IMP

Process View

Homo sapiens

16 genes annotated in human

specification of symmetry

The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "specification of symmetry"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "specification of symmetry" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD3	SMAD family member 3	0.991	Human Mouse
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.561
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.546	Human
SMAD2	SMAD family member 2	0.541
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.522
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.432	Mouse
BMPR1A	bone morphogenetic protein receptor, type IA	0.423	Human Zebrafish
SMAD7	SMAD family member 7	0.419	Human
SMAD1	SMAD family member 1	0.410	Human
RHOA	ras homolog gene family, member A	0.259	Fly
NOTCH1	notch 1	0.257	Zebrafish Mouse
TGFB1	transforming growth factor, beta 1	0.217
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.202
MAP2K4	mitogen-activated protein kinase kinase 4	0.199	Zebrafish
TSC2	tuberous sclerosis 2	0.190
BMP2	bone morphogenetic protein 2	0.188	Human Zebrafish
TBX5	T-box 5	0.171	Zebrafish
GSK3B	glycogen synthase kinase 3 beta	0.171
ATF2	activating transcription factor 2	0.162
FSTL1	follistatin-like 1	0.160
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.136
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.119
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.099	Human Zebrafish
FLNC	filamin C, gamma	0.093
TP53	tumor protein p53	0.085
JAG1	jagged 1	0.084
YY1	YY1 transcription factor	0.077
FKBP1A	FK506 binding protein 1A, 12kDa	0.075
TGFBR1	transforming growth factor, beta receptor 1	0.065	Human
CHRD	chordin	0.063	Zebrafish
SMAD4	SMAD family member 4	0.062	Human
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.061
ARHGAP1	Rho GTPase activating protein 1	0.059
GATA4	GATA binding protein 4	0.058	Zebrafish Mouse
PBX1	pre-B-cell leukemia homeobox 1	0.057
SMAD5	SMAD family member 5	0.052	Human Zebrafish
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.047
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.044
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.043
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.040
EZR	ezrin	0.036	Fly
ZFYVE9	zinc finger, FYVE domain containing 9	0.035
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.035	Zebrafish
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.035
SASS6	spindle assembly 6 homolog (C. elegans)	0.034
TJP1	tight junction protein 1 (zona occludens 1)	0.033
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.032
AXIN1	axin 1	0.032	Zebrafish
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.032
ACVR1	activin A receptor, type I	0.032
CD44	CD44 molecule (Indian blood group)	0.029
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.028
TCF4	transcription factor 4	0.028
CDT1	chromatin licensing and DNA replication factor 1	0.028
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.028
GDF5	growth differentiation factor 5	0.028
MAPK8	mitogen-activated protein kinase 8	0.027	Zebrafish Mouse Fly
SIRT1	sirtuin 1	0.026
PML	promyelocytic leukemia	0.026
MARK3	MAP/microtubule affinity-regulating kinase 3	0.026
PKP4	plakophilin 4	0.025
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.025
FGF10	fibroblast growth factor 10	0.025
MKL2	MKL/myocardin-like 2	0.024
LRP6	low density lipoprotein receptor-related protein 6	0.024	Mouse
ARRB2	arrestin, beta 2	0.024
PTCH1	patched 1	0.023
APC	adenomatous polyposis coli	0.023
MAPK9	mitogen-activated protein kinase 9	0.022	Fly
CXXC5	CXXC finger protein 5	0.022
EPAS1	endothelial PAS domain protein 1	0.022
BMP1	bone morphogenetic protein 1	0.022	Zebrafish
GLI1	GLI family zinc finger 1	0.022
HDAC2	histone deacetylase 2	0.021
JUN	jun proto-oncogene	0.020
SMAD6	SMAD family member 6	0.020	Human
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.020	Zebrafish Mouse
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.019
FZD1	frizzled homolog 1 (Drosophila)	0.019
NOTCH3	notch 3	0.019
RBBP7	retinoblastoma binding protein 7	0.018
EP300	E1A binding protein p300	0.018
CENPJ	centromere protein J	0.018
PSEN2	presenilin 2 (Alzheimer disease 4)	0.018
BBS2	Bardet-Biedl syndrome 2	0.018
MKL1	megakaryoblastic leukemia (translocation) 1	0.018
FGF1	fibroblast growth factor 1 (acidic)	0.017
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.017
SNIP1	Smad nuclear interacting protein 1	0.016
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.016
TTC8	tetratricopeptide repeat domain 8	0.016
MYOD1	myogenic differentiation 1	0.016
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.015
MEIS2	Meis homeobox 2	0.015
NOG	noggin	0.015
NCOR1	nuclear receptor corepressor 1	0.015
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.014
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.014
RUNX1	runt-related transcription factor 1	0.014
NOTCH2	notch 2	0.014	Mouse
MAPK1	mitogen-activated protein kinase 1	0.014
ZMYND11	zinc finger, MYND-type containing 11	0.014
MAML1	mastermind-like 1 (Drosophila)	0.013
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.013
FGF7	fibroblast growth factor 7	0.013
SFPQ	splicing factor proline/glutamine-rich	0.013
ARRB1	arrestin, beta 1	0.013
PELP1	proline, glutamate and leucine rich protein 1	0.013
PDGFC	platelet derived growth factor C	0.013
PLXNB1	plexin B1	0.013
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.013
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.013
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.012	Zebrafish
ENG	endoglin	0.012	Mouse
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.012
MYOCD	myocardin	0.012
TGFB3	transforming growth factor, beta 3	0.012
PRKG1	protein kinase, cGMP-dependent, type I	0.011
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.011
NCOR2	nuclear receptor corepressor 2	0.011
EXOC7	exocyst complex component 7	0.011
MEF2A	myocyte enhancer factor 2A	0.011
COL2A1	collagen, type II, alpha 1	0.011
SP1	Sp1 transcription factor	0.011
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.010
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.010
JUP	junction plakoglobin	0.010
ARL6	ADP-ribosylation factor-like 6	0.010
YBX1	Y box binding protein 1	0.010
NCF1	neutrophil cytosolic factor 1	0.010
BBS7	Bardet-Biedl syndrome 7	0.010
DBP	D site of albumin promoter (albumin D-box) binding protein	0.010
FLNB	filamin B, beta	0.010
WNT3A	wingless-type MMTV integration site family, member 3A	0.010	Mouse
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.010