IMP

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Homo sapiens

23 genes annotated in human

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insulin receptor signaling pathway

GO:0008286

The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "insulin receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "insulin receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
PTPN1	protein tyrosine phosphatase, non-receptor type 1	1.000	Mouse Rat
GRB2	growth factor receptor-bound protein 2	1.000
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.994	Rat Worm
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.992
INSR	insulin receptor	0.988
EGFR	epidermal growth factor receptor	0.963
CREBBP	CREB binding protein	0.949
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.933	Rat
GRB10	growth factor receptor-bound protein 10	0.866	Mouse Rat
NCOA1	nuclear receptor coactivator 1	0.859
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.768
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.762	Rat
BCAR1	breast cancer anti-estrogen resistance 1	0.752	Rat
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.616
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.588
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.575	Human
NCF1	neutrophil cytosolic factor 1	0.558
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.523	Rat
PLCG1	phospholipase C, gamma 1	0.492
GSK3B	glycogen synthase kinase 3 beta	0.475	Human
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.455
FYN	FYN oncogene related to SRC, FGR, YES	0.451
IRS2	insulin receptor substrate 2	0.406	Human Mouse Fly
JAK2	Janus kinase 2	0.317
GHR	growth hormone receptor	0.300
NCOA2	nuclear receptor coactivator 2	0.282
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.277
PRKCA	protein kinase C, alpha	0.237	Mouse
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.224
PRKCZ	protein kinase C, zeta	0.218
SORBS3	sorbin and SH3 domain containing 3	0.206
CUL1	cullin 1	0.188	Fly
IRS1	insulin receptor substrate 1	0.179
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.175
RXRA	retinoid X receptor, alpha	0.163
NCK1	NCK adaptor protein 1	0.150	Fly
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.143
EP300	E1A binding protein p300	0.141
AR	androgen receptor	0.139
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.138
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.122
CAV1	caveolin 1, caveolae protein, 22kDa	0.117
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.117
KAT2B	K(lysine) acetyltransferase 2B	0.100
SIRT1	sirtuin 1	0.098
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.098
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.095
ESR1	estrogen receptor 1	0.095
SH3RF1	SH3 domain containing ring finger 1	0.091
RARA	retinoic acid receptor, alpha	0.091
SH2B1	SH2B adaptor protein 1	0.086	Fly
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.086
EIF4E	eukaryotic translation initiation factor 4E	0.081
MAPK14	mitogen-activated protein kinase 14	0.078
POU5F1	POU class 5 homeobox 1	0.078
STAT5B	signal transducer and activator of transcription 5B	0.076
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.074
NCF2	neutrophil cytosolic factor 2	0.073
EPOR	erythropoietin receptor	0.072
RPTOR	regulatory associated protein of MTOR, complex 1	0.067
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.063
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.062
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.059
PTK2	PTK2 protein tyrosine kinase 2	0.058
MAPT	microtubule-associated protein tau	0.056
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.055
RICTOR	RPTOR independent companion of MTOR, complex 2	0.054
MAPK3	mitogen-activated protein kinase 3	0.054
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.053
STAT5A	signal transducer and activator of transcription 5A	0.050
BCL3	B-cell CLL/lymphoma 3	0.049
PDPK1	3-phosphoinositide dependent protein kinase-1	0.049
CREB1	cAMP responsive element binding protein 1	0.048
RAB6A	RAB6A, member RAS oncogene family	0.043
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.042
SOS1	son of sevenless homolog 1 (Drosophila)	0.041
SOCS1	suppressor of cytokine signaling 1	0.039	Mouse
MED15	mediator complex subunit 15	0.037
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.037
SMAD3	SMAD family member 3	0.035
IL1R1	interleukin 1 receptor, type I	0.035
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.034
VAV1	vav 1 guanine nucleotide exchange factor	0.033
