IMP

Process View

Homo sapiens

1 genes annotated in human

negative regulation of reactive oxygen species biosynthetic process

GO:1903427

Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of reactive oxygen species biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of reactive oxygen species biosynthetic process" (in gray)

Name	Description	Probability
IRAK2	interleukin-1 receptor-associated kinase 2	0.975
CAV2	caveolin 2	0.687
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.254
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.242
IL10RA	interleukin 10 receptor, alpha	0.157
PTEN	phosphatase and tensin homolog	0.126
EGFR	epidermal growth factor receptor	0.125
CAPN1	calpain 1, (mu/I) large subunit	0.096
JAK2	Janus kinase 2	0.093
PTPRF	protein tyrosine phosphatase, receptor type, F	0.093
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.082
MPDZ	multiple PDZ domain protein	0.078
CALCA	calcitonin-related polypeptide alpha	0.073
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.070
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.066
JAK1	Janus kinase 1	0.064
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.062
EGR2	early growth response 2	0.061
F2R	coagulation factor II (thrombin) receptor	0.059
BCL3	B-cell CLL/lymphoma 3	0.056
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.054
TNIP2	TNFAIP3 interacting protein 2	0.053
PRKCDBP	protein kinase C, delta binding protein	0.051
SSTR2	somatostatin receptor 2	0.048
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.048
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.045
STAT5A	signal transducer and activator of transcription 5A	0.045
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.043
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.041
OSBPL8	oxysterol binding protein-like 8	0.039
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.038
DLG2	discs, large homolog 2 (Drosophila)	0.038
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.033
C2orf18	chromosome 2 open reading frame 18	0.031
SDPR	serum deprivation response	0.031
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.030
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.029
SSTR3	somatostatin receptor 3	0.029
TXNRD1	thioredoxin reductase 1	0.029
MBNL1	muscleblind-like (Drosophila)	0.028
FAS	Fas (TNF receptor superfamily, member 6)	0.028
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.027
NRIP1	nuclear receptor interacting protein 1	0.026
PIAS3	protein inhibitor of activated STAT, 3	0.026
DLG1	discs, large homolog 1 (Drosophila)	0.026
SHANK1	SH3 and multiple ankyrin repeat domains 1	0.025
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.025
DLC1	deleted in liver cancer 1	0.024
KCNF1	potassium voltage-gated channel, subfamily F, member 1	0.024
CFLAR	CASP8 and FADD-like apoptosis regulator	0.024
GJA1	gap junction protein, alpha 1, 43kDa	0.024
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.024
CDK17	cyclin-dependent kinase 17	0.023
SPAG9	sperm associated antigen 9	0.021
KDM2A	lysine (K)-specific demethylase 2A	0.021
GJA4	gap junction protein, alpha 4, 37kDa	0.021
DRD2	dopamine receptor D2	0.019
ADAM17	ADAM metallopeptidase domain 17	0.018
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.018
DOK4	docking protein 4	0.018
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.018
CISH	cytokine inducible SH2-containing protein	0.018
PTRF	polymerase I and transcript release factor	0.017
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.017
CD44	CD44 molecule (Indian blood group)	0.017
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.017
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.017
EDNRB	endothelin receptor type B	0.017
PROCR	protein C receptor, endothelial	0.017
LTK	leukocyte receptor tyrosine kinase	0.016
CD59	CD59 molecule, complement regulatory protein	0.016
HRH3	histamine receptor H3	0.016
BLK	B lymphoid tyrosine kinase	0.016
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.016
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.016
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.016
IRS1	insulin receptor substrate 1	0.016
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.016
PNOC	prepronociceptin	0.016
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.016
GPRASP1	G protein-coupled receptor associated sorting protein 1	0.015
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.015
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.015
MORC4	MORC family CW-type zinc finger 4	0.015
FRS2	fibroblast growth factor receptor substrate 2	0.015
OGDHL	oxoglutarate dehydrogenase-like	0.015
TNIP1	TNFAIP3 interacting protein 1	0.015
CORT	cortistatin	0.015
ERBB2IP	erbb2 interacting protein	0.015
CALCRL	calcitonin receptor-like	0.015
NCOA1	nuclear receptor coactivator 1	0.015
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.015
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.015
EMX1	empty spiracles homeobox 1	0.015
SP1	Sp1 transcription factor	0.015
PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	0.015
SETD7	SET domain containing (lysine methyltransferase) 7	0.015
OXT	oxytocin, prepropeptide	0.015
STAT2	signal transducer and activator of transcription 2, 113kDa	0.015
FOSL2	FOS-like antigen 2	0.015
CAPN2	calpain 2, (m/II) large subunit	0.015
IL4R	interleukin 4 receptor	0.014
FNDC3A	fibronectin type III domain containing 3A	0.014
SOX1	SRY (sex determining region Y)-box 1	0.014
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.014
FGF8	fibroblast growth factor 8 (androgen-induced)	0.014
ZEB2	zinc finger E-box binding homeobox 2	0.014
GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	0.014
BICD1	bicaudal D homolog 1 (Drosophila)	0.014
IGF1R	insulin-like growth factor 1 receptor	0.014
UTS2R	urotensin 2 receptor	0.014
CCKBR	cholecystokinin B receptor	0.014
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.014
IRF1	interferon regulatory factor 1	0.014
DEDD	death effector domain containing	0.013
PNLIPRP1	pancreatic lipase-related protein 1	0.013
