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Homo sapiens

21 genes annotated in human

Multi-species View

negative regulation of ossification

GO:0030279

Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of ossification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of ossification" (in gray)

Name	Description	Probability	Func Analog Organism
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.985
CCR5	chemokine (C-C motif) receptor 5	0.974	Human
CCL5	chemokine (C-C motif) ligand 5	0.861	Human
CCL4	chemokine (C-C motif) ligand 4	0.836	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.735	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.542
NCOR2	nuclear receptor corepressor 2	0.525
SKIL	SKI-like oncogene	0.449	Human
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.359
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.349
CCL22	chemokine (C-C motif) ligand 22	0.343	Human
SMAD3	SMAD family member 3	0.259	Mouse
MEF2A	myocyte enhancer factor 2A	0.243	Human
IFNG	interferon, gamma	0.232
HDAC4	histone deacetylase 4	0.230	Human Mouse
SQSTM1	sequestosome 1	0.221
INSR	insulin receptor	0.202
VCAN	versican	0.199
IL2RB	interleukin 2 receptor, beta	0.192
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.177
CCL3	chemokine (C-C motif) ligand 3	0.154
JAG1	jagged 1	0.152
CXCL11	chemokine (C-X-C motif) ligand 11	0.142
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.138	Human
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.134
SMAD4	SMAD family member 4	0.134
CCR1	chemokine (C-C motif) receptor 1	0.117
CCR4	chemokine (C-C motif) receptor 4	0.110	Human
MEF2C	myocyte enhancer factor 2C	0.103
CXCR6	chemokine (C-X-C motif) receptor 6	0.095	Human
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.089
NCOR1	nuclear receptor corepressor 1	0.086
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.085
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.085
HDAC9	histone deacetylase 9	0.084	Human
CCL2	chemokine (C-C motif) ligand 2	0.082	Human
RUNX1	runt-related transcription factor 1	0.082
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.081
POU5F1	POU class 5 homeobox 1	0.080
CCR7	chemokine (C-C motif) receptor 7	0.078	Human
BCL6	B-cell CLL/lymphoma 6	0.078
EPAS1	endothelial PAS domain protein 1	0.077
CXCR3	chemokine (C-X-C motif) receptor 3	0.075	Human
ING2	inhibitor of growth family, member 2	0.073
CCR2	chemokine (C-C motif) receptor 2	0.072	Human
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.071
CCL13	chemokine (C-C motif) ligand 13	0.070	Human
CXCL13	chemokine (C-X-C motif) ligand 13	0.069
SETD8	SET domain containing (lysine methyltransferase) 8	0.067
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.062	Mouse
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.062
CCND1	cyclin D1	0.062
MAML1	mastermind-like 1 (Drosophila)	0.058
CCL8	chemokine (C-C motif) ligand 8	0.056	Human
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.056	Mouse
DPP4	dipeptidyl-peptidase 4	0.053
IL10	interleukin 10	0.052
KDM2B	lysine (K)-specific demethylase 2B	0.051
SMO	smoothened homolog (Drosophila)	0.050
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.050
PCGF1	polycomb group ring finger 1	0.049
NOTCH1	notch 1	0.049	Mouse
GATA2	GATA binding protein 2	0.046
ENG	endoglin	0.046
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.046	Mouse
SLAMF7	SLAM family member 7	0.044
CCL7	chemokine (C-C motif) ligand 7	0.044	Human
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.044
CCL11	chemokine (C-C motif) ligand 11	0.043	Human
EP300	E1A binding protein p300	0.042
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.042
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.041
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.040	Mouse
HTT	huntingtin	0.039
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.039
VHL	von Hippel-Lindau tumor suppressor	0.039
IRF4	interferon regulatory factor 4	0.038
BMP1	bone morphogenetic protein 1	0.038
HIPK3	homeodomain interacting protein kinase 3	0.038
SELL	selectin L	0.037
IL8	interleukin 8	0.036
TCF12	transcription factor 12	0.036
IL1B	interleukin 1, beta	0.035
MYOD1	myogenic differentiation 1	0.035
ARRDC3	arrestin domain containing 3	0.034
CAPRIN2	caprin family member 2	0.034
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.034
MATK	megakaryocyte-associated tyrosine kinase	0.034
PRKD2	protein kinase D2	0.033
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.032
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.032
EGLN1	egl nine homolog 1 (C. elegans)	0.031
IL1R2	interleukin 1 receptor, type II	0.031
CREBBP	CREB binding protein	0.030
IL2RG	interleukin 2 receptor, gamma	0.029
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.029
TGFBR1	transforming growth factor, beta receptor 1	0.029
EGLN3	egl nine homolog 3 (C. elegans)	0.029
FOXP3	forkhead box P3	0.028
SP1	Sp1 transcription factor	0.028
IDE	insulin-degrading enzyme	0.027
PTEN	phosphatase and tensin homolog	0.027
FGF2	fibroblast growth factor 2 (basic)	0.027
BMP2	bone morphogenetic protein 2	0.026
GATA4	GATA binding protein 4	0.026
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.026	Mouse
CSF1R	colony stimulating factor 1 receptor	0.025
LRP6	low density lipoprotein receptor-related protein 6	0.025	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.024
