox 1	0.011
NCK1	NCK adaptor protein 1	0.011
EPOR	erythropoietin receptor	0.011
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.011
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.011
DPPA4	developmental pluripotency associated 4	0.011
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.011
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.011
PTPN18	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	0.011	Human
NDUFA3	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	0.011
SOS2	son of sevenless homolog 2 (Drosophila)	0.011
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.011
CD72	CD72 molecule	0.011
MBP	myelin basic protein	0.010
ERRFI1	ERBB receptor feedback inhibitor 1	0.010
SIGLEC10	sialic acid binding Ig-like lectin 10	0.010
WIPF1	WAS/WASL interacting protein family, member 1	0.010
MTPN	myotrophin	0.010
SOS1	son of sevenless homolog 1 (Drosophila)	0.010