AFF2	AF4/FMR2 family, member 2	0.013
PECAM1	platelet/endothelial cell adhesion molecule	0.013
CD80	CD80 molecule	0.013
ESR1	estrogen receptor 1	0.013
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.013
FOXD3	forkhead box D3	0.013
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.013
GRM5	glutamate receptor, metabotropic 5	0.013
VWF	von Willebrand factor	0.013
QKI	quaking homolog, KH domain RNA binding (mouse)	0.013
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.013
CAV1	caveolin 1, caveolae protein, 22kDa	0.013
GRM1	glutamate receptor, metabotropic 1	0.013
STRN3	striatin, calmodulin binding protein 3	0.013
PRKCG	protein kinase C, gamma	0.013
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.013
LMO2	LIM domain only 2 (rhombotin-like 1)	0.013
EMCN	endomucin	0.013
THPO	thrombopoietin	0.012
GHR	growth hormone receptor	0.012
IFNGR1	interferon gamma receptor 1	0.012
PNP	purine nucleoside phosphorylase	0.012
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.012
MYD88	myeloid differentiation primary response gene (88)	0.012
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.012
SPRED1	sprouty-related, EVH1 domain containing 1	0.012
SYN2	synapsin II	0.012
SOCS5	suppressor of cytokine signaling 5	0.012
SH2D1B	SH2 domain containing 1B	0.012
HOXD8	homeobox D8	0.012
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.012
CDK6	cyclin-dependent kinase 6	0.012
CALY	calcyon neuron-specific vesicular protein	0.012
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.012
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.012
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.012
NEUROG3	neurogenin 3	0.012
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.011
SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	0.011
FGF3	fibroblast growth factor 3	0.011
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.011
NEURL	neuralized homolog (Drosophila)	0.011
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.011
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.011
ICAM1	intercellular adhesion molecule 1	0.011
CD4	CD4 molecule	0.011
BCAR1	breast cancer anti-estrogen resistance 1	0.011
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.011
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
EFR3A	EFR3 homolog A (S. cerevisiae)	0.011
TJP1	tight junction protein 1 (zona occludens 1)	0.011
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.011
CORO1A	coronin, actin binding protein, 1A	0.011
LITAF	lipopolysaccharide-induced TNF factor	0.011
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.011
SRI	sorcin	0.011
TLX2	T-cell leukemia homeobox 2	0.011
BHLHE40	basic helix-loop-helix family, member e40	0.011
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.011
STAT5B	signal transducer and activator of transcription 5B	0.011
DOK6	docking protein 6	0.011
BIRC3	baculoviral IAP repeat containing 3	0.011
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.011
TBX1	T-box 1	0.011
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.011
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.011
GPR6	G protein-coupled receptor 6	0.011
BMX	BMX non-receptor tyrosine kinase	0.011
RIN2	Ras and Rab interactor 2	0.011
BMP4	bone morphogenetic protein 4	0.011
NXPH1	neurexophilin 1	0.011
EGF	epidermal growth factor	0.011
SMAD3	SMAD family member 3	0.011
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.011
CCND1	cyclin D1	0.011
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.011
CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.011
FRK	fyn-related kinase	0.011
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.011
MMRN1	multimerin 1	0.011
CHGB	chromogranin B (secretogranin 1)	0.011
FOXL1	forkhead box L1	0.011
MBL2	mannose-binding lectin (protein C) 2, soluble	0.011
VSTM2A	V-set and transmembrane domain containing 2A	0.011
SDS	serine dehydratase	0.011
MPZL1	myelin protein zero-like 1	0.011
FPR3	formyl peptide receptor 3	0.011
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.011
GDF10	growth differentiation factor 10	0.010
KCNK4	potassium channel, subfamily K, member 4	0.010
CHRD	chordin	0.010
IL27	interleukin 27	0.010
ITGA9	integrin, alpha 9	0.010
ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	0.010
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.010
ADRA1B	adrenergic, alpha-1B-, receptor	0.010
ALPI	alkaline phosphatase, intestinal	0.010
NOS2	nitric oxide synthase 2, inducible	0.010
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.010
VAV2	vav 2 guanine nucleotide exchange factor	0.010
GAB1	GRB2-associated binding protein 1	0.010
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.010
IL2RA	interleukin 2 receptor, alpha	0.010
FFAR2	free fatty acid receptor 2	0.010
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.010
POU4F3	POU class 4 homeobox 3	0.010
GHRHR	growth hormone releasing hormone receptor	0.010
SSFA2	sperm specific antigen 2	0.010
DICER1	dicer 1, ribonuclease type III	0.010
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.010
MATN4	matrilin 4	0.010
ITPKA	inositol-trisphosphate 3-kinase A	0.010
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.010
CHD1	chromodomain helicase DNA binding protein 1	0.010
TNP2	transition protein 2 (during histone to protamine replacement)	0.010
PKP4	plakophilin 4	0.010
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.010
GFAP	glial fibrillary acidic protein	0.010
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.010
NKX2-8	NK2 homeobox 8	0.010
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.010
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.010
PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	0.010
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	0.010
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.010
FGF7	fibroblast growth factor 7	0.010
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.010
SLC32A1	solute carrier family 32 (GABA vesicular transporter), member 1	0.010
KCNJ4	potassium inwardly-rectifying channel, subfamily J, member 4	0.010