IMP

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Homo sapiens

22 genes annotated in human

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positive regulation of phospholipase activity

GO:0010518

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of phospholipase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of phospholipase activity" (in gray)

Name	Description	Probability	Func Analog Organism
FGF1	fibroblast growth factor 1 (acidic)	1.000	Human
FGFR2	fibroblast growth factor receptor 2	1.000
FGFR1	fibroblast growth factor receptor 1	0.999
ARRB1	arrestin, beta 1	0.960
CCR5	chemokine (C-C motif) receptor 5	0.954
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.926
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.867
CCL2	chemokine (C-C motif) ligand 2	0.768	Human
PLCG1	phospholipase C, gamma 1	0.738
CCL5	chemokine (C-C motif) ligand 5	0.734
CXCL9	chemokine (C-X-C motif) ligand 9	0.712
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.689
CCL4	chemokine (C-C motif) ligand 4	0.659	Human
CTGF	connective tissue growth factor	0.641
ARFIP2	ADP-ribosylation factor interacting protein 2	0.588
SPRR2A	small proline-rich protein 2A	0.540
FGF7	fibroblast growth factor 7	0.448	Human
ANG	angiogenin, ribonuclease, RNase A family, 5	0.411
CCL8	chemokine (C-C motif) ligand 8	0.387	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.355	Human
PTEN	phosphatase and tensin homolog	0.326
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.321
RNASE4	ribonuclease, RNase A family, 4	0.271	Human
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.253
VEGFA	vascular endothelial growth factor A	0.246
LAT	linker for activation of T cells	0.244
MPDZ	multiple PDZ domain protein	0.235
FGF10	fibroblast growth factor 10	0.226	Human
PTPRB	protein tyrosine phosphatase, receptor type, B	0.223
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.196
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.195
CCL13	chemokine (C-C motif) ligand 13	0.192	Human
CDH5	cadherin 5, type 2 (vascular endothelium)	0.191
SELE	selectin E	0.170
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.169
CCL19	chemokine (C-C motif) ligand 19	0.169	Human
RLN3	relaxin 3	0.163
DARC	Duffy blood group, chemokine receptor	0.142
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.135
ARCN1	archain 1	0.133
CCR7	chemokine (C-C motif) receptor 7	0.131
TMED2	transmembrane emp24 domain trafficking protein 2	0.123
NRP1	neuropilin 1	0.116
IDE	insulin-degrading enzyme	0.113
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.112
IL6	interleukin 6 (interferon, beta 2)	0.110
FGFR3	fibroblast growth factor receptor 3	0.089
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.087
SOS1	son of sevenless homolog 1 (Drosophila)	0.085
CCL11	chemokine (C-C motif) ligand 11	0.085	Human
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.082
IL10	interleukin 10	0.077
TIMP3	TIMP metallopeptidase inhibitor 3	0.074
IFNG	interferon, gamma	0.072
BCAR1	breast cancer anti-estrogen resistance 1	0.068
IL1B	interleukin 1, beta	0.067
VCAM1	vascular cell adhesion molecule 1	0.066
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.066	Human
BET1	blocked early in transport 1 homolog (S. cerevisiae)	0.066
GAB1	GRB2-associated binding protein 1	0.062
CCR3	chemokine (C-C motif) receptor 3	0.060
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.058
GHR	growth hormone receptor	0.057
CPA3	carboxypeptidase A3 (mast cell)	0.057
FGF2	fibroblast growth factor 2 (basic)	0.056
IL18RAP	interleukin 18 receptor accessory protein	0.056
CCR1	chemokine (C-C motif) receptor 1	0.053
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.053
COPB2	coatomer protein complex, subunit beta 2 (beta prime)	0.052
SHB	Src homology 2 domain containing adaptor protein B	0.051
STAT4	signal transducer and activator of transcription 4	0.051
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.051
CCL7	chemokine (C-C motif) ligand 7	0.050	Human
MAPK10	mitogen-activated protein kinase 10	0.050
CCL3	chemokine (C-C motif) ligand 3	0.049	Human