COL6A2	collagen, type VI, alpha 2	0.024
CD40LG	CD40 ligand	0.024
IL10RA	interleukin 10 receptor, alpha	0.023
ATN1	atrophin 1	0.023
CCL19	chemokine (C-C motif) ligand 19	0.023	Human
CCR3	chemokine (C-C motif) receptor 3	0.022	Human
RGS1	regulator of G-protein signaling 1	0.022
S100A4	S100 calcium binding protein A4	0.022
IL1F5	interleukin 1 family, member 5 (delta)	0.022
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.021
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.021
ATXN1L	ataxin 1-like	0.021
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.021
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.021
FBLN1	fibulin 1	0.020
BCL2L1	BCL2-like 1	0.020
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.020
IL7R	interleukin 7 receptor	0.019
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.019
CD48	CD48 molecule	0.019
CXCL12	chemokine (C-X-C motif) ligand 12	0.019
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.019
IL18RAP	interleukin 18 receptor accessory protein	0.018
CCL21	chemokine (C-C motif) ligand 21	0.018
SMAD7	SMAD family member 7	0.018
CD83	CD83 molecule	0.018
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.017
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.017
IDO1	indoleamine 2,3-dioxygenase 1	0.017
THBS1	thrombospondin 1	0.017
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.017	Rat
EBI3	Epstein-Barr virus induced 3	0.017
HRG	histidine-rich glycoprotein	0.016
RUNX2	runt-related transcription factor 2	0.016
ATXN1	ataxin 1	0.016
DARC	Duffy blood group, chemokine receptor	0.016
PICALM	phosphatidylinositol binding clathrin assembly protein	0.016
GPR171	G protein-coupled receptor 171	0.016
PTPRC	protein tyrosine phosphatase, receptor type, C	0.015
BMP7	bone morphogenetic protein 7	0.015
CD163	CD163 molecule	0.015
ESR1	estrogen receptor 1	0.015
ZEB2	zinc finger E-box binding homeobox 2	0.015
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.015
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.015
CXCR5	chemokine (C-X-C motif) receptor 5	0.015	Human
TCF4	transcription factor 4	0.015
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.014
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.014
SOCS3	suppressor of cytokine signaling 3	0.014
SSX4	synovial sarcoma, X breakpoint 4	0.014
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.014
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.014
PRRC2A	proline-rich coiled-coil 2A	0.014
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.014
CD22	CD22 molecule	0.013
SELPLG	selectin P ligand	0.013
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.013
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.013
SMAD5	SMAD family member 5	0.013
LAG3	lymphocyte-activation gene 3	0.013
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.013
GABARAP	GABA(A) receptor-associated protein	0.013
IRS1	insulin receptor substrate 1	0.013
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.013
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.013
SLAMF8	SLAM family member 8	0.013
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.013
CHSY1	chondroitin sulfate synthase 1	0.013
SALL2	sal-like 2 (Drosophila)	0.013
WNT2	wingless-type MMTV integration site family member 2	0.013
LTBP4	latent transforming growth factor beta binding protein 4	0.012
IL13	interleukin 13	0.012
CCR6	chemokine (C-C motif) receptor 6	0.012	Human
C3AR1	complement component 3a receptor 1	0.012
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.012
MEGF11	multiple EGF-like-domains 11	0.012
NKG7	natural killer cell group 7 sequence	0.012
AR	androgen receptor	0.012
CCR9	chemokine (C-C motif) receptor 9	0.012	Human
RUNX3	runt-related transcription factor 3	0.012
SMAD1	SMAD family member 1	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.012
PLEK	pleckstrin	0.012
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.011
PTPRA	protein tyrosine phosphatase, receptor type, A	0.011
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.011
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.011
CXCR4	chemokine (C-X-C motif) receptor 4	0.011	Human
CLEC7A	C-type lectin domain family 7, member A	0.011
PID1	phosphotyrosine interaction domain containing 1	0.011
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.011
TBX21	T-box 21	0.011
RGS16	regulator of G-protein signaling 16	0.011
ADAMDEC1	ADAM-like, decysin 1	0.011
CCL23	chemokine (C-C motif) ligand 23	0.011	Human
CLIC4	chloride intracellular channel 4	0.011
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.011
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.011
WNT3A	wingless-type MMTV integration site family, member 3A	0.011
SIX6	SIX homeobox 6	0.011
IL4	interleukin 4	0.011
IL6	interleukin 6 (interferon, beta 2)	0.011
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
GZMK	granzyme K (granzyme 3; tryptase II)	0.011
ULK1	unc-51-like kinase 1 (C. elegans)	0.010
BCL2A1	BCL2-related protein A1	0.010
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.010
CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.010
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.010
ACVR1	activin A receptor, type I	0.010
GPR25	G protein-coupled receptor 25	0.010
LRRK2	leucine-rich repeat kinase 2	0.010