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.032	Mouse
EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3	0.032
LAT	linker for activation of T cells	0.032
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.030
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.029
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.029
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.028
IGF1R	insulin-like growth factor 1 receptor	0.027	Human Fly
LIMS1	LIM and senescent cell antigen-like domains 1	0.026
HDAC6	histone deacetylase 6	0.026
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.025	Human
DOCK1	dedicator of cytokinesis 1	0.025
IL1RAP	interleukin 1 receptor accessory protein	0.025
CSK	c-src tyrosine kinase	0.025
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.025
EEF2K	eukaryotic elongation factor-2 kinase	0.024
SNAP25	synaptosomal-associated protein, 25kDa	0.024
KIAA1217	KIAA1217	0.024
SRCIN1	SRC kinase signaling inhibitor 1	0.023
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.023
CYBA	cytochrome b-245, alpha polypeptide	0.022
CD28	CD28 molecule	0.022
MAPK1	mitogen-activated protein kinase 1	0.022
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.022
SKP1	S-phase kinase-associated protein 1	0.022	Fly
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.021
GRB7	growth factor receptor-bound protein 7	0.021
FBXW11	F-box and WD repeat domain containing 11	0.021	Fly
RHOU	ras homolog gene family, member U	0.021
ITGB1BP3	integrin beta 1 binding protein 3	0.021
HMOX2	heme oxygenase (decycling) 2	0.021
NCF4	neutrophil cytosolic factor 4, 40kDa	0.021
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.021
BTRC	beta-transducin repeat containing	0.020	Fly
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.020
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.019
NCOR1	nuclear receptor corepressor 1	0.018
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.018
CEP250	centrosomal protein 250kDa	0.018
AKT1S1	AKT1 substrate 1 (proline-rich)	0.018
NOP56	NOP56 ribonucleoprotein homolog (yeast)	0.017
TRIM9	tripartite motif containing 9	0.017
CTTN	cortactin	0.017
PRKCB	protein kinase C, beta	0.017
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.016
MED25	mediator complex subunit 25	0.016
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.016
FOXO1	forkhead box O1	0.016	Human Mouse Worm Fly
PTPRE	protein tyrosine phosphatase, receptor type, E	0.016	Mouse Rat
FOXO3	forkhead box O3	0.015	Human Fly
FBXW7	F-box and WD repeat domain containing 7	0.015
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.015
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.015
VAV3	vav 3 guanine nucleotide exchange factor	0.015
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.015
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.015
SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.015
FYB	FYN binding protein	0.014
CDCP1	CUB domain containing protein 1	0.014
SH2B3	SH2B adaptor protein 3	0.014	Fly
PTPRB	protein tyrosine phosphatase, receptor type, B	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
SOCS2	suppressor of cytokine signaling 2	0.014
PHF3	PHD finger protein 3	0.014
ITSN1	intersectin 1 (SH3 domain protein)	0.014
PUM2	pumilio homolog 2 (Drosophila)	0.013
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.013
IGF2	insulin-like growth factor 2 (somatomedin A)	0.013
FBN3	fibrillin 3	0.013
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.013
WEE1	WEE1 homolog (S. pombe)	0.013
GLTPD1	glycolipid transfer protein domain containing 1	0.013
CD97	CD97 molecule	0.013
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.013
CAV2	caveolin 2	0.012
IGF2R	insulin-like growth factor 2 receptor	0.012
STK10	serine/threonine kinase 10	0.012
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.012
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.012
EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1	0.012
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.012
MUC1	mucin 1, cell surface associated	0.011
NCOA3	nuclear receptor coactivator 3	0.011
BCR	breakpoint cluster region	0.011
C17orf28	chromosome 17 open reading frame 28	0.011
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.011	Human
IL12RB2	interleukin 12 receptor, beta 2	0.011
PTK6	PTK6 protein tyrosine kinase 6	0.011
SH3RF3	SH3 domain containing ring finger 3	0.010
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.010
CREBZF	CREB/ATF bZIP transcription factor	0.010
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.010