SPAG9	sperm associated antigen 9	0.049
ADORA3	adenosine A3 receptor	0.048
IL2RB	interleukin 2 receptor, beta	0.047
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.047
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.047
CXCL13	chemokine (C-X-C motif) ligand 13	0.046
CCL22	chemokine (C-C motif) ligand 22	0.044
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.043	Human
CLN3	ceroid-lipofuscinosis, neuronal 3	0.040
HPGDS	hematopoietic prostaglandin D synthase	0.039
ARF4	ADP-ribosylation factor 4	0.038
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.038
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.037
NKG7	natural killer cell group 7 sequence	0.035
CXCL10	chemokine (C-X-C motif) ligand 10	0.035
FRS2	fibroblast growth factor receptor substrate 2	0.034
SLA	Src-like-adaptor	0.034
CCR4	chemokine (C-C motif) receptor 4	0.033
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.033
ARRDC3	arrestin domain containing 3	0.033
IL7R	interleukin 7 receptor	0.032
GNLY	granulysin	0.032
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.031
FPR3	formyl peptide receptor 3	0.031
CH25H	cholesterol 25-hydroxylase	0.031
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.031
APOC1	apolipoprotein C-I	0.030
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.030
COPG	coatomer protein complex, subunit gamma	0.030
GZMK	granzyme K (granzyme 3; tryptase II)	0.029
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.029
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.028
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.028
FYB	FYN binding protein	0.028
CXCL11	chemokine (C-X-C motif) ligand 11	0.028
KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.028
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.028
HDC	histidine decarboxylase	0.026
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.026
LDLR	low density lipoprotein receptor	0.026
AMOTL2	angiomotin like 2	0.025
CTSW	cathepsin W	0.025
CYTH2	cytohesin 2	0.025
RGS16	regulator of G-protein signaling 16	0.025
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.025
SEC22B	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)	0.024
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.024
CD83	CD83 molecule	0.024
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.023
CARD11	caspase recruitment domain family, member 11	0.023
CD28	CD28 molecule	0.023
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.023
F13A1	coagulation factor XIII, A1 polypeptide	0.022
CD34	CD34 molecule	0.022
DPP4	dipeptidyl-peptidase 4	0.022
PDGFA	platelet-derived growth factor alpha polypeptide	0.022
COPB1	coatomer protein complex, subunit beta 1	0.021
GPR171	G protein-coupled receptor 171	0.021
RNH1	ribonuclease/angiogenin inhibitor 1	0.021
C4orf14	chromosome 4 open reading frame 14	0.021
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.020
TPSB2	tryptase beta 2 (gene/pseudogene)	0.020
CTSG	cathepsin G	0.020
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	0.020
SSTR3	somatostatin receptor 3	0.020
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.020
CXCL12	chemokine (C-X-C motif) ligand 12	0.019
NNMT	nicotinamide N-methyltransferase	0.019
COPG2	coatomer protein complex, subunit gamma 2	0.019
CXCL5	chemokine (C-X-C motif) ligand 5	0.019
IL10RA	interleukin 10 receptor, alpha	0.019
TBX21	T-box 21	0.019
TNF	tumor necrosis factor	0.018
CST7	cystatin F (leukocystatin)	0.018
RAB1A	RAB1A, member RAS oncogene family	0.018
CMA1	chymase 1, mast cell	0.018
CCR2	chemokine (C-C motif) receptor 2	0.018
COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)	0.017
CRMP1	collapsin response mediator protein 1	0.017
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.017
CD69	CD69 molecule	0.017
AKAP2	A kinase (PRKA) anchor protein 2	0.017
C2	complement component 2	0.016
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.016
VEGFC	vascular endothelial growth factor C	0.016
C3	complement component 3	0.016
BDKRB2	bradykinin receptor B2	0.016	Human
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.016
ATP6V1F	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F	0.016
RGS1	regulator of G-protein signaling 1	0.016
MAPT	microtubule-associated protein tau	0.015
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.015	Human
FGF8	fibroblast growth factor 8 (androgen-induced)	0.015
GORASP2	golgi reassembly stacking protein 2, 55kDa	0.015
C9orf16	chromosome 9 open reading frame 16	0.015
CD40LG	CD40 ligand	0.015
RET	ret proto-oncogene	0.015
CCL23	chemokine (C-C motif) ligand 23	0.015	Human
TRAT1	T cell receptor associated transmembrane adaptor 1	0.015
SELPLG	selectin P ligand	0.015
CXCR6	chemokine (C-X-C motif) receptor 6	0.014
EZR	ezrin	0.014
SOS2	son of sevenless homolog 2 (Drosophila)	0.014
VCAN	versican	0.014
CD2	CD2 molecule	0.014
AIG1	androgen-induced 1	0.014
MPO	myeloperoxidase	0.014
HSPG2	heparan sulfate proteoglycan 2	0.014
GHRHR	growth hormone releasing hormone receptor	0.014
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.014
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.013
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.013
ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	0.013
GNMT	glycine N-methyltransferase	0.013
PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	0.013
APLNR	apelin receptor	0.013
PRKCQ	protein kinase C, theta	0.013
SOCS3	suppressor of cytokine signaling 3	0.013
CLC	Charcot-Leyden crystal protein	0.013
FOLR2	folate receptor 2 (fetal)	0.013
CALM3	calmodulin 3 (phosphorylase kinase, delta)	0.013
MGP	matrix Gla protein	0.013
AKAP12	A kinase (PRKA) anchor protein 12	0.013
SDS	serine dehydratase	0.013
MMRN1	multimerin 1	0.012
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.012
C1orf93	chromosome 1 open reading frame 93	0.012
PRF1	perforin 1 (pore forming protein)	0.012
MLF2	myeloid leukemia factor 2	0.012
FLT4	fms-related tyrosine kinase 4	0.012	Human
GNAS	GNAS complex locus	0.012
MAPK8	mitogen-activated protein kinase 8	0.012
IL5RA	interleukin 5 receptor, alpha	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.012
NLRP3	NLR family, pyrin domain containing 3	0.012
FLT3	fms-related tyrosine kinase 3	0.012	Human
ICOS	inducible T-cell co-stimulator	0.012
GFPT1	glutamine--fructose-6-phosphate transaminase 1	0.012
ZP2	zona pellucida glycoprotein 2 (sperm receptor)	0.011
TREM2	triggering receptor expressed on myeloid cells 2	0.011
IL2RA	interleukin 2 receptor, alpha	0.011
GOLGA5	golgin A5	0.011
TSHR	thyroid stimulating hormone receptor	0.011
CD2BP2	CD2 (cytoplasmic tail) binding protein 2	0.011
TFEC	transcription factor EC	0.011
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.011
CD160	CD160 molecule	0.011
CCL21	chemokine (C-C motif) ligand 21	0.011
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.011
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.011
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.011
WNT2	wingless-type MMTV integration site family member 2	0.011
PTPRA	protein tyrosine phosphatase, receptor type, A	0.011
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.011	Human
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.011
YIPF5	Yip1 domain family, member 5	0.011
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.011
XCL2	chemokine (C motif) ligand 2	0.011
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.011
BDKRB1	bradykinin receptor B1	0.011	Human
SERP1	stress-associated endoplasmic reticulum protein 1	0.011
LRRC32	leucine rich repeat containing 32	0.011
ERLEC1	endoplasmic reticulum lectin 1	0.011
CCDC115	coiled-coil domain containing 115	0.011
ADRB3	adrenergic, beta-3-, receptor	0.010	Human
DNASE1L3	deoxyribonuclease I-like 3	0.010
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.010
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.010
GPR6	G protein-coupled receptor 6	0.010
C12orf23	chromosome 12 open reading frame 23	0.010
CXCL2	chemokine (C-X-C motif) ligand 2	0.010
CHI3L2	chitinase 3-like 2	0.010
TBC1D10A	TBC1 domain family, member 10A	0.010
TMEM106A	transmembrane protein 106A	0.010
THBS2	thrombospondin 2	